{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:43:14Z","timestamp":1768693394960,"version":"3.49.0"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Top Young Science and Technology Talents of Guizhou Provincial Department of Education","award":["[2024]330"],"award-info":[{"award-number":["[2024]330"]}]},{"name":"Top Young Science and Technology Talents of Guizhou Provincial Department of Education","award":["ZK [2024] normal 351"],"award-info":[{"award-number":["ZK [2024] normal 351"]}]},{"name":"Top Young Science and Technology Talents of Guizhou Provincial Department of Education","award":["ZK [2023] normal 422"],"award-info":[{"award-number":["ZK [2023] normal 422"]}]},{"name":"Top Young Science and Technology Talents of Guizhou Provincial Department of Education","award":["[2022]222"],"award-info":[{"award-number":["[2022]222"]}]},{"name":"Basic Research Program of Guizhou Provincial Department of Science and Technology","award":["[2024]330"],"award-info":[{"award-number":["[2024]330"]}]},{"name":"Basic Research Program of Guizhou Provincial Department of Science and Technology","award":["ZK [2024] normal 351"],"award-info":[{"award-number":["ZK [2024] normal 351"]}]},{"name":"Basic Research Program of Guizhou Provincial Department of Science and Technology","award":["ZK [2023] normal 422"],"award-info":[{"award-number":["ZK [2023] normal 422"]}]},{"name":"Basic Research Program of Guizhou Provincial Department of Science and Technology","award":["[2022]222"],"award-info":[{"award-number":["[2022]222"]}]},{"name":"Youth Talent Development Project of Guizhou Provincial Department of Education","award":["[2024]330"],"award-info":[{"award-number":["[2024]330"]}]},{"name":"Youth Talent Development Project of Guizhou Provincial Department of Education","award":["ZK [2024] normal 351"],"award-info":[{"award-number":["ZK [2024] normal 351"]}]},{"name":"Youth Talent Development Project of Guizhou Provincial Department of Education","award":["ZK [2023] normal 422"],"award-info":[{"award-number":["ZK [2023] normal 422"]}]},{"name":"Youth Talent Development Project of Guizhou Provincial Department of Education","award":["[2022]222"],"award-info":[{"award-number":["[2022]222"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Rosa roxburghii Tratt is widely cultivated in southwestern areas of China for a range of purposes, including food and medicine. To enhance its application value, one previously undescribed compound (1) and six known compounds (2\u20137) were isolated from the roots of R. roxburghii. The structures of compounds (1\u20137) were determined through NMR, HR-MS, and CD experiments, and by comparison of their spectroscopic data with values from the literature. Roxbubenzoate A (1) contained a benzoyl glucuronosyl glycerol scaffold featuring a rare \u03b1-glucuronosyl linkage. Seven compounds (1\u20137) were tested for their anti-inflammatory, \u03b1-glucosidase-inhibitory, and radical-scavenging activities. Compound 3 showed a significant inhibitory effect on the release of NO in LPS-induced RAW264.7 macrophages, with an IC50 value of 7.8 \u00b1 0.2 \u03bcM. Compounds 2, 4, and 7 exhibited moderate inhibitory activity against \u03b1-glucosidase, with inhibition rates of 50.1%, 46.7%, and 41.1% at a concentration of 200 \u03bcM, respectively. Compounds 1, 2, and 6 exhibited moderate ABTS radical-scavenging activity, with IC50 values of 107.0 \u00b1 1.1, 142.6 \u00b1 0.8, and 128.3 \u00b1 1.2 \u03bcM, respectively. The network pharmacological analysis and molecular docking results suggested that 3 may be able to treat inflammation by binding TNF-\u03b1 and IL-6 targets. Finally, the expression of IL-6 and TNF-\u03b1 in LPS-induced RAW264.7 macrophages was detected through ELISA, and 3 showed a strong inhibitory effect on IL-6 release. These findings offer a novel perspective on the development of rich medicinal plant resources from R. roxburghii roots.<\/jats:p>","DOI":"10.3390\/ijms26031353","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T04:47:31Z","timestamp":1738817251000},"page":"1353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biological Activities of Constituents from Rosa roxburghii and Their Mechanisms Based on Network Pharmacology and Biological Verification"],"prefix":"10.3390","volume":"26","author":[{"given":"Li-Juan","family":"Xiang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Liang","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Xiang","family":"Long","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8074-686X","authenticated-orcid":false,"given":"Xin","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114290","DOI":"10.1016\/j.phytochem.2024.114290","article-title":"Chemical constituents with their alpha-glucosidase inhibitory activity from the whole plant of Ceratophyllum demersum","volume":"229","author":"Duong","year":"2024","journal-title":"Phytochemistry"},{"key":"ref_2","first-page":"38","article-title":"Ethnobotanical Study on Rosa roxburghii in Guizhou","volume":"22","author":"Li","year":"2016","journal-title":"China Acad. 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