{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:48:11Z","timestamp":1777081691949,"version":"3.51.4"},"reference-count":77,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council of Taiwan","award":["NSTC 112-2410-H-431-009"],"award-info":[{"award-number":["NSTC 112-2410-H-431-009"]}]},{"name":"National Science and Technology Council of Taiwan","award":["NSTC 113-2923-H-431-001-MY3"],"award-info":[{"award-number":["NSTC 113-2923-H-431-001-MY3"]}]},{"name":"National Science and Technology Council of Taiwan","award":["NSTC 113-2410-H-431-015-MY2"],"award-info":[{"award-number":["NSTC 113-2410-H-431-015-MY2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>How to determine suitable animal models of anxiety disorders and post-traumatic stress disorders (PTSD) for screening anxiolytic drugs and linking preclinical and clinical research is a crucial issue. This review paper provides background knowledge and critical determination to the animal models for discussing this issue. Moreover, this article analyzes the characteristics, properties, advantages, and disadvantages of various animal models of anxiety disorders and PTSD. It offers an overview of the pathophysiology, treatments, prevalence, and symptoms of anxiety disorders in the clinics. Furthermore, it comprehensively discusses pharmacological treatments and neural mechanisms, as well as the types and properties of the animal models of anxiety disorders in shaping and testing anxiety behaviors. In light of the previous literature discussion, we can understand the different functions of the animal models of anxiety disorders and PTSD to help us link preclinical and clinical research. Animal models are used in advanced drug discovery programs, specifically in psychiatry and neuroscience research. The challenge for the future will be to keep pace with developing the appropriate animal models of anxiolytic drugs to improve the translation of large datasets obtained to clinics.<\/jats:p>","DOI":"10.3390\/ijms26041414","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:07:56Z","timestamp":1738922876000},"page":"1414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Anxiety Disorders and Post-Traumatic Stress Disorders for Screening Anxiolytic Drugs and Linking Preclinical and Clinical Research"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-8496","authenticated-orcid":false,"given":"Anna","family":"Koz\u0142owska","sequence":"first","affiliation":[{"name":"Department of Human Physiology and Pathophysiology, Collegium Medicum, University of Warmia and Mazury, Warszawska Av, 30, 10-082 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7522-2991","authenticated-orcid":false,"given":"Wan-Jiun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Psychology, Fo Guang University, Yilan County 26247, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai-Chuang","family":"Shyu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-7302","authenticated-orcid":false,"given":"Andrew Chih Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychology, Fo Guang University, Yilan County 26247, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"176994","DOI":"10.1016\/j.ejphar.2024.176994","article-title":"Anxiety disorders: Treatments, models, and circuitry mechanisms","volume":"983","author":"Ren","year":"2024","journal-title":"Eur. 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