{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:51:31Z","timestamp":1790905891598,"version":"4.1.0"},"reference-count":86,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271013"],"award-info":[{"award-number":["32271013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["202310286036Z"],"award-info":[{"award-number":["202310286036Z"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Training Program of Innovation and Entrepreneurship for Undergraduates","award":["32271013"],"award-info":[{"award-number":["32271013"]}]},{"name":"National Training Program of Innovation and Entrepreneurship for Undergraduates","award":["202310286036Z"],"award-info":[{"award-number":["202310286036Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Muscular dystrophy is a group of complicated, genetically heterogeneous disorders characterized by progressive muscle weakness and degeneration. Due to the intricate nature, understanding the molecular mechanisms underlying muscular dystrophy presents significant challenges. Drosophila, as a versatile and genetically tractable model organism, offers substantial advantages in muscular dystrophy research. In the present review, we summarize the application of Drosophila in studying various types of muscular dystrophy, highlighting the insights gained through genetic manipulations, disease modeling, and the exploration of molecular pathways. Drosophila serves as a powerful system for understanding disease progression, exploring the roles of key genes in muscle function and pathology, and identifying novel therapeutic targets. The review highlights the significant role of Drosophila in advancing our understanding of muscular dystrophy.<\/jats:p>","DOI":"10.3390\/ijms26041459","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T05:53:22Z","timestamp":1739166802000},"page":"1459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Drosophila melanogaster: A Model Organism in Muscular Dystrophy Studies"],"prefix":"10.3390","volume":"26","author":[{"given":"Yu","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4965-3176","authenticated-orcid":false,"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayibota","family":"Tulehalede","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Meng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huashuai","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Sha","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-8870","authenticated-orcid":false,"given":"Junhua","family":"Geng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Nanjing 210096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-0854.2006.00523.x","article-title":"Golgi complex organization in skeletal muscle: A role for Golgi-mediated glycosylation in muscular dystrophies?","volume":"8","author":"Percival","year":"2007","journal-title":"Traffic"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Nickolls, A.R., and Bonnemann, C.G. 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