{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:20:47Z","timestamp":1792804847863,"version":"4.5.0"},"reference-count":79,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Endowment Fund \u201cDochki-Materi\u201d","id":[{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The vector of modern obstetrics is aimed at finding ways to predict various placenta-associated complications, including those associated with neuronal dysfunction on in fetal growth restriction (FGR). The technology of fetal neuronal exosome (FNE) isolation from the maternal bloodstream opens up unique opportunities for detecting early signs of fetal brain damage. Using this method, FNEs were isolated from the blood of pregnant women with and without early-onset FGR, and the expression of a number of proteins in their composition was assessed (Western blotting). Significant changes in the level of proteins involved in neurogenesis (pro-BDNF (brain-derived neurotrophic factor), pro-NGF (nerve growth factor), TAG1\/Contactin2) and presynaptic transmission (Synapsin 1, Synaptophysin) were revealed. The preliminary data on the expression of FNE proteins that perform post-translational modifications\u2014sumoylation (SUMO 1, UBC9) and neddylation (NEDD8, UBC12)\u2014were obtained. A relationship was established between altered protein expression and neonatal outcomes in newborns with growth restriction. Our study opens up new possibilities for non-invasive prenatal monitoring of fetal neurodevelopment disorders and possibilities of their correction in placenta-associated diseases.<\/jats:p>","DOI":"10.3390\/ijms26041497","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:34:32Z","timestamp":1739252072000},"page":"1497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Non-Invasive Assessment of Neurogenesis Dysfunction in Fetuses with Early-Onset Growth Restriction Using Fetal Neuronal Exosomes Isolating from Maternal Blood: A Pilot Study"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-6224","authenticated-orcid":false,"given":"Vladislava","family":"Gusar","sequence":"first","affiliation":[{"name":"Laboratory of Applied Transcriptomics, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kan","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-3464","authenticated-orcid":false,"given":"Anastasia","family":"Leonova","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostic Methods and Personalized Medicine, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaliy","family":"Chagovets","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolomics and Bioinformatics, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tyutyunnik","sequence":"additional","affiliation":[{"name":"Center for Scientific and Clinical Research, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. 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