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Soluplus\u00ae (SLP), an amphiphilic graft copolymer made of polyethylene glycol, polyvinyl caprolactam, and polyvinyl acetate, has been gaining interest in recent years as it addresses these limitations by acting as a versatile carrier. Its ability to form stable amorphous dispersions and enhance drug solubility, as well as its physicochemical properties, support its role as a key excipient in advanced drug delivery systems. Recent investigations have demonstrated the adaptability of SLP in addressing drug delivery requirements, offering controlled release, improved targeting, and superior therapeutic outcomes. This review examines some key formulation methods that make use of SLP, including hot-melt extrusion, spray drying, electrospinning, drug\u2013polymer layering, and capsule and tablet formulations, highlighting the capacity of SLP to overcome formulation challenges. Biomedical applications of SLP have also been explored, with a focus on its role in improving the delivery of antitumoral, anti-inflammatory, antimicrobial, and antiparasitic drugs.<\/jats:p>","DOI":"10.3390\/ijms26041499","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:34:32Z","timestamp":1739252072000},"page":"1499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Soluplus\u00ae-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-5213","authenticated-orcid":false,"given":"Nerea","family":"Guembe-Michel","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Science, University of Navarra, 31080 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-7316","authenticated-orcid":false,"given":"Paul","family":"Nguewa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Navarra Institute for Health Research (IdisNA), University of Navarra, 31080 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-6710","authenticated-orcid":false,"given":"Gustavo","family":"Gonz\u00e1lez-Gaitano","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Science, University of Navarra, 31080 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2005.11.024","article-title":"Formulation and biological evaluation of glimepiride-cyclodextrin-polymer systems","volume":"309","author":"Ammar","year":"2006","journal-title":"Int. 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