{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:59:27Z","timestamp":1767664767345,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Chemical Technology, University of Pardubice","award":["SGS_2025_001","ID: 90254","23-06465S"],"award-info":[{"award-number":["SGS_2025_001","ID: 90254","23-06465S"]}]},{"name":"e-INFRA CZ project","award":["SGS_2025_001","ID: 90254","23-06465S"],"award-info":[{"award-number":["SGS_2025_001","ID: 90254","23-06465S"]}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["SGS_2025_001","ID: 90254","23-06465S"],"award-info":[{"award-number":["SGS_2025_001","ID: 90254","23-06465S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["SGS_2025_001","ID: 90254","23-06465S"],"award-info":[{"award-number":["SGS_2025_001","ID: 90254","23-06465S"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In this study, three dinuclear copper(II) complexes of ligand 2,6-bis[(N-methyl-piperazine-1-yl)methyl]-4-formyl phenol (L1) and one of 2,6-bis[(N-methylpiperazine-1-yl)methyl]-4-formyl phenol dimethylacetal (L2) with copper(II) ions have been investigated as new types of biomimetic catalysts for the oxidative transformation of different aminophenols and phenyldiamines. All the complexes of interest were newly synthesized and further characterized by IR spectroscopy, UV-Vis and mass spectrometry, X-ray diffraction, and selected electrochemical measurements. Crystal structures of these dinuclear copper(II) complexes have revealed that the coordination-shell geometry of copper atoms is close to a tetragonal pyramid. Catecholase, phenoxazinone synthase, and horseradish peroxidase-like activities were observed in pure methanol and water\u2013methanol mixtures in the presence of molecular oxygen. The potential applicability of the complexes under study is discussed with respect to their possibilities and limitations in the replacement of natural copper-containing oxidoreductases in the oxidative degradation of water-insoluble chlorinated aminophenols in the dye industry or in the production of phenoxazine-based drugs.<\/jats:p>","DOI":"10.3390\/ijms26041603","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T10:36:58Z","timestamp":1739443018000},"page":"1603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dinuclear Copper(II) Complexes of 2,6-Bis[(N-Methylpiperazine-1-yl)methyl]-4-Formyl Phenol Ligand: Promising Biomimetic Catalysts for Dye Residue Degradation and Drug Synthesis"],"prefix":"10.3390","volume":"26","author":[{"given":"Michaela","family":"B\u00e1rtov\u00e1","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Li\u0161ka","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry of the CAS, Dolej\u0161kova 3, 182 23 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vendula","family":"Studen\u00e1","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Sciences, Charles University, Albertov 2030, Prague 2, 120 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Vojt\u00ed\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Sciences, Charles University, Albertov 2030, Prague 2, 120 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0589-735X","authenticated-orcid":false,"given":"Michal","family":"Ka\u0161par","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Mikysek","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1044-2991","authenticated-orcid":false,"given":"Lenka","family":"\u010ceslov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-345X","authenticated-orcid":false,"given":"Ivan","family":"\u0160vancara","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-3659","authenticated-orcid":false,"given":"Milan","family":"S\u00fds","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"148806","DOI":"10.1016\/j.scitotenv.2021.148806","article-title":"Assessment of the compounds formed by oxidative reaction between p-toluenediamine and p-aminophenol in hair dyeing processes: Detection, mutagenic and toxicological properties","volume":"795","author":"Souza","year":"2021","journal-title":"Sci. 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