{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:35:40Z","timestamp":1782909340193,"version":"3.54.5"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union-NextGenerationEU through the National Recovery and Resilience Plan of the Republic of Bulgaria, project","award":["BG-RRP-2.004-0004-C01"],"award-info":[{"award-number":["BG-RRP-2.004-0004-C01"]}]},{"name":"European Union-NextGenerationEU through the National Recovery and Resilience Plan of the Republic of Bulgaria, project","award":["5\/2022"],"award-info":[{"award-number":["5\/2022"]}]},{"name":"European Union-NextGenerationEU through the National Recovery and Resilience Plan of the Republic of Bulgaria, project","award":["BG-RRP-2.004-0006-C02"],"award-info":[{"award-number":["BG-RRP-2.004-0006-C02"]}]},{"name":"Faculty of Medicine at Trakia University\u2014Stara Zagora","award":["BG-RRP-2.004-0004-C01"],"award-info":[{"award-number":["BG-RRP-2.004-0004-C01"]}]},{"name":"Faculty of Medicine at Trakia University\u2014Stara Zagora","award":["5\/2022"],"award-info":[{"award-number":["5\/2022"]}]},{"name":"Faculty of Medicine at Trakia University\u2014Stara Zagora","award":["BG-RRP-2.004-0006-C02"],"award-info":[{"award-number":["BG-RRP-2.004-0006-C02"]}]},{"name":"ulgarian Ministry of Education and Science in the frames of the Bulgarian National Recovery and Resilience Plan, Component \u201cInnovative Bulgaria\u201d, Project","award":["BG-RRP-2.004-0004-C01"],"award-info":[{"award-number":["BG-RRP-2.004-0004-C01"]}]},{"name":"ulgarian Ministry of Education and Science in the frames of the Bulgarian National Recovery and Resilience Plan, Component \u201cInnovative Bulgaria\u201d, Project","award":["5\/2022"],"award-info":[{"award-number":["5\/2022"]}]},{"name":"ulgarian Ministry of Education and Science in the frames of the Bulgarian National Recovery and Resilience Plan, Component \u201cInnovative Bulgaria\u201d, Project","award":["BG-RRP-2.004-0006-C02"],"award-info":[{"award-number":["BG-RRP-2.004-0006-C02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The carotid body (CB), the main peripheral arterial chemoreceptor, exhibits considerable structural and neurochemical plasticity in response to pathological conditions such as high blood pressure. Previous studies have shown that morphological alterations in the hypertensive CB are characterized by enlarged parenchyma due to cellular hypertrophy and hyperplasia, and vasodilation. To test whether hypertension can also induce neoangiogenesis and modulate its chemosensory function, we examined the immunohistochemical expression of two angiogenic factors, vascular endothelial growth factor (VEGF) and endothelin-1 (ET), and their corresponding receptors in the CB of adult spontaneously hypertensive rats (SHRs), and compared their expression patterns to that of age-matched normotensive Wistar rats (NWR). We found an increased VEGF-A and B, and VEGFR-2 expression in glomus and endothelial cells in the enlarged CB glomeruli of SHRs compared with that in NWR. Conversely, weaker immunoreactivity to VEGFR-1 was detected in cell clusters of the hypertensive CB. The expression of endothelin-converting enzyme 1 and its receptor ETA was higher in a subset of glomus cells in the normotensive CB, while the immunoreactivity to the ETB receptor was enhanced in endothelial cells of CB blood vessels in SHRs. The elevated endothelial expression of VEGF and ET-1 suggests their role as local vascular remodeling factors in the adaptation to hypertension, though their involvement in the cellular rearrangement and modulation of chemosensory function could also be implied.<\/jats:p>","DOI":"10.3390\/ijms26041620","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T03:20:52Z","timestamp":1739503252000},"page":"1620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered Expression Levels of Angiogenic Peptides in the Carotid Body of Spontaneously Hypertensive Rats"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-7755","authenticated-orcid":false,"given":"Dimitrinka Y.","family":"Atanasova","sequence":"first","affiliation":[{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"},{"name":"Department of Anatomy, Faculty of Medicine, Trakia University, 6003 Stara Zagora, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-940X","authenticated-orcid":false,"given":"Pavel I.","family":"Rashev","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"},{"name":"Institute of Biology and Immunology of Reproduction \u201cAcad. Kiril Bratanov\u201d, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena S.","family":"Mourdjeva","sequence":"additional","affiliation":[{"name":"Institute of Biology and Immunology of Reproduction \u201cAcad. Kiril Bratanov\u201d, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina V.","family":"Pupaki","sequence":"additional","affiliation":[{"name":"Institute of Biology and Immunology of Reproduction \u201cAcad. Kiril Bratanov\u201d, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Hristova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Trakia University, 6003 Stara Zagora, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel D.","family":"Dandov","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, Medical University of Sofia, 1431 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai E.","family":"Lazarov","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"},{"name":"Department of Anatomy and Histology, Medical University of Sofia, 1431 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-031-44757-0_1","article-title":"Carotid body: The primary peripheral arterial chemoreceptor","volume":"237","author":"Lazarov","year":"2023","journal-title":"Adv. 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