{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:49:53Z","timestamp":1788259793617,"version":"build-2803163510"},"reference-count":105,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ecretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["20241600"],"award-info":[{"award-number":["20241600"]}]},{"name":"ecretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["20240556"],"award-info":[{"award-number":["20240556"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hedeoma piperita Benth. (Lamiaceae) is a native medicinal plant from Mexico. It grows in pine, oak, and oyamel forests, as well as grasslands. In the Pur\u00e9pecha Plateau of Michoac\u00e1n, it is called quiensabe and traditionally used to treat stomach pain, colic, cough, and low blood pressure, among other ailments. This study aimed to determine the phytochemical profile of infusions and ethanolic extracts of the stems and green and purple leaves of H. piperita collected in Cher\u00e1n, Michoac\u00e1n. Total phenols, flavonoids, anthocyanins, and terpenoids were analyzed using UV\u2013visible spectrophotometry; specific phenolic acids and flavonoids were detected by high performance thin layer chromatography (HPTLC); and the volatile profile of stems, green and purple leaves was determined by solid phase microextraction in GC-MS. Biological activities such as antioxidant activities (via DPPH and ABTS methods), antihypertensive activities (angiotensin converting enzyme (ACE) inhibition), antibacterial activities (minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC), anti-inflammatory activities (xanthine oxidase enzyme (XOD) inhibition) and antidiabetic activities (\u03b1-glucosidase enzyme inhibition) were evaluated in vitro. Results showed key compounds like rosmarinic acid, luteolin, menthone, menthol, and pulegone were identified using HPTLC and SPME\/GC-MS, with organ-specific variations. Green and purple leaves infusions inhibited DPPH and ABTS+ by 90\u201399% (IC50 3.3\u20133.8 and 7.4\u201311.5 \u00b5g\/mL, respectively) and purple leaves infusion showed a 69.88% XOD enzyme inhibition (IC50 47.991 \u00b5g\/mL) and an 85.12% \u03b1-glucosidase enzyme inhibition (IC50 72.49 \u00b5g\/mL). Purple leaves ethanolic extract exhibited the lowest MIC and MBC against Shigella flexneri and ACE inhibition at 97.25% (IC50 11.19 \u00b5g\/mL). These results demonstrate the biological potential of H. piperita in the development of natural drugs and expand its use as an herbal remedy.<\/jats:p>","DOI":"10.3390\/ijms26041640","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T11:14:41Z","timestamp":1739531681000},"page":"1640","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phytochemistry and Biological Activities of Hedeoma piperita Benth. (Quiensabe)"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-1297","authenticated-orcid":false,"given":"Jeanette Guadalupe","family":"C\u00e1rdenas-Valdovinos","sequence":"first","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Centro de Investigaci\u00f3n en Biotecnolog\u00eda Aplicada (CIBA-IPN), Tepetitla 90700, Tlaxcala, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-7506","authenticated-orcid":false,"given":"Hortencia Gabriela","family":"Mena-Violante","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Centro Interdisciplinario de Investigaci\u00f3n para el Desarrollo Integral Regional Unidad Michoac\u00e1n (CIIDIR-IPN Unidad Michoac\u00e1n), Jiquilpan 59510, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor de F\u00e1tima","family":"Rosas-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Centro de Investigaci\u00f3n en Biotecnolog\u00eda Aplicada (CIBA-IPN), Tepetitla 90700, Tlaxcala, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-9354","authenticated-orcid":false,"given":"Mar\u00eda Valentina","family":"Angoa-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Centro Interdisciplinario de Investigaci\u00f3n para el Desarrollo Integral Regional Unidad Michoac\u00e1n (CIIDIR-IPN Unidad Michoac\u00e1n), Jiquilpan 59510, Michoac\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Luna-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Centro de Investigaci\u00f3n en Biotecnolog\u00eda Aplicada (CIBA-IPN), Tepetitla 90700, Tlaxcala, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","unstructured":"SEMARNAT, Secretar\u00eda de Medio Ambiente y Recursos Naturales (2021, June 06). 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