{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:02:22Z","timestamp":1791543742079,"version":"4.3.4"},"reference-count":200,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The relationship between neuroinflammation and depression is a complex area of research that has garnered significant attention in recent years. Neuroinflammation, characterized by the activation of glial cells and the release of pro-inflammatory cytokines, has been implicated in the pathophysiology of depression. The relationship between neuroinflammation and depression is bidirectional; not only can inflammation contribute to the onset of depressive symptoms, but depression itself can also exacerbate inflammatory responses, creating a vicious cycle that complicates treatment and recovery. The present comprehensive review aimed to explore the current findings on the interplay between neuroinflammation and depression, as well as the mechanisms, risk factors, and therapeutic implications. The mechanisms by which neuroinflammation induces depressive-like behaviors are diverse. Neuroinflammation can increase pro-inflammatory cytokines, activate the hypothalamus\u2013pituitary\u2013adrenal (HPA) axis, and impair serotonin synthesis, all of which contribute to depressive symptoms. Furthermore, the activation of microglia has been linked to the release of inflammatory mediators that can disrupt neuronal function and contribute to mood disorders. Stress-induced neuroinflammatory responses can lead to the release of pro-inflammatory cytokines that not only affect brain function but also influence behavior and mood. Understanding these mechanisms is crucial for developing targeted therapies that can mitigate the effects of neuroinflammation on mood disorders.<\/jats:p>","DOI":"10.3390\/ijms26041645","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T11:14:41Z","timestamp":1739531681000},"page":"1645","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Unraveling the Complex Interplay Between Neuroinflammation and Depression: A Comprehensive Review"],"prefix":"10.3390","volume":"26","author":[{"given":"Andreea","family":"S\u0103lcudean","sequence":"first","affiliation":[{"name":"Department of Ethics and Social Sciences, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-9060","authenticated-orcid":false,"given":"Ramona-Amina","family":"Popovici","sequence":"additional","affiliation":[{"name":"Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Bv., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3959-9901","authenticated-orcid":false,"given":"Dana Emanuela","family":"Pitic","sequence":"additional","affiliation":[{"name":"Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Bv., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"S\u00e2rbu","sequence":"additional","affiliation":[{"name":"Doctoral School of Pharmacy, Victor Babes University of Medicine and Pharmacy of Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Boroghina","sequence":"additional","affiliation":[{"name":"Doctoral School of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Bv., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Jomaa","sequence":"additional","affiliation":[{"name":"Doctoral School of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Bv., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matin Asad","family":"Salehi","sequence":"additional","affiliation":[{"name":"Doctoral School of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Bv., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alsayed Ahmad Mhd","family":"Kher","sequence":"additional","affiliation":[{"name":"Doctoral School of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Bv., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-0123","authenticated-orcid":false,"given":"Maria Melania","family":"Lica","sequence":"additional","affiliation":[{"name":"Department of Ethics and Social Sciences, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Raluca","family":"Bodo","sequence":"additional","affiliation":[{"name":"Department of Ethics and Social Sciences, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-1142","authenticated-orcid":false,"given":"Virgil Radu","family":"Enatescu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","first-page":"967","article-title":"Neuroinflammation in the Amygdala Is Associated with Recent Depressive Symptoms","volume":"8","author":"Zhang","year":"2023","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12974-022-02684-8","article-title":"Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1017\/S1461145711001891","article-title":"Enriched pathways for major depressive disorder identified from a genome-wide association study","volume":"15","author":"Kao","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/jorc.12162","article-title":"Exploring depression amongst kidney transplant recipients: A literature review","volume":"42","author":"Veater","year":"2016","journal-title":"J. Ren. Care"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Samara, A., Murphy, T., Strain, J., Rutlin, J., Sun, P., Neyman, O., Sreevalsan, N., Shimony, J.S., Ances, B.M., and Song, S.-K. (2020). Neuroinflammation and white matter alterations in obesity assessed by diffusion basis spectrum imaging. Front. Hum. Neurosci., 13.","DOI":"10.3389\/fnhum.2019.00464"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1258\/ijsa.2009.009451","article-title":"Depression associated with antiretroviral drug therapy in HIV: Case report and overview","volume":"23","author":"Kaestner","year":"2012","journal-title":"Int. J. STD Aids"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e028527","DOI":"10.1136\/bmjopen-2018-028527","article-title":"Complementary therapies for clinical depression: An overview of systematic reviews","volume":"9","author":"Haller","year":"2019","journal-title":"BMJ Open"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1192\/j.eurpsy.2020.24","article-title":"Cognitive functioning and lifetime major depressive disorder in UK biobank","volume":"63","author":"Nooij","year":"2020","journal-title":"Eur. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fornaro, M., De Berardis, D., Perna, G., Solmi, M., Veronese, N., Orsolini, L., Buonaguro, E.F., Iasevoli, F., K\u00f6hler, C.A., and Carvalho, A.F. (2017). Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews. Biomed Res. Int., 2017.","DOI":"10.1155\/2017\/3084859"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41386-018-0148-z","article-title":"Sex differences and the neurobiology of affective disorders","volume":"44","author":"Rubinow","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/mp.2009.94","article-title":"Sex, trauma, stress hormones and depression","volume":"15","author":"Young","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1055\/s-0032-1312592","article-title":"Sex, stress, and mood disorders: At the intersection of adrenal and gonadal hormones","volume":"44","author":"Fiedler","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000504388","article-title":"Biological Sex and IgE Sensitization Influence Severity of Depression and Cortisol Levels in Atopic Dermatitis","volume":"236","author":"Vinnik","year":"2020","journal-title":"Dermatology"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Qin, D.D., Rizak, J., Feng, X.L., Yang, S.C., L\u00fc, L.B., Pan, L., Yin, Y., and Hu, X.T. (2016). Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour. Sci. Rep., 6.","DOI":"10.1038\/srep30187"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Seney, M.L., Ekong, K.I., Ding, Y., Tseng, G.C., and Sibille, E. (2013). Sex chromosome complement regulates expression of mood-related genes. Biol. Sex Differ., 4.","DOI":"10.1186\/2042-6410-4-20"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.yfrne.2014.03.008","article-title":"Sex differences in stress-related psychiatric disorders: Neurobiological perspectives","volume":"35","author":"Bangasser","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.20319\/lijhls.2019.53.4162","article-title":"How can we use neurotransmitters in emotion and reward system to study depression?","volume":"5","author":"Zhang","year":"2019","journal-title":"LIFE Int. J. Health Life-Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Silverstein, L.B., and Goodrich, T.J. (2003). Gender, marriage, and depression. Feminist Family Therapy: Empowerment in Social Context, American Psychological Association.","DOI":"10.1037\/10615-000"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e2122310","DOI":"10.1001\/jamanetworkopen.2021.22310","article-title":"Recognizing the Complexity of Psychosocial Factors Associated with Children\u2019s Development-the Case of Maternal Depression","volume":"4","author":"Jensen","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1037\/a0018747","article-title":"Reactivity to daily stressors in adulthood: The importance of stressor type in characterizing risk factors","volume":"25","author":"Hay","year":"2010","journal-title":"Psychol. Aging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1037\/a0023632","article-title":"Relations of sars-related stressors and coping to Chinese college students\u2019 psychological adjustment during the 2003 Beijing sars epidemic","volume":"58","author":"Main","year":"2011","journal-title":"J. Couns. Psychol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/WNR.0000000000001832","article-title":"Chronic multiple mild stress induces sustained adverse psychological states in rats","volume":"33","author":"Yu","year":"2022","journal-title":"Neuroreport"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.31925\/farmacia.2023.3.23","article-title":"The efficacy of antidepressive treatment on COVID-19 pandemic-related depressive symptoms\u2014A prospective, single-center, questionnaire-based study","volume":"71","author":"Nan","year":"2023","journal-title":"Farmacia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1037\/hea0001328","article-title":"Type D personality and cardiovascular reactivity to acute psychological stress: A systematic review and meta-analysis","volume":"42","year":"2023","journal-title":"Health Psychol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1037\/a0040064","article-title":"Building resilience through exposure to stressors: The effects of challenges versus hindrances","volume":"21","author":"Crane","year":"2016","journal-title":"J. Occup. Health Psychol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1111\/ejn.15721","article-title":"Effects of psychological stress and cortisol on decision making and modulating factors: A systematic review","volume":"56","author":"Duque","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1037\/cdp0000461","article-title":"Latinx adolescents facing multiple stressors and the protective role of families","volume":"27","author":"Montoro","year":"2021","journal-title":"Cult. Divers. Ethn. Minor. Psychol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1037\/a0036707","article-title":"Stigma-related stressors, coping self-efficacy, and physical health in lesbian, gay, and bisexual individuals","volume":"61","author":"Denton","year":"2014","journal-title":"J. Couns. Psychol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1108\/IJBPA-02-2020-0011","article-title":"A systematic review of mental stressors in the construction industry","volume":"39","author":"Tijani","year":"2020","journal-title":"Int. J. Build. Pathol. Adapt."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cardozo, B., Crawford, C., Eriksson, C., Zhu, J., Sabin, M., Ager, A., Foy, D., Snider, L., Scholte, W., and Kaiser, R. (2012). Psychological distress, depression, anxiety, and burnout among international humanitarian aid workers: A longitudinal study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044948"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pang, S., Wu, H., Wang, Q., Cai, M., Shi, W., and Shang, J. (2014). Chronic stress suppresses the expression of cutaneous hypothalamic-pituitary-adrenocortical axis elements and melanogenesis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098283"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.psyneuen.2012.11.004","article-title":"Influence of hypothalamic il-6\/gp130 receptor signaling on the HPA axis response to chronic stress","volume":"38","author":"Girotti","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"367619","DOI":"10.1093\/ecam\/nep218","article-title":"Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats","volume":"2011","author":"Liu","year":"2011","journal-title":"Evid. -Based Complement. Altern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.neuroscience.2006.05.011","article-title":"Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons","volume":"141","author":"Zhu","year":"2006","journal-title":"Neuroscience"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhu, L., Liu, M., Li, H., Liu, X., Chen, C., Han, Z., Wu, H.-Y., Jing, X., Zhou, H.-H., and Suh, H. (2014). The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097689"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bouligand, J., Delemer, B., Hecart, A.C., Meduri, G., Viengchareun, S., Amazit, L., Trabado, S., F\u00e8ve, B., Guiochon-Mantel, A., and Young, J. (2010). Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013563"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.3892\/mmr.2015.4406","article-title":"Investigation into hippocampal nerve cell damage through the mineralocorticoid receptor in mice","volume":"12","author":"Sasaki","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ng.3283","article-title":"NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells","volume":"47","author":"Paugh","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1210\/jc.2006-2830","article-title":"A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance","volume":"92","author":"Charmandari","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1073\/pnas.0800888106","article-title":"Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter","volume":"106","author":"Numakawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/nn.3266","article-title":"Glucocorticoid receptors recruit the CaMKII\u03b1-BDNF-CREB pathways to mediate memory consolidation","volume":"15","author":"Chen","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kinlein, S.A., Wilson, C.D., and Karatsoreos, I.N. (2015). Dysregulated hypothalamic-pituitary-adrenal axis function contributes to altered endocrine and neurobehavioral responses to acute stress. Front. Psychiatry, 6.","DOI":"10.3389\/fpsyt.2015.00031"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1037\/abn0000087","article-title":"Predicting first onset of depression in young girls: Interaction of diurnal cortisol and negative life events","volume":"124","author":"LeMoult","year":"2015","journal-title":"J. Abnorm. Psychol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jadohealth.2017.06.005","article-title":"Diurnal cortisol interacts with stressful events to prospectively predict depressive symptoms in adolescent girls","volume":"61","author":"Schuler","year":"2017","journal-title":"J. Adolesc. Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/acps.12576","article-title":"Recovery from major depressive disorder episode after non-pharmacological treatment is associated with normalized cytokine levels","volume":"134","author":"Dahl","year":"2016","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Melnikov, M., and Lopatina, A. (2022). Th17-cells in depression: Implication in multiple sclerosis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1010304"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2174\/1570159X14666160106155331","article-title":"Systems genomics support for immune and inflammation hypothesis of depression","volume":"14","author":"Sharma","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, J., Yang, J., Han, D., Zhao, X., Ma, J., Ban, B., Zhu, X., Yang, Y., Cao, D., and Qiu, X. (2018). Dvl3 polymorphism interacts with life events and pro-inflammatory cytokines to influence major depressive disorder susceptibility. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-31530-2"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Barreto, R.A., Walker, F.R., Dunkley, P.R., Day, T.A., and Smith, D.W. (2012). Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?. BMC Neurosci., 13.","DOI":"10.1186\/1471-2202-13-125"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhu, X., Dong, J., Han, B., Huang, R., Zhang, A., Xia, Z., Chang, H., Chao, J., and Yao, H. (2017). Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior. Front. Behav. Neurosci., 11.","DOI":"10.3389\/fnbeh.2017.00203"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3233\/JAD-148009","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI). Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults","volume":"45","author":"Nho","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbi.2019.04.041","article-title":"Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation","volume":"85","author":"Gialluisi","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s12035-023-03737-6","article-title":"Acupuncture ameliorates depression-like behaviors through modulating the neuroinflammation mediated by the TLR4 signaling pathway in rats exposed to chronic restraint stress","volume":"61","author":"Jiang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e2935","DOI":"10.1002\/brb3.2935","article-title":"Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p\/HECTD1 axis","volume":"13","author":"Chen","year":"2023","journal-title":"Brain Behav."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: A review","volume":"53","author":"Troubat","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s11427-020-1815-6","article-title":"Microglia in depression: Current perspectives","volume":"64","author":"Jia","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12974-017-0964-9","article-title":"Lentivirus-mediated interleukin-1\u03b2 (IL-1\u03b2) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice","volume":"14","author":"Li","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2174\/1871527315666160321104749","article-title":"Disease-induced neuroinflammation and depression","volume":"15","author":"Benatti","year":"2016","journal-title":"CNS Neurol. Disord.-Drug Targets"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/s41380-022-01841-y","article-title":"Gut microbiota regulates chronic ethanol exposure-induced depressive-like behavior through hippocampal NLRP3-mediated neuroinflammation","volume":"28","author":"Yao","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12974-017-0904-8","article-title":"The role of microglial P2X7: Modulation of cell death and cytokine release","volume":"14","author":"He","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1007\/s12035-017-0584-5","article-title":"Cocaine-mediated downregulation of MIR-124 activates microglia by targeting KLF4 and TLR4 signaling","volume":"55","author":"Periyasamy","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12974-021-02250-8","article-title":"NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1\/PGC-1\u03b1 pathway","volume":"18","author":"Zhao","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"13507","DOI":"10.1080\/21655979.2022.2078549","article-title":"Microrna-124 modulates neuroinflammation in acute methanol poisoning rats via targeting kr\u00fcppel-like factor-6","volume":"13","author":"Zhou","year":"2022","journal-title":"Bioengineered"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000528502","article-title":"Mir-124 reduced neuroinflammation after traumatic brain injury by inhibiting traf6","volume":"30","author":"Yang","year":"2023","journal-title":"Neuroimmunomodulation"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Rahimian, R., Belliveau, C., Chen, R., and Mechawar, N. (2022). Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.871997"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biopsych.2017.05.026","article-title":"Stress-induced neuronal colony stimulating factor 1 provokes microglia-mediated neuronal remodeling and depressive-like behavior","volume":"83","author":"Wohleb","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"955","DOI":"10.7150\/thno.76553","article-title":"Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the MPFC","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhang, J., Tasaki, T., Tsukamoto, M., Wang, K., Kubo, K., and Chen, H. (2022). Deletion of wnt10a is implicated in hippocampal neurodegeneration in mice. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071500"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer\u2019s disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Xian, X., Cai, L.L., Li, Y., Wang, R.C., Xu, Y.H., Chen, Y.J., Xie, Y.H., Zhu, X.L., and Li, Y.F. (2022). Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression. J. Nanobiotechnology, 20.","DOI":"10.1186\/s12951-022-01332-w"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Dong, H., Wang, Y., Zhang, X., Zhang, X., Qian, Y., Ding, H., and Zhang, S. (2019). Stabilization of brain mast cells alleviates LPS-induced neuroinflammation by inhibiting microglia activation. Front. Cell. Neurosci., 13.","DOI":"10.3389\/fncel.2019.00191"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: Evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson\u2019s disease","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1523\/JNEUROSCI.2110-16.2016","article-title":"Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer\u2019s Disease","volume":"37","author":"Jay","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 Binds to Apolipoproteins, Including APOE and CLU\/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-015-0040-9","article-title":"TREM2 in CNS homeostasis and neurodegenerative disease","volume":"10","author":"Painter","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Korvatska, O., Kiianitsa, K., Ratushny, A., Matsushita, M., Beeman, N., Chien, W.M., Satoh, J.I., Dorschner, M.O., Keene, C.D., and Bammler, T.K. (2020). Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer\u2019s Disease Brain. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.559342"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/WCO.0000000000000911","article-title":"The role of innate immune genes in Alzheimer\u2019s disease","volume":"34","author":"Griciuc","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","article-title":"Alzheimer\u2019s disease risk gene CD33 inhibits microglial uptake of amyloid beta","volume":"78","author":"Griciuc","year":"2013","journal-title":"Neuron"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000492596","article-title":"CD33 in Alzheimer\u2019s Disease\u2014Biology, Pathogenesis, and Therapeutics: A Mini-Review","volume":"65","author":"Zhao","year":"2019","journal-title":"Gerontology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.06.010","article-title":"TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer\u2019s Disease","volume":"103","author":"Griciuc","year":"2019","journal-title":"Neuron"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Beckers, L., Rashid, M., Lee, A.J., Chatila, Z.K., Tamucci, K.A., Talcoff, R.C., Hall, J.L., Bennett, D.A., Vardarajan, B.N., and Bradshaw, E.M. (2024). CD33 and SHP-1\/PTPN6 Interaction in Alzheimer\u2019s Disease. Genes, 15.","DOI":"10.20944\/preprints202407.0168.v1"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Shaw, B.C., Katsumata, Y., Simpson, J.F., Fardo, D.W., and Estus, S. (2021). Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer\u2019s Disease Risk Reveal a Potential Role for SIGLEC14. Genes, 12.","DOI":"10.3390\/genes12071008"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Lona-Durazo, F., Reynolds, R.H., Scholz, S.W., Ryten, M., and Gagliano Taliun, S.A. (2023). Regional genetic correlations highlight relationships between neurodegenerative disease loci and the immune system. Commun. Biol., 6.","DOI":"10.1038\/s42003-023-05113-5"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"08518","DOI":"10.1016\/j.heliyon.2021.e08518","article-title":"Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and Huntington\u2019s disease (HD)","volume":"7","author":"Mukherjee","year":"2021","journal-title":"Heliyon"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-017-0184-x","article-title":"Late onset Alzheimer\u2019s disease genetics implicates microglial pathways in disease risk","volume":"12","author":"Efthymiou","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13024-017-0197-5","article-title":"TREM2 in Neurodegenerative Diseases","volume":"12","author":"Jay","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jad.2015.08.036","article-title":"Peripheral inflammation during abnormal mood states in bipolar I disorder","volume":"187","author":"Fiedorowicz","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1017\/S1092852921000018","article-title":"Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: A pathway toward neurodegeneration and neuroprogression? A theoretical review","volume":"27","author":"Palagini","year":"2021","journal-title":"CNS Spectr."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Zou, W., Feng, R., and Yang, Y. (2018). Changes in the serum levels of inflammatory cytokines in antidepressant drug-na\u00efve patients with major depression. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197267"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acschemneuro.8b00386","article-title":"Could probiotics be used to mitigate neuroinflammation?","volume":"10","author":"Frank","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1098\/rspb.2009.2148","article-title":"Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis","volume":"277","author":"Walker","year":"2010","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.psyneuen.2017.10.011","article-title":"Molecular changes associated with escitalopram response in a stress-based model of depression","volume":"87","author":"Benatti","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuron.2009.11.032","article-title":"Dual roles for perivascular macrophages in immune-to-brain signaling","volume":"65","author":"Serrats","year":"2010","journal-title":"Neuron"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1037\/abn0000348","article-title":"Course of ante- and postnatal depressive symptoms related to mothers\u2019 HPA axis regulation","volume":"127","author":"Laurent","year":"2018","journal-title":"J. Abnorm. Psychol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.psyneuen.2009.12.007","article-title":"Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence","volume":"35","author":"Adam","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"105625","DOI":"10.1016\/j.psyneuen.2021.105625","article-title":"Cortisol and development of depression in adolescence and young adulthood\u2014A systematic review and meta-analysis","volume":"136","author":"Zajkowska","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Chen, L., Wang, X., Zhang, Y., Zhong, H., Wang, C., Gao, P., and Li, B. (2021). Daidzein alleviates hypothalamic-pituitary-adrenal axis hyperactivity, ameliorates depression-like behavior, and partly rectifies circulating cytokine imbalance in two rodent models of depression. Front. Behav. Neurosci., 15.","DOI":"10.3389\/fnbeh.2021.671864"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/PSY.0000000000000097","article-title":"Day-to-day dynamics of associations between sleep, napping, fatigue, and the cortisol diurnal rhythm in women diagnosed as having breast cancer","volume":"76","author":"Tell","year":"2014","journal-title":"Psychosom. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.psyneuen.2012.08.004","article-title":"Chronicity of depressive problems and the cortisol response to psychosocial stress in adolescents: The trails study","volume":"38","author":"Booij","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"8707","DOI":"10.1039\/C9RA00020H","article-title":"Inhibition of acid-sensing ion channels reduces the hypothalamus-pituitary-adrenal axis activity and ameliorates depression-like behavior in rats","volume":"9","author":"Zhou","year":"2019","journal-title":"RSC Adv."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/nyas.13217","article-title":"Cortisol dysregulation: The bidirectional link between stress, depression, and type 2 diabetes mellitus","volume":"1391","author":"Joseph","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.euroneuro.2015.04.009","article-title":"Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis","volume":"25","author":"Cai","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/npp.2016.169","article-title":"Genetic contributions of inflammation to depression","volume":"42","author":"Barnes","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumor necrosis factor \u03b2 and c-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Arteaga-Henr\u00edquez, G., Simon, M., Burger, B., Weidinger, E., Wijkhuijs, A., Arolt, V., Birkenhager, T.K., Musil, R., M\u00fcller, N., and Drexhage, H.A. (2019). Low-grade inflammation as a predictor of antidepressant and anti-inflammatory therapy response in MDD patients: A systematic review of the literature in combination with an analysis of experimental data collected in the eu-moodinflame consortium. Front. Psychiatry, 10.","DOI":"10.3389\/fpsyt.2019.00458"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/s41380-019-0395-3","article-title":"Shared mechanisms between coronary heart disease and depression: Findings from a large UK general population-based cohort","volume":"25","author":"Khandaker","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/mp.2011.67","article-title":"Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-\u03b1-induced depression in patients with chronic hepatitis C","volume":"17","author":"Smith","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Kalinovic, R., Pascariu, A., Vlad, G., Nitusca, D., S\u0103lcudean, A., Sirbu, I.O., Marian, C., and Enatescu, V.R. (2024). Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia. Pharmaceuticals, 17.","DOI":"10.3390\/ph17010085"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Salcudean, A., and Lica, M.M. (2024). The Role of Systemic Family Psychotherapy in Glycemic Control for Children with Type 1 Diabetes. Children, 11.","DOI":"10.3390\/children11010104"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/jamapsychiatry.2014.1332","article-title":"Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life","volume":"71","author":"Khandaker","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-14-53","article-title":"Systemic inflammation, depression and obstructive pulmonary function: A population-based study","volume":"14","author":"Lu","year":"2013","journal-title":"Respir. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/PSY.0b013e3182924cf4","article-title":"Association between promoter methylation of serotonin transporter gene and depressive symptoms: A monozygotic twin study","volume":"75","author":"Zhao","year":"2013","journal-title":"Psychosom. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"7286","DOI":"10.3390\/cimb45090461","article-title":"DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression","volume":"45","author":"Pelikan","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1080\/15592294.2017.1341026","article-title":"Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis","volume":"12","author":"Smith","year":"2017","journal-title":"Epigenetics"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00213-011-2307-3","article-title":"A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice","volume":"218","author":"Lee","year":"2011","journal-title":"Psychopharmacology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.5498\/wjp.v12.i9.1264","article-title":"Why do we not reverse the path? Stress can cause depression, reduction of brain-derived neurotrophic factor and increased inflammation","volume":"12","author":"Claro","year":"2022","journal-title":"World J. Psychiatry"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: A social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/15592294.2015.1039221","article-title":"Maternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation","volume":"10","author":"Braithwaite","year":"2015","journal-title":"Epigenetics"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"395","DOI":"10.31887\/DCNS.2014.16.3\/amenke","article-title":"Epigenetic alterations in depression and antidepressant treatment","volume":"16","author":"Menke","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","article-title":"A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression","volume":"70","author":"Raison","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1289\/ehp.1306560","article-title":"Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice","volume":"121","author":"Bolton","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/toxsci\/kfy014","article-title":"Aging exacerbates neuroinflammatory outcomes induced by acute ozone exposure","volume":"163","author":"Tyler","year":"2018","journal-title":"Toxicol. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"R\u0103chit\u0103, A., Strete, G.E., Suciu, L.M., Ghiga, D.V., S\u0103lcudean, A., and M\u0103rginean, C. (2022). Psychological Stress Perceived by Pregnant Women in the Last Trimester of Pregnancy. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19148315"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"R\u0103chit\u0103, A.I.C., Strete, G.E., S\u0103lcudean, A., Ghiga, D.V., Hu\u021banu, A., Muntean, L.M., Suciu, L.M., and M\u0103rginean, C. (2023). The Relationship between Psychological Suffering, Value of Maternal Cortisol during Third Trimester of Pregnancy and Breastfeeding Initiation. Medicina, 59.","DOI":"10.3390\/medicina59020339"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbi.2012.05.006","article-title":"Depressive symptoms enhance stress-induced inflammatory responses","volume":"31","author":"Fagundes","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1523\/JNEUROSCI.2568-17.2018","article-title":"Corticosterone production during repeated social defeat causes monocyte mobilization from the bone marrow, glucocorticoid resistance, and neurovascular adhesion molecule expression","volume":"38","author":"Niraula","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.clinthera.2020.02.018","article-title":"Psychological stress-induced immune response and risk of Alzheimer\u2019s disease in veterans from Operation Enduring Freedom and operation Iraqi freedom","volume":"42","author":"Kempuraj","year":"2020","journal-title":"Clin. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"16091","DOI":"10.1523\/JNEUROSCI.2400-10.2010","article-title":"The toll-like receptor-3 agonist polyinosinic: Polycytidylic acid triggers nigrostriatal dopaminergic degeneration","volume":"30","author":"Deleidi","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"S\u0103lcudean, A., Nan, A.G., Bodo, C.R., Cosma, M.C., Strete, E.G., and Lica, M.M. (2023). Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood. Diagnostics, 13.","DOI":"10.3390\/diagnostics13111868"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1089\/neu.2020.7010","article-title":"Sleep disruption exacerbates and prolongs the inflammatory response to traumatic brain injury","volume":"37","author":"Tapp","year":"2020","journal-title":"J. Neurotrauma"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2346126","DOI":"10.1155\/2020\/2346126","article-title":"Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1\u03b2 Gene: A Randomized, Placebo-Controlled Clinical Trial","volume":"2020","author":"Gualtieri","year":"2020","journal-title":"Mediators Inflamm."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/cen3.12537","article-title":"Tumor necrosis factor receptor 2: A potential target for antidepressant drug development","volume":"10","author":"Seymour","year":"2019","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3892\/etm.2014.1734","article-title":"Association analysis of the glucocorticoid receptor gene (NR3C1) haplotypes (ER22\/23EK, N363S, BclI) with mood and anxiety disorders in patients with asthma","volume":"8","author":"Panek","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","article-title":"Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation","volume":"25","author":"Bailey","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.3892\/mmr.2017.7235","article-title":"Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus","volume":"16","author":"Chen","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.amjmed.2014.04.011","article-title":"Depression, dietary habits, and cardiovascular events among women with suspected myocardial ischemia","volume":"127","author":"Rutledge","year":"2014","journal-title":"Am. J. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S1092852913000667","article-title":"Metabolic syndrome and major depression","volume":"19","author":"Marazziti","year":"2013","journal-title":"CNS Spectr."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Garcia-Toro, M., Gili, M., Ibarra, O., Monz\u00f3n, S., Vives, M., Campayo, J., Gomez-Juanes, R., and Roca, M. (2014). Metabolic syndrome improvement in depression six months after prescribing simple hygienic-dietary recommendations. BMC Res. Notes, 7.","DOI":"10.1186\/1756-0500-7-339"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Hall, S., Yuen, J.W., and Grant, G.D. (2018). Bioactive Constituents in Caffeinated and Decaffeinated Coffee and Their Effect on the Risk of Depression\u2014A Comparative Constituent Analysis Study. Beverages, 4.","DOI":"10.3390\/beverages4040079"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5530\/pres.15.2.027","article-title":"Preparation of camellia sinensis (green tea) and acacia nilotica (babul) herbal formulation and its anti-inflammatory activity","volume":"15","author":"Varshini","year":"2023","journal-title":"Pharmacogn. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/mp.2010.113","article-title":"Depressive symptoms and inflammation increase in a prospective study of older adults: A protective effect of a healthy (Mediterranean-style) diet","volume":"16","author":"Milaneschi","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3934\/microbiol.2024034","article-title":"Antioxidant and anti-inflammatory properties of water kefir microbiota and its bioactive metabolites for health promoting bio-functional products and applications","volume":"10","author":"Papadopoulou","year":"2024","journal-title":"AIMS Microbiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/0269881112473791","article-title":"Cocoa polyphenols enhance positive mood states but not cognitive performance: A randomized, placebo-controlled trial","volume":"27","author":"Pase","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Lin, K., Li, Y., Toit, E.D., Wendt, L., and Sun, J. (2021). Effects of Polyphenol Supplementations on Improving Depression, Anxiety, and Quality of Life in Patients With Depression. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.765485"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1038\/tp.2014.135","article-title":"Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice","volume":"5","author":"Stringer","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"26331055241280638","DOI":"10.1177\/26331055241280638","article-title":"Cacao Ameliorates Amyloid Beta-Induced Cognitive and Non-Cognitive Disturbances","volume":"19","author":"Basir","year":"2024","journal-title":"Neurosci. Insights"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Micek, A., Jurek, J., Owczarek, M., Guerrera, I., Torrisi, S.A., Castellano, S., Grosso, G., Alshatwi, A.A., and Godos, J. (2023). Polyphenol-Rich Beverages and Mental Health Outcomes. Antioxidants, 12.","DOI":"10.3390\/antiox12020272"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/advances\/nmz117","article-title":"Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review","volume":"11","author":"Bayes","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Barfoot, K.L., Forster, R., and Lamport, D.J. (2021). Mental Health in New Mothers: A Randomised Controlled Study into the Effects of Dietary Flavonoids on Mood and Perceived Quality of Life. Nutrients, 13.","DOI":"10.3390\/nu13072383"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1080\/09637486.2017.1292221","article-title":"Regular consumption of HolisFiit, a polyphenol-rich extract-based food supplement, improves mind and body well-being of overweight and slightly obese volunteers: A randomized, double-blind, parallel trial","volume":"68","author":"Romain","year":"2017","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Ji, C., Yang, J., Lin, L., and Chen, S. (2022). Physical exercise ameliorates anxiety, depression, and sleep quality in college students: Experimental evidence from exercise intensity and frequency. Behav. Sci., 12.","DOI":"10.3390\/bs12030061"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21846\/TST.2019.1-2.2","article-title":"The effect of three-week exercise program on sleep quality and depression symptoms in female adults","volume":"4","year":"2019","journal-title":"Testnev. Sport. Tudom\u00e1ny"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.jand.2012.08.026","article-title":"Fruit, vegetable, and antioxidant intakes are lower in older adults with depression","volume":"112","author":"Payne","year":"2012","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Francis, H., Stevenson, R., Chambers, J., Gupta, D., Newey, B., and Lim, C. (2019). A brief diet intervention can reduce symptoms of depression in young adults\u2014A randomized controlled trial. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222768"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2147\/PRBM.S403788","article-title":"Relationship between physical exercise and cognitive impairment among older adults with type 2 diabetes: Chain mediating roles of sleep quality and depression","volume":"16","author":"Zhang","year":"2023","journal-title":"Psychol. Res. Behav. Manag."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Passos, G., Poyares, D., Santana, M., Teixeira, A., Lira, F., Youngstedt, S., dos Santos, R.V.T., Tufik, S., and de Mello, M.T. (2014). Exercise improves immune function, antidepressive response, and sleep quality in patients with chronic primary insomnia. Biomed Res. Int., 2014.","DOI":"10.1155\/2014\/498961"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Garcia-Toro, M., Ibarra, O., Gili, M., Salv\u00e0, J., Monz\u00f3n, S., Vives, M., Serrano, M.J., Garcia-Campayo, J., and Roca, M. (2010). Effectiveness of hygienic-dietary recommendations as enhancers of antidepressant treatment in patients with depression: Study protocol of a randomized controlled trial. BMC Public Health, 10.","DOI":"10.1186\/1471-2458-10-404"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/TIN.0000000000000206","article-title":"Healthy sleep leads to improved nutrition and exercise in college females","volume":"35","author":"Adams","year":"2020","journal-title":"Top. Clin. Nutr."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2147\/IJGM.S70456","article-title":"Prophylactic onabotulinumtoxina in patients with chronic migraine and comorbid depression: An open-label, multicenter, pilot study of efficacy, safety, and effect on headache-related disability, depression, and anxiety","volume":"8","author":"Boudreau","year":"2015","journal-title":"Int. J. Gen. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"15728","DOI":"10.3390\/ijerph121215015","article-title":"Physical comorbidities in depression co-occurring with anxiety: A cross-sectional study in the Czech primary care system","volume":"12","author":"Winkler","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"686","DOI":"10.31925\/farmacia.2023.4.4","article-title":"New directions in pharmacological treatment with sglt-2 inhibitor molecules in the light of current guidelines for diabetes mellitus, heart failure and kidney disease","volume":"71","author":"Tilinca","year":"2023","journal-title":"Farmacia"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Lica, M.M., Papai, A., Salcudean, A., Crainic, M., Covaciu, C.G., and Mihai, A. (2021). Assessment of Psychopathology in Adolescents with Insulin-Dependent Diabetes (IDD) and the Impact on Treatment Management. Children, 8.","DOI":"10.3390\/children8050414"},{"key":"ref_163","first-page":"120","article-title":"Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: Impact on psychopathology and transition to psychosis","volume":"40","author":"Nelson","year":"2012","journal-title":"Schizophr. Bull."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2190\/PM.45.2.a","article-title":"The impact of physical and psychological comorbid conditions on the quality of life of patients with acute myocardial infarction: A multi-center, cross-sectional observational study from Turkey","volume":"45","author":"Aydemir","year":"2013","journal-title":"Int. J. Psychiatry Med."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"\u0150sz, B.E., J\u00eetc\u0103, G., S\u0103lcudean, A., Rusz, C.M., and Vari, C.E. (2023). Benzydamine-An Affordable Over-the-Counter Drug with Psychoactive Properties-From Chemical Structure to Possible Pharmacological Properties. Pharmaceuticals, 16.","DOI":"10.3390\/ph16040566"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Agarwal, P., Pan, X., and Sambamoorthi, U. (2013). Depression treatment patterns among individuals with osteoarthritis: A cross-sectional study. BMC Psychiatry, 13.","DOI":"10.1186\/1471-244X-13-121"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/acps.13016","article-title":"Efficacy of anti-inflammatory treatment on major depressive disorder or depressive symptoms: Meta-analysis of clinical trials","volume":"139","author":"Lydholm","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/cncr.31859","article-title":"C-reactive protein and its association with depression in patients receiving treatment for metastatic lung cancer","volume":"125","author":"McFarland","year":"2018","journal-title":"Cancer"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Yrondi, A., Aouizerate, B., El-Hage, W., Moli\u00e8re, F., Thalamas, C., Delcourt, N., Sporer, M., Taib, S., Schmitt, L., and Arlicot, N. (2018). Assessment of translocator protein density, as a marker of neuroinflammation, in major depressive disorder: A pilot, multicenter, comparative, controlled, brain pet study (infladep study). Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00326"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbi.2017.05.002","article-title":"Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes","volume":"65","author":"Isgren","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/mp.2016.167","article-title":"Antidepressant activity of anti-cytokine treatment: A systematic review and meta-analysis of clinical trials of chronic inflammatory conditions","volume":"23","author":"Kappelmann","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41398-022-02297-y","article-title":"Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression","volume":"13","author":"Guo","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"G\u00f3rska-Ciebiada, M., Saryusz-Wolska, M., Borkowska, A., Ciebiada, M., and Loba, J. (2015). Serum levels of inflammatory markers in depressed elderly patients with diabetes and mild cognitive impairment. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120433"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"66","DOI":"10.31925\/farmacia.2024.1.6","article-title":"Pilot study to evaluate adherence to treatment using the mars scale on a sample of Romanian patients with cardiovascular diseases","volume":"72","author":"Strete","year":"2024","journal-title":"Farmacia"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1038\/tp.2013.87","article-title":"The association between immune activation and manic symptoms in patients with a depressive disorder","volume":"3","author":"Becking","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00213-015-3919-9","article-title":"Low-grade inflammation predicts persistence of depressive symptoms","volume":"233","author":"Zalli","year":"2015","journal-title":"Psychopharmacology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbi.2012.04.009","article-title":"The role of immune genes in the association between depression and inflammation: A review of recent clinical studies","volume":"31","author":"Bufalino","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/WNF.0000000000000448","article-title":"The effects of ibuprofen consumption on the incidence of postpartum depression","volume":"44","author":"Kapulsky","year":"2021","journal-title":"Clin. Neuropharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1192\/bjp.bp.115.177683","article-title":"Baseline characteristics and treatment-emergent risk factors associated with cerebrovascular event and death with risperidone in dementia patients","volume":"209","author":"Howard","year":"2016","journal-title":"Br. J. Psychiatry"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jad.2021.02.012","article-title":"Lifestyle medicine for depression: A meta-analysis of randomized controlled trials","volume":"284","author":"Wong","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/da.23249","article-title":"Meditation-based lifestyle modification in mild to moderate depression-a randomized controlled trial","volume":"39","author":"Bringmann","year":"2022","journal-title":"Depress. Anxiety"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/obr.12752","article-title":"A systematic review and meta-analysis of lifestyle interventions in women of reproductive age with overweight or obesity: The effects on symptoms of depression and anxiety","volume":"19","author":"Dammen","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Taylor, K., Simpson, S., Jelinek, G., Neate, S., Livera, A., Brown, C., O\u2019Kearney, E., Marck, C.H., and Weiland, T.J. (2018). Longitudinal associations of modifiable lifestyle factors with positive depression screen over 2.5 years in an international cohort of people living with multiple sclerosis. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00526"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/cncr.34849","article-title":"Lower risk of depression after smoking cessation and alcohol abstinence in patients with gastric cancer who underwent gastrectomy: A population-based, nationwide cohort study","volume":"129","author":"Chung","year":"2023","journal-title":"Cancer"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"297","DOI":"10.11604\/pamj.2022.42.297.31414","article-title":"Depression and chronic kidney disease: A cross-sectional study based at Buganda Medical Center, northwestern Tanzania","volume":"42","author":"Munisi","year":"2022","journal-title":"Pan Afr. Med. J."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Hayward, J., Jacka, F., Waters, E., and Allender, S. (2014). Lessons from obesity prevention for the prevention of mental disorders: The primordial prevention approach. BMC Psychiatry, 14.","DOI":"10.1186\/s12888-014-0254-3"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Toghyani, M., Kajbaf, M., and Ghamarani, A. (Zahedan J. Res. Med. Sci., 2018). What does the Islamic lifestyle say about depression management?, Zahedan J. Res. Med. Sci., in press.","DOI":"10.5812\/zjrms.67766"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Finucane, F. (2023). Factors associated with weight loss and health gains in a structured lifestyle modification program for adults with severe obesity: A prospective cohort study. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1257061"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1176\/appi.ps.003622012","article-title":"Clinically significant improved fitness and weight loss among overweight persons with serious mental illness","volume":"64","author":"Bartels","year":"2013","journal-title":"Psychiatr. Serv."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10072-015-2089-1","article-title":"Engagement in a program promoting lifestyle modification is associated with better patient-reported outcomes for people with MS","volume":"36","author":"Hadgkiss","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.psyneuen.2015.02.011","article-title":"Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers","volume":"56","author":"Dahl","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneuroim.2015.06.004","article-title":"The effect of pro-inflammatory cytokines in cognitive behavioral therapy","volume":"285","author":"Moreira","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jad.2010.04.004","article-title":"MRI signal hyperintensities and treatment remission of geriatric depression","volume":"126","author":"Walton","year":"2010","journal-title":"J. Affect. Disord."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M., and Dalton, B. (2019). Cytokine research in depression: Principles, challenges, and open questions. Front. Psychiatry, 10.","DOI":"10.3389\/fpsyt.2019.00030"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpsychores.2011.02.013","article-title":"A stepwise psychotherapy intervention for reducing risk in coronary artery disease (spirr-cad)\u2014Rationale and design of a multicenter, randomized trial in depressed patients with cad","volume":"71","author":"Albus","year":"2011","journal-title":"J. Psychosom. Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"483","DOI":"10.31925\/farmacia.2020.3.14","article-title":"The presence of peripheral inflammatory markers in patients with major depressive disorder, the associated symptoms profile and the antidepressant efficacy of celecoxib","volume":"68","author":"Enatescu","year":"2020","journal-title":"Farmacia"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1176\/appi.ajp.2010.09091327","article-title":"Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction","volume":"167","author":"Raue","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Herlo, L.F., Salcudean, A., Sirli, R., Iurciuc, S., Herlo, A., Nelson-Twakor, A., Alexandrescu, L., and Dumache, R. (2024). Gut Microbiota Signatures in Colorectal Cancer as a Potential Diagnostic Biomarker in the Future: A Systematic Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147937"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jagp.2013.01.013","article-title":"Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response","volume":"21","author":"Mackin","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"3000605211006633","DOI":"10.1177\/03000605211006633","article-title":"Distribution of microRNAs associated with major depressive disorder among blood compartments","volume":"49","author":"Homorogan","year":"2021","journal-title":"J. Int. Med. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/4\/1645\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:34:43Z","timestamp":1760027683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/4\/1645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":200,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijms26041645"],"URL":"https:\/\/doi.org\/10.3390\/ijms26041645","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]}}}