{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T01:56:41Z","timestamp":1769306201950,"version":"3.49.0"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Development and Innovation Fund","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}]},{"name":"National Research Development and Innovation Fund","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}]},{"name":"National Research Development and Innovation Fund","award":["TKCS-2021\/32"],"award-info":[{"award-number":["TKCS-2021\/32"]}]},{"name":"National Research Development and Innovation Fund","award":["BO\/00513\/23\/5"],"award-info":[{"award-number":["BO\/00513\/23\/5"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["TKCS-2021\/32"],"award-info":[{"award-number":["TKCS-2021\/32"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["BO\/00513\/23\/5"],"award-info":[{"award-number":["BO\/00513\/23\/5"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hungarian E\u00f6tv\u00f6s Lor\u00e1nd Research Network","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}]},{"name":"Hungarian E\u00f6tv\u00f6s Lor\u00e1nd Research Network","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}]},{"name":"Hungarian E\u00f6tv\u00f6s Lor\u00e1nd Research Network","award":["TKCS-2021\/32"],"award-info":[{"award-number":["TKCS-2021\/32"]}]},{"name":"Hungarian E\u00f6tv\u00f6s Lor\u00e1nd Research Network","award":["BO\/00513\/23\/5"],"award-info":[{"award-number":["BO\/00513\/23\/5"]}]},{"name":"EK\u00d6P-24-4 University Research Scholarship Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovationa Fund (Istv\u00e1n Sz\u00e1sz and Vikt\u00f3ria Koroknai)","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}]},{"name":"EK\u00d6P-24-4 University Research Scholarship Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovationa Fund (Istv\u00e1n Sz\u00e1sz and Vikt\u00f3ria Koroknai)","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}]},{"name":"EK\u00d6P-24-4 University Research Scholarship Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovationa Fund (Istv\u00e1n Sz\u00e1sz and Vikt\u00f3ria Koroknai)","award":["TKCS-2021\/32"],"award-info":[{"award-number":["TKCS-2021\/32"]}]},{"name":"EK\u00d6P-24-4 University Research Scholarship Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovationa Fund (Istv\u00e1n Sz\u00e1sz and Vikt\u00f3ria Koroknai)","award":["BO\/00513\/23\/5"],"award-info":[{"award-number":["BO\/00513\/23\/5"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["TKCS-2021\/32"],"award-info":[{"award-number":["TKCS-2021\/32"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["BO\/00513\/23\/5"],"award-info":[{"award-number":["BO\/00513\/23\/5"]}]},{"name":"University of Debrecen Program for Scientific Publication","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}]},{"name":"University of Debrecen Program for Scientific Publication","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}]},{"name":"University of Debrecen Program for Scientific Publication","award":["TKCS-2021\/32"],"award-info":[{"award-number":["TKCS-2021\/32"]}]},{"name":"University of Debrecen Program for Scientific Publication","award":["BO\/00513\/23\/5"],"award-info":[{"award-number":["BO\/00513\/23\/5"]}]},{"name":"University of Debrecen Scientific Research Bridging Fund (DETKA)","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}]},{"name":"University of Debrecen Scientific Research Bridging Fund (DETKA)","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}]},{"name":"University of Debrecen Scientific Research Bridging Fund (DETKA)","award":["TKCS-2021\/32"],"award-info":[{"award-number":["TKCS-2021\/32"]}]},{"name":"University of Debrecen Scientific Research Bridging Fund (DETKA)","award":["BO\/00513\/23\/5"],"award-info":[{"award-number":["BO\/00513\/23\/5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Recent evidence has highlighted the critical role of lipids in tumor biology. In this study, we analyzed the plasma lipid profiles of 151 melanoma patients (University of Debrecen, Department of Dermatology, Hungary) to examine the associations between specific lipid species and commonly used LDL-C lipid parameters, as well as the Breslow thickness and ulceration of primary tumors. Our analysis included patients who underwent primary tumor resection, comprising 83 individuals without metastases and 68 with metastases at the time of blood sampling. Lipid profiling was performed using the Lipidyzer\u2122 platform, which targets over 1100 lipid species. Following quality control filtering, 802 lipids were included in the subsequent analyses. Ten lipids were found to have decreased plasma levels, while one lipid exhibited elevated plasma levels, both associated with an increased risk of higher Breslow thickness. Additionally, patients with thicker tumors (\u22652 mm) demonstrated significantly higher LDL-C levels after adjusting for age, sex, therapy, and tumor presence (p = 0.032). Using forward stepwise regression, we identified a combination of four lipids\u2014(CE(20:5), LCER(24:1), PE(P18:1\/18:1), and LPE(18:2))\u2014that demonstrated the strongest correlation with Breslow depth (AUC = 0.779, as determined by ROC analysis). Additionally, we identified 11 lipids significantly associated with tumor ulceration. Stepwise regression analysis further revealed two lipids (FFA(16:0) and PC(15:0\/18:1)) capable of predicting tumor ulceration with an AUC score of 0.740. These findings suggest that individual lipid metabolism may influence tumor thickness and ulceration during the development and progression of primary melanoma.<\/jats:p>","DOI":"10.3390\/ijms26041716","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:48:22Z","timestamp":1739778502000},"page":"1716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Plasma Lipid Patterns and LDL Cholesterol Levels with Breslow Thickness and Ulceration in Melanoma Patients"],"prefix":"10.3390","volume":"26","author":[{"given":"Istv\u00e1n","family":"Sz\u00e1sz","sequence":"first","affiliation":[{"name":"HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikt\u00f3ria","family":"Koroknai","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcnde","family":"V\u00e1rv\u00f6lgyi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-4066","authenticated-orcid":false,"given":"S\u00e1ndor","family":"Sz\u0171cs","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5539-907X","authenticated-orcid":false,"given":"P\u00e9ter","family":"Pik\u00f3","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2877-4740","authenticated-orcid":false,"given":"Gabriella","family":"Emri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Janka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-4372","authenticated-orcid":false,"given":"Imre L\u0151rinc","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-6669","authenticated-orcid":false,"given":"R\u00f3za","family":"\u00c1d\u00e1ny","sequence":"additional","affiliation":[{"name":"HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"},{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-2321","authenticated-orcid":false,"given":"Margit","family":"Bal\u00e1zs","sequence":"additional","affiliation":[{"name":"HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"},{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00000658-197011000-00017","article-title":"Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma","volume":"172","author":"Breslow","year":"1970","journal-title":"Ann. Surg."},{"key":"ref_2","first-page":"39","article-title":"Lentigo maligna and lentigo-maligna melanoma","volume":"55","author":"Clark","year":"1969","journal-title":"Am. J. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.5694\/j.1326-5377.1991.tb121217.x","article-title":"Factors related to the presentation of patients with thick primary melanomas","volume":"154","author":"Hersey","year":"1991","journal-title":"Med. J. Aust."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1046\/j.1365-2133.2001.04071.x","article-title":"Clinical correlates of Breslow thickness of malignant melanoma","volume":"144","author":"Osborne","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/00000658-197812000-00004","article-title":"A multifactorial analysis of melanoma: Prognostic histopathological features comparing Clark\u2019s and Breslow\u2019s staging methods","volume":"188","author":"Balch","year":"1978","journal-title":"Ann. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1001\/archderm.144.4.515","article-title":"Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program","volume":"144","author":"Lachiewicz","year":"2008","journal-title":"Arch. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/bjd.13489","article-title":"Clinical and histological features of head and neck melanoma: A population-based study in France","volume":"172","author":"Dabouz","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/ajd.13091","article-title":"Factors affecting Breslow thickness: Results from a survey of 114 Western Australian patients with thicker melanoma","volume":"60","author":"Hille","year":"2019","journal-title":"Australas. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.addr.2020.07.013","article-title":"Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention","volume":"159","author":"Butler","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hao, Y., Li, D., Xu, Y., Ouyang, J., Wang, Y., Zhang, Y., Li, B., Xie, L., and Qin, G. (2019). Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data. BMC Bioinform., 20.","DOI":"10.1186\/s12859-019-2734-4"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e15070","DOI":"10.1111\/exd.15070","article-title":"Deciphering cutaneous melanoma prognosis through LDL metabolism: Single-cell transcriptomics analysis via 101 machine learning algorithms","volume":"33","author":"Xie","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Szasz, I., Koroknai, V., Varvolgyi, T., Pal, L., Szucs, S., Piko, P., Emri, G., Janka, E., Szabo, I.L., and Adany, R. (2024). Identification of Plasma Lipid Alterations Associated with Melanoma Metastasis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084251"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2147\/CCID.S372287","article-title":"Ulcerated Cutaneous Melanoma: A Review of the Clinical, Histologic, and Molecular Features Associated with a Clinically Aggressive Histologic Phenotype","volume":"15","author":"Barricklow","year":"2022","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41419-023-06110-6","article-title":"Stromal cells in the tumour microenvironment: Accomplices of tumour progression?","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/(SICI)1097-0142(20000201)88:3<589::AID-CNCR15>3.0.CO;2-I","article-title":"Breslow thickness and clark level in melanoma: Support for including level in pathology reports and in American Joint Committee on Cancer Staging","volume":"88","author":"Marghoob","year":"2000","journal-title":"Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10555-022-10059-x","article-title":"The adipocyte microenvironment and cancer","volume":"41","author":"Mukherjee","year":"2022","journal-title":"Cancer Metastasis Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12326","DOI":"10.18632\/oncotarget.3619","article-title":"Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a\/androgen receptor (AR)\/TGF-beta1\/Smad\/MMP9 signals","volume":"6","author":"Xie","year":"2015","journal-title":"Oncotarget"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/jcb.25463","article-title":"Effect of Adipocyte Secretome in Melanoma Progression and Vasculogenic Mimicry","volume":"117","author":"Coelho","year":"2016","journal-title":"J. Cell Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Stoica, C., Ferreira, A.K., Hannan, K., and Bakovic, M. (2022). Bilayer Forming Phospholipids as Targets for Cancer Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095266"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4829180","DOI":"10.1155\/2017\/4829180","article-title":"Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease","volume":"2017","author":"Patel","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tan, L.T., Chan, K.G., Pusparajah, P., Lee, W.L., Chuah, L.H., Khan, T.M., Lee, L.H., and Goh, B.H. (2017). Targeting Membrane Lipid a Potential Cancer Cure?. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00012"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8646","DOI":"10.3748\/wjg.v20.i26.8646","article-title":"Lipid levels in serum and cancerous tissues of colorectal cancer patients","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1007\/s00392-023-02260-x","article-title":"Large-scale lipidomics profiling reveals characteristic lipid signatures associated with an increased cardiovascular risk","volume":"112","author":"Harm","year":"2023","journal-title":"Clin. Res. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3322\/caac.21409","article-title":"Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual","volume":"67","author":"Gershenwald","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1309\/AJCPW56PHGLFTKZC","article-title":"Prognostic stratification of ulcerated melanoma: Not only the extent matters","volume":"142","author":"Schmidt","year":"2014","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/SLA.0b013e31824c4b0b","article-title":"Prognostic importance of the extent of ulceration in patients with clinically localized cutaneous melanoma","volume":"255","author":"Haydu","year":"2012","journal-title":"Ann. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"HMDB 5.0: The Human Metabolome Database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Bowman, E.R., Cameron, C., Richardson, B., Kulkarni, M., Gabriel, J., Kettelhut, A., Hornsby, L., Kwiek, J.J., Turner, A.N., and Malvestutto, C. (2020). In Vitro Exposure of Leukocytes to HIV Preexposure Prophylaxis Decreases Mitochondrial Function and Alters Gene Expression Profiles. Antimicrob. Agents Chemother., 65.","DOI":"10.1128\/AAC.01755-20"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lodge, S., Lawler, N.G., Gray, N., Masuda, R., Nitschke, P., Whiley, L., Bong, S.H., Yeap, B.B., Dwivedi, G., and Spraul, M. (2023). Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411614"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Saito, K., Gemma, A., Tatsumi, K., Hattori, N., Ushiki, A., Tsushima, K., Saito, Y., Abe, M., Horimasu, Y., and Kashiwada, T. (2022). Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-24406-z"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Luczaj, W., Jastrzab, A., do Rosario Domingues, M., Domingues, P., and Skrzydlewska, E. (2021). Changes in Phospholipid\/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168700"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/curroncol28010085","article-title":"Blood Cholesterol and Outcome of Patients with Cancer under Regular Cardiological Surveillance","volume":"28","author":"Hohneck","year":"2021","journal-title":"Curr. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.12669\/pjms.341.14841","article-title":"Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage","volume":"34","author":"Raza","year":"2018","journal-title":"Pak. J. Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Rodrigues Dos Santos, C., Fonseca, I., Dias, S., and Mendes de Almeida, J.C. (2014). Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumour progression. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-132"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.ejca.2007.09.004","article-title":"Is statin use associated with a reduced incidence, a reduced Breslow thickness or delayed metastasis of melanoma of the skin?","volume":"43","author":"Koomen","year":"2007","journal-title":"Eur. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Piko, P., Pal, L., Szucs, S., Kosa, Z., Sandor, J., and Adany, R. (2021). Obesity-Related Changes in Human Plasma Lipidome Determined by the Lipidyzer Platform. Biomolecules, 11.","DOI":"10.3390\/biom11020326"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Franko, A., Merkel, D., Kovarova, M., Hoene, M., Jaghutriz, B.A., Heni, M., Konigsrainer, A., Papan, C., Lehr, S., and Haring, H.U. (2018). Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation. Nutrients, 10.","DOI":"10.3390\/nu10091314"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-1-4939-7592-1_15","article-title":"Direct Infusion-Tandem Mass Spectrometry (DI-MS\/MS) Analysis of Complex Lipids in Human Plasma and Serum Using the Lipidyzer Platform","volume":"1730","author":"Ubhi","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1194\/jlr.S120001025","article-title":"Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures","volume":"61","author":"Liebisch","year":"2020","journal-title":"J. Lipid Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/4\/1716\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:36:22Z","timestamp":1760027782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/4\/1716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijms26041716"],"URL":"https:\/\/doi.org\/10.3390\/ijms26041716","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]}}}