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Emerging evidence highlights the significance of the cystathionine \u03b3-lyase (CSE)\/hydrogen sulfide (H2S) signaling pathway as a pivotal regulator in the molecular and physiological adaptations induced by exercise. This review comprehensively examines the biosynthesis and metabolism of H2S, its distribution in different muscle tissues, and the mechanisms by which CSE\/H2S influences muscle contraction, repair, and protein synthesis. Additionally, it explores how CSE\/H2S modulates insulin signaling pathways, glucose uptake, and lipid metabolism, thereby enhancing insulin sensitivity. The potential of H2S donors as exercise supplements is also discussed, highlighting their ability to improve exercise performance and metabolic health. Current research advancements, including the application of multi-omics approaches, are reviewed to provide a deeper understanding of the complex molecular networks involved. Furthermore, the challenges and future directions in CSE\/H2S research are addressed, emphasizing the need for further mechanistic studies and clinical applications. This review underscores the therapeutic potential of targeting the CSE\/H2S pathway to optimize the benefits of exercise and improve metabolic health.<\/jats:p>","DOI":"10.3390\/ijms26041741","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T06:41:12Z","timestamp":1739860872000},"page":"1741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CSE\/H2S Signaling Pathways in Enhancing Muscle Function and Insulin Sensitivity During Exercise"],"prefix":"10.3390","volume":"26","author":[{"given":"Miaomiao","family":"Xu","sequence":"first","affiliation":[{"name":"School of Physical Education and Health, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"},{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-2100","authenticated-orcid":false,"given":"Xiaoguang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Sports and Health, Guangzhou Sport University, Guangzhou 510500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danting","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Physical Education and Health, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Physical Education and Health, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Lu","sequence":"additional","affiliation":[{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"eadr8849","DOI":"10.1126\/sciadv.adr8849","article-title":"Determinants of Increased Muscle Insulin Sensitivity of Exercise-Trained versus Sedentary Normal Weight and Overweight Individuals","volume":"11","author":"Pesta","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/oby.23986","article-title":"The Associations of \u201cWeekend Warrior\u201d and Regularly Active Physical Activity with Abdominal and General Adiposity in US Adults","volume":"32","author":"Lei","year":"2024","journal-title":"Obesity"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mambrini, S.P., Grillo, A., Colosimo, S., Zarpellon, F., Pozzi, G., Furlan, D., Amodeo, G., and Bertoli, S. (2024). Diet and Physical Exercise as Key Players to Tackle MASLD through Improvement of Insulin Resistance and Metabolic Flexibility. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1426551"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jshs.2023.06.005","article-title":"The Influence of Resistance Exercise Training Prescription Variables on Skeletal Muscle Mass, Strength, and Physical Function in Healthy Adults: An Umbrella Review","volume":"13","author":"Mcleod","year":"2024","journal-title":"J. Sport Health Sci."},{"key":"ref_5","first-page":"167","article-title":"Foot Exercises in Controlling Blood Sugar Levels in Elderly People with DM at the Baraka Community Health Center, Enrekang Regency, South Sulawesi","volume":"2","author":"Rosdiana","year":"2024","journal-title":"Int. J. Health Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.freeradbiomed.2024.08.010","article-title":"Exercise-Specific Adaptations in Human Skeletal Muscle: Molecular Mechanisms of Making Muscles Fit and Mighty","volume":"223","author":"Thomas","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, J., Zhang, S., Li, C., Zhang, X., Shan, Y., Zhang, Z., Bo, H., and Zhang, Y. (2024). Endurance Exercise-Induced Histone Methylation Modification Involved in Skeletal Muscle Fiber Type Transition and Mitochondrial Biogenesis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-72088-6"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102316","DOI":"10.1016\/j.arr.2024.102316","article-title":"Role of the Gut\u2013Muscle Axis in Mitochondrial Function of Ageing Muscle under Different Exercise Modes","volume":"98","author":"Xie","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1002\/jcsm.13348","article-title":"TAZ Stimulates Exercise-Induced Muscle Satellite Cell Activation via Pard3\u2013P38 MAPK\u2013TAZ Signalling Axis","volume":"14","author":"Kim","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhang, X., Zhao, Y., Guo, D., Luo, M., Zhang, Q., Zhang, L., and Zhang, D. (2024). Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK. Cardiovasc. Drugs Ther.","DOI":"10.1007\/s10557-024-07564-2"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2347139","DOI":"10.1080\/13510002.2024.2347139","article-title":"Skeletal Muscle Cystathionine \u03b3-Lyase Deficiency Promotes Obesity and Insulin Resistance and Results in Hyperglycemia and Skeletal Muscle Injury upon HFD in Mice","volume":"29","author":"Lu","year":"2024","journal-title":"Redox Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kaleta, K., Janik, K., Rydz, L., Wr\u00f3bel, M., and Jurkowska, H. (2024). Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes. Biomolecules, 14.","DOI":"10.3390\/biom14070746"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Flori, L., Benedetti, G., Calderone, V., and Testai, L. (2024). Hydrogen Sulfide and Irisin, Potential Allies in Ensuring Cardiovascular Health. Antioxidants, 13.","DOI":"10.3390\/antiox13050543"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2024.08.001","article-title":"Cystathionine Gamma-Lyase Deficiency Exaggerates Diethylnitrosamine-Induced Liver Damage in Mice","volume":"151","author":"Ligi","year":"2024","journal-title":"Nitric Oxide"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/jcsm.13560","article-title":"Hydrogen Sulfide Inhibits Skeletal Muscle Ageing by Up-Regulating Autophagy through Promoting Deubiquitination of Adenosine 5\u2032-Monophosphate (AMP)-Activated Protein Kinase A1 via Ubiquitin Specific Peptidase 5","volume":"15","author":"Yang","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/ars.2021.0256","article-title":"Hydrogen Sulfide Signaling in the Tumor Microenvironment: Implications in Cancer Progression and Therapy","volume":"40","author":"Cerqueira","year":"2024","journal-title":"Antioxid. Redox Signal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2023.05.009","article-title":"Novel Ray of Hope for Diabetic Wound Healing: Hydrogen Sulfide and Its Releasing Agents","volume":"58","author":"Shi","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s43032-024-01662-0","article-title":"Oxidative Stress-Induced Hormonal Disruption in Male Reproduction","volume":"31","author":"Rotimi","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Kumar, R., and Matson, J.B. (2024). Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide. Macromol. Biosci., 24.","DOI":"10.1002\/mabi.202300138"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114172","DOI":"10.1016\/j.yexcr.2024.114172","article-title":"Recent Advances in the Role of Hydrogen Sulfide in Age-Related Diseases","volume":"441","author":"Zhang","year":"2024","journal-title":"Exp. Cell Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Munteanu, C., Popescu, C., Vl\u0103dulescu-Trandafir, A.-I., and Onose, G. (2024). Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review. Antioxidants, 13.","DOI":"10.3390\/antiox13101158"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"107180","DOI":"10.1016\/j.phrs.2024.107180","article-title":"Hydrogen Sulfide Supplementation as a Potential Treatment for Primary Mitochondrial Diseases","volume":"203","author":"Slade","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Liu, Y.-F., Zhang, Y.-X., Zhu, Y.-W., Tang, A.-Q., Liang, H.-B., Yang, Y.-L., Zhai, Y.-K., Ji, X.-Y., and Wu, D.-D. (Antioxid. Redox Signal., 2024). Hydrogen Sulfide in Musculoskeletal Diseases: Molecular Mechanisms and Therapeutic Opportunities, Antioxid. Redox Signal., online ahead of print.","DOI":"10.1089\/ars.2024.0625"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Xu, M., Liu, X., Bao, P., Wang, Y., Zhu, X., Liu, Y., Ni, X., and Lu, J. (2022). Skeletal Muscle CSE Deficiency Leads to Insulin Resistance in Mice. Antioxidants, 11.","DOI":"10.3390\/antiox11112216"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12935-024-03317-1","article-title":"Pan-Inhibition of the Three H2S Synthesizing Enzymes Restrains Tumor Progression and Immunosuppression in Breast Cancer","volume":"24","author":"Dawoud","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5530\/pj.2024.16.48","article-title":"Hydrogen Sulfide and Cystathionine \u03b3\u2013Lyase with Oxidants and Antioxidants Levels for Patients with Epilepsy Diseases","volume":"16","year":"2024","journal-title":"Pharmacogn. J."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Si, Y., Song, N., and Ji, Y. (2024). Bioinformatics Analysis of the Clinical Value and Potential Mechanisms of CBS\/H2S in Glioma Through 1027 Samples, Research Square Platform.","DOI":"10.21203\/rs.3.rs-3942047\/v1"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e202411133","DOI":"10.1002\/ange.202411133","article-title":"Orthogonal Persulfide Generation through Precision Tools Provides Insights into Mitochondrial Sulfane Sulfur","volume":"136","author":"Manna","year":"2024","journal-title":"Angew. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"He, K., Tan, B., Lu, A., Bai, L., Song, C., Miao, Y., Liu, B., Chen, Q., Teng, X., and Dai, J. (2024). Asynchronous Changes of Hydrogen Sulfide and Its Generating Enzymes in Most Tissues with the Aging Process. Biosci. Rep., 44.","DOI":"10.1042\/BSR20240320"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2211241","DOI":"10.1002\/adma.202211241","article-title":"Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on down Syndrome","volume":"36","author":"Derry","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_31","first-page":"23119","article-title":"Treadmill Exercise Increases Cystathionine \u03b3 Lyase Expression and Decreases Inflammation in Skeletal Muscles of High Fat Diet Induced Obese Rats","volume":"9","author":"Wu","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jare.2020.02.013","article-title":"Hydrogen Sulfide Regulates Insulin Secretion and Insulin Resistance in Diabetes Mellitus, a New Promising Target for Diabetes Mellitus Treatment? A Review","volume":"27","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Parsanathan, R., and Jain, S.K. (2022). Hydrogen Sulfide Regulates Irisin and Glucose Metabolism in Myotubes and Muscle of HFD-Fed Diabetic Mice. Antioxidants, 11.","DOI":"10.3390\/antiox11071369"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.niox.2024.09.006","article-title":"Hydrogen Sulfide Upregulates SIRT1 to Inhibit Ox-HDL-Induced Endothelial Cell Damage and Mitochondrial Dysfunction","volume":"152","author":"Zhao","year":"2024","journal-title":"Nitric Oxide"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.niox.2024.01.004","article-title":"Hydrogen Sulfide (H2S) Metabolism: Unraveling Cellular Regulation, Disease Implications, and Therapeutic Prospects for Precision Medicine","volume":"144","author":"Pandey","year":"2024","journal-title":"Nitric Oxide"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jare.2020.04.002","article-title":"Abnormalities of Hydrogen Sulfide and Glutathione Pathways in Mitochondrial Dysfunction","volume":"27","author":"Quinzii","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s13181-019-00710-5","article-title":"Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development","volume":"15","author":"Ng","year":"2019","journal-title":"J. Med. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e202401003","DOI":"10.1002\/anie.202401003","article-title":"Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H2S Mediated Persulfidation. Angew","volume":"63","author":"Stoltzfus","year":"2024","journal-title":"Chem. Int. Ed."},{"key":"ref_39","first-page":"9752698","article-title":"Endogenous CSE\/Hydrogen Sulfide System Regulates the Effects of Glucocorticoids and Insulin on Muscle Protein Synthesis","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Omorou, M., Liu, N., Huang, Y., Al-Ward, H., Gao, M., Mu, C., Zhang, L., and Hui, X. (2022). Cystathionine Beta-Synthase in Hypoxia and Ischemia\/Reperfusion: A Current Overview. Arch. Biochem. Biophys., 718.","DOI":"10.1016\/j.abb.2022.109149"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rao, S.P., Dobariya, P., Bellamkonda, H., and More, S.S. (2023). Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12030603"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cmet.2024.12.008","article-title":"Ergothioneine Improves Healthspan of Aged Animals by Enhancing cGPDH Activity through CSE-Dependent Persulfidation","volume":"37","author":"Petrovic","year":"2025","journal-title":"Cell Metab."},{"key":"ref_43","first-page":"238","article-title":"Mechanisms Underpinning the Effect of Exercise on the Non-Alcoholic Fatty Liver Disease: Review","volume":"24","author":"Bekheit","year":"2025","journal-title":"EXCLI J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.niox.2014.11.012","article-title":"Role of Hydrogen Sulfide in Skeletal Muscle Biology and Metabolism","volume":"46","author":"Veeranki","year":"2015","journal-title":"Nitric Oxide"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2300622","DOI":"10.1002\/mnfr.202300622","article-title":"Allicin Promotes Glucose Uptake by Activating AMPK through CSE\/H2S-Induced S-Sulfhydration in a Muscle-Fiber Dependent Way in Broiler Chickens","volume":"68","author":"Li","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zhang, H., Pan, J., Huang, S., Chen, X., Chang, A.C.Y., Wang, C., Zhang, J., and Zhang, H. (2024). Hydrogen Sulfide Protects Cardiomyocytes from Doxorubicin-Induced Ferroptosis through the SLC7A11\/GSH\/GPx4 Pathway by Keap1 S-Sulfhydration and Nrf2 Activation. Redox Biol., 70.","DOI":"10.1016\/j.redox.2024.103066"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"176345","DOI":"10.1016\/j.ejphar.2024.176345","article-title":"Investigating the Impact of Protein S-Sulfhydration Modification on Vascular Diseases: A Comprehensive Review","volume":"966","author":"Pang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Chen, T., Bai, D., Gong, C., Cao, Y., Yan, X., and Peng, R. (2024). Hydrogen Sulfide Mitigates Mitochondrial Dysfunction and Cellular Senescence in Diabetic Patients: Potential Therapeutic Applications. Biochem. Pharmacol., 230.","DOI":"10.1016\/j.bcp.2024.116556"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Li, R.-Y., and Guo, L. (2024). Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073605"},{"key":"ref_50","first-page":"331","article-title":"The role of endogenous H2S in experimental metabolic syndrome","volume":"28","author":"Birulina","year":"2024","journal-title":"RUDN J. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"176266","DOI":"10.1016\/j.ejphar.2023.176266","article-title":"Hydrogen Sulfide Ameliorates Hypertension and Vascular Dysfunction Induced by Insulin Resistance in Rats by Reducing Oxidative Stress and Activating eNOS","volume":"963","author":"Hong","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological Roles of Hydrogen Sulfide in Mammalian Cells, Tissues, and Organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/jcsm.13440","article-title":"Control of Muscle Satellite Cell Function by Specific Exercise-Induced Cytokines and Their Applications in Muscle Maintenance","volume":"15","author":"Guo","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1007\/s00421-024-05549-5","article-title":"Integrative Effects of Resistance Training and Endurance Training on Mitochondrial Remodeling in Skeletal Muscle","volume":"124","author":"Zhao","year":"2024","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_55","first-page":"621","article-title":"PGC-1\u03b1 Affects Skeletal Muscle and Adipose Tissue Development by Regulating Mitochondrial Biogenesis. Mol. Genet","volume":"297","author":"Kong","year":"2022","journal-title":"Genomics"},{"key":"ref_56","first-page":"504","article-title":"Unlocking the Science of Physical Endurance: Training Techniques and Biological Factors","volume":"55","author":"Yendrizal","year":"2024","journal-title":"Retos Nuevas Tend. En Educ. F\u00edsica Deporte Recreaci\u00f3n"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Luo, X., Zhang, H., Cao, X., Yang, D., Yan, Y., Lu, J., Wang, X., and Wang, H. (2023). Endurance Exercise-Induced Fgf21 Promotes Skeletal Muscle Fiber Conversion through TGF-\u03921 and P38 MAPK Signaling Pathway. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411401"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"108590","DOI":"10.1016\/j.isci.2023.108590","article-title":"Glucose Restriction Enhances Oxidative Fiber Formation: A Multi-Omic Signal Network Involving AMPK and CaMK2","volume":"27","author":"Zhang","year":"2024","journal-title":"iScience"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"E240","DOI":"10.1152\/ajpendo.00503.2020","article-title":"Is GLUT4 Translocation the Answer to Exercise-Stimulated Muscle Glucose Uptake?","volume":"320","author":"Richter","year":"2021","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1042\/BCJ20210185","article-title":"Interactions between Insulin and Exercise","volume":"478","author":"Richter","year":"2021","journal-title":"Biochem. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.freeradbiomed.2024.09.004","article-title":"Exercise Performance and Health: Role of GLUT4","volume":"224","author":"McGee","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wang, H., Wang, J., Zhu, Y., Yan, H., and Lu, Y. (2021). Effects of Different Intensity Exercise on Glucose Metabolism and Hepatic IRS\/PI3K\/AKT Pathway in SD Rats Exposed with TCDD. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182413141"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"166126","DOI":"10.1016\/j.bbadis.2021.166126","article-title":"MOTS-c Interacts Synergistically with Exercise Intervention to Regulate PGC-1\u03b1 Expression, Attenuate Insulin Resistance and Enhance Glucose Metabolism in Mice via AMPK Signaling Pathway. Biochim. Biophys","volume":"1867","author":"Yang","year":"2021","journal-title":"Acta BBA Mol. Basis Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Atakan, M.M., Ko\u015far, \u015e.N., G\u00fczel, Y., Tin, H.T., and Yan, X. (2021). The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue. Nutrients, 13.","DOI":"10.3390\/nu13051459"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/bs.acc.2019.11.003","article-title":"Chapter Three\u2014Omics and the Molecular Exercise Physiology","volume":"Volume 96","author":"Makowski","year":"2020","journal-title":"Advances in Clinical Chemistry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e70153","DOI":"10.1096\/fj.202401420RR","article-title":"Time-Series Transcriptomics Reveals Distinctive mRNA Expression Dynamics Associated with Gene Ontology Specificity and Protein Expression in Skeletal Muscle after Electrical Stimulation-Induced Resistance Exercise","volume":"38","author":"Kusano","year":"2024","journal-title":"FASEB J."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Beiter, T., Z\u00fcgel, M., Hudemann, J., Schild, M., Fragasso, A., Burgstahler, C., Kr\u00fcger, K., Mooren, F.C., Steinacker, J.M., and Nie\u00df, A.M. (2024). The Acute, Short-, and Long-Term Effects of Endurance Exercise on Skeletal Muscle Transcriptome Profiles. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052881"},{"key":"ref_68","first-page":"e14334","article-title":"Mass Spectrometry-Based Proteomics Approaches to Interrogate Skeletal Muscle Adaptations to Exercise. Scand","volume":"34","author":"Cervone","year":"2024","journal-title":"J. Med. Sci. Sports"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Bhat, A., Abu, R., Jagadesan, S., Vellichirammal, N.N., Pendyala, V.V., Yu, L., Rudebush, T.L., Guda, C., Zucker, I.H., and Kumar, V. (2023). Quantitative Proteomics Identifies Novel Nrf2-Mediated Adaptative Signaling Pathways in Skeletal Muscle Following Exercise Training. Antioxidants, 12.","DOI":"10.3390\/antiox12010151"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wu, L., Wang, J., Cao, X., Tian, Y., and Li, J. (2022). Effect of Acute High-Intensity Exercise on Myocardium Metabolic Profiles in Rat and Human Study via Metabolomics Approach. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-10976-5"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ohmura, H., Mukai, K., Takahashi, Y., and Takahashi, T. (2021). Metabolomic Analysis of Skeletal Muscle before and after Strenuous Exercise to Fatigue. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-90834-y"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"115339","DOI":"10.1016\/j.bbr.2024.115339","article-title":"Impact of Aerobic Exercise on Brain Metabolism: Insights from Spatial Metabolomic Analysis","volume":"478","author":"Zheng","year":"2025","journal-title":"Behav. Brain Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wang, F., Wu, W., He, X., Qian, P., Chang, J., Lu, Z., Guo, J., Bao, Y., Guan, H., and Zhang, T. (2024). Effects of Moderate Intensity Exercise on Liver Metabolism in Mice Based on Multi-Omics Analysis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-82150-y"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"142479","DOI":"10.1016\/j.foodchem.2024.142479","article-title":"Integrative Transcriptomic, Proteomic and Metabolomic Analyses Yields Insights into Muscle Fiber Type in Cattle","volume":"468","author":"Tan","year":"2025","journal-title":"Food Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e34917","DOI":"10.1016\/j.heliyon.2024.e34917","article-title":"The Effect of High-Intensity Interval Training on Type 2 Diabetic Muscle: A Metabolomics-Based Study","volume":"10","author":"Khoramipour","year":"2024","journal-title":"Heliyon"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Katz, D.H., Lindholm, M.E., and Ashley, E.A. (2025). Charting the Molecular Terrain of Exercise: Energetics, Exerkines, and the Future of Multiomic Mapping. Physiology, 40.","DOI":"10.1152\/physiol.00024.2024"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1038\/s41467-024-45966-w","article-title":"The Impact of Exercise on Gene Regulation in Association with Complex Trait Genetics","volume":"15","author":"Vetr","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-023-06877-w","article-title":"Temporal Dynamics of the Multi-Omic Response to Endurance Exercise Training","volume":"629","author":"Amar","year":"2024","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jacques, M., Landen, S., Sharples, A.P., Garnham, A., Schittenhelm, R., Stele, J., Heikkinen, A., Sillanp\u00e4\u00e4, E., Ollikainen, M., and Broatch, J. (2024). Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration. BioRxiv, 2024-07.","DOI":"10.1101\/2024.07.14.603458"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1113\/EP091059","article-title":"An Exercise Physiologist\u2019s Guide to Metabolomics","volume":"109","author":"Owens","year":"2024","journal-title":"Exp. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.18203\/2320-6012.ijrms20240691","article-title":"Significance of calcium: Its correlation with red and white muscle contraction, fatigue and potential","volume":"12","author":"Castro","year":"2024","journal-title":"Int. J. Res. Med. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jphs.2022.04.004","article-title":"The Excitatory Effect of Hydrogen Sulfide on Rat Colonic Muscle Contraction and the Underlying Mechanism","volume":"149","author":"Quan","year":"2022","journal-title":"J. Pharmacol. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"172455","DOI":"10.1016\/j.ejphar.2019.172455","article-title":"Hydrogen Sulfide Inhibited L-Type Calcium Channels (CaV1.2) via up-Regulation of the Channel Sulfhydration in Vascular Smooth Muscle Cells","volume":"858","author":"Dai","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1139\/cjpp-2018-0501","article-title":"Restoration of Skeletal Muscle Homeostasis by Hydrogen Sulfide during Hyperhomocysteinemia-Mediated Oxidative\/ER Stress Condition. Can","volume":"97","author":"Majumder","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Cui, T., Liu, W., Yu, C., Ren, J., Li, Y., Shi, X., Li, Q., and Zhang, J. (2022). Protective Effects of Allicin on Acute Myocardial Infarction in Rats via Hydrogen Sulfide-Mediated Regulation of Coronary Arterial Vasomotor Function and Myocardial Calcium Transport. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.752244"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"H950","DOI":"10.1152\/ajpheart.00600.2023","article-title":"Calcium Signaling in Endothelial and Vascular Smooth Muscle Cells: Sex Differences and the Influence of Estrogens and Androgens","volume":"326","author":"Palacios","year":"2024","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.freeradbiomed.2024.03.025","article-title":"From Powerhouse to Regulator: The Role of Mitoepigenetics in Mitochondrion-Related Cellular Functions and Human Diseases","volume":"218","author":"Donato","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.niox.2023.05.002","article-title":"Hydrogen Sulfide Alleviates Heart Failure with Preserved Ejection Fraction in Mice by Targeting Mitochondrial Abnormalities via PGC-1\u03b1","volume":"136\u2013137","author":"Huang","year":"2023","journal-title":"Nitric Oxide"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Cheng, D., Long, J., Zhao, L., and Liu, J. (2023). Hydrogen: A Rising Star in Gas Medicine as a Mitochondria-Targeting Nutrient via Activating Keap1-Nrf2 Antioxidant System. Antioxidants, 12.","DOI":"10.20944\/preprints202310.1953.v1"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Huang, D., Jing, G., and Zhu, S. (2023). Regulation of Mitochondrial Respiration by Hydrogen Sulfide. Antioxidants, 12.","DOI":"10.3390\/antiox12081644"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e38661","DOI":"10.1016\/j.heliyon.2024.e38661","article-title":"Exogenous Hydrogen Sulfide Enhances Myogenic Differentiation of C2C12 Myoblasts under High Palmitate Stress","volume":"10","author":"Lu","year":"2024","journal-title":"Heliyon"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Xu, M., Zhang, Q., Liu, X., Lu, L., and Li, Z. (2024). Impact of Alpha-Ketoglutarate on Skeletal Muscle Health and Exercise Performance: A Narrative Review. Nutrients, 16.","DOI":"10.3390\/nu16223968"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kaczmarek, A., Kaczmarek, M., Cia\u0142owicz, M., Clemente, F.M., Wola\u0144ski, P., Badicu, G., and Murawska-Cia\u0142owicz, E. (2021). The Role of Satellite Cells in Skeletal Muscle Regeneration\u2014The Effect of Exercise and Age. Biology, 10.","DOI":"10.3390\/biology10101056"},{"key":"ref_94","unstructured":"Shuang, T. (2019). The Interaction Among Hydrogen Sulfide, Estrogen and Insulin-like Growth Factor-1 in Vascular Smooth Muscle Cells. [Ph.D. Thesis, Laurentian University]."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s00018-022-04636-0","article-title":"Hydrogen Sulfide as a Therapeutic Option for the Treatment of Duchenne Muscular Dystrophy and Other Muscle-Related Diseases. Cell","volume":"79","author":"Myszka","year":"2022","journal-title":"Mol. Life Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.niox.2021.08.004","article-title":"H2S Signaling and Extracellular Matrix Remodeling in Cardiovascular Diseases: A Tale of Tense Relationship","volume":"116","author":"Zhu","year":"2021","journal-title":"Nitric Oxide"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Paul, B.D., Snyder, S.H., and Kashfi, K. (2021). Effects of Hydrogen Sulfide on Mitochondrial Function and Cellular Bioenergetics. Redox Biol., 38.","DOI":"10.1016\/j.redox.2020.101772"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jshs.2022.10.003","article-title":"Exercise Sustains the Hallmarks of Health","volume":"12","author":"Qiu","year":"2023","journal-title":"J. Sport Health Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11332-020-00670-2","article-title":"Effects of High Intensity Interval Training and Aging on Cardiac Muscle Apoptosis Markers in C57BL\/6 Mice","volume":"17","author":"Soori","year":"2021","journal-title":"Sport Sci. Health"},{"key":"ref_101","first-page":"e21511","article-title":"Cystathionine Gamma-Lyase\/H2S Signaling Facilitates Myogenesis under Aging and Injury Condition","volume":"35","author":"Zhang","year":"2021","journal-title":"FASEB J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-024-01868-w","article-title":"The Potential Role of Hydrogen Sulfide in Cancer Cell Apoptosis","volume":"10","author":"Gao","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Wu, D., Luo, N., Wang, L., Zhao, Z., Bu, H., Xu, G., Yan, Y., Che, X., Jiao, Z., and Zhao, T. (2017). Hydrogen Sulfide Ameliorates Chronic Renal Failure in Rats by Inhibiting Apoptosis and Inflammation through ROS\/MAPK and NF-\u03baB Signaling Pathways. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-00557-2"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/ars.2023.0401","article-title":"Mechanisms Underlying the Hydrogen Sulfide Actions: Target Molecules and Downstream Signaling Pathways. Antioxid","volume":"40","author":"Tao","year":"2024","journal-title":"Redox Signal."},{"key":"ref_105","unstructured":"Majumder, A. (2018). Effects of Hydrogen Sulfide in Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy. [Ph.D. Thesis, University of Louisville]."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"\u0141oboda, A., and Dulak, J. (2024). Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy. Cells, 13.","DOI":"10.3390\/cells13020158"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10522-021-09929-8","article-title":"Exercise Renovates H2S and Nrf2-Related Antioxidant Pathways to Suppress Apoptosis in the Natural Ageing Process of Male Rat Cortex","volume":"22","author":"Lin","year":"2021","journal-title":"Biogerontology"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Xu, M., Liu, X., Bao, P., Wang, Y.J., Lu, J., and Liu, Y.J. (2022). H2S Protects against Immobilization-Induced Muscle Atrophy via Reducing Oxidative Stress and Inflammation. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.844539"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"26","DOI":"10.20517\/jca.2022.16","article-title":"Hydrogen Sulfide: The Gas That Fuels Longevity","volume":"2","author":"Blackwood","year":"2022","journal-title":"J. Cardiovasc. Aging"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11325-024-03216-9","article-title":"Exogenous H2S Targeting PI3K\/AKT\/mTOR Pathway Alleviates Chronic Intermittent Hypoxia-Induced Myocardial Damage through Inhibiting Oxidative Stress and Enhancing Autophagy","volume":"29","author":"Zheng","year":"2024","journal-title":"Sleep Breath."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1080\/02640414.2013.868921","article-title":"Effect of Sulphurous Mineral Water in Haematological and Biochemical Markers of Muscle Damage after an Endurance Exercise in Well-Trained Athletes","volume":"32","author":"Soria","year":"2014","journal-title":"J. Sports Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6825452","DOI":"10.1155\/2018\/6825452","article-title":"Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology","volume":"2018","author":"Bitar","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Adel, M., Elsayed, H.R.H., El-Nablaway, M., Hamed, S., Eladl, A., Fouad, S., El Nashar, E.M., Al-Otaibi, M.L., and Rabei, M.R. (2022). Targeting Hydrogen Sulfide Modulates Dexamethasone-Induced Muscle Atrophy and Microvascular Rarefaction, through Inhibition of NOX4 and Induction of MGF, M2 Macrophages and Endothelial Progenitors. Cells, 11.","DOI":"10.3390\/cells11162500"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jare.2020.06.023","article-title":"Persulfidation of Transcription Factor FOXO1 at Cysteine 457: A Novel Mechanism by Which H2S Inhibits Vascular Smooth Muscle Cell Proliferation","volume":"27","author":"Tian","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Haberecht-M\u00fcller, S., Kr\u00fcger, E., and Fielitz, J. (2021). Out of Control: The Role of the Ubiquitin Proteasome System in Skeletal Muscle during Inflammation. Biomolecules, 11.","DOI":"10.3390\/biom11091327"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"C609","DOI":"10.1152\/ajpcell.00147.2018","article-title":"Hydrogen Sulfide Alleviates Hyperhomocysteinemia-Mediated Skeletal Muscle Atrophy via Mitigation of Oxidative and Endoplasmic Reticulum Stress Injury","volume":"315","author":"Majumder","year":"2018","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Chen, R., Zheng, Y., Zhou, C., Dai, H., Wang, Y., Chu, Y., and Luo, J. (2024). N-Acetylcysteine Attenuates Sepsis-Induced Muscle Atrophy by Downregulating Endoplasmic Reticulum Stress. Biomedicines, 12.","DOI":"10.3390\/biomedicines12040902"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Lv, S., Liu, H., and Wang, H. (2021). Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136715"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e13829","DOI":"10.1111\/eci.13829","article-title":"Exercise Restores Endogenous H2S Synthesis and Mitochondrial Function in the Heart of Old Rats","volume":"52","author":"Strutynska","year":"2022","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1186\/s12967-024-05621-w","article-title":"VEGFB Ameliorates Insulin Resistance in NAFLD via the PI3K\/AKT Signal Pathway","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Munteanu, C., Rotariu, M., Turnea, M., Dogaru, G., Popescu, C., Sp\u00eenu, A., Andone, I., Postoiu, R., Ionescu, E.V., and Oprea, C. (2022). Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)\u2014A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126720"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Lin, Y.-C., Zeng, W.-T., and Lee, D.-Y. (2023). H2S- and Redox-State-Mediated PTP1B S-Sulfhydration in Insulin Signaling. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032898"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Chen, X., Zhao, X., Lan, F., Zhou, T., Cai, H., Sun, H., Kong, W., and Kong, W. (2017). Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-13251-0"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Liu, J., Mesfin, F.M., Hunter, C.E., Olson, K.R., Shelley, W.C., Brokaw, J.P., Manohar, K., and Markel, T.A. (2022). Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter. Antioxidants, 11.","DOI":"10.3390\/antiox11091788"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"F301","DOI":"10.1152\/ajprenal.00266.2023","article-title":"Macrophage Polarization and Signaling in Diabetic Kidney Disease: A Catalyst for Disease Progression","volume":"326","author":"Youssef","year":"2024","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11010-021-04278-z","article-title":"Hydrogen Sulfide Plays a Potential Alternative for the Treatment of Metabolic Disorders of Diabetic Cardiomyopathy","volume":"477","author":"Deng","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e13680","DOI":"10.1111\/eci.13680","article-title":"Hydrogen Sulphide in Liver Glucose\/Lipid Metabolism and Non-Alcoholic Fatty Liver Disease","volume":"52","author":"Mateus","year":"2022","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbagen.2015.08.003","article-title":"H2S-Induced S-Sulfhydration of Pyruvate Carboxylase Contributes to Gluconeogenesis in Liver Cells. Biochim. Biophys","volume":"1850","author":"Ju","year":"2015","journal-title":"Acta BBA Gen. Subj."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/ptr.6923","article-title":"Pharmacological Modulation of the Hydrogen Sulfide (HS) System by Dietary HS-Donors: A Novel Promising Strategy in the Prevention and Treatment of Type 2 Diabetes Mellitus","volume":"35","author":"Piragine","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1038\/s41467-023-41304-8","article-title":"The Master Energy Homeostasis Regulator PGC-1\u03b1 Exhibits an mRNA Nuclear Export Function","volume":"14","author":"Mihaylov","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"119803","DOI":"10.1016\/j.lfs.2021.119803","article-title":"A Comprehensive Review of Sirtuins: With a Major Focus on Redox Homeostasis and Metabolism","volume":"282","author":"Shahgaldi","year":"2021","journal-title":"Life Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"508409","DOI":"10.1155\/2015\/508409","article-title":"Mechanisms Linking Inflammation to Insulin Resistance","volume":"2015","author":"Chen","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2017.11.004","article-title":"H2S Protects Lipopolysaccharide-Induced Inflammation by Blocking NF\u03baB Transactivation in Endothelial Cells","volume":"338","author":"Bourque","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Saha, S., Buttari, B., Panieri, E., Profumo, E., and Saso, L. (2020). An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. Molecules, 25.","DOI":"10.3390\/molecules25225474"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/ars.2020.8249","article-title":"New Therapeutic Approaches Using Hydrogen Sulfide Donors in Inflammation and Immune Response. Antioxid","volume":"35","author":"Li","year":"2021","journal-title":"Redox Signal."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"111990","DOI":"10.1016\/j.intimp.2024.111990","article-title":"Hydrogen Sulfide Regulates Macrophage Polarization and Necroptosis to Accelerate Diabetic Skin Wound Healing","volume":"132","author":"He","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Merz, T., McCook, O., Brucker, C., Waller, C., Calzia, E., Radermacher, P., and Datzmann, T. (2022). H2S in Critical Illness\u2014A New Horizon for Sodium Thiosulfate?. Biomolecules, 12.","DOI":"10.3390\/biom12040543"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a Novel, Water-Soluble Hydrogen Sulfide\u2013Releasing Molecule (GYY4137)","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2200349","DOI":"10.1002\/adtp.202200349","article-title":"Current Status and Future Prospects of Hydrogen Sulfide Donor-Based Delivery Systems","volume":"6","author":"Lu","year":"2023","journal-title":"Adv. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/ars.2020.8206","article-title":"Activation of Endogenous H2S Biosynthesis or Supplementation with Exogenous H2S Enhances Adipose Tissue Adipogenesis and Preserves Adipocyte Physiology in Humans","volume":"35","author":"Comas","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Munteanu, C., Onose, G., Po\u0219taru, M., Turnea, M., Rotariu, M., and Galaction, A.I. (2024). Hydrogen Sulfide and Gut Microbiota: Their Synergistic Role in Modulating Sirtuin Activity and Potential Therapeutic Implications for Neurodegenerative Diseases. Pharmaceuticals, 17.","DOI":"10.3390\/ph17111480"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Vo, T.T.T., Huynh, T.D., Wang, C.-S., Lai, K.-H., Lin, Z.-C., Lin, W.-N., Chen, Y.-L., Peng, T.-Y., Wu, H.-C., and Lee, I.-T. (2022). The Potential Implications of Hydrogen Sulfide in Aging and Age-Related Diseases through the Lens of Mitohormesis. Antioxidants, 11.","DOI":"10.3390\/antiox11081619"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1089\/ars.2022.0077","article-title":"The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling. Antioxid","volume":"38","author":"Olson","year":"2023","journal-title":"Redox Signal."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Batall\u00e9, G., Bai, X., and Pol, O. (2022). The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice. Antioxidants, 11.","DOI":"10.3390\/antiox11071271"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Zhao, L., Liu, X., Zhang, J., Dong, G., Xiao, W., and Xu, X. (2020). Hydrogen Sulfide Alleviates Skeletal Muscle Fibrosis via Attenuating Inflammation and Oxidative Stress. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.533690"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcp.2017.12.010","article-title":"H2S and Polysulfide Metabolism: Conventional and Unconventional Pathways","volume":"149","author":"Olson","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Zhao, H., Liu, H., Yang, Y., Lan, T., Wang, H., and Wu, D. (2022). Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137170"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"cvac066.041","DOI":"10.1093\/cvr\/cvac066.041","article-title":"Regular Exercise Increases H2S Levels in Mitochondria and Cardiac Tissue, Enhances Genes Expression of H2S-Synthesizing Enzymes and Prevents Mitochondrial Swelling","volume":"118","author":"Luchkova","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Magli, E., Perissutti, E., Santagada, V., Caliendo, G., Corvino, A., Esposito, G., Esposito, G., Fiorino, F., Migliaccio, M., and Scognamiglio, A. (2021). H2S Donors and Their Use in Medicinal Chemistry. Biomolecules, 11.","DOI":"10.3390\/biom11121899"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen Sulfide-Based Therapeutics: Exploiting a Unique but Ubiquitous Gasotransmitter","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1139\/cjpp-2016-0611","article-title":"Exercise Restores Bioavailability of Hydrogen Sulfide and Promotes Autophagy Influx in Livers of Mice Fed with High-Fat Diet","volume":"95","author":"Wang","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1089\/ars.2019.7824","article-title":"Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis. Antioxid","volume":"32","author":"Zhang","year":"2020","journal-title":"Redox Signal."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"172","DOI":"10.34172\/jsums.796","article-title":"The Effect of Eight Weeks of High-Intensity Interval Training with L-Cysteine Consumption on Interleukin-13 and Oxidative Stress of Heart Tissue in Young Rats with Type 2 Diabetes","volume":"25","author":"Davoudi","year":"2023","journal-title":"J. Shahrekord Univ. Med. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"176","DOI":"10.12680\/balneo.2021.438","article-title":"Hydrogen Sulfide (H2S)\u2014Therapeutic Relevance in Rehabilitation and Balneotherapy Systematic Literature Review and Meta-Analysis Based on the PRISMA Paradigm","volume":"12","author":"Munteanu","year":"2021","journal-title":"Balneo PRM Res. J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jare.2020.05.018","article-title":"Emerging Analytical Tools for the Detection of the Third Gasotransmitter H2S, a Comprehensive Review","volume":"27","author":"Ibrahim","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Tovar-Lopez, F.J. (2023). Recent Progress in Micro- and Nanotechnology-Enabled Sensors for Biomedical and Environmental Challenges. Sensors, 23.","DOI":"10.3390\/s23125406"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Chun, Y.L., Eom, W.-J., Lee, J.H., Nguyen, T.N.C., Park, K.-H., Chung, H.-J., Seo, H., Huh, Y., Kim, S.H., and Yeo, S.G. (2022). Investigation of the Hydrogen Sulfide Signaling Pathway in Schwann Cells during Peripheral Nerve Degeneration: Multi-Omics Approaches. Antioxidants, 11.","DOI":"10.3390\/antiox11081606"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12953-023-00221-w","article-title":"Effects of \u039c-Conotoxin GIIIB on the Cellular Activity of Mouse Skeletal Musculoblast: Combined Transcriptome and Proteome Analysis","volume":"21","author":"Wu","year":"2023","journal-title":"Proteome Sci."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Pandey, T., Kaundal, R.S., and Pandey, V. (2024). Biophysical Characterization of Hydrogen Sulfide: A Fundamental Exploration in Understanding Significance in Cell Signaling. Biophys. Chem., 314.","DOI":"10.1016\/j.bpc.2024.107317"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/4\/1741\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:36:57Z","timestamp":1760027817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/4\/1741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":159,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijms26041741"],"URL":"https:\/\/doi.org\/10.3390\/ijms26041741","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}