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Key inflammatory biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6), lipopolysaccharides (LPS), zonulin (ZO-1), and netrin-1 (Ntn1), are discussed in the context of intestinal barrier integrity and chronic inflammation. Dysbiosis, characterized by alterations in microbial composition and function, directly modulates the levels and activity of these biomarkers, exacerbating inflammatory responses and compromising epithelial barriers. The disruption of microbiota is further correlated with increased intestinal permeability and chronic inflammation, serving as a precursor to conditions like type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease. Additionally, this review examines therapeutic strategies, including probiotics and prebiotics, designed to restore microbial balance, mitigate inflammation, and enhance metabolic homeostasis. Emerging evidence positions microbiota-targeted interventions as critical components in the advancement of precision medicine, offering promising avenues for diagnosing and treating inflammatory and metabolic disorders.<\/jats:p>","DOI":"10.3390\/ijms26041773","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T08:36:46Z","timestamp":1739954206000},"page":"1773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Microbiota and Inflammatory Markers: A Review of Their Interplay, Clinical Implications, and Metabolic Disorders"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3364-0913","authenticated-orcid":false,"given":"Emiliano","family":"Pe\u00f1a-Dur\u00e1n","sequence":"first","affiliation":[{"name":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2120-1819","authenticated-orcid":false,"given":"Jes\u00fas Jonathan","family":"Garc\u00eda-Galindo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Calle Sierra Mojada 950, Independencia Oriente, Guadalajara 44340, Mexico"},{"name":"Departamento Acad\u00e9mico Aparatos y Sistemas II, Decanato de Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara, Zapopan 44670, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Daniel","family":"L\u00f3pez-Murillo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Calle Sierra Mojada 950, Independencia Oriente, Guadalajara 44340, Mexico"},{"name":"Departamento Acad\u00e9mico Aparatos y Sistemas I, Decanato de Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara, Zapopan 44670, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8853-5629","authenticated-orcid":false,"given":"Alfredo","family":"Huerta-Huerta","sequence":"additional","affiliation":[{"name":"Hospital Medica de la Ciudad, Santa Catalina, Calle. 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