{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:22:01Z","timestamp":1785014521232,"version":"3.55.0"},"reference-count":44,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KAWASAKI Foundation for Medical Science and Medical Welfare","award":["JP 24K20203"],"award-info":[{"award-number":["JP 24K20203"]}]},{"name":"KAWASAKI Foundation for Medical Science and Medical Welfare","award":["TBU2019-2-2"],"award-info":[{"award-number":["TBU2019-2-2"]}]},{"name":"JSPS KAKENHI","award":["JP 24K20203"],"award-info":[{"award-number":["JP 24K20203"]}]},{"name":"JSPS KAKENHI","award":["TBU2019-2-2"],"award-info":[{"award-number":["TBU2019-2-2"]}]},{"name":"Tokushima Bunri University Grant for Educational Reform and Collaborative Research","award":["JP 24K20203"],"award-info":[{"award-number":["JP 24K20203"]}]},{"name":"Tokushima Bunri University Grant for Educational Reform and Collaborative Research","award":["TBU2019-2-2"],"award-info":[{"award-number":["TBU2019-2-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Periodontitis is one of the most common diseases associated with the lifestyle habits of adults and is caused by the formation of biofilms, called dental plaques, in periodontal pockets by oral bacteria, such as Porphyromonas gingivalis. Bangle, Zingiber purpureum Rosc. (Indonesian ginger), a native Indonesian plant, has been traditionally consumed as food and medicine across Southeast Asia. The cis- and trans-banglenes, components of the rhizomes of Z. purpureum, have been reported to possess neurotrophic activity. Hexane extract of bangle exhibited antibacterial activity against P. gingivalis, with a minimum inhibitory concentration of 8 \u03bcg\/mL. We isolated several compounds from the active fractions through the bioassay-guided isolation of hexane extract. Further, we found that c- and t-banglene inhibited the growth of P. gingivalis at 4 \u00b5g\/mL; however, these compounds showed no antibacterial effects against oral microorganisms. We also observed that c- and t-banglenes resulted in 47% and 40% reductions in biofilm formation. In conclusion, our results suggest that banglene has specific antibacterial effects against the periodontopathogen P. gingivalis, with minimal impact on oral microorganisms. Thus, banglene has potential applications in the prevention of periodontitis without the risk of substituted microbisms.<\/jats:p>","DOI":"10.3390\/ijms26051787","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:03:17Z","timestamp":1740024197000},"page":"1787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antibacterial Activity of Banglene Extracted from Indonesian Ginger \u201cBangle\u201d Against Porphyromonas gingivalis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1485-5325","authenticated-orcid":false,"given":"Mayu","family":"Sebe","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki 701-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoka","family":"Senoura","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki 701-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki 701-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wako","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki 701-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagisa","family":"Yano","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Harada","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-172X","authenticated-orcid":false,"given":"Yoshiyasu","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-3128","authenticated-orcid":false,"given":"Miwa","family":"Kubo","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki 701-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: An introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontology 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1902\/jop.2004.75.8.1077","article-title":"Occurrence of Porphyromonas gingivalis and Tannerella forsythensis in periodantally diseased and healthy subjects","volume":"75","author":"Yang","year":"2004","journal-title":"J. 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