{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:19:31Z","timestamp":1788826771426,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["H19\/01\/a0\/024"],"award-info":[{"award-number":["H19\/01\/a0\/024"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["08\/FY2021\/EX\/109-A163"],"award-info":[{"award-number":["08\/FY2021\/EX\/109-A163"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["NCCSCF-R-YR2022-APR-ECCRS1"],"award-info":[{"award-number":["NCCSCF-R-YR2022-APR-ECCRS1"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016017","name":"Duke-NUS","doi-asserted-by":"publisher","award":["H19\/01\/a0\/024"],"award-info":[{"award-number":["H19\/01\/a0\/024"]}],"id":[{"id":"10.13039\/100016017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016017","name":"Duke-NUS","doi-asserted-by":"publisher","award":["08\/FY2021\/EX\/109-A163"],"award-info":[{"award-number":["08\/FY2021\/EX\/109-A163"]}],"id":[{"id":"10.13039\/100016017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016017","name":"Duke-NUS","doi-asserted-by":"publisher","award":["NCCSCF-R-YR2022-APR-ECCRS1"],"award-info":[{"award-number":["NCCSCF-R-YR2022-APR-ECCRS1"]}],"id":[{"id":"10.13039\/100016017","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cancer Centre Singapore","award":["H19\/01\/a0\/024"],"award-info":[{"award-number":["H19\/01\/a0\/024"]}]},{"name":"National Cancer Centre Singapore","award":["08\/FY2021\/EX\/109-A163"],"award-info":[{"award-number":["08\/FY2021\/EX\/109-A163"]}]},{"name":"National Cancer Centre Singapore","award":["NCCSCF-R-YR2022-APR-ECCRS1"],"award-info":[{"award-number":["NCCSCF-R-YR2022-APR-ECCRS1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is common and poses significant morbidity of lasting impact to young, pre-menopausal women, while ovarian cancer is a lethal gynecologic condition. Both conditions need better treatment. The human omentum is an apron of adipose tissue in the abdominopelvic cavity, the same space in which endometriosis and ovarian cancer manifest. We aim to determine molecular cues emitted by the omentum that aid the trans-coelomic spread of endometriosis and ovarian cancer in the abdomen\u2013pelvic\/peritoneal space. Endometriosis and ovarian cancer patients were prospectively recruited. Primary cell cultures of surgically-resected omentum, endometriosis and ovarian cancer were generated, and conditioned media (CM) from the omentum was derived. They were used for in vitro assays to evaluate the effect of the omentum on cell migration, angiogenesis and proliferation in endometriosis and ovarian cancer. Omental CM promoted cell migration in primary cultures of endometriosis and ovarian cancer. Omental CM contained high levels of HGF, SDF-1a, MCP-1, VEGF-A, IL-6 and IL-8. The observed cell migration was blocked by c-MET inhibition, suggesting that HGF\/c-MET signaling mediates cell migration in endometriosis and ovarian cancer. Furthermore, PTTG1 was consistently upregulated in the migrated cells in both endometriosis and ovarian cancer. The omentum provides a favorable environment for trans-coelomic spread of endometriosis and ovarian cancer. HGF, c-MET and PTTG1 are potential therapeutic targets for inhibiting the abdomen\u2013pelvic\/peritoneal spread of endometriosis and ovarian cancer.<\/jats:p>","DOI":"10.3390\/ijms26051822","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T11:03:37Z","timestamp":1740049417000},"page":"1822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cell Migration in Endometriosis Responds to Omentum-Derived Molecular Cues Similar to Ovarian Cancer"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-204X","authenticated-orcid":false,"given":"Kah Yee","family":"Goh","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6837-5267","authenticated-orcid":false,"given":"Su Chin","family":"Tham","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence You De","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravichandran","family":"Nadarajah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Chin Hong","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Singapore General Hospital, Academia, College Road, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing Lih","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Singapore General Hospital, Academia, College Road, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tew Hong","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"},{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghee Kheng","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Wei Keat","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemashree","family":"Rajesh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4963-3116","authenticated-orcid":false,"given":"Hong Liang","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Tein","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ling","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah Weng","family":"Lau","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore"},{"name":"Department of Pathology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos Zhi En","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Singapore General Hospital, Academia, College Road, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Mantoo","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Singapore General Hospital, Academia, College Road, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inny","family":"Busmanis","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Singapore General Hospital, Academia, College Road, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hock","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Yong Kuei","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6045-2266","authenticated-orcid":false,"given":"Wai Loong","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-1661","authenticated-orcid":false,"given":"Qiu Ju","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Kuie","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chit Fang","family":"Cheok","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore"},{"name":"Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-0206","authenticated-orcid":false,"given":"Darren Wan-Teck","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583, Singapore"},{"name":"Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore"},{"name":"Office of Academic and Clinical Development, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-3187","authenticated-orcid":false,"given":"Elaine Hsuen","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2023). Endometriosis: Fact Sheet, World Health Organization."},{"key":"ref_2","first-page":"11","article-title":"Endometriosis and Ovarian Cancer: An Integrative Review (Endometriosis and Ovarian Cancer)","volume":"18","author":"Brilhante","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cca.2019.02.016","article-title":"Endometriosis-Associated Ovarian Cancer: What Have We Learned so Far?","volume":"493","author":"Chen","year":"2019","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0090-8258(92)90079-X","article-title":"Endometrioid Carcinoma of the Ovary and Endometriosis: The Association in Postmenopausal Women","volume":"47","author":"DePriest","year":"1992","journal-title":"Gynecol. Oncol."},{"key":"ref_5","first-page":"1023","article-title":"Malignant Neoplasms Arising in Endometriosis","volume":"75","author":"Heaps","year":"1990","journal-title":"Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0020-7292(97)00238-5","article-title":"Prevalence of Ovarian Endometriosis in Epithelial Ovarian Cancer","volume":"59","author":"Jimbo","year":"1997","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0301-2115(03)00047-2","article-title":"Prevalence of Endometriosis in Malignant Epithelial Ovary Tumours","volume":"109","author":"Oral","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1158\/1055-9965.EPI-05-0394","article-title":"Relationship of Benign Gynecologic Diseases to Subsequent Risk of Ovarian and Uterine Tumors","volume":"14","author":"Brinton","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1470-2045(11)70404-1","article-title":"Association between Endometriosis and Risk of Histological Subtypes of Ovarian Cancer: A Pooled Analysis of Case-Control Studies","volume":"13","author":"Pearce","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/jama.2024.9210","article-title":"Endometriosis Typology and Ovarian Cancer Risk","volume":"332","author":"Barnard","year":"2024","journal-title":"JAMA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1614814","article-title":"Cancer-Associated Mutations in Endometriosis without Cancer","volume":"376","author":"Anglesio","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_12","first-page":"93","article-title":"Metastatic or Embolic Endometriosis, Due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation","volume":"3","author":"Sampson","year":"1927","journal-title":"Am. J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer Statistics for the Year 2020: An Overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s13402-020-00513-9","article-title":"Current Insights into the Metastasis of Epithelial Ovarian Cancer\u2014Hopes and Hurdles","volume":"43","author":"Yousefi","year":"2020","journal-title":"Cell. Oncol. Dordr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Duarte Mendes, A., Freitas, A.R., Vicente, R., Vitorino, M., Vaz Batista, M., Silva, M., and Braga, S. (2023). Adipocyte Microenvironment in Ovarian Cancer: A Critical Contributor?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242316589"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/s41388-018-0637-x","article-title":"An Evolving Story of the Metastatic Voyage of Ovarian Cancer Cells: Cellular and Molecular Orchestration of the Adipose-Rich Metastatic Microenvironment","volume":"38","author":"Motohara","year":"2019","journal-title":"Oncogene"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_19","first-page":"169","article-title":"The Omentum","volume":"6","author":"Platell","year":"2000","journal-title":"World J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm.2492","article-title":"Adipocytes Promote Ovarian Cancer Metastasis and Provide Energy for Rapid Tumor Growth","volume":"17","author":"Nieman","year":"2011","journal-title":"Nat. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/s41388-019-1090-1","article-title":"MCP-1\/CCR-2 Axis in Adipocytes and Cancer Cell Respectively Facilitates Ovarian Cancer Peritoneal Metastasis","volume":"39","author":"Sun","year":"2020","journal-title":"Oncogene"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kim, H.J. (2022). Therapeutic Strategies for Ovarian Cancer in Point of HGF\/c-MET Targeting. Med. Kaunas Lith., 58.","DOI":"10.3390\/medicina58050649"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/(SICI)1097-0215(19991112)83:4<476::AID-IJC7>3.0.CO;2-V","article-title":"Hepatocyte Growth Factor (HGF) in Ovarian Epithelial Tumour Fluids Stimulates the Migration of Ovarian Carcinoma Cells","volume":"83","author":"Sowter","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0303-7207(03)00067-4","article-title":"Hepatocyte Growth Factor Modulates Motility and Invasiveness of Ovarian Carcinomas via Ras Mediated Pathway","volume":"202","author":"Ueoka","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1054\/bjoc.1999.1016","article-title":"Hepatocyte Growth Factor Modulates Motility and Invasiveness of Ovarian Carcinomas via Ras-Mediated Pathway","volume":"82","author":"Ueoka","year":"2000","journal-title":"Br. J. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1515\/hmbci-2014-0037","article-title":"Adipose Tissue, Obesity and Adipokines: Role in Cancer Promotion","volume":"21","author":"Booth","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian Cancer Development and Metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10555-013-9456-2","article-title":"Ovarian Cancer Microenvironment: Implications for Cancer Dissemination and Chemoresistance Acquisition","volume":"33","author":"Thibault","year":"2014","journal-title":"Cancer Metastasis Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"C444","DOI":"10.1152\/ajpcell.00188.2015","article-title":"Cellular and Molecular Processes in Ovarian Cancer Metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis","volume":"309","author":"Yeung","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1007\/s13277-016-4887-3","article-title":"Milky Spots: Omental Functional Units and Hotbeds for Peritoneal Cancer Metastasis","volume":"37","author":"Liu","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/obr.12450","article-title":"Omentum and Bone Marrow: How Adipocyte-Rich Organs Create Tumour Microenvironments Conducive for Metastatic Progression","volume":"17","author":"Diedrich","year":"2016","journal-title":"Obes. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1210\/jc.2003-030874","article-title":"Hepatocyte Growth Factor\/Met System Promotes Endometrial and Endometriotic Stromal Cell Invasion via Autocrine and Paracrine Pathways","volume":"89","author":"Yoshida","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"eabq5858","DOI":"10.1126\/scitranslmed.abq5858","article-title":"A Long-Acting Anti-IL-8 Antibody Improves Inflammation and Fibrosis in Endometriosis","volume":"15","author":"Sato","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Arici, A. (2002). Local Cytokines in Endometrial Tissue: The Role of Interleukin-8 in the Pathogenesis of Endometriosis. Ann. N. Y. Acad. Sci., 955.","DOI":"10.1111\/j.1749-6632.2002.tb02770.x"},{"key":"ref_35","first-page":"4785","article-title":"MCP-1 Promotes Invasion and Adhesion of Human Ovarian Cancer Cells","volume":"33","author":"Furukawa","year":"2013","journal-title":"Anticancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3727\/096504015X14343704124430","article-title":"CXCL12-CXCR4 Axis Promotes Proliferation, Migration, Invasion, and Metastasis of Ovarian Cancer","volume":"22","author":"Guo","year":"2014","journal-title":"Oncol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.cej.0000236259.88146.a4","article-title":"Stromal-Cell Derived Factor-1 Regulates Epithelial Ovarian Cancer Cell Invasion by Activating Matrix Metalloproteinase-9 and Matrix Metalloproteinase-2","volume":"16","author":"Yuecheng","year":"2007","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","article-title":"Angiogenic Signaling Pathways and Anti-Angiogenic Therapy for Cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Szulc-Kielbik, I., Kielbik, M., Nowak, M., and Klink, M. (2021). The Implication of IL-6 in the Invasiveness and Chemoresistance of Ovarian Cancer Cells. Systematic Review of Its Potential Role as a Biomarker in Ovarian Cancer Patients. Biochim. Biophys. Acta Rev. Cancer, 1876.","DOI":"10.1016\/j.bbcan.2021.188639"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1091\/mbc.e10-10-0838","article-title":"PTTG1\/Securin Modulates Microtubule Nucleation and Cell Migration","volume":"22","author":"Espina","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1210\/en.2013-1646","article-title":"The PTTG1-Binding Factor (PBF\/PTTG1IP) Regulates P53 Activity in Thyroid Cells","volume":"155","author":"Read","year":"2014","journal-title":"Endocrinology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1677\/JME-08-0176","article-title":"Transcriptional Targets for Pituitary Tumor-Transforming Gene-1","volume":"43","author":"Tong","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1126\/science.285.5426.418","article-title":"Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis","volume":"285","author":"Zou","year":"1999","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1757-2215-1-6","article-title":"PTTG: An Important Target Gene for Ovarian Cancer Therapy","volume":"1","author":"Panguluri","year":"2008","journal-title":"J. Ovarian Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/s12015-019-09911-5","article-title":"PTTG1: A Unique Regulator of Stem\/Cancer Stem Cells in the Ovary and Ovarian Cancer","volume":"15","author":"Parte","year":"2019","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12032-020-01398-2","article-title":"Suppression of PTTG1 Inhibits Cell Angiogenesis, Migration and Invasion in Glioma Cells","volume":"37","author":"Cui","year":"2020","journal-title":"Med. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/carcin\/bgt158","article-title":"PTTG1 Promotes Migration and Invasion of Human Non-Small Cell Lung Cancer Cells and Is Modulated by miR-186","volume":"34","author":"Li","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_48","first-page":"137","article-title":"Small Interfering RNA against PTTG: A Novel Therapy for Ovarian Cancer","volume":"31","author":"Malik","year":"2007","journal-title":"Int. J. Oncol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/1822\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:39:01Z","timestamp":1760027941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/1822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["ijms26051822"],"URL":"https:\/\/doi.org\/10.3390\/ijms26051822","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]}}}