{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:31:35Z","timestamp":1776587495752,"version":"3.51.2"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["24KJD430010"],"award-info":[{"award-number":["24KJD430010"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["JC2023043"],"award-info":[{"award-number":["JC2023043"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["BK20240948"],"award-info":[{"award-number":["BK20240948"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nantong Jiangsu Scientific Research Project of China","award":["24KJD430010"],"award-info":[{"award-number":["24KJD430010"]}]},{"name":"Nantong Jiangsu Scientific Research Project of China","award":["JC2023043"],"award-info":[{"award-number":["JC2023043"]}]},{"name":"Nantong Jiangsu Scientific Research Project of China","award":["BK20240948"],"award-info":[{"award-number":["BK20240948"]}]},{"name":"Natural Science Foundation of Jiangsu Province of China","award":["24KJD430010"],"award-info":[{"award-number":["24KJD430010"]}]},{"name":"Natural Science Foundation of Jiangsu Province of China","award":["JC2023043"],"award-info":[{"award-number":["JC2023043"]}]},{"name":"Natural Science Foundation of Jiangsu Province of China","award":["BK20240948"],"award-info":[{"award-number":["BK20240948"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Transcription factors Fzc9 and Pdr802, characterized by their Zn2Cys6 DNA-binding domain, are essential for the virulence of Cryptococcus neoformans in lung and brain infections. Notably, the in vivo roles of Fzc9 and Pdr802 in contributing to the pathogenicity of C. neoformans are not adequately reflected by the phenotypic characteristics observed in vitro. This study investigates the effects of gene deletion of FZC9 or PDR802 on the proteomic and metabolomic profiles of C. neoformans. Using mass spectrometry analysis, we identified significant changes in protein abundance and metabolite levels, particularly in pathways related to ATP synthesis. These findings deepen our understanding of the metabolic roles of Fzc9 and Pdr802, suggesting potential targets for the development of novel therapeutic strategies against C. neoformans infections.<\/jats:p>","DOI":"10.3390\/ijms26051824","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T11:03:37Z","timestamp":1740049417000},"page":"1824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transcription Factors Fzc9 and Pdr802 Regulate ATP Levels and Metabolism in Cryptococcus neoformans"],"prefix":"10.3390","volume":"26","author":[{"given":"Yuanyuan","family":"Ma","sequence":"first","affiliation":[{"name":"Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-7987","authenticated-orcid":false,"given":"Peng","family":"Xue","sequence":"additional","affiliation":[{"name":"Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: Human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. 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