{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:51:50Z","timestamp":1792929110585,"version":"4.5.0"},"reference-count":161,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Receptors for the immunoglobulin G constant fraction (Fc\u03b3Rs) are widely expressed in cells of the immune system. Complement-independent phagocytosis prompted Fc\u03b3R research to show that the engagement of IgG immune complexes with Fc\u03b3Rs triggers a variety of cell host immune responses, such as phagocytosis, antibody-dependent cell cytotoxicity, and NETosis, among others. However, variants of these receptors have been implicated in the development of and susceptibility to autoimmune diseases such as systemic lupus erythematosus. Currently, the knowledge of Fc\u03b3R variants is a required field of antibody therapeutics, which includes the engineering of recombinant soluble human Fc gamma receptors, enhancing the inhibitory and blocking the activating Fc\u03b3Rs function, vaccines, and organ transplantation. Importantly, recent interest in Fc\u03b3Rs is the antibody-dependent enhancement (ADE), a mechanism by which the pathogenesis of certain viral infections is enhanced. ADEs may be responsible for the severity of the SARS-CoV-2 infection. Therefore, Fc\u03b3Rs have become a current research topic. Therefore, this review briefly describes some of the historical knowledge about the Fc\u03b3R type I family in humans, including the structure, affinity, and mechanism of ligand binding, Fc\u03b3Rs in diseases such as systemic lupus erythematosus (SLE), and the potential therapeutic approaches related to these receptors in SLE.<\/jats:p>","DOI":"10.3390\/ijms26051851","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:39:07Z","timestamp":1740119947000},"page":"1851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Comprehensive Review of Fc Gamma Receptors and Their Role in Systemic Lupus Erythematosus"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1393-653X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Sep\u00falveda-Delgado","sequence":"first","affiliation":[{"name":"Research Division, Servicios de Salud IMSS BIENESTAR, Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula 30700, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Llorente","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Hern\u00e1ndez-Do\u00f1o","sequence":"additional","affiliation":[{"name":"Physiology and Pharmacology Department, Chemistry and Pharmacy Faculty, Universidad de El Salvador, San Salvador 01101, El Salvador"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00352843","article-title":"The polymorphic Fc? receptor II gene maps to human chromosome 1q","volume":"29","author":"Grundy","year":"1989","journal-title":"Immunogenetics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00188811","article-title":"The human FCG1 gene encoding the high-affinity Fc?RI maps to chromosome 1q21","volume":"38","author":"Dietzsch","year":"1993","journal-title":"Immunogenetics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00218905","article-title":"Human high-affinity Fc?RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization","volume":"93","author":"Takai","year":"1994","journal-title":"Hum. 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