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Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for the treatment of OA are reviewed for both single-function and multifunctional lubricants. Single-function lubricants mainly include glycosaminoglycans, lubricin, and phospholipids, whereas multifunctional lubricants are composed of lubricating and anti-inflammatory bifunctional hydrogels, stem cell-loaded lubricating hydrogels, and drug-loaded lubricating nanoparticles. This review emphasizes the importance of restoring joint lubrication capacity for the treatment of OA and explores the structural features, lubrication properties, and role of these lubricants in modulating intracellular inflammatory responses and metabolism. Current challenges and future research directions in this field are also discussed, with the aim of providing a scientific basis and new ideas for the clinical treatment of OA.<\/jats:p>","DOI":"10.3390\/ijms26051856","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:26:32Z","timestamp":1740129992000},"page":"1856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lubrication for Osteoarthritis: From Single-Function to Multifunctional Lubricants"],"prefix":"10.3390","volume":"26","author":[{"given":"Wen","family":"Chen","sequence":"first","affiliation":[{"name":"School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, China"},{"name":"Jiangxi Provincial Key Laboratory of Tissue Engineering (2024SSY06291), Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Ye","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Tissue Engineering (2024SSY06291), Gannan Medical University, Ganzhou 341000, China"},{"name":"School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Tissue Engineering (2024SSY06291), Gannan Medical University, Ganzhou 341000, China"},{"name":"School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-9702","authenticated-orcid":false,"given":"Renjian","family":"Xie","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Tissue Engineering (2024SSY06291), Gannan Medical University, Ganzhou 341000, China"},{"name":"School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunming","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China"},{"name":"School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2005513","DOI":"10.1002\/adma.202005513","article-title":"Recent progress in cartilage lubrication","volume":"33","author":"Lin","year":"2021","journal-title":"Adv. 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