{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:36:57Z","timestamp":1785771417703,"version":"3.56.0"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In this work, we describe the synthesis of three new meso-arylporphyrins, named meso-tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (H2TNPP), meso-tetrakis [4-(picolinoyloxy)phenyl] porphyrin (H2TPPP), and meso-tetrakis [4-(isonicotinoyloxy) phenyl] porphyrin (H2TIPP). These new synthesized meso-arylporphyrins are characterized using spectroscopic analysis: Fourier Transform Infrared Spectroscopy (FTIR) and One-dimensional Nuclear Magnetic Resonance (1D NMR), and mass spectrometry (MS). The photophysical studies (UV\u2013visible absorption, singlet oxygen (1O2) luminescence, and fluorescence emissions) demonstrate their potential uses as photosensitizers (PSs) in photodynamic therapy (PDT) applications. An in vitro investigation of the anti-fungal activity of H2TNPP, H2TPPP, and H2TIPP against Candida (C.) species (C. albicans, C. glabrata, and C. tropicalis) reveals that their minimum inhibitory concentration (MIC) values ranged from 1.25 to 5 mg\/mL. In addition, their in vitro anti-fungal susceptibilities against three dermatophyte clinical isolates (Trichophyton rubrum, Microsporum canis, and Trichophyton mentagrophytes) are also evaluated and they demonstrate good anti-fungal activities. A molecular docking study of these meso-arylporphyrins as anti-fungal agents against C. tropicalis extracellular aspartic proteinases, Protein data Bank in Europe (PDBe code: 1J71) and Trichophyton rubrum Sialidases (PDBe code: 7P1D) underlines the possible interactions of H2TNPP, H2TPPP, and H2TIPP with the key amino acid residues of these fungal target proteins.<\/jats:p>","DOI":"10.3390\/ijms26051991","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T13:39:06Z","timestamp":1740490746000},"page":"1991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis, Physicochemical Properties and Anti-Fungal Activities of New Meso-Arylporphyrins"],"prefix":"10.3390","volume":"26","author":[{"given":"Hayfa","family":"Mkacher","sequence":"first","affiliation":[{"name":"Laboratory of Physical Chemistry of Materials, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia"},{"name":"Universit\u00e9 de Lorraine, CNRS, LCPM, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3145-0165","authenticated-orcid":false,"given":"Raja","family":"Cha\u00e2bane-Banaoues","sequence":"additional","affiliation":[{"name":"Laboratory of Medical and Molecular Parasitology-Mycology (LP3M), Faculty of Pharmacy, University of Monastir, LR12ES08, Monastir 5000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soukaina","family":"Hrichi","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Chemistry of Materials, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia"},{"name":"Laboratory of Medical and Molecular Parasitology-Mycology (LP3M), Faculty of Pharmacy, University of Monastir, LR12ES08, Monastir 5000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-9597","authenticated-orcid":false,"given":"Philippe","family":"Arnoux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, LRGP, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamouda","family":"Babba","sequence":"additional","affiliation":[{"name":"Laboratory of Medical and Molecular Parasitology-Mycology (LP3M), Faculty of Pharmacy, University of Monastir, LR12ES08, Monastir 5000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-3864","authenticated-orcid":false,"given":"C\u00e9line","family":"Frochot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, LRGP, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Nasri","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Chemistry of Materials, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-1632","authenticated-orcid":false,"given":"Samir","family":"Acherar","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, LCPM, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global Incidence and Mortality of Severe Fungal Disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. 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