{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:28:54Z","timestamp":1792265334081,"version":"4.4.0"},"reference-count":90,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dalian Medical University Foundation for Teaching Reform Project of Undergraduate Innovative Talents Training","award":["112306010123"],"award-info":[{"award-number":["112306010123"]}]},{"name":"Dalian Medical University Foundation for Teaching Reform Project of Undergraduate Innovative Talents Training","award":["2024-BSLH-041"],"award-info":[{"award-number":["2024-BSLH-041"]}]},{"name":"Liaoning Province Science and Technology Plan Alliance Fund project","award":["112306010123"],"award-info":[{"award-number":["112306010123"]}]},{"name":"Liaoning Province Science and Technology Plan Alliance Fund project","award":["2024-BSLH-041"],"award-info":[{"award-number":["2024-BSLH-041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The management of inflammatory bowel disease (IBD), which is characterized by immunodeficiency, has attracted increasing attention, highlighting the necessity for more precise and streamlined diagnostic approaches in clinics. Calprotectin, an immune cell-derived protein with inherent anti-inflammatory and antimicrobial properties, plays a pivotal role in immune regulation and intestinal homeostasis. Its expression levels are intricately linked to IBD activity, enabling differentiation between inflammatory and non-inflammatory states while predicting recurrence risks. As a non-invasive biomarker, fecal calprotectin (FC) and serum calprotectin (SC) analysis offers high reproducibility and clinical utility, facilitating both IBD diagnosis and real-time disease monitoring. Beyond its diagnostic specificity in distinguishing IBD from other gastrointestinal disorders, calprotectin also emerges as a promising therapeutic target, due to its dual role in modulating inflammatory pathways and interacting with the gut microbiota. With collaborative advancements in standardized detection protocols and innovative research methodologies, it is anticipated that calprotectin-based strategies will be integrated into mainstream clinical practice for IBD.<\/jats:p>","DOI":"10.3390\/ijms26051996","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T07:45:08Z","timestamp":1740469508000},"page":"1996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Role of Calprotectin in the Diagnosis and Treatment of Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Wenqian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China"},{"name":"Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfu","family":"Cao","sequence":"additional","affiliation":[{"name":"Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/540S97a","article-title":"Inflammatory bowel disease","volume":"11","author":"Hodson","year":"2016","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative Colitis in Adults: A Review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000527422","article-title":"New and Emerging Treatments for Inflammatory Bowel Disease","volume":"104","author":"Higashiyama","year":"2023","journal-title":"Digestion"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.3748\/wjg.v30.i15.2068","article-title":"Combination treatment of inflammatory bowel disease: Present status and future perspectives","volume":"4","author":"Triantafillidis","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S2468-1253(23)00284-4","article-title":"Challenges in the diagnosis and treatment of inflammatory bowel disease in Latin America","volume":"9","author":"Balderramo","year":"2024","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cca.2020.08.025","article-title":"Calprotectin in inflammatory bowel disease","volume":"510","author":"Qujeq","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_7","first-page":"e45019","article-title":"Fecal Calprotectin and Organic Gastrointestinal Disease: A Systematic Review","volume":"15","author":"Asiri","year":"2023","journal-title":"Cureus"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Li, J., Xu, M., Qian, W., Ling, F., Chen, Y., Li, S., Cheng, Y., and Zhu, L. (2023). Clinical value of fecal calprotectin for evaluating disease activity in patients with Crohn\u2019s disease. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1186665"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/bs.acc.2018.07.005","article-title":"Fecal Calprotectin","volume":"87","author":"Ayling","year":"2018","journal-title":"Adv. Clin. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Inciarte-Mundo, J., Frade-Sosa, B., and Sanmart\u00ed, R. (2022). From bench to bedside: Calprotectin (S100A8\/S100A9) as a biomarker in rheumatoid arthritis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1001025"},{"key":"ref_11","first-page":"93341","article-title":"Fecal calprotectin in pediatric gastrointestinal diseases: Pros and cons","volume":"13","author":"Saeed","year":"2024","journal-title":"World J. Clin. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Austermann, J., Roth, J., and Barczyk-Kahlert, K. (2022). The Good and the Bad: Monocytes\u2019 and Macrophages\u2019 Diverse Functions in Inflammation. Cells, 11.","DOI":"10.3390\/cells11121979"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.3748\/wjg.v30.i24.3022","article-title":"Fecal calprotectin and endoscopic scores: The cornerstones in clinical practice for evaluating mucosal healing in inflammatory bowel disease","volume":"30","author":"Sassaki","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., and Ma, J. (2018). S100A8\/A9 in Inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01298"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pharmthera.2016.07.015","article-title":"S100A8\/A9: From basic science to clinical application","volume":"11","author":"Pruenster","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e00617","DOI":"10.14309\/ctg.0000000000000617","article-title":"Fecal Calprotectin for the Diagnosis and Management of Inflammatory Bowel Diseases","volume":"14","author":"Kapel","year":"2023","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e068947","DOI":"10.1136\/bmj-2021-068947","article-title":"The role of faecal calprotectin in the diagnosis of inflammatory bowel disease","volume":"380","author":"Deputy","year":"2023","journal-title":"BMJ"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cgh.2022.07.027","article-title":"Prognostic Value of Fecal Calprotectin to Inform Treat-to-Target Monitoring in Ulcerative Colitis","volume":"21","author":"Dulai","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MIB.0b013e3182810066","article-title":"Fecal calprotectin more accurately reflects endoscopic activity of ulcerative colitis than the Lichtiger Index, C-reactive protein, platelets, hemoglobin, and blood leukocytes","volume":"19","author":"Schoepfer","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Orfei, M., Gasparetto, M., Hensel, K.O., Zellweger, F., Heuschkel, R.B., and Zilbauer, M. (2021). Guidance on the interpretation of faecal calprotectin levels in children. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246091"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cesaro, A., Anceriz, N., Plante, A., Pag\u00e9, N., Tardif, M.R., and Tessier, P.A. (2012). An inflammation loop orchestrated by S100A9 and calprotectin is critical for development of arthritis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045478"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/rheumatology\/kead405","article-title":"Calprotectin: Two sides of the same coin","volume":"63","author":"Carnazzo","year":"2024","journal-title":"Rheumatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0014-5793(99)01322-8","article-title":"Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8\/A9 protein complex","volume":"460","author":"Kerkhoff","year":"1999","journal-title":"FEBS Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1053\/j.gastro.2020.08.019","article-title":"S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants","volume":"159","author":"Willers","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17562848231206991","DOI":"10.1177\/17562848231206991","article-title":"A systematic review on diagnosis and treatment of gastrointestinal diseases by magnetically controlled capsule endoscopy and artificial intelligence","volume":"16","author":"Wang","year":"2023","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_27","first-page":"1149","article-title":"Clinical Significance of Faecal Calprotectin in Differentiating Inflammatory Bowel Disease from Irritable Bowel Syndrome","volume":"33","author":"Chowdhury","year":"2024","journal-title":"Mymensingh Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1097\/MEG.0000000000002276","article-title":"Assessing aCCess to Investigations in Inflammatory Bowel Disease (ACCID): Results from an international survey","volume":"33","author":"Ding","year":"2021","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_29","first-page":"Epub ahead of print","article-title":"Intestinal ultrasound at diagnosis of pediatric inflammatory bowel disease compared to endoscopy","volume":"12","author":"Khan","year":"2024","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e13077","DOI":"10.1002\/jgh3.13077","article-title":"Clinical performance of fecal calprotectin, lactoferrin, and hemoglobin for evaluating the disease activity of IBD and detecting colorectal tumors","volume":"8","author":"Yamakawa","year":"2024","journal-title":"JGH Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/apt.17754","article-title":"Systematic review with meta-analysis: Diagnostic performance of faecal calprotectin in distinguishing inflammatory bowel disease from irritable bowel syndrome in adults","volume":"58","author":"Dajti","year":"2023","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yerushalmy-Feler, A., Spencer, E.A., Dolinger, M.T., Suskind, D.L., Mitrova, K., Hradsky, O., Conrad, M.A., Kelsen, J.R., Uhlig, H.H., and Tzivinikos, C. (2024). Upadacitinib for Induction of Remission in Pediatric Ulcerative Colitis: An International Multi-center Study. J. Crohns Colitis, jjae182.","DOI":"10.1093\/ecco-jcc\/jjae182"},{"key":"ref_33","first-page":"1","article-title":"The importance of growth differentiation factor 15 and interleukin 6 serum levels in inflammatory bowel diseases","volume":"11","author":"Koureta","year":"2024","journal-title":"J. Physiol. Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.medcli.2024.09.009","article-title":"Plasma calprotectin as a biomarker of inflammatory activity in ulcerative colitis","volume":"164","author":"Temido","year":"2025","journal-title":"Med. Clin."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.2460\/ajvr.73.12.1900","article-title":"Serum calprotectin concentrations in dogs with idiopathic inflammatory bowel disease","volume":"73","author":"Heilmann","year":"2012","journal-title":"Am. J. Vet. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1007\/s10620-019-05675-7","article-title":"Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity","volume":"64","author":"Amara","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1053\/j.gastro.2023.09.029","article-title":"AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Crohn\u2019s Disease","volume":"165","author":"Ananthakrishnan","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1136\/gutjnl-2024-332475","article-title":"Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families","volume":"73","author":"Jacobs","year":"2024","journal-title":"Gut"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12979-023-00410-3","article-title":"Inflammatory markers and physical frailty: Towards clinical application","volume":"21","author":"Pan","year":"2024","journal-title":"Immun. Ageing"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.3748\/wjg.v29.i47.6111","article-title":"Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission","volume":"29","author":"Ishida","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MEG.0000000000002842","article-title":"The role of new inflammatory indices in the prediction of endoscopic and histological activity in inflammatory bowel disease patients","volume":"37","author":"Cesaro","year":"2025","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jpn3.12408","article-title":"Upadacitinib is associated with clinical response and steroid-free remission for children and adolescents with inflammatory bowel disease","volume":"80","author":"Runde","year":"2025","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"izae262","DOI":"10.1093\/ibd\/izae262","article-title":"Fecal Myeloperoxidase Levels Reflect Disease Activity in Children With Crohn\u2019s Disease","volume":"11","author":"Edwards","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/j.gastro.2023.11.304","article-title":"Dysbiosis and Associated Stool Features Improve Prediction of Response to Biological Therapy in Inflammatory Bowel Disease","volume":"166","author":"Caenepeel","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/med.21893","article-title":"Inflammatory bowel disease biomarkers","volume":"42","author":"Liu","year":"2022","journal-title":"Med. Res. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/apt.18154","article-title":"Faecal biomarkers for diagnosis and prediction of disease course in treatment-na\u00efve patients with IBD","volume":"60","author":"Peterson","year":"2024","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/jgh3.12972","article-title":"Diagnostic value of fecal calprotectin in primary care patients with gastrointestinal symptoms: A retrospective Swedish cohort study","volume":"7","author":"Rendek","year":"2023","journal-title":"JGH Open"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Biedermann, L., Doulberis, M., Schreiner, P., Nielsen, O.H., The, F.O., Brand, S., Burk, S., Hruz, P., Juillerat, P., and Krieger-Gr\u00fcbel, C. (2024). Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative Colitis: A Randomized Controlled Trial. Nutrients, 16.","DOI":"10.3390\/nu16234197"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1016\/j.cgh.2023.03.026","article-title":"Longitudinal Fecal Calprotectin Profiles Characterize Disease Course Heterogeneity in Crohn\u2019s Disease","volume":"21","author":"Plevris","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/clinchem\/hvad051","article-title":"Fecal Calprotectin in Gastrointestinal Disease","volume":"69","author":"Murray","year":"2023","journal-title":"Clin. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"izae145","DOI":"10.1093\/ibd\/izae145","article-title":"Intestinal Ultrasound, Fecal Calprotectin, and Their Combination to Predict Endoscopic Mucosal Healing in Ulcerative Colitis: A Real-Life Cross-Sectional Study","volume":"7","author":"Yzet","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"123090","DOI":"10.1016\/j.lfs.2024.123090","article-title":"Zinc pyrithione ameliorates colitis in mice by interacting on intestinal epithelial TRPA1 and TRPV4 channels","volume":"358","author":"Zhang","year":"2024","journal-title":"Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"jjae167","DOI":"10.1093\/ecco-jcc\/jjae167","article-title":"Impact of histological remission for predicting clinical relapse in Crohn\u2019s disease: A post-hoc analysis of the prospective STORI cohort","volume":"11","author":"Reenaers","year":"2024","journal-title":"J. Crohns Colitis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/jgh.14995","article-title":"Elevated fecal calprotectin and lactoferrin associated with small intestinal lesions in patients with Beh\u00e7et disease","volume":"35","author":"Hayashida","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/ajg.2016.342","article-title":"Serum Calprotectin: A Novel Diagnostic and Prognostic Marker in Inflammatory Bowel Diseases","volume":"111","author":"Kalla","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1021\/acschembio.4c00265","article-title":"Development of Luminescent Biosensors for Calprotectin","volume":"19","author":"Lan","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1021\/acscentsci.3c00773","article-title":"Functional Microgel Enables Effective Delivery and Colonization of Probiotics for Treating Colitis","volume":"9","author":"Chen","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, R., Ceacero-Heras, D., Tena-Garitaonaindia, M., \u00c1lvarez-Mercado, A., G\u00e1mez-Belmonte, R., Chazin, W., de Medina, F.S., and Mart\u00ednez-Augustin, O. (2024). Intestinal inflammation marker calprotectin regulates epithelial intestinal zinc metabolism and proliferation in mouse jejunal organoids. Biomed. Pharmacother., 174.","DOI":"10.1016\/j.biopha.2024.116555"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/ecco-jcc\/jjad188","article-title":"Higher Serum Infliximab Concentrations Following Subcutaneous Dosing are Associated with Deep Remission in Patients with Inflammatory Bowel Disease","volume":"18","author":"Roblin","year":"2024","journal-title":"J. Crohns Colitis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1007\/s10620-024-08422-9","article-title":"Real-World Outcomes of Patients Starting Intravenous and Transitioning to Subcutaneous Vedolizumab in Inflammatory Bowel Disease","volume":"69","author":"Lamichhane","year":"2024","journal-title":"Dig. Dis. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jgg.2024.03.009","article-title":"Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8\/9 expression","volume":"51","author":"Meng","year":"2024","journal-title":"J. Genet. Genom."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/ibd\/izad289","article-title":"Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course","volume":"30","author":"Thorsvik","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"184","DOI":"10.15403\/jgld-5482","article-title":"Diet Optimization in Inflammatory Bowel Disease: Impact on Disease Relapse and Inflammatory Markers. A 1-year Prospective Trial","volume":"33","author":"Preda","year":"2024","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/myc.13238","article-title":"Gut mycobiome: The probable determinative role of fungi in IBD patients","volume":"64","author":"Shahrokh","year":"2021","journal-title":"Mycoses"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"105381","DOI":"10.1016\/j.micpath.2021.105381","article-title":"The role of enteric dysbacteriosis and modulation of gut microbiota in the treatment of inflammatory bowel disease","volume":"165","author":"Niu","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S648","DOI":"10.1093\/ecco-jcc\/jjz203.963","article-title":"P835 Correlation between microbial markers and faecal calprotectin in IBD patients","volume":"14","author":"Oliver","year":"2020","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"i241","DOI":"10.1093\/ecco-jcc\/jjac190.0206","article-title":"P076 Abdominal pain severity for IBD in remission correlates with genetic clustering and enzymatic activity of faeces-derived Candida albicans strains","volume":"17","author":"Maasland","year":"2023","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1093\/ibd\/izae020.023","article-title":"The modulatory effect of prebiotic inulin-type fructans on the microbiome profile of children with inflammatory bowel disease: A double-blind randomized controlled trial","volume":"30","author":"Breton","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"S554","DOI":"10.1093\/ecco-jcc\/jjy222.985","article-title":"P861 Differences in bacteroidal genotypes between newly diagnosed ulcerative colitis patients and healthy controls","volume":"13","author":"Baston","year":"2019","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"jjae189","DOI":"10.1093\/ecco-jcc\/jjae189","article-title":"Open Label Vancomycin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Improved Colonic Disease Activity and Associations With Changes in Host-Microbiome-Metabolomic Signatures","volume":"19","author":"Quraishi","year":"2025","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Carlsen, K., Thingholm, L.B., Dempfle, A., Malham, M., Bang, C., Franke, A., and Wewer, V. (2024). Gut microbiota diversity repeatedly diminishes over time following maintenance infliximab infusions in paediatric IBD patients. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0311604"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1093\/ecco-jcc\/jjab076.235","article-title":"P107 Monitoring inflammatory bowel disease in clinical practice using gut microbial markers in faecal samples. Prospective study in a clinical cohort","volume":"15","year":"2021","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ibd\/izae032","article-title":"Comparison of Fecal Calprotectin and Myeloperoxidase in Predicting Outcomes in Inflammatory Bowel Disease","volume":"31","author":"Swaminathan","year":"2025","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/erv.2983","article-title":"Faecal calprotectin: Marker of intestinal inflammatory process in anorexia nervosa? A preliminary study","volume":"31","author":"Moubayed","year":"2023","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/ueg2.12446","article-title":"Fecal occult blood and calprotectin testing to prioritize primary care patients for colonoscopy referral: The advantage study","volume":"11","author":"Lanas","year":"2023","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00383-023-05534-7","article-title":"Fecal calprotectin as a non-invasive marker for the prediction of post-necrotizing enterocolitis stricture","volume":"39","author":"Chen","year":"2023","journal-title":"Pediatr. Surg. Int."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s12664-023-01450-9","article-title":"Fecal calprotectin in patients with liver cirrhosis","volume":"42","author":"Jothimani","year":"2023","journal-title":"Indian J. Gastroenterol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.36740\/WLek\/195168","article-title":"Differentiated approach to management of patients with irritable bowel syndrome and ulcerative colitis in non-alcoholic fatty liver disease","volume":"77","author":"Sirchak","year":"2024","journal-title":"Wiadomosci Lek."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Parke, \u00c5., Unge, C., Yu, D., Sund\u00e9n-Cullberg, J., and Str\u00e5lin, K. (2023). Plasma calprotectin as an indicator of need of transfer to intensive care in patients with suspected sepsis at the emergency department. BMC Emerg. Med., 23.","DOI":"10.1186\/s12873-023-00785-y"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Saviano, A., Migneco, A., Brigida, M., Petruzziello, C., Zanza, C., Savioli, G., Franceschi, F., and Ojetti, V. (2024). Serum Calprotectin in the Evaluation of Gastrointestinal Diseases: An Ace up Your Sleeve?. Medicina, 60.","DOI":"10.3390\/medicina60050762"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Waldecker-Gall, S., Waldecker, C.B., Babel, N., Baraliakos, X., Seibert, F., and Westhoff, T.H. (2024). Urinary calprotectin as a diagnostic tool for detecting significant bacteriuria. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-62605-y"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Zhou, Z., Ouboter, L.F., Peeters, K.C.M.J., Hawinkels, L.J.A.C., Holman, F., Pascutti, M.F., Barnhoorn, M.C., and Jong, A.E.v.d.M.-D. (2023). Crohn\u2019s Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities. J. Clin. Med., 12.","DOI":"10.3390\/jcm12020466"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jped.2022.01.006","article-title":"Systematic review on fecal calprotectin in cystic fibrosis","volume":"99","author":"Lazzarotto","year":"2022","journal-title":"J. Pediatr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"29","DOI":"10.23736\/S0031-0808.18.03405-5","article-title":"Fecal calprotectin: Beyond intestinal organic diseases","volume":"60","author":"Caviglia","year":"2018","journal-title":"Panminerva Medica"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Becker, M.A.J., Stevens, T.W., de Voogd, F.A.E., Wildenberg, M.E., D\u2019haens, G.R.A.M., Gecse, K.B., and Buskens, C.J. (2024). Clinical relevance of calprotectin in patients with perianal fistulas in Crohn\u2019s disease and cryptoglandular fistulas. United Eur. Gastroenterol. J., 12.","DOI":"10.1002\/ueg2.12622"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Heilmann, R.M., Riggers, D.S., Trewin, I., K\u00f6ller, G., and Kathrani, A. (2024). Treatment success in cats with chronic enteropathy is associated with a decrease in fecal calprotectin concentrations. Front. Vet. Sci., 11.","DOI":"10.3389\/fvets.2024.1390681"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"jjae123","DOI":"10.1093\/ecco-jcc\/jjae123","article-title":"Fecal Calprotectin Diagnostic Level Gradient Along the Small Bowel in Patients With Crohn\u2019s Disease","volume":"19","author":"Ukashi","year":"2025","journal-title":"J. Crohns Colitis"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.dld.2024.09.010","article-title":"Fecal calprotectin measurement as a biomarker of severe disease phenotype in celiac disease and non-celiac enteropathies","volume":"57","author":"Schiepatti","year":"2024","journal-title":"Dig. Liver Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5005\/jp-journals-10018-1411","article-title":"Comparison of Fecal Calprotectin with Different Endoscopic Scores in the Assessment of Ulcerative Colitis (UC) Activity and Its Utility in Differentiating IBS from IBD","volume":"13","author":"Acharya","year":"2023","journal-title":"Euroasian J. Hepato-Gastroenterol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000527846","article-title":"Positioning and Usefulness of Biomarkers in Inflammatory Bowel Disease","volume":"104","author":"Sakurai","year":"2023","journal-title":"Digestion"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/1996\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:42:08Z","timestamp":1760028128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/1996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":90,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["ijms26051996"],"URL":"https:\/\/doi.org\/10.3390\/ijms26051996","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]}}}