{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:14:33Z","timestamp":1771884873010,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Zebrafish have the ability, to a certain extent, to distinguish between different types of stimuli, including distinguishing between videos of conspecifics and non-conspecifics, a skill known as stimulus discrimination. In this study, we investigated the effects of oxytocin on this ability in albino and non-albino zebrafish models, focusing on the correlations between albinism, sensory deficiencies, and socio-emotional behaviors. Our hypothesis is based on the premise that oxytocin influences socio-emotional behaviors in zebrafish, with varying effects depending on phenotype (albino vs. non-albino), social context, and treatment duration. Studies have shown that albino zebrafish have more pronounced sensory deficiencies, meaning they may benefit more from oxytocin in terms of increased social comfort and interactions with conspecifics, while non-albino zebrafish would experience a reduction in defensive behaviors and anxiety. To test this, two experiments were conducted: one assessing the responses to video predator stimuli and the other comparing social interactions with real and video conspecifics. The results showed significant differences between the two groups: non-albino zebrafish exhibited stronger long-term reductions in anxiety-related behaviors, such as reaction speed and freezing, suggesting that oxytocin regulates defensive responses and aggression. Meanwhile, albino zebrafish showed greater improvements in social interactions, reflecting the nuanced, phenotype-dependent effects of oxytocin. These results not only confirm existing research but also highlight the therapeutic potential of oxytocin in treating socio-emotional deficiencies.<\/jats:p>","DOI":"10.3390\/ijms26052070","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T03:37:57Z","timestamp":1740627477000},"page":"2070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Oxytocin on Stimulus Discrimination of Zebrafish Albino and Non-Albino Models"],"prefix":"10.3390","volume":"26","author":[{"given":"Ana-Maria","family":"Danila","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 20A, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-1436","authenticated-orcid":false,"given":"Alexandra","family":"Savuca","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 20A, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin Stelian","family":"Ciobica","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 20A, 700505 Iasi, Romania"},{"name":"Centre of Biomedical Research, Romanian Academy, Bd. Carol I, No. 8, 700506 Iasi, Romania"},{"name":"Academy of Romanian Scientists, Str. Splaiul Independentei No. 54, Sector 5, 050094 Bucharest, Romania"},{"name":"\u201cIon Haulica\u201d Institute, Apollonia University, P\u0103curari Street 11, 700511 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-3497","authenticated-orcid":false,"given":"Irina Luciana","family":"Gurzu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Interdisciplinarity, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-6771","authenticated-orcid":false,"given":"Mircea Nicusor","family":"Nicoara","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 20A, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1834-9142","authenticated-orcid":false,"given":"Bogdan","family":"Gurzu","sequence":"additional","affiliation":[{"name":"Department of Morfofunctional Sciences, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16th Universitatii Street, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/OPX.0b013e3181a5254c","article-title":"Albinism: Classification, clinical characteristics, and recent findings","volume":"86","author":"Summers","year":"2009","journal-title":"Optom. Vis. Sci."},{"key":"ref_2","unstructured":"Bolognia, J., Jorizzo, J., and Schaffer, J. (2012). Dermatology, Saunders Elsevier. [3rd ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/03014460500075423","article-title":"Oculocutaneous albinism in southern Africa: Population structure, health, and genetic care","volume":"32","author":"Lund","year":"2005","journal-title":"Ann. Hum. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/jmg.34.9.733","article-title":"Oculocutaneous albinism in an isolated Tonga community in Zimbabwe","volume":"34","author":"Lund","year":"1997","journal-title":"J. Med. Genet."},{"key":"ref_5","first-page":"383","article-title":"Prevalence of albinism in the South African negro","volume":"61","author":"Kromberg","year":"1982","journal-title":"S. Afr. Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1750-1172-2-43","article-title":"Oculocutaneous albinism","volume":"2","author":"Ek","year":"2007","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1684\/ejd.2011.1633","article-title":"Genetic skin diseases predisposing to basal cell carcinoma","volume":"22","author":"Castori","year":"2012","journal-title":"Eur. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1600-0625.2009.00896.x","article-title":"A review of genetic disorders of hypopigmentation: Lessons learned from the biology of melanocytes","volume":"18","author":"Dessinioti","year":"2009","journal-title":"Exp. Dermatol."},{"key":"ref_9","first-page":"13","article-title":"Albinism and its implications with vision","volume":"34","author":"Kirkwood","year":"2009","journal-title":"Insight"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41436-020-00997-8","article-title":"Dopachrome tautomerase variants in patients with oculocutaneous albinism","volume":"23","author":"Pennamen","year":"2021","journal-title":"Genet. Med."},{"key":"ref_11","first-page":"82","article-title":"Oculocutaneous albinism: New insights and new genes","volume":"29","author":"Wei","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/pcmr.12688","article-title":"Molecular characterization of a series of 990 index patients with albinism","volume":"31","author":"Lasseaux","year":"2018","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.conb.2014.06.013","article-title":"Fish bioacoustics","volume":"28","author":"Ladich","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/archderm.138.5.629","article-title":"Attitudes and beliefs of an albino population toward sun avoidance: Advice and services provided by an outreach albino clinic in Tanzania","volume":"138","author":"McBride","year":"2002","journal-title":"Arch. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/her\/17.3.365","article-title":"A health intervention programme for children with albinism at a special school in South Africa","volume":"17","author":"Lund","year":"2002","journal-title":"Health Educ. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0277-9536(89)90026-9","article-title":"Psychological aspects of albinism: An exploratory study with Nigerian (Igbo) albino subjects","volume":"29","author":"Ezeilo","year":"1989","journal-title":"Soc. Sci. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0079-6123(01)33005-4","article-title":"Oxytocin: Who needs it?","volume":"133","author":"Insel","year":"2001","journal-title":"Prog. Brain Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-3223(01)01268-9","article-title":"The neurobiology of social recognition, approach, and avoidance","volume":"51","author":"Young","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nature03701","article-title":"Oxytocin increases trust in humans","volume":"435","author":"Kosfeld","year":"2005","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/00332747.1999.11024859","article-title":"Preliminary research on plasma oxytocin in normal cycling women: Investigating emotion and interpersonal distress","volume":"62","author":"Turner","year":"1999","journal-title":"Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1523\/JNEUROSCI.22-09-03306.2002","article-title":"The neuroscience of natural rewards: Relevance to addictive drugs","volume":"22","author":"Kelley","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/j.1460-9568.2008.06184.x","article-title":"Oxytocin reduces anxiety via ERK1\/2 activation: Local effect within the rat hypothalamic paraventricular nucleus","volume":"27","author":"Blume","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"ref_23","first-page":"15","article-title":"Oxytocin as a potential therapeutic agent in anxiety and depression","volume":"9","author":"Kozak","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.psyneuen.2013.06.019","article-title":"The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences","volume":"38","author":"Olff","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_25","unstructured":"Parker, M.O., Gaviria, J., Haigh, A., Millington, M.E., and Brown, V.J. (2019). Rewarding outcomes of social interactions are regulated by the amygdala and oxytocin system. Sci. Rep., 9."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Jin, Y., Song, D., Yan, Y., Quan, Z., and Qing, H. (2023). The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310430"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/01.PSY.0000074003.35911.41","article-title":"Mindfulness based stress reduction in relation to quality of life, mood, symptoms outpatients","volume":"65","author":"Carlson","year":"2003","journal-title":"Psychosom. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0145482X8307700201","article-title":"Albinism: A survey attitudes and behavior","volume":"77","author":"Bright","year":"1983","journal-title":"J. Vis. Impair. Blind."},{"key":"ref_29","first-page":"65","article-title":"Is Oxytocin relevant for the affective disorders?","volume":"12","author":"Ciobica","year":"2016","journal-title":"Acta Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Braasch, I., Schartl, M., and Volff, J.N. (2007). Evolution of pigment synthesis pathways by gene and genome duplication in fish. BMC Evol. Biol., 7.","DOI":"10.1186\/1471-2148-7-74"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/pcmr.12205","article-title":"Oca2 regulation of chromatophore differentiation and number is cell type specific in zebrafish","volume":"27","author":"Beirl","year":"2014","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1098-1004(1999)13:2<99::AID-HUMU2>3.0.CO;2-C","article-title":"Molecular basis of albinism: Mutations and polymorphisms of pigmentation genes associated with albinism","volume":"13","author":"Oetting","year":"1999","journal-title":"Hum. Mutat."},{"key":"ref_34","unstructured":"Goodson, J.L., and Thompson, R.R. (2020). Oxytocin receptors regulate social preference in zebrafish. PLoS ONE, 15."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbr.2008.10.044","article-title":"Olfactory conditioning in the zebrafish (Danio rerio)","volume":"198","author":"Braubach","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.beproc.2013.06.007","article-title":"Rapid, accurate time estimation in zebrafish (Danio rerio)","volume":"99","author":"Cerutti","year":"2013","journal-title":"Behav. Process"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/cz\/zow077","article-title":"Animated images in the analysis of zebrafish behavior","volume":"63","author":"Gerlai","year":"2017","journal-title":"Curr. Zool."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/zeb.2014.1041","article-title":"Live predators, robots, and computer-animated images elicit differential avoidance responses in zebrafish","volume":"12","author":"Ladu","year":"2015","journal-title":"Zebrafish"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/neu.10165","article-title":"Behavioral genetic approaches to visual system development and function in zebrafish","volume":"54","author":"Neuhauss","year":"2003","journal-title":"J. Neurobiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1749-4877.2008.00131.x","article-title":"Lateral line system of fish","volume":"4","author":"Bleckmann","year":"2009","journal-title":"Integr. Zool."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/zeb.2013.0969","article-title":"Induction of social behavior in zebrafish: Live versus computer animated fish as stimuli","volume":"11","author":"Qin","year":"2014","journal-title":"Zebrafish"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/s41593-019-0452-x","article-title":"Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets","volume":"22","author":"Wee","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_43","first-page":"859848","article-title":"The effects of social vs. individual housing of zebrafish on whole-body cortisol and behavior in two tests of anxiety","volume":"239","author":"Onarheim","year":"2020","journal-title":"Psychopharmacology"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Fontana, B., Alnassar, N., and Parker, M.O. (2021). The zebrafish (Danio rerio) anxiety test battery: Comparison of behavioral responses in the novel tank diving and light-dark tasks following exposure to anxiogenic and anxiolytic compounds. Sci. Rep., 11.","DOI":"10.1007\/s00213-021-05990-w"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/FBP.0000000000000338","article-title":"The impact of stress on social behavior in adult zebrafish (Danio rerio)","volume":"29","author":"Saszik","year":"2018","journal-title":"Behav. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.anbehav.2013.04.011","article-title":"Development of aggressive phenotypes in zebrafish: Interactions of age, experience and social status","volume":"86","author":"Ricci","year":"2013","journal-title":"Anim. Behav."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chuang, H.J., Chang, C.Y., Ho, H.P., and Chou, M.Y. (2021). Oxytocin signaling acts as a marker for environmental stressors in Zebrafish. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147459"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Takayanagi, Y., and Tatsushi, O. (2021). Roles of Oxytocin in Stress Responses, Allostasis and Resilience. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010150"},{"key":"ref_49","first-page":"23","article-title":"Individual Differences Underlying Susceptibility to Addiction: Role for the Endogenous Oxytocin System","volume":"119","author":"Sumracki","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1365-2826.2008.01726.x","article-title":"Brain oxytocin: A key regulator of emotional and social behaviours in both females and males","volume":"20","author":"Neumann","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"ref_51","first-page":"e258","article-title":"Sniffing around oxytocin: Review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy","volume":"3","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1038\/npp.2010.123","article-title":"Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder","volume":"35","author":"Labuschagne","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gemmer, A., Mirkes, K., Anneser, L., Eilers, T., Kibat, C., Mathuru, A., Ryu, S., and Schuman, E. (2022). Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Sci. Rep., 12.","DOI":"10.1038\/s41598-022-07990-y"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.31887\/DCNS.2017.19.2\/cjones","article-title":"Oxytocin and social functioning","volume":"19","author":"Jones","year":"2017","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/112_2022_72","article-title":"Role of Oxytocin in different neuropsychiatric, neurodegenerative, and neurodevelopmental disorders","volume":"186","author":"Ghazy","year":"2023","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Landin, J., Hovey, D., Xu, B., Lagman, D., Zettergren, A., Larhammar, D., Kettunen, P., and Westberg, L. (2020). Oxytocin receptors regulate social preference in Zebrafish. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-61073-4"},{"key":"ref_57","first-page":"113004","article-title":"Modulation of social preference by oxytocin in the zebrafish Danio rerio behavior","volume":"399","author":"Singh","year":"2021","journal-title":"Brain Res."},{"key":"ref_58","unstructured":"Umeoka, E.H., Garc\u00eda-Chequer, A.J., and Oliveira, R.F. (2020). Oxytocin modulates dopamine release in the nucleus accumbens shell of zebrafish: Differential effect in social approach and focal visiting. Front. Behav. Neurosci., 14."},{"key":"ref_59","first-page":"14","article-title":"Anxiolytic effects of oxytocin in zebrafish: Investigating the role of oxytocin receptor subtypes and the receptor antagonist atosiban","volume":"113","author":"Silva","year":"2019","journal-title":"Peptides"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1523\/JNEUROSCI.2939-20.2021","article-title":"Developmental Effects of Oxytocin Neurons on Social Affiliation and Processing of Social Information","volume":"41","author":"Nunes","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1523\/JNEUROSCI.3984-05.2005","article-title":"Oxytocin modulates neural circuitry for social cognition and fear in humans","volume":"25","author":"Kirsch","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_62","first-page":"2097","article-title":"Role of Oxytocin receptors in modulation of fear by social memory","volume":"231","author":"Tronson","year":"2013","journal-title":"Psychopharmacology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.37358\/RC.17.7.5734","article-title":"Preliminary data regarding the effects of Oxytocin administration on the oxidative stress status of Zebrafish (Danio rerio)","volume":"68","author":"Balmus","year":"2017","journal-title":"Rev. Chim."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Robea, M.A., Ciobica, A., Curpan, A.S., Plavan, G., Strungaru, S., Lefter, R., and Nicoara, M. (2021). Preliminary results regarding sleep in a zebrafish model of autism spectrum disorder. Brain Sci., 11.","DOI":"10.3390\/brainsci11050556"},{"key":"ref_65","first-page":"49","article-title":"Stability-indicating HPLC method for the determination of the stability of oxytocin parenteral solutions prepared in polyolefin bags","volume":"6","author":"Kaushal","year":"2012","journal-title":"Drug Discov. Ther."},{"key":"ref_66","unstructured":"Kassi, G.B., Zer\u00e9, M.G., Stanislas, S.Y., and N\u2019douba, V. (2023, June 13). R\u00e9gime Alimentaire de Ctenopoma Petherici (Perciformes, Anabantidae) Dans La Rivi\u00e8re Agn\u00e9by et Dans Le Lac de Barrage Hydro\u00e9lectrique d\u2019Ayam\u00e9 2 (C\u00f4te d\u2019Ivoire). Available online: https:\/\/popups.uliege.be\/2295-8010."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbr.2010.07.028","article-title":"An automated predator avoidance task in zebrafish","volume":"216","author":"Ahmed","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Haghani, S., Karia, M., Cheng, R.-K., and Mathuru, A.S. (2019). An automated assay system to study novel tank induced anxiety. Front. Behav. Neurosci., 13.","DOI":"10.3389\/fnbeh.2019.00180"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Savuca, A., Chelaru, I.A., Balmus, I.M., Curpan, A.S., Nicoara, M.N., and Ciobica, A.S. (2024). Toxicological response of zebrafish exposed to polymeric material cocktails and valproic acid. Sustainability, 16.","DOI":"10.20944\/preprints202402.0290.v1"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/2070\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:43:03Z","timestamp":1760028183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/2070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":69,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["ijms26052070"],"URL":"https:\/\/doi.org\/10.3390\/ijms26052070","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]}}}