{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:06:56Z","timestamp":1783386416958,"version":"3.54.6"},"reference-count":90,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondazione Italiana Endometriosi"},{"name":"Progetto Genomico"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is a pathological condition characterized by the presence of the endometrial tissue, outside the uterine cavity. It affects nearly 10% of women of reproductive age and is responsible for infertility, chronic pain, and the weakening of the quality of life. Various pathogenetic mechanisms have been suggested; however, the essential pathogenesis of endometriosis remains insufficiently comprehended. A comprehensive literature search was conducted in databases such as PubMed, Scopus, and Web of Science up to December 2024. Inclusion criteria encompassed studies investigating the pathogenetic mechanisms of endometriosis, while exclusion criteria included reviews, case reports, and studies lacking primary data. The analyzed studies explored multiple pathogenetic mechanisms, including retrograde menstruation, coelomic metaplasia, embryological defects, stem cell involvement, and epigenetic modifications. Special emphasis was placed on the role of uterine adenogenesis factors in the development and progression of endometriosis. A deeper understanding of the various pathogenetic mechanisms underlying endometriosis is crucial for advancing targeted therapeutic strategies. Further research into uterine adenogenesis factors may provide new insights into the disease\u2019s pathophysiology and pave the way for novel treatment approaches.<\/jats:p>","DOI":"10.3390\/ijms26052076","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T03:37:57Z","timestamp":1740627477000},"page":"2076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Role of Adenogenesis Factors in the Pathogenesis of Endometriosis"],"prefix":"10.3390","volume":"26","author":[{"given":"Pietro G.","family":"Signorile","sequence":"first","affiliation":[{"name":"Italian Endometriosis Foundation, Formello (RM), 00060 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-3842","authenticated-orcid":false,"given":"Alfonso","family":"Baldi","sequence":"additional","affiliation":[{"name":"Italian Endometriosis Foundation, Formello (RM), 00060 Rome, Italy"},{"name":"Department of Life Science, Health and Health Professions, Link Campus University, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Viceconte","sequence":"additional","affiliation":[{"name":"Italian Endometriosis Foundation, Formello (RM), 00060 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Boccellino","sequence":"additional","affiliation":[{"name":"Italian Endometriosis Foundation, Formello (RM), 00060 Rome, Italy"},{"name":"Department of Life Science, Health and Health Professions, Link Campus University, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.2147\/IJWH.S488351","article-title":"Causal Relationship between Endometriosis, Female Infertility, and Primary Ovarian Failure through Bidirectional Mendelian Randomization","volume":"16","author":"Guo","year":"2024","journal-title":"Int. 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