{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:38:26Z","timestamp":1791607106189,"version":"4.3.4"},"reference-count":98,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common cause of dementia worldwide. Pathological deposits of neurotoxin proteins within the brain, such as amyloid-\u03b2 and hyperphosphorylated tau tangles, are prominent features in AD. The prion protein (PrP) is involved in neurodegeneration via its conversion from the normal cellular form (PrPC) to the infection prion protein scrapie (PrPSc) form. Some studies indicated that post-translationally modified PrPC isoforms play a fundamental role in AD pathological progression. Several studies have shown that the interaction of A\u03b2 oligomers (A\u03b2os) with the N-terminal residues of the PrPC protein region appears critical for neuronal toxicity. PrPC-A\u03b2 binding always occurs in AD brains and is never detected in non-demented controls, and the binding of A\u03b2 aggregates to PrPC is restricted to the N-terminus of PrPC. In this study, we aimed to gather all of the recent information about the connections between PrPC and AD, with potential clinical implications.<\/jats:p>","DOI":"10.3390\/ijms26052097","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T05:13:58Z","timestamp":1740633238000},"page":"2097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cellular Prion Protein and Amyloid-\u03b2 Oligomers in Alzheimer\u2019s Disease\u2014Are There Connections?"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-4299","authenticated-orcid":false,"given":"Micha\u0142","family":"Fu\u0142ek","sequence":"first","affiliation":[{"name":"Department and Clinic of Diabetology, Hypertension and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-663X","authenticated-orcid":false,"given":"Naomi","family":"Hachiya","sequence":"additional","affiliation":[{"name":"Shonan Research Center, New-STEP Research Center, Central Glass Co., Ltd., Shonan Health Innovation Park 26-1, Muraoka Higashi, Fujisawa 251-8555, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-2098","authenticated-orcid":false,"given":"Martyna","family":"Gachowska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-6923","authenticated-orcid":false,"given":"Jan Aleksander","family":"Besz\u0142ej","sequence":"additional","affiliation":[{"name":"Department and Clinic of Psychiatry, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-8248","authenticated-orcid":false,"given":"El\u017cbieta","family":"Bartoszewska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-8920","authenticated-orcid":false,"given":"Donata","family":"Kurpas","sequence":"additional","affiliation":[{"name":"Division of Research Methodology, Department of Nursing, Faculty of Nursing and Midwifery, Wroclaw Medical University, 51-618 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3101-5021","authenticated-orcid":false,"given":"Tomasz","family":"Kurpi\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1338-1382","authenticated-orcid":false,"given":"Hanna","family":"Adamska","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, Marciniak Lower Silesian Specialist Hospital, 54-049 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-7070","authenticated-orcid":false,"given":"Rafa\u0142","family":"Por\u0119ba","sequence":"additional","affiliation":[{"name":"Department of Biological Principles of Physical Activity, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-150X","authenticated-orcid":false,"given":"Szymon","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Copper Health Center, 59-301 Lubin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-774X","authenticated-orcid":false,"given":"Katarzyna","family":"Fu\u0142ek","sequence":"additional","affiliation":[{"name":"Department and Clinic of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-2470","authenticated-orcid":false,"given":"Jerzy","family":"Leszek","sequence":"additional","affiliation":[{"name":"Department and Clinic of Psychiatry, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41593-018-0289-8","article-title":"Tau Impairs Neural Circuits, Dominating Amyloid-\u03b2 Effects, in Alzheimer Models in Vivo","volume":"22","author":"Busche","year":"2019","journal-title":"Nat. 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