{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:11:16Z","timestamp":1785521476393,"version":"3.56.0"},"reference-count":136,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Key Program of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430035"],"award-info":[{"award-number":["82430035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Key Program of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023AFA038"],"award-info":[{"award-number":["2023AFA038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Key Program of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021YFF0702303"],"award-info":[{"award-number":["2021YFF0702303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Key Program of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024YFC2511101"],"award-info":[{"award-number":["2024YFC2511101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Key Program of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023YFE0203200"],"award-info":[{"award-number":["2023YFE0203200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Key Program of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024BRA019"],"award-info":[{"award-number":["2024BRA019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012556","name":"Foundation for Innovative Research Groups of Hubei Province","doi-asserted-by":"publisher","award":["82430035"],"award-info":[{"award-number":["82430035"]}],"id":[{"id":"10.13039\/501100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012556","name":"Foundation for Innovative Research Groups of Hubei Province","doi-asserted-by":"publisher","award":["2023AFA038"],"award-info":[{"award-number":["2023AFA038"]}],"id":[{"id":"10.13039\/501100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012556","name":"Foundation for Innovative Research Groups of Hubei Province","doi-asserted-by":"publisher","award":["2021YFF0702303"],"award-info":[{"award-number":["2021YFF0702303"]}],"id":[{"id":"10.13039\/501100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012556","name":"Foundation for Innovative Research Groups of Hubei Province","doi-asserted-by":"publisher","award":["2024YFC2511101"],"award-info":[{"award-number":["2024YFC2511101"]}],"id":[{"id":"10.13039\/501100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012556","name":"Foundation for Innovative Research Groups of Hubei Province","doi-asserted-by":"publisher","award":["2023YFE0203200"],"award-info":[{"award-number":["2023YFE0203200"]}],"id":[{"id":"10.13039\/501100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012556","name":"Foundation for Innovative Research Groups of Hubei Province","doi-asserted-by":"publisher","award":["2024BRA019"],"award-info":[{"award-number":["2024BRA019"]}],"id":[{"id":"10.13039\/501100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["82430035"],"award-info":[{"award-number":["82430035"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023AFA038"],"award-info":[{"award-number":["2023AFA038"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0702303"],"award-info":[{"award-number":["2021YFF0702303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2511101"],"award-info":[{"award-number":["2024YFC2511101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0203200"],"award-info":[{"award-number":["2023YFE0203200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024BRA019"],"award-info":[{"award-number":["2024BRA019"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["82430035"],"award-info":[{"award-number":["82430035"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2023AFA038"],"award-info":[{"award-number":["2023AFA038"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2021YFF0702303"],"award-info":[{"award-number":["2021YFF0702303"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024YFC2511101"],"award-info":[{"award-number":["2024YFC2511101"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2023YFE0203200"],"award-info":[{"award-number":["2023YFE0203200"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024BRA019"],"award-info":[{"award-number":["2024BRA019"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The calcium- and integrin-binding protein (CIB) family, comprising four evolutionarily conserved members (CIB1, CIB2, CIB3, and CIB4), is characterized by canonical EF-hand motifs. The functions of CIBs in the inner ear have been investigated, although further research is still necessary to gain a comprehensive understanding of them. Among the CIB family members, CIB2 is essential for auditory function. CIB3 and CIB2 jointly participate in the regulation of balance. Beyond their sensory roles, CIBs exhibit multifunctionality through calcium-dependent interactions with diverse molecular partners, contributing to the pathogenesis of various conditions, including neurological disorders, cardiovascular diseases, cancer, and male infertility. In this review, we discuss the conserved structure of the CIB family, highlighting its contributions to various biological functions. We also summarize the distribution and function of the CIB family, emphasizing the pivotal roles of CIB2 and CIB3 in hearing and balance.<\/jats:p>","DOI":"10.3390\/ijms26052223","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T04:10:42Z","timestamp":1740975042000},"page":"2223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Diverse Functions of the Calcium- and Integrin-Binding Protein Family"],"prefix":"10.3390","volume":"26","author":[{"given":"Xiaoying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3491-0175","authenticated-orcid":false,"given":"Zhangyi","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-3715","authenticated-orcid":false,"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Province Clinic Research Center for Deafness and Vertigo, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1074\/jbc.M411515200","article-title":"Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-Hand-Containing Proteins","volume":"280","author":"Gentry","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1139\/o2012-021","article-title":"Biophysical and Structural Studies of the Human Calcium- and Integrin-Binding Protein Family: Understanding Their Functional Similarities and Differences","volume":"90","author":"Huang","year":"2012","journal-title":"Biochem. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1074\/jbc.272.8.4651","article-title":"Identification of a Novel Calcium-Binding Protein That Interacts with the Integrin \u03b1IIb Cytoplasmic Domain","volume":"272","author":"Naik","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, J., Yao, X., Li, W., Du, H., Tang, M., Xiong, W., Chai, R., and Xu, Z. (2017). Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Front. Mol. Neurosci., 10.","DOI":"10.3389\/fnmol.2017.00401"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/ng.2426","article-title":"Alterations of the CIB2 Calcium- and Integrin-Binding Protein Cause Usher Syndrome Type 1J and Nonsyndromic Deafness DFNB48","volume":"44","author":"Riazuddin","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Patel, K., Giese, A.P., Grossheim, J.M., Hegde, R.S., Delio, M., Samanich, J., Riazuddin, S., Frolenkov, G.I., Cai, J., and Ahmed, Z.M. (2015). A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141259"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.15252\/emmm.201708087","article-title":"CIB2, Defective in Isolated Deafness, Is Key for Auditory Hair Cell Mechanotransduction and Survival","volume":"9","author":"Michel","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41467-017-00061-1","article-title":"CIB2 Interacts with TMC1 and TMC2 and Is Essential for Mechanotransduction in Auditory Hair Cells","volume":"8","author":"Giese","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1523\/JNEUROSCI.1807-22.2023","article-title":"CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells","volume":"43","author":"Wang","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Giese, A.P.J., Weng, W.-H., Kindt, K.S., Chang, H.H.V., Montgomery, J.S., Ratzan, E.M., Beirl, A.J., Rivera, R.A., Lotthammer, J.M., and Walujkar, S. (2024). Complexes of Vertebrate TMC1\/2 and CIB2\/3 Proteins Form Hair-Cell Mechanotransduction Cation Channels. bioRxiv.","DOI":"10.7554\/eLife.89719.2.sa0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.neuron.2021.05.007","article-title":"CIB2 and CIB3 Are Auxiliary Subunits of the Mechanotransduction Channel of Hair Cells","volume":"109","author":"Liang","year":"2021","journal-title":"Neuron"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Vallone, R., Dal Cortivo, G., D\u2019Onofrio, M., and Dell\u2019Orco, D. (2018). Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00274"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004410051207","article-title":"Intracellular Neuronal Calcium Sensor Proteins: A Family of EF-Hand Calcium-Binding Proteins in Search of a Function","volume":"295","author":"Braunewell","year":"1999","journal-title":"Cell Tissue Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"W270","DOI":"10.1093\/nar\/gkz357","article-title":"Evolview v3: A Webserver for Visualization, Annotation, and Management of Phylogenetic Trees","volume":"47","author":"Subramanian","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1021\/bi700200z","article-title":"Domain Stability and Metal-Induced Folding of Calcium- and Integrin-Binding Protein 1","volume":"46","author":"Yamniuk","year":"2007","journal-title":"Biochemistry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1021\/bi035432b","article-title":"Metal Ion Binding Properties and Conformational States of Calcium- and Integrin-Binding Protein","volume":"43","author":"Yamniuk","year":"2004","journal-title":"Biochemistry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.abb.2009.05.002","article-title":"Biochemical Characterization and Expression Analysis of a Novel EF-Hand Ca2+ Binding Protein Calmyrin2 (Cib2) in Brain Indicates Its Function in NMDA Receptor Mediated Ca2+ Signaling","volume":"487","author":"Blazejczyk","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12154-009-0032-8","article-title":"Protein Myristoylation in Health and Disease","volume":"3","author":"Wright","year":"2010","journal-title":"J. Chem. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Dal Cortivo, G., and Dell\u2019Orco, D. (2022). Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073552"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1083\/jcb.145.6.1277","article-title":"A Myristoylated Calcium-Binding Protein That Preferentially Interacts with the Alzheimer\u2019s Disease Presenilin 2 Protein","volume":"145","author":"Stabler","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1074\/jbc.M109.068395","article-title":"Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-Binding Protein 1","volume":"285","author":"Jarman","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1159\/000481873","article-title":"The Emerging Roles of CIB1 in Cancer","volume":"43","author":"Wang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1021\/ja2111306","article-title":"Structural Basis for the Activation of Platelet Integrin \u03b1IIb\u03b23 by Calcium- and Integrin-Binding Protein 1","volume":"134","author":"Huang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1160\/TH08-06-0351","article-title":"Characterization of Calcium- and Integrin-Binding Protein 1 (CIB1) Knockout Platelets: Potential Compensation by CIB Family Members","volume":"100","author":"DeNofrio","year":"2008","journal-title":"Thromb. Haemost."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s11033-008-9383-4","article-title":"Molecular Characterization of the Sheep CIB1 Gene","volume":"36","author":"Yu","year":"2009","journal-title":"Mol. Biol. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/biolre\/ioaa059","article-title":"CIB4 Is Essential for the Haploid Phase of Spermatogenesis in Mice","volume":"103","author":"Xu","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1042\/bj3420729","article-title":"Calcium-Dependent Properties of CIB Binding to the Integrin \u03b1IIb Cytoplasmic Domain and Translocation to the Platelet Cytoskeleton","volume":"342","author":"Shock","year":"1999","journal-title":"Biochem. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1110\/ps.041312805","article-title":"Calcium- and Magnesium-dependent Interactions between Calcium- and Integrin-binding Protein and the Integrin \u03b1IIb Cytoplasmic Domain","volume":"14","author":"Yamniuk","year":"2005","journal-title":"Protein Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kostyak, J.C., and Naik, U.P. (2011). Calcium- and Integrin-Binding Protein 1 Regulates Endomitosis and Its Interaction with Polo-like Kinase 3 Is Enhanced in Endomitotic Dami Cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014513"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8507","DOI":"10.1128\/MCB.01488-06","article-title":"CIB1 Is Essential for Mouse Spermatogenesis","volume":"26","author":"Yuan","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2010.01.004","article-title":"Alternative Splicing and Tissue Expression of CIB4 Gene in Sheep Testis","volume":"120","author":"Yu","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tips.2005.04.008","article-title":"The Darker Side of Ca2+ Signaling by Neuronal Ca2+-Sensor Proteins: From Alzheimer\u2019s Disease to Cancer","volume":"26","author":"Braunewell","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2990.2005.00646.x","article-title":"The Alzheimer Disease-Related Calcium-Binding Protein Calmyrin Is Present in Human Forebrain with an Altered Distribution in Alzheimer\u2019s as Compared to Normal Ageing Brains","volume":"31","author":"Bernstein","year":"2005","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yoon, K.W., Yang, H.-S., Kim, Y.M., Kim, Y., Kang, S., Sun, W., Naik, U.P., Parise, L.V., and Choi, E.-J. (2017). CIB1 Protects against MPTP-Induced Neurotoxicity through Inhibiting ASK1. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-12379-3"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/1873-3468.13795","article-title":"Ca2+ Functions as a Molecular Switch That Controls the Mutually Exclusive Complex Formation of Pyridoxal Phosphatase with CIB1 or Calmodulin","volume":"594","author":"Jeanclos","year":"2020","journal-title":"FEBS Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"29621","DOI":"10.1074\/jbc.M701448200","article-title":"Diffusion and Not Active Transport Underlies and Limits ERK1\/2 Synapse-to-Nucleus Signaling in Hippocampal Neurons","volume":"282","author":"Wiegert","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1038\/s41467-021-24056-1","article-title":"CIB2 Regulates mTORC1 Signaling and Is Essential for Autophagy and Visual Function","volume":"12","author":"Sethna","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Linnert, J., Knapp, B., G\u00fcler, B.E., Boldt, K., Ueffing, M., and Wolfrum, U. (2023). Usher Syndrome Proteins ADGRV1 (USH2C) and CIB2 (USH1J) Interact and Share a Common Interactome Containing TRiC\/CCT-BBS Chaperonins. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1199069"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nm.2181","article-title":"CIB1 Is a Regulator of Pathological Cardiac Hypertrophy","volume":"16","author":"Heineke","year":"2010","journal-title":"Nat. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.1996.03530440037034","article-title":"The Progression from Hypertension to Congestive Heart Failure","volume":"275","author":"Levy","year":"1996","journal-title":"JAMA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0008-6363(01)00493-X","article-title":"Calcineurin and Hypertrophic Heart Disease: Novel Insights and Remaining Questions","volume":"53","author":"Bueno","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.0000109415.17511.18","article-title":"Calcineurin\/NFAT Coupling Participates in Pathological, but Not Physiological, Cardiac Hypertrophy","volume":"94","author":"Wilkins","year":"2004","journal-title":"Circ. Res."},{"key":"ref_43","first-page":"1726","article-title":"Calcium- and Integrin-Binding Protein-1 and Calcineurin Are Upregulated in the Right Atrial Myocardium of Patients with Atrial Fibrillation","volume":"14","author":"Zhao","year":"2012","journal-title":"EP Eur."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1161\/CIRCULATIONAHA.122.062660","article-title":"CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling","volume":"147","author":"Wang","year":"2023","journal-title":"Circulation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1074\/jbc.M110643200","article-title":"Calcium Integrin-Binding Protein Activates Platelet Integrin \u03b1IIb\u03b23","volume":"277","author":"Tsuboi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1055\/s-0037-1616223","article-title":"All in the Family: Primary Megakaryocytes for Studies of Platelet \u03b1IIb\u03b23 Signaling","volume":"86","author":"Shattil","year":"2001","journal-title":"Thromb. Haemost."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1021\/bi400678y","article-title":"Identification of Novel Integrin Binding Partners for Calcium and Integrin Binding Protein 1 (CIB1): Structural and Thermodynamic Basis of CIB1 Promiscuity","volume":"52","author":"Freeman","year":"2013","journal-title":"Biochemistry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1182\/blood-2003-05-1703","article-title":"Calcium-and Integrin-Binding Protein Regulates Focal Adhesion Kinase Activity during Platelet Spreading on Immobilized Fibrinogen","volume":"102","author":"Naik","year":"2003","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/j.1538-7836.2009.03581.x","article-title":"CIB1 Deficiency Results in Impaired Thrombosis: The Potential Role of CIB1 in Outside-in Signaling through Integrin \u03b1IIb\u03b23","volume":"7","author":"Naik","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/cvm-2-6-278","article-title":"Therapeutic Angiogenesis for Cardiovascular Disease","volume":"2","author":"Ng","year":"2001","journal-title":"Trials"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCRESAHA.107.157586","article-title":"CIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis","volume":"101","author":"Zayed","year":"2007","journal-title":"Circ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.200502090","article-title":"Essential Role of CIB1 in Regulating PAK1 Activation and Cell Migration","volume":"170","author":"Leisner","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e31198","DOI":"10.1002\/jcp.31198","article-title":"Role of Calcium Integrin-Binding Protein 1 in the Mechanobiology of the Liver Endothelium","volume":"239","author":"Wang","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/geno.1999.5909","article-title":"Cloning, Sequence Analysis, and Chromosomal Localization of the Novel Human Integrin A11 Subunit (ITGA11)","volume":"60","author":"Lehnert","year":"1999","journal-title":"Genomics"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1046\/j.0014-2956.2001.02681.x","article-title":"NBR1 Interacts with Fasciculation and Elongation Protein Zeta-1 (FEZ1) and Calcium and Integrin Binding Protein (CIB) and Shows Developmentally Restricted Expression in the Neural Tube","volume":"269","author":"Whitehouse","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4236\/abc.2014.41009","article-title":"Interaction of Calcium- and Integrin-Binding Protein 1 with Integrin \u03b111 and Its Possible Involvement in Pulmonary Fibrosis","volume":"4","author":"Yoshida","year":"2014","journal-title":"Adv. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1038\/s41467-024-49724-w","article-title":"Identification of Unique Cell Type Responses in Pancreatic Islets to Stress","volume":"15","author":"Maestas","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10815-014-0177-4","article-title":"Calcium- and Integrin-Binding Protein-1 Is down-Regulated in the Sperm of Patients with Oligoasthenozoospermia: CIB1 Expression in Patients with Oligoasthenozoospermia","volume":"31","author":"Sun","year":"2014","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Mohammadabadi, M.R., Jafari, A.H.D., and Bordbar, F. (2017). Molecular Analysis of CIB4 Gene and Protein in Kermani Sheep. Braz. J. Med. Biol. Res., 50.","DOI":"10.1590\/1414-431x20176177"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"14587","DOI":"10.1074\/jbc.R200022200","article-title":"Integrins: Redundant or Important Players in Skeletal Muscle?","volume":"278","author":"Mayer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"24760","DOI":"10.1074\/jbc.M801166200","article-title":"Cib2 Binds Integrin \u03b17B\u03b21D and Is Reduced in Laminin A2 Chain-Deficient Muscular Dystrophy","volume":"283","author":"Bigotti","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.200505131","article-title":"CIB1 Is an Endogenous Inhibitor of Agonist-Induced Integrin \u03b1IIb\u03b23 Activation","volume":"172","author":"Yuan","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1042\/BCJ20190410","article-title":"Calcium-Induced Dissociation of CIB1 from ASK1 Regulates Agonist-Induced Activation of the P38 MAPK Pathway in Platelets","volume":"476","author":"Patel","year":"2019","journal-title":"Biochem. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1096\/fj.201500073R","article-title":"CIB1: A Small Protein with Big Ambitions","volume":"30","author":"Leisner","year":"2016","journal-title":"FASEB J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10549-015-3458-4","article-title":"CIB1 Depletion Impairs Cell Survival and Tumor Growth in Triple-Negative Breast Cancer","volume":"152","author":"Black","year":"2015","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/BJ20131395","article-title":"DNA-PKcs-Interacting Protein KIP Binding to TRF2 Is Required for the Maintenance of Functional Telomeres","volume":"463","author":"Khadka","year":"2014","journal-title":"Biochem. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"34750","DOI":"10.1074\/jbc.M401843200","article-title":"DNA-Protein Kinase Catalytic Subunit-Interacting Protein KIP Binds Telomerase by Interacting with Human Telomerase Reverse Transcriptase","volume":"279","author":"Lee","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"26468","DOI":"10.1074\/jbc.M203527200","article-title":"EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response","volume":"277","author":"Henderson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17389","DOI":"10.1073\/pnas.0812259106","article-title":"CIB1 Functions as a Ca2+-Sensitive Modulator of Stress-Induced Signaling by Targeting ASK1","volume":"106","author":"Yoon","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00262-004-0645-2","article-title":"G1P3, an Interferon Inducible Gene 6-16, Is Expressed in Gastric Cancers and Inhibits Mitochondrial-Mediated Apoptosis in Gastric Cancer Cell Line TMK-1 Cell","volume":"54","author":"Tahara","year":"2005","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1002\/jcb.23255","article-title":"Contra-Regulation of Calcium- and Integrin-Binding Protein 1-Induced Cell Migration on Fibronectin by PAK1 and MAP Kinase Signaling","volume":"112","author":"Naik","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2040-2384-2-17","article-title":"Tumor Growth and Angiogenesis Is Impaired in CIB1 Knockout Mice","volume":"2","author":"Zayed","year":"2010","journal-title":"J. Angiogenesis Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1158\/0008-5472.CAN-17-0025","article-title":"CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Godinho-Santos, A., Hance, A.J., Gon\u00e7alves, J., and Mammano, F. (2016). CIB1 and CIB2 Are HIV-1 Helper Factors Involved in Viral Entry. Sci. Rep., 6.","DOI":"10.1038\/srep30927"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"de Jong, S.J., Imahorn, E., Itin, P., Uitto, J., Orth, G., Jouanguy, E., Casanova, J.-L., and Burger, B. (2018). Epidermodysplasia Verruciformis: Inborn Errors of Immunity to Human Beta-Papillomaviruses. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01222"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng1044","article-title":"Mutations in Two Adjacent Novel Genes Are Associated with Epidermodysplasia Verruciformis","volume":"32","author":"Ramoz","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1084\/jem.20170308","article-title":"The Human CIB1\u2013EVER1\u2013EVER2 Complex Governs Keratinocyte-Intrinsic Immunity to \u03b2-Papillomaviruses","volume":"215","author":"Matos","year":"2018","journal-title":"J. Exp. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"16086","DOI":"10.1074\/jbc.RA120.013045","article-title":"Expression of a TMC6-TMC8-CIB1 Heterotrimeric Complex in Lymphocytes Is Regulated by Each of the Components","volume":"295","author":"Wu","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Bandyopadhyay, C., Valiya-Veettil, M., Dutta, D., Chakraborty, S., and Chandran, B. (2014). CIB1 Synergizes with EphrinA2 to Regulate Kaposi\u2019s Sarcoma-Associated Herpesvirus Macropinocytic Entry in Human Microvascular Dermal Endothelial Cells. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003941"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1083\/jcb.75.2.339","article-title":"Actin Filaments in Sensory Hairs of Inner Ear Receptor Cells","volume":"75","author":"Flock","year":"1977","journal-title":"J. Cell Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1073\/pnas.74.6.2407","article-title":"Sensitivity, Polarity, and Conductance Change in the Response of Vertebrate Hair Cells to Controlled Mechanical Stimuli","volume":"74","author":"Hudspeth","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuron.2020.07.007","article-title":"Molecular Crux of Hair Cell Mechanotransduction Machinery","volume":"107","author":"Kang","year":"2020","journal-title":"Neuron"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"103706","DOI":"10.1016\/j.mcn.2022.103706","article-title":"Mechanotransduction in Mammalian Sensory Hair Cells","volume":"120","author":"Caprara","year":"2022","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"a033167","DOI":"10.1101\/cshperspect.a033167","article-title":"Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex","volume":"9","author":"Cunningham","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.neuron.2018.07.033","article-title":"TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells","volume":"99","author":"Pan","year":"2018","journal-title":"Neuron"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/ng842","article-title":"Dominant and Recessive Deafness Caused by Mutations of a Novel Gene, TMC1, Required for Cochlear Hair-Cell Function","volume":"30","author":"Kurima","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00424-014-1582-3","article-title":"Transmembrane Channel-like (TMC) Genes Are Required for Auditory and Vestibular Mechanosensation","volume":"467","author":"Kawashima","year":"2015","journal-title":"Pfl\u00fcg. Arch.-Eur. J. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1016\/j.neuron.2024.06.013","article-title":"Sequence Variations and Accessory Proteins Adapt TMC Functions to Distinct Sensory Modalities","volume":"112","author":"Jiang","year":"2024","journal-title":"Neuron"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.neuron.2024.11.009","article-title":"Human TMC1 and TMC2 Are Mechanically Gated Ion Channels","volume":"113","author":"Fu","year":"2024","journal-title":"Neuron"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuron.2020.03.033","article-title":"TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells","volume":"107","author":"Cunningham","year":"2020","journal-title":"Neuron"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"112245","DOI":"10.1016\/j.celrep.2023.112245","article-title":"The Tetraspan LHFPL5 Is Critical to Establish Maximal Force Sensitivity of the Mechanotransduction Channel of Cochlear Hair Cells","volume":"42","author":"Qiu","year":"2023","journal-title":"Cell Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.neuron.2014.10.041","article-title":"TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells","volume":"84","author":"Zhao","year":"2014","journal-title":"Neuron"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2012.10.041","article-title":"TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells","volume":"151","author":"Xiong","year":"2012","journal-title":"Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuron.2020.03.026","article-title":"Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels","volume":"107","author":"Tang","year":"2020","journal-title":"Neuron"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1038\/s41467-024-51850-4","article-title":"LOXHD1 Is Indispensable for Maintaining TMC1 Auditory Mechanosensitive Channels at the Site of Force Transmission","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exer.2005.11.010","article-title":"Molecular Basis of Human Usher Syndrome: Deciphering the Meshes of the Usher Protein Network Provides Insights into the Pathomechanisms of the Usher Disease","volume":"83","author":"Reiners","year":"2006","journal-title":"Exp. Eye Res."},{"key":"ref_97","first-page":"2515841420952194","article-title":"Usher Syndrome: Clinical Features, Molecular Genetics and Advancing Therapeutics","volume":"12","author":"Toms","year":"2020","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Fuster-Garc\u00eda, C., Garc\u00eda-Boh\u00f3rquez, B., Rodr\u00edguez-Mu\u00f1oz, A., Aller, E., Jaijo, T., Mill\u00e1n, J.M., and Garc\u00eda-Garc\u00eda, G. (2021). Usher Syndrome: Genetics of a Human Ciliopathy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136723"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/cge.13170","article-title":"Variants in CIB2 Cause DFNB48 and Not USH1J","volume":"93","author":"Booth","year":"2018","journal-title":"Clin. Genet."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/MAO.0000000000002054","article-title":"Genetics of Usher Syndrome: New Insights from a Meta-Analysis","volume":"40","author":"Jouret","year":"2019","journal-title":"Otol. Neurotol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ncb1219","article-title":"Myosin-XVa Is Required for Tip Localization of Whirlin and Differential Elongation of Hair-Cell Stereocilia","volume":"7","author":"Belyantseva","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1083\/jcb.86.1.244","article-title":"The Organization of Actin Filaments in the Stereocilia of Cochlear Hair Cells","volume":"86","author":"Tilney","year":"1980","journal-title":"J. Cell Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1073\/pnas.1017114108","article-title":"Usher Type 1G Protein sans Is a Critical Component of the Tip-Link Complex, a Structure Controlling Actin Polymerization in Stereocilia","volume":"108","author":"Caberlotto","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1172\/JCI60405","article-title":"Mechanotransduction in Mouse Inner Ear Hair Cells Requires Transmembrane Channel-like Genes","volume":"121","author":"Kawashima","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e24661","DOI":"10.7554\/eLife.24661","article-title":"Mechanotransduction Current Is Essential for Stability of the Transducing Stereocilia in Mammalian Auditory Hair Cells","volume":"6","author":"Freeman","year":"2017","journal-title":"eLife"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/ejhg.2015.157","article-title":"Novel and Recurrent CIB2 Variants, Associated with Nonsyndromic Deafness, Do Not Affect Calcium Buffering and Localization in Hair Cells","volume":"24","author":"Seco","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/jcp.30545","article-title":"BAIAP2L2 Is Required for the Maintenance of Mechanotransducing Stereocilia of Cochlear Hair Cells","volume":"237","author":"Yan","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Giese, A.P.J., Parker, A., Rehman, S., Brown, S.D.M., Riazuddin, S., Vander Kooi, C.W., Bowl, M.R., and Ahmed, Z.M. (2024). CIB2 Function Is Distinct from Whirlin in the Development of Cochlear Stereocilia Staircase Pattern. bioRxiv.","DOI":"10.1101\/2024.07.30.605852"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Aristiz\u00e1bal-Ram\u00edrez, I., Dragich, A.K., Giese, A.P.J., Sofia Zuluaga-Osorio, K., Watkins, J., Davies, G.K., Hadi, S.E., Riazuddin, S., Vander Kooi, C.W., and Ahmed, Z.M. (2023). Calcium and Integrin-Binding Protein 2 (CIB2) Controls Force Sensitivity of the Mechanotransducer Channels in Cochlear Outer Hair Cells. bioRxiv.","DOI":"10.1101\/2023.07.09.545606"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41467-023-44230-x","article-title":"The Piezo Channel Is a Mechano-Sensitive Complex Component in the Mammalian Inner Ear Hair Cell","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41586-022-05314-8","article-title":"Structures of the TMC-1 Complex Illuminate Mechanosensory Transduction","volume":"610","author":"Jeong","year":"2022","journal-title":"Nature"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nn1822","article-title":"Structural Basis for Modulation of Kv4 K+ Channels by Auxiliary KChIP Subunits","volume":"10","author":"Wang","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nn.4449","article-title":"Mechanosensory Hair Cells Express Two Molecularly Distinct Mechanotransduction Channels","volume":"20","author":"Wu","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e70006","DOI":"10.1002\/brx2.70006","article-title":"Mechanosensitive Piezo Channels and Their Potential Roles in Peripheral Auditory Perception","volume":"2","author":"Yi","year":"2024","journal-title":"Brain-X"},{"key":"ref_115","first-page":"624","article-title":"The Roles of USH1 Proteins and PDZ Domain-Containing USH Proteins in USH2 Complex Integrity in Cochlear Hair Cells","volume":"26","author":"Zou","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1152\/jn.00746.2003","article-title":"Comparative Morphology of Rodent Vestibular Periphery. I. Saccular and Utricular Maculae","volume":"93","author":"Desai","year":"2005","journal-title":"J. Neurophysiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev-neuro-061010-113710","article-title":"Vestibular Hair Cells and Afferents: Two Channels for Head Motion Signals","volume":"34","author":"Eatock","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1152\/jn.1988.60.1.182","article-title":"The Vestibular Nerve of the Chinchilla. II. Relation between Afferent Response Properties and Peripheral Innervation Patterns in the Semicircular Canals","volume":"60","author":"Baird","year":"1988","journal-title":"J. Neurophysiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1007\/s00415-015-7909-y","article-title":"Vestibular Animal Models: Contributions to Understanding Physiology and Disease","volume":"263","author":"Straka","year":"2016","journal-title":"J. Neurol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1038\/s41467-024-48491-y","article-title":"Single-Cell Transcriptomic Atlas Reveals Increased Regeneration in Diseased Human Inner Ear Balance Organs","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1038\/s41467-024-53153-0","article-title":"Precise Genetic Control of ATOH1 Enhances Maturation of Regenerated Hair Cells in the Mature Mouse Utricle","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Wu, D.K., and Kelley, M.W. (2012). Molecular Mechanisms of Inner Ear Development. Cold Spring Harb. Perspect. Biol., 4.","DOI":"10.1101\/cshperspect.a008409"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"G\u00e1lvez, H., Abell\u00f3, G., and Giraldez, F. (2017). Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons. Front. Cell Dev. Biol., 5.","DOI":"10.3389\/fcell.2017.00021"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"a033266","DOI":"10.1101\/cshperspect.a033266","article-title":"Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity","volume":"10","author":"Montcouquiol","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41467-019-13710-4","article-title":"Retinoic Acid Degradation Shapes Zonal Development of Vestibular Organs and Sensitivity to Transient Linear Accelerations","volume":"11","author":"Ono","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"dev192070","DOI":"10.1242\/dev.192070","article-title":"Retinoic Acid Synthesis and Autoregulation Mediate Zonal Patterning of Vestibular Organs and Inner Ear Morphogenesis","volume":"147","author":"Ono","year":"2020","journal-title":"Development"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e1298232023","DOI":"10.1523\/JNEUROSCI.1298-23.2023","article-title":"Transmembrane Channel-like (Tmc) Subunits Contribute to Frequency Sensitivity in the Zebrafish Utricle","volume":"44","author":"Sun","year":"2024","journal-title":"J. Neurosci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1038\/s41467-024-49892-9","article-title":"In Silico Fragment-Based Discovery of CIB1-Directed Anti-Tumor Agents by FRASE-Bot","volume":"15","author":"An","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1900582","DOI":"10.1002\/advs.201900582","article-title":"Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer","volume":"6","author":"Wayne","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.7150\/ijbs.96031","article-title":"Deubiquitination of CIB1 by USP14 Promotes Lenvatinib Resistance via the PAK1-ERK1\/2 Axis in Hepatocellular Carcinoma","volume":"20","author":"Xu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"12277","DOI":"10.18632\/aging.206086","article-title":"CIB2 Mediates Acquired Gefitinib Resistance by Inducing ZEB1 Expression and Epithelial-Mesenchymal Transition","volume":"16","author":"Zhou","year":"2024","journal-title":"Aging"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/S0140-6736(23)02874-X","article-title":"AAV1-hOTOF Gene Therapy for Autosomal Recessive Deafness 9: A Single-Arm Trial","volume":"403","author":"Lv","year":"2024","journal-title":"Lancet"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2402166","DOI":"10.1002\/advs.202402166","article-title":"AAV-Mediated Gene Therapy for Hereditary Deafness: Progress and Perspectives","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"295ra108","DOI":"10.1126\/scitranslmed.aab1996","article-title":"Tmc Gene Therapy Restores Auditory Function in Deaf Mice","volume":"7","author":"Askew","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41467-018-08264-w","article-title":"Improved TMC1 Gene Therapy Restores Hearing and Balance in Mice with Genetic Inner Ear Disorders","volume":"10","author":"Pan","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Marcovich, I., Baer, N.K., Shubina-Oleinik, O., Eclov, R., Beard, C.W., and Holt, J.R. (2022). Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7\/11. Biomolecules, 12.","DOI":"10.3390\/biom12070914"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/2223\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:45:09Z","timestamp":1760028309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/5\/2223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":136,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["ijms26052223"],"URL":"https:\/\/doi.org\/10.3390\/ijms26052223","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]}}}