{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:16:07Z","timestamp":1788524167800,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hainan Province Natural Science Foundation","award":["823MS107"],"award-info":[{"award-number":["823MS107"]}]},{"name":"Hainan Province Natural Science Foundation","award":["2023S001007"],"award-info":[{"award-number":["2023S001007"]}]},{"name":"Hainan Province Natural Science Foundation","award":["2022S032"],"award-info":[{"award-number":["2022S032"]}]},{"name":"Hainan Province Natural Science Foundation","award":["ZDYF2023SHFZ141"],"award-info":[{"award-number":["ZDYF2023SHFZ141"]}]},{"name":"Hainan Province Natural Science Foundation","award":["HNYT20240003"],"award-info":[{"award-number":["HNYT20240003"]}]},{"name":"Guangdong Province Provincial Science and Technology Innovation Strategy Project","award":["823MS107"],"award-info":[{"award-number":["823MS107"]}]},{"name":"Guangdong Province Provincial Science and Technology Innovation Strategy Project","award":["2023S001007"],"award-info":[{"award-number":["2023S001007"]}]},{"name":"Guangdong Province Provincial Science and Technology Innovation Strategy Project","award":["2022S032"],"award-info":[{"award-number":["2022S032"]}]},{"name":"Guangdong Province Provincial Science and Technology Innovation Strategy Project","award":["ZDYF2023SHFZ141"],"award-info":[{"award-number":["ZDYF2023SHFZ141"]}]},{"name":"Guangdong Province Provincial Science and Technology Innovation Strategy Project","award":["HNYT20240003"],"award-info":[{"award-number":["HNYT20240003"]}]},{"name":"Maoming Special Science and Technology Project","award":["823MS107"],"award-info":[{"award-number":["823MS107"]}]},{"name":"Maoming Special Science and Technology Project","award":["2023S001007"],"award-info":[{"award-number":["2023S001007"]}]},{"name":"Maoming Special Science and Technology Project","award":["2022S032"],"award-info":[{"award-number":["2022S032"]}]},{"name":"Maoming Special Science and Technology Project","award":["ZDYF2023SHFZ141"],"award-info":[{"award-number":["ZDYF2023SHFZ141"]}]},{"name":"Maoming Special Science and Technology Project","award":["HNYT20240003"],"award-info":[{"award-number":["HNYT20240003"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["823MS107"],"award-info":[{"award-number":["823MS107"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["2023S001007"],"award-info":[{"award-number":["2023S001007"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["2022S032"],"award-info":[{"award-number":["2022S032"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["ZDYF2023SHFZ141"],"award-info":[{"award-number":["ZDYF2023SHFZ141"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["HNYT20240003"],"award-info":[{"award-number":["HNYT20240003"]}]},{"name":"Hainan Province Outstanding Talent Team Development","award":["823MS107"],"award-info":[{"award-number":["823MS107"]}]},{"name":"Hainan Province Outstanding Talent Team Development","award":["2023S001007"],"award-info":[{"award-number":["2023S001007"]}]},{"name":"Hainan Province Outstanding Talent Team Development","award":["2022S032"],"award-info":[{"award-number":["2022S032"]}]},{"name":"Hainan Province Outstanding Talent Team Development","award":["ZDYF2023SHFZ141"],"award-info":[{"award-number":["ZDYF2023SHFZ141"]}]},{"name":"Hainan Province Outstanding Talent Team Development","award":["HNYT20240003"],"award-info":[{"award-number":["HNYT20240003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dalbergia odorifera is widely used to treat cardiovascular diseases. Our research group found that Dalbergia odorifera volatile oil has a good anti-myocardial ischemic effect, and its main pharmacodynamic components are trans-nerolol and its oxides. However, the exact mechanisms underlying this effect have not yet been elucidated. This study aimed to explore the potential myocardial protective effects of trans-nerolol and its underlying molecular mechanisms. Molecular docking was used to predict and visualize the possible mechanism of the anti-apoptotic myocardial protection by trans-nerolol. The myocardial protective effect of trans-nerolol was evaluated by observing pathological injury, myocardial enzyme levels, oxidation, antioxidant levels, and the expression of related proteins. Molecular docking results showed that trans-nerolol binds closely to cytochrome C (Cytc) and apoptosis-related proteins, suggesting that it may play a role in interacting with these target proteins. The results showed that pre-treatment with dose-dependent trans-nerolol significantly mitigated the myocardial histological damage; decreased lactate dehydrogenase (LDH), creatinine kinase (CK), alanine transaminase (ALT), and aspartate transaminase (AST) levels; reduced nitric oxide (NO) production, hydrogen peroxide (H2O2), and lipid peroxide (LPO); and increased the total antioxidant content (T-AOC), glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) activities compared with the model group. In addition, dose-dependent trans-nerolol significantly increased the Na+-K+-ATPase and Ca2+-Mg2+-ATPase levels. Moreover, trans-nerolol markedly reduced the endogenous and external apoptotic pathways; downregulated the protein expression of Cytc, apoptotic protease activating factor-1 (Apaf1), Fibroblast-associated (Fas), Cysteine-aspartate protease 3 (Caspase3), Cysteine-aspartate protease 8 (Caspase8), and Cysteine-aspartate protease 9 (Caspase9); and upregulated the expression of Heat shock protein 70 (Hsp70) and B-cell lymphoma-2 (Bcl-2). These data indicate that trans-nerolol exerts protective effects against myocardial ischemia (MI), and its mechanism is associated with the suppression of the Cytc- and caspase-signaling pathways. Trans-nerolol has a therapeutic effect on MI, and its mechanism of action is related to its anti-apoptotic effect. These results suggest that Dalbergia odorifera has a potential role to be developed as an MI-promoting therapeutic agent.<\/jats:p>","DOI":"10.3390\/ijms26052251","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:37:17Z","timestamp":1740987437000},"page":"2251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dalbergia odorifera Trans-Nerolidol Protects Against Myocardial Ischemia via Downregulating Cytochrome- and Caspases-Signaling Pathways in Isoproterenol-Induced Rats"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-2638","authenticated-orcid":false,"given":"Canhong","family":"Wang","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"},{"name":"Guangdong Key Laboratory of Green Agricultural Products Processing and Intelligent Equipment, Guangdong University of Petrochemical Technology, Maoming 525099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Wu","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"},{"name":"Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Hainan Medical University, Haikou 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Gong","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-7467","authenticated-orcid":false,"given":"Xiangsheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Meng","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Mou","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8629-8463","authenticated-orcid":false,"given":"Yinfeng","family":"Tan","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Hainan Medical University, Haikou 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhe","family":"Wei","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China"},{"name":"Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1080\/09168451.2014.993916","article-title":"Ethanol 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