{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:17:23Z","timestamp":1773155843627,"version":"3.50.1"},"reference-count":83,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Preserving ovarian function is important to women\u2019s reproductive health. It is necessary for fertility and maintaining the overall hormonal balance. Platelet-rich plasma (PRP) is an autologous plasma containing a predominately platelet concentrate prepared from fresh blood. It has been observed that PRP injections into the ovary can renew the functional cells of the cortical layer of the ovary follicles and reactivate the production of sex hormones. It may improve a woman\u2019s fertility in the case of premature ovarian failure, the condition after chemotherapy treatment, or during the climacteric period. The main markers to evaluate the procedure\u2019s success are elevated anti-M\u00fcllerin hormone and enlarged count level of atrial follicles in ovaries. The aim of this review is to identify the ovarian PRP procedure success markers and point out the electrochemical sensor techniques. Literature was selected depending on including and excluding criteria; studies were sorted by topics in two blocks: PRP biomarkers and electrochemistry. As PRP acts as a regenerative care, electrochemical biosensors can provide accurate, real-time data to evaluate the biological response to PRP therapy. The biosensors\u2019 ability to monitor hormonal levels and follicle development serves as objective markers of the effectiveness of PRP in restoring ovarian function. Together, these approaches enable a more precise evaluation of ovarian health and fertility outcomes after PRP intervention.<\/jats:p>","DOI":"10.3390\/ijms26052317","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:54:38Z","timestamp":1741154078000},"page":"2317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Platelet-Rich Plasma and Electrochemical Biosensors: A Novel Approach to Ovarian Function Evaluation and Diagnostics"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-6792","authenticated-orcid":false,"given":"Tatjana","family":"Ivaskiene","sequence":"first","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08410 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0605-3317","authenticated-orcid":false,"given":"Greta","family":"Kaspute","sequence":"additional","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08410 Vilnius, Lithuania"},{"name":"Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), Sauletekio Av. 3, LT-10257 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egle","family":"Bareikiene","sequence":"additional","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08410 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-3777","authenticated-orcid":false,"given":"Urte","family":"Prentice","sequence":"additional","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08410 Vilnius, Lithuania"},{"name":"Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), Sauletekio Av. 3, LT-10257 Vilnius, Lithuania"},{"name":"Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania"},{"name":"Department of Mechatronics, Robotics and Digital Manufacturing, Faculty of Mechanics, Vilnius Gediminas Technical University, Plytines St. 25, LT-10105 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12884-024-06251-2","article-title":"The Value of Intraovarian Autologous Platelet Rich Plasma in Women with Poor Ovarian Reserve or Ovarian Insufficiency: A Systematic Review and Meta-Analysis","volume":"24","author":"Maged","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref_2","first-page":"1","article-title":"Regenerative Effect of Intraovarian Injection of Activated Autologous Platelet Rich Plasma: Serum Anti-Mullerian Hormone Levels Measured Among Poor-Prognosis In Vitro Fertilization Patients","volume":"2020","author":"Sills","year":"2020","journal-title":"Int. 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