{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:00:58Z","timestamp":1791302458053,"version":"4.1.0"},"reference-count":168,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["31701827"],"award-info":[{"award-number":["31701827"]}]},{"name":"National Natural Science Foundation of China","award":["32402430"],"award-info":[{"award-number":["32402430"]}]},{"name":"National Natural Science Foundation of China","award":["ZR2023MC095"],"award-info":[{"award-number":["ZR2023MC095"]}]},{"name":"National Natural Science Foundation of China","award":["2020M671984"],"award-info":[{"award-number":["2020M671984"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["31701827"],"award-info":[{"award-number":["31701827"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["32402430"],"award-info":[{"award-number":["32402430"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["ZR2023MC095"],"award-info":[{"award-number":["ZR2023MC095"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["2020M671984"],"award-info":[{"award-number":["2020M671984"]}]},{"name":"China Postdoctoral Science Foundation","award":["31701827"],"award-info":[{"award-number":["31701827"]}]},{"name":"China Postdoctoral Science Foundation","award":["32402430"],"award-info":[{"award-number":["32402430"]}]},{"name":"China Postdoctoral Science Foundation","award":["ZR2023MC095"],"award-info":[{"award-number":["ZR2023MC095"]}]},{"name":"China Postdoctoral Science Foundation","award":["2020M671984"],"award-info":[{"award-number":["2020M671984"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>4(3H)-quinazolinone is a functional scaffold that exists widely both in natural products and synthetic organic compounds. Its drug-like derivatives have been extensively synthesized with interesting biological features including anticancer, anti-inflammatory, antiviral, antimalarial, antibacterial, antifungal, and herbicidal, etc. In this review, we highlight the medicinal and agrochemical versatility of the 4(3H)-quinazolinone scaffold according to the studies published in the past six years (2019\u20132024), and comprehensively give a summary of the target recognition, structure\u2013activity relationship, and mechanism of its analogs. The present review is expected to provide valuable guidance for discovering novel lead compounds containing 4(3H)-quinazolinone moiety in both drug and agrochemical research.<\/jats:p>","DOI":"10.3390\/ijms26062473","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:02:59Z","timestamp":1741608179000},"page":"2473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["4(3H)-Quinazolinone: A Natural Scaffold for Drug and Agrochemical Discovery"],"prefix":"10.3390","volume":"26","author":[{"given":"Ke","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Biotechnology, The University of Suwon, Hwaseong-si 18323, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junehyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, The University of Suwon, Hwaseong-si 18323, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phumbum","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, The University of Suwon, Hwaseong-si 18323, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3117-7553","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, The University of Suwon, Hwaseong-si 18323, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0235-5281","authenticated-orcid":false,"given":"Kang","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"BBA-Gen. Subj."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1039\/C4NP00064A","article-title":"Natural product and natural product derived drugs in clinical trials","volume":"31","author":"Butler","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/ps.3744","article-title":"Natural products for pest control: An analysis of their role, value and future","volume":"70","author":"Gerwick","year":"2014","journal-title":"Pest Manag. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1002\/anie.201505863","article-title":"Capturing biological activity in natural product fragments by chemical synthesis","volume":"55","author":"Crane","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/med.21377","article-title":"Strategies for the optimization of natural leads to anticancer drugs or drug candidates","volume":"36","author":"Xiao","year":"2016","journal-title":"Med. Res. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cell.2015.11.031","article-title":"A new golden age of natural products drug discovery","volume":"163","author":"Shen","year":"2015","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ps.4458","article-title":"Natural products, their derivatives, mimics and synthetic equivalents: Role in agrochemical discovery","volume":"73","author":"Sparks","year":"2017","journal-title":"Pest Manag. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1431085","DOI":"10.1080\/2162402X.2018.1431085","article-title":"The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells","volume":"7","author":"Li","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Talib, W.H., Alsayed, A.R., Barakat, M., Abu-Taha, M.I., and Mahmod, A.I. (2021). Targeting drug chemo-resistance in cancer using natural products. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101353"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"nwac206","DOI":"10.1093\/nsr\/nwac206","article-title":"Natural products and drug discovery","volume":"9","author":"Newman","year":"2022","journal-title":"Natl. Sci. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.drudis.2015.01.009","article-title":"An analysis of FDA-approved drugs: Natural products and their derivatives","volume":"21","author":"Patridge","year":"2016","journal-title":"Drug Discov. Today"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/ijc.29023","article-title":"Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1","volume":"136","author":"Dossi","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hlca.19720550126","article-title":"Stoffwechselprodukte von mikroorganismen. 98. mitteilung. phosphinothricin und phosphinothricyl-alanyl-alanin","volume":"55","author":"Bayer","year":"1972","journal-title":"Helv. Chim. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10937404.2019.1689878","article-title":"Properties, toxicity and current applications of the biolarvicide spinosad","volume":"23","author":"Santos","year":"2020","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchem.2479","article-title":"Counting on natural products for drug design","volume":"8","author":"Rodrigues","year":"2016","journal-title":"Nat. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/17460441.2016.1272757","article-title":"The structural modification of natural products for novel drug discovery","volume":"12","author":"Yao","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.fitote.2015.04.012","article-title":"Insights into drug discovery from natural products through structural modification","volume":"103","author":"Chen","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1039\/C5OB00169B","article-title":"Design and synthesis of analogues of natural products","volume":"13","author":"Maier","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.apsb.2016.06.003","article-title":"The modification of natural products for medical use","volume":"7","author":"Guo","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"115031","DOI":"10.1016\/j.ejmech.2022.115031","article-title":"Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship","volume":"247","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/med.21466","article-title":"Biologically active quinoline and quinazoline alkaloids part I","volume":"38","author":"Shang","year":"2018","journal-title":"Med. Res. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/med.21492","article-title":"Biologically active quinoline and quinazoline alkaloids part II","volume":"38","author":"Shang","year":"2018","journal-title":"Med. Res. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1021\/acs.jafc.6b01772","article-title":"Structural diversity and biological activities of indole diketopiperazine alkaloids from fungi","volume":"64","author":"Ma","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1021\/acs.jafc.8b05037","article-title":"Plant resources, chemical constituents, and bioactivities of tea plants from the genus Camellia section Thea","volume":"67","author":"Meng","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fitote.2017.05.001","article-title":"Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives","volume":"119","author":"He","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejmech.2016.03.025","article-title":"Isocoumarins, miraculous natural products blessed with diverse pharmacological activities","volume":"116","author":"Saeed","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Song, C., Yang, J., Zhang, M., Ding, G., Jia, C., Qin, J., and Guo, L. (2021). Marine natural products: The important resource of biological insecticide. Chem. Biodivers., 18.","DOI":"10.1002\/cbdv.202001020"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140476","DOI":"10.1016\/j.foodchem.2024.140476","article-title":"Antimicrobial activities of natural flavonoids against foodborne pathogens and their application in food industry","volume":"460","author":"Wu","year":"2024","journal-title":"Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"21364","DOI":"10.1021\/acs.jafc.4c05294","article-title":"Recent advances in phenazine natural products: Biosynthesis and metabolic engineering","volume":"72","author":"Huang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"16126","DOI":"10.1021\/acs.jafc.2c06136","article-title":"High value-added application of natural plant products in crop protection: Construction and pesticidal activities of piperine-type ester derivatives and their toxicology study","volume":"70","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1002\/anie.201302365","article-title":"4-Hydroxyphenylpyruvate dioxygenase inhibitors in combination with safeners: Solutions for modern and sustainable agriculture","volume":"52","author":"Ahrens","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s40265-023-01891-8","article-title":"Rezafungin: First approval","volume":"83","author":"Syed","year":"2023","journal-title":"Drugs"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/cid\/ciaa336","article-title":"Lefamulin: A novel semisynthetic pleuromutilin antibiotic for community-acquired bacterial pneumonia","volume":"71","author":"Watkins","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Duraes, F., and Sousa, E. (2019). Omadacycline: A newly approved antibacterial from the class of tetracyclines. Pharmaceuticals, 12.","DOI":"10.3390\/ph12020063"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/acs.oprd.7b00033","article-title":"Patent review of manufacturing routes to fifth-generation cephalosporin drugs. Part 1, ceftolozane","volume":"21","author":"Hughes","year":"2017","journal-title":"Org. Process Res. Dev."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Alsibaee, A.M., Al-Yousef, H.M., and Al-Salem, H.S. (2023). Quinazolinones, the winning horse in drug discovery. Molecules, 28.","DOI":"10.3390\/molecules28030978"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3987\/COM-97-S65","article-title":"Two new pyrroloquinazolinoquinoline alkaloids from Peganum nigellastrum","volume":"46","author":"Nomura","year":"1997","journal-title":"Heterocycles"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8764","DOI":"10.1021\/acs.jafc.0c04278","article-title":"Luotonin A and its derivatives as novel antiviral and antiphytopathogenic fungus agents","volume":"68","author":"Hao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gettler, J., Markovic, M., Ko\u00f3\u0161, P., and Gracza, T. (2024). Recent advances in the research on luotonins A, B, and E. Molecules, 29.","DOI":"10.3390\/molecules29153522"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"114651","DOI":"10.1016\/j.indcrop.2022.114651","article-title":"Discovery of febrifugine with specific anti-Phytophthora oomycete activity isolated from Dichroa febrifuga Lour","volume":"178","author":"Zhang","year":"2022","journal-title":"Ind. Crops Prod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/ptr.1365","article-title":"Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice","volume":"17","author":"Ishih","year":"2003","journal-title":"Phytother. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1021\/np980495u","article-title":"Circumdatins D, E, and F: Further fungal benzodiazepine analogues from Aspergillus ochraceus","volume":"62","author":"Breinholt","year":"1999","journal-title":"J. Nat. Prod."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.phrs.2018.12.019","article-title":"Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu)","volume":"141","author":"Tian","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2478\/acph-2021-0020","article-title":"Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment","volume":"71","author":"Zeng","year":"2021","journal-title":"Acta Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1016\/j.bmc.2017.07.003","article-title":"Recent synthetic and medicinal perspectives of tryptanthrin","volume":"25","author":"Kaur","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Vivek-Ananth, R.P., Rana, A., Rajan, N., Biswal, H.S., and Samal, A. (2020). In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection. Molecules, 25.","DOI":"10.3390\/molecules25173822"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1021\/np020163w","article-title":"Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata","volume":"65","author":"Lee","year":"2002","journal-title":"J. Nat. Prod."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/1961217a0","article-title":"Bronchodilating action of vasicinone and related compounds","volume":"196","author":"Cambridge","year":"1962","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"E370","DOI":"10.1152\/ajpendo.1987.252.3.E370","article-title":"Asperlicin antagonizes stimulatory effects of cholecystokinin on isolated islets","volume":"252","author":"Zawalich","year":"1987","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/10286020.2015.1042373","article-title":"Antitumor quinazoline alkaloids from the seeds of Peganum harmala","volume":"17","author":"Wang","year":"2015","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/BF00564251","article-title":"Pegamine: A new alkaloid from Peganum harmala","volume":"6","author":"Khashimov","year":"1970","journal-title":"Chem. Nat. Compd."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1021\/np0101898","article-title":"Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives","volume":"64","author":"Molina","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1128\/AAC.47.6.1948-1951.2003","article-title":"Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits","volume":"47","author":"Capilla","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1248\/cpb.31.2799","article-title":"Formation route of sulfur-containing metabolites of afloqualone, a new centrally acting muscle relaxant, in rat","volume":"31","author":"Otsuka","year":"1983","journal-title":"Chem. Pharm. Bull."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/00304948.2018.1462058","article-title":"An efficient, convenient, and solvent-free synthesis of 2,3-dihydroquinazolin-4(1H)-ones using montmorillonite-KSF clay as a heterogeneous catalyst","volume":"50","author":"Tekale","year":"2018","journal-title":"Org. Prep. Proced. Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14283","DOI":"10.1021\/acssuschemeng.8b02940","article-title":"Cu(II)\u2013glucose: Sustainable catalyst for the synthesis of quinazolinones in a biomass-derived solvent 2-methylTHF and application for the synthesis of diproqualone","volume":"6","author":"Dubey","year":"2018","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"101964","DOI":"10.1016\/j.legalmed.2021.101964","article-title":"Detection and quantification of psychotropic drug etaqualone in human hair using GC\u2013MS\/MS","volume":"53","author":"Yang","year":"2021","journal-title":"Leg. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/138955712798995048","article-title":"Balaglitazone: A second generation peroxisome proliferator-activated receptor (PPAR) gamma (\u03b3) agonist","volume":"12","author":"Agrawal","year":"1983","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2016.12.041","article-title":"Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation","volume":"103","author":"Tsuchida","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1097\/CAD.0000000000001155","article-title":"Regulations of expressions of rat\/human sulfotransferases by anticancer drug, nolatrexed, and micronutrients","volume":"33","author":"Maitia","year":"2022","journal-title":"Anticancer Drug"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1182\/blood-2016-02-702761","article-title":"Idelalisib in the management of lymphoma","volume":"128","author":"Cheah","year":"2016","journal-title":"Blood"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1021\/acs.jmedchem.1c02001","article-title":"Ispinesib as an effective warhead for the design of autophagosome-tethering chimeras: Discovery of potent degraders of nicotinamide phosphoribosyltransferase (NAMPT)","volume":"65","author":"Dong","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00706-011-0525-3","article-title":"Synthesis and anticonvulsant evaluation of some novel 4(3H)-quinazolinones","volume":"142","author":"ElTahir","year":"2011","journal-title":"Monatsh. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/annonc\/mdf054","article-title":"Raltitrexed: Current clinical status and future directions","volume":"13","author":"Cunningham","year":"2002","journal-title":"Ann. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cropro.2019.03.020","article-title":"Integration between Pseudomonas protegens strains and fluquinconazole for the control of take-all in wheat","volume":"121","author":"Gamboa","year":"2019","journal-title":"Crop Prot."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1007\/s00216-024-05428-0","article-title":"Rapid immunochemical methods for the analysis of proquinazid in strawberry QuEChERS extracts","volume":"416","author":"Mercader","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bpa.2013.10.010","article-title":"The global burden of cancer","volume":"27","author":"Popat","year":"2013","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"de C\u00e1rcer, G. (2019). The mitotic cancer target polo-like kinase 1: Oncogene or tumor suppressor?. Genes, 10.","DOI":"10.3390\/genes10030208"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10133","DOI":"10.1021\/acs.jmedchem.2c00614","article-title":"Polo-like kinase 1 inhibitors in human cancer therapy: Development and therapeutic potential","volume":"65","author":"Zhang","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14087","DOI":"10.1021\/acs.jmedchem.0c01669","article-title":"Identification of a new heterocyclic scaffold for inhibitors of the polo-box domain of polo-like kinase 1","volume":"63","author":"Alverez","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejmech.2018.11.061","article-title":"Type IIA-Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides","volume":"163","author":"Eldehna","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Blanc1, J., Geney, R., and Menet, C. (2013). Type II kinase inhibitors: An opportunity in cancer for rational design. Anticancer Agents Med. Chem., 13, 731\u2013747.","DOI":"10.2174\/1871520611313050008"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Abd El-Karim, S.S., Syam, Y.M., El Kerdawy, A.M., and Abdel-Mohsen, H.T. (2024). Rational design and synthesis of novel quinazolinone N-acetohydrazides as type II multi-kinase inhibitors and potential anticancer agents. Bioorg. Chem., 142.","DOI":"10.1016\/j.bioorg.2023.106920"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0092-8674(02)01083-8","article-title":"PKB binding proteins: Getting in on the Akt","volume":"111","author":"Brazil","year":"2002","journal-title":"Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157489211793980079","article-title":"Recent development of anticancer therapeutics targeting Akt","volume":"6","author":"Morrow","year":"2011","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.2174\/138161211797249224","article-title":"Targeting the AKT pathway in glioblastoma","volume":"17","author":"McDowell","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2174\/09298673113209990106","article-title":"Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells","volume":"20","author":"Cassinelli","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pharmthera.2016.12.001","article-title":"Maximising the potential of AKT inhibitors as anti-cancer treatments","volume":"172","author":"Brown","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Noser, A.A., El-Naggar, M., Donia, T., and Abdelmonsef, A.H. (2020). Synthesis, in silico and in vitro assessment of new quinazolinones as anticancer agents via potential AKT inhibition. Molecules, 25.","DOI":"10.3390\/molecules25204780"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101994","DOI":"10.1016\/j.ctrv.2020.101994","article-title":"The significance of epidermal growth factor receptor uncommon mutations in nonsmall cell lung cancer: A systematic review and critical appraisal","volume":"85","author":"Gristina","year":"2020","journal-title":"Cancer Treat. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"112640","DOI":"10.1016\/j.ejmech.2020.112640","article-title":"Novel quinazoline-based EGFR kinase inhibitors: A review focusing on SAR and molecular docking studies (2015\u20132019)","volume":"204","author":"Bhatia","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"136622","DOI":"10.1016\/j.molstruc.2023.136622","article-title":"Novel quinazolinone derivatives as anticancer agents: Design, synthesis, biological evaluation and computational studies","volume":"1295","author":"Ataollahi","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.molcel.2015.10.040","article-title":"Targeting the DNA damage response in cancer","volume":"60","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrc2342","article-title":"DNA repair pathways as targets for cancer therapy","volume":"8","author":"Helleday","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Lu, H., and Davis, A.J. (2021). Human RecQ helicases in DNA double-strand break repair. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.640755"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bpc.2016.11.005","article-title":"Distinct functions of human RecQ helicases during DNA replication","volume":"225","author":"Urban","year":"2017","journal-title":"Biophys. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev-biochem-060713-035428","article-title":"Human RecQ helicases in DNA repair, recombination, and replication","volume":"83","author":"Croteau","year":"2014","journal-title":"Annu. Rev. Biochem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nature02253","article-title":"The bloom\u2019s syndrome helicase suppresses crossing over during homologous recombination","volume":"426","author":"Wu","year":"2003","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nsmb1267","article-title":"Role for BLM in replication-fork restart and suppression of origin firing after replicative stress","volume":"14","author":"Davies","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.chembiol.2012.10.016","article-title":"A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells","volume":"20","author":"Nguyen","year":"2013","journal-title":"Chem. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1021\/acs.jmedchem.9b00083","article-title":"Discovery of isaindigotone derivatives as novel bloom\u2019s syndrome protein (BLM) helicase inhibitors that disrupt the BLM\/DNA interactions and regulate the homologous recombination repair","volume":"62","author":"Yin","year":"2019","journal-title":"J. Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9752","DOI":"10.1021\/acs.jmedchem.0c00917","article-title":"Design, synthesis, and evaluation of new quinazolinone derivatives that inhibit bloom\u2019s syndrome protein (BLM) helicase, trigger DNA damage at the telomere region, and synergize with PARP inhibitors","volume":"63","author":"Wang","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Haggag, H.S., Aboukhatwa, S.M., Nafie, M.S., Paul, A., Sharafeldin, N., Oliver, A.W., and El-Hamamsy, M.H. (2024). Design and synthesis of quinazolin-4-one derivatives as potential anticancer agents and investigation of their interaction with RecQ helicases. Bioorg. Chem., 144.","DOI":"10.1016\/j.bioorg.2023.107086"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/17460441.2022.2055545","article-title":"The design and discovery of topoisomerase I inhibitors as anticancer therapies","volume":"17","author":"Selas","year":"2022","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1158\/1078-0432.CCR-19-1089","article-title":"Targeting topoisomerase I in the era of precision medicine","volume":"25","author":"Thomas","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.bmc.2010.10.057","article-title":"3-Arylisoquinolines as novel topoisomerase I inhibitors","volume":"19","author":"Khadka","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Huang, W.-Y., Zhang, X.-R., Lyu, L., Wang, S.-Q., and Zhang, X.-T. (2020). Pyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluation in vitro and in vivo. Bioorg. Chem., 99.","DOI":"10.1016\/j.bioorg.2020.103814"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s00044-021-02749-y","article-title":"Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors","volume":"30","author":"Xiang","year":"2021","journal-title":"Med. Chem. Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Havre, P.A., Dang, L.H., Ohnuma, K., Iwata, S., Morimoto, C., and Dang, N.H. (2013). CD26 expression on T-anaplastic large cell lymphoma (ALCL) line karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-517"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41590-019-0321-5","article-title":"Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth","volume":"20","author":"Hollande","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1195300","article-title":"Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-\u03b1","volume":"330","author":"Kraman","year":"2010","journal-title":"Science"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1002\/cam4.2278","article-title":"Dipeptidyl peptidase 4 inhibitors as novel agents in improving survival in diabetic patients with colorectal cancer and lung cancer: A surveillance epidemiology and endpoint research medicare study","volume":"8","author":"Bishnoi","year":"2019","journal-title":"Cancer Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"19515","DOI":"10.1039\/D0NJ03774E","article-title":"Design, synthesis, molecular simulation, and biological activities of novel quinazolinone-pyrimidine hybrid derivatives as dipeptidyl peptidase-4 inhibitors and anticancer agents","volume":"44","author":"Emami","year":"2020","journal-title":"New J. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.dnarep.2018.08.022","article-title":"The comings and goings of PARP-1 in response to DNA damage","volume":"71","author":"Pascal","year":"2018","journal-title":"DNA Repair"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.molcel.2022.02.021","article-title":"The expanding universe of PARP1-mediated molecular and therapeutic mechanisms","volume":"82","author":"Huang","year":"2022","journal-title":"Molecular Cell"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1021\/acs.jmedchem.1c02139","article-title":"Small-molecule inhibitors of tankyrases as prospective therapeutics for cancer","volume":"65","author":"Yu","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"7897","DOI":"10.1021\/acs.jmedchem.9b00656","article-title":"Discovery and optimization of 2-arylquinazolin-4-ones into a potent and selective tankyrase inhibitor modulating Wnt pathway activity","volume":"62","author":"Buchstaller","year":"2019","journal-title":"J. Med. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1021\/acs.jmedchem.9b02097","article-title":"Discovery of a dual tubulin polymerization and cell division cycle 20 homologue inhibitor via structural modification on apcin","volume":"63","author":"Huang","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1021\/acs.jmedchem.9b01896","article-title":"Discovery of a novel dual-target inhibitor of ERK1 and ERK5 that induces regulated cell death to overcome compensatory mechanism in specific tumor types","volume":"63","author":"Wang","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"103914","DOI":"10.1016\/j.drudis.2024.103914","article-title":"Dual-target inhibitors of cholinesterase and GSK-3\u03b2 to modulate alzheimer\u2019s disease","volume":"29","author":"He","year":"2024","journal-title":"Drug Discov. Today"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Liu, Y., Ma, Q., Kong, X., Huo, X., Dong, Z., Ma, Y., Yang, K., Niu, W., and Zhang, K. (2024). Design of balanced dual-target inhibitors of EGFR and microtubule. Bioorg. Chem., 143.","DOI":"10.1016\/j.bioorg.2023.107087"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"15702","DOI":"10.1021\/acs.jmedchem.1c00932","article-title":"Discovery of a dual tubulin and poly(ADP-ribose) polymerase-1 inhibitor by structure-based pharmacophore modeling, virtual screening, molecular docking, and biological evaluation","volume":"64","author":"Zheng","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2013.12.009","article-title":"A Targeting modality for destruction of RNA polymerase I that possesses anticancer activity","volume":"25","author":"Peltonen","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"138083","DOI":"10.1016\/j.molstruc.2024.138083","article-title":"Design and synthesis of BMH-21-like quinazolinone derivatives as potential anti-cancer agents","volume":"1308","author":"Shourkaei","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/jcs.00609","article-title":"The phosphoinositide (PI) 3-kinase family","volume":"116","author":"Foster","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrm2882","article-title":"The emerging mechanisms of isoform-specific PI3K signalling","volume":"11","author":"Vanhaesebroeck","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1021\/acs.jmedchem.8b01298","article-title":"Evolution of PI3K\u03b3 and \u03b4 inhibitors for inflammatory and autoimmune diseases","volume":"62","author":"Perry","year":"2019","journal-title":"J. Med. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"152747","DOI":"10.1016\/j.tox.2021.152747","article-title":"Distinct roles of PI3K\u03b4 and PI3K\u03b3 in a toluene diisocyanate-induced murine asthma model","volume":"454","author":"Xu","year":"2021","journal-title":"Toxicology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11905","DOI":"10.1021\/acs.jmedchem.3c00508","article-title":"Discovery of highly selective and orally bioavailable PI3K\u03b4 inhibitors with anti-inflammatory activity for treatment of acute lung injury","volume":"66","author":"Tang","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1021\/acs.jmedchem.8b02014","article-title":"Discovery, optimization, and evaluation of potent and highly selective PI3K\u03b3\u2013PI3K\u03b4 dual inhibitors","volume":"62","author":"Jia","year":"2019","journal-title":"J. Med. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1021\/acs.jmedchem.1c00004","article-title":"Discovery, optimization, and evaluation of quinazolinone derivatives with novel linkers as orally efficacious phosphoinositide-3-kinase delta inhibitors for treatment of inflammatory diseases","volume":"64","author":"Liu","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1021\/acs.chemrev.0c00215","article-title":"Structural and chemical biology of the interaction of cyclooxygenase with substrates and non-steroidal anti-inflammatory drugs","volume":"120","author":"Rouzer","year":"2020","journal-title":"Chem. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1080\/14756366.2021.1956912","article-title":"Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: Anti-inflammatory, analgesic and anticancer activities","volume":"36","author":"Sakr","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cmi.2016.12.027","article-title":"Sexually acquired Zika virus: A systematic review","volume":"23","author":"Moreira","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"11348","DOI":"10.1021\/cr500233q","article-title":"Biochemistry and medicinal chemistry of the dengue virus protease","volume":"114","author":"Nitsche","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barr\u00e9 Syndrome outbreak associated with Zika virus infection in French Polynesia: A case-control study","volume":"387","author":"Blake","year":"2016","journal-title":"Lancet"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"10746","DOI":"10.1021\/acs.jmedchem.3c00924","article-title":"Quinazolinone compounds have potent antiviral activity against Zika and Dengue virus","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(23)01249-7","article-title":"Malaria","volume":"402","author":"Poespoprodjo","year":"2023","journal-title":"Lancet"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"12582","DOI":"10.1021\/acs.jmedchem.1c00441","article-title":"Discovery and structure\u2013activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials","volume":"64","author":"Laleu","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"8886","DOI":"10.1021\/jm500981k","article-title":"Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach","volume":"57","author":"Nara","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990\u20132021: A systematic analysis with forecasts to 2050","volume":"404","author":"Naghavi","year":"2024","journal-title":"Lancet"},{"key":"ref_134","unstructured":"WHO (2019). Global Tuberculosis Report 2019."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/jm5012947","article-title":"Structure guided lead generation for M. Tuberculosis thymidylate kinase (Mtb TMK): Discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors","volume":"58","author":"Naik","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"137600","DOI":"10.1016\/j.molstruc.2024.137600","article-title":"Design, synthesis and biological evaluation of novel pyrido-[2,3-d]-pyrimidin-2-amine analogues as antimycobacterial agents","volume":"1303","author":"Kumar","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1021\/acs.jmedchem.0c01374","article-title":"2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent antimycobacterial agents activated by deazaflavin (F420)-dependent nitroreductase (Ddn)","volume":"64","author":"Jian","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1002\/anie.201800260","article-title":"Small molecules targeting mycobacterium tuberculosis Type II NADH dehydrogenase exhibit antimycobacterial activity","volume":"57","author":"Harbut","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/acsinfecdis.0c00252","article-title":"Synthesis, structure-activity relationship, and mechanistic studies of aminoquinazolinones displaying antimycobacterial activity","volume":"6","author":"Akester","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1021\/acs.jmedchem.1c00334","article-title":"Identification of unique quinazolone thiazoles as novel structural scaffolds for potential Gram-negative bacterial conquerors","volume":"64","author":"Wang","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"9839","DOI":"10.1021\/acs.jafc.0c03369","article-title":"Diaryl ether: A privileged scaffold for drug and agrochemical discovery","volume":"68","author":"Chen","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bjp.2019.05.007","article-title":"Evaluation of Argentinean medicinal plants and isolation of their bioactive compounds as an alternative for the control of postharvest fruits phytopathogenic fungi","volume":"29","author":"Stegmayer","year":"2019","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejmech.2010.10.022","article-title":"Antifungal agents. Part 4: Synthesis and antifungal activities of novel indole [1,2-c]-1,2,4-benzotriazine derivatives against phytopathogenic fungi in vitro","volume":"46","author":"Xu","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1021\/acs.jafc.0c05475","article-title":"Design, synthesis, and structure-activity relationship of quinazolinone derivatives as potential fungicides","volume":"69","author":"Peng","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"13165","DOI":"10.1021\/acs.jafc.2c04933","article-title":"Expedient discovery for novel antifungal leads inhibiting Fusarium graminearum: 3-(phenylamino)quinazolin-4(3H)-ones deriving from systematic optimizations on a tryptanthrin structure","volume":"70","author":"Wang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Zhou, R., Zhan, W., Yuan, C., Zhang, T., Mao, P., Sun, Z., An, Y., and Xue, W. (2023). Design, synthesis and antifungal activity of novel 1,4-pentadiene-3-one containing quinazolinone. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032599"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41579-022-00710-3","article-title":"Evasion of plant immunity by microbial pathogens","volume":"20","author":"Wang","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.biotechadv.2013.11.001","article-title":"Threats and opportunities of plant pathogenic bacteria","volume":"32","author":"Tarkowski","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"14232","DOI":"10.1021\/acs.jafc.3c03738","article-title":"Design, synthesis, and mechanism of novel 9-aliphatic amine tryptanthrin derivatives against phytopathogenic bacteria","volume":"71","author":"Zhang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1021\/acs.jafc.2c07264","article-title":"Design, synthesis, antibacterial evaluation, three-dimensional quantitative structure\u2013activity relationship, and mechanism of novel quinazolinone derivatives","volume":"71","author":"Shao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"19277","DOI":"10.1021\/acs.jafc.3c03670","article-title":"Synthesis, X-Ray crystal structure, and antimicrobial studies of new quinazolin-4(3H)-one derivatives containing the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole moiety and 4-piperidinyl linker","volume":"71","author":"Wu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"30826","DOI":"10.1021\/acsomega.1c05256","article-title":"Design, synthesis, antibacterial activity, antiviral activity, and mechanism of myricetin derivatives containing a quinazolinone moiety","volume":"6","author":"Liu","year":"2021","journal-title":"ACS Omega"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev-phyto-082712-102332","article-title":"Continuous and emerging challenges of potato virus Y in potato","volume":"51","author":"Karasev","year":"2013","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/ps.3892","article-title":"Effect of insecticide-treated potato plants on aphid behavior and potato virus Y acquisition","volume":"71","author":"Boquel","year":"2015","journal-title":"Pest Manag. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1021\/acs.jafc.5b06112","article-title":"Spatial configuration and 3D conformation directed design, synthesis, antiviral activity, and structure-activity relationships (SARs) of phenanthroindolizidine analogues","volume":"64","author":"Su","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/viro.2000.0638","article-title":"Closterovirus encoded HSP70 homolog and p61 in addition to both coat proteins function in efficient virion assembly","volume":"278","author":"Satyanarayana","year":"2000","journal-title":"Virology"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/viro.1999.0155","article-title":"Genetic analysis of the cell-to-cell movement of beet yellows closterovirus","volume":"268","author":"Alzhanova","year":"2000","journal-title":"Virology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1021\/acs.jafc.7b01035","article-title":"Facile synthesis of novel vanillin derivatives incorporating a bis(2-hydroxyethyl)dithhioacetal moiety as antiviral agents","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1021\/acs.jafc.0c00686","article-title":"Discovery of Potent and Novel Quinazolinone Sulfide Inhibitors with Anti-ToCV Activity","volume":"68","author":"Ran","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1021\/acs.jafc.0c00086","article-title":"Design, synthesis, and anti-ToCV activity of novel 4(3H)-quinazolinone derivatives bearing dithioacetal moiety","volume":"68","author":"Zu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1021\/acs.jafc.1c03171","article-title":"First report on anti-TSWV activities of quinazolinone derivatives containing a dithioacetal moiety","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"14459","DOI":"10.1021\/acs.jafc.1c03555","article-title":"Synthesis, anti-tomato spotted wilt virus activities, and interaction mechanisms of novel dithioacetal derivatives containing a 4(3H)-quinazolinone pyrimidine ring","volume":"69","author":"Zu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1021\/acs.jafc.0c02101","article-title":"Discovery of tryptanthrins as novel antiviral and anti-phytopathogenic-fungus agents","volume":"68","author":"Hao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"104019","DOI":"10.1016\/j.arabjc.2022.104019","article-title":"Design, synthesis, biological activity evaluation and mechanism of action of myricetin derivatives containing thioether quinazolinone","volume":"15","author":"Liu","year":"2022","journal-title":"Arab. J. Chem."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Gong, C., Meng, K., Sun, Z., Zeng, W., An, Y., Zou, H., Qiu, Y., Liu, D., and Xue, W. (2024). Flavonol derivatives containing a quinazolinone moiety: Design, synthesis, and antiviral activity. Chem. Biodivers., 21.","DOI":"10.1002\/cbdv.202301737"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Wang, C., Chen, K., Li, N., Fu, S., Li, P., Ji, L., Liu, G., Wang, X., and Lei, K. (2022). Design, synthesis, mode of action and herbicidal evaluation of quinazolin-4(3H)-one derivatives based on aryloxyphenoxypropionate motif. Agronomy, 12.","DOI":"10.3390\/agronomy12081840"},{"key":"ref_167","first-page":"9445","article-title":"Synthesis, herbicidal activity, and molecular mode of action evaluation of novel aryloxyphenoxypropionate\/amide derivatives containing a quinazolinone moiety","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Wang, S.M., Li, N., Han, S.B., Fu, S.Y., Chen, K., Cheng, W.J., and Lei, K. (2024). Synthesis, herbicidal activity, and molecular mode of action evaluation of novel quinazolinone-phenoxypropionate hybrids containing a diester moiety. Agronomy, 14.","DOI":"10.20944\/preprints202409.0061.v1"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/6\/2473\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:50:13Z","timestamp":1760028613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/6\/2473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":168,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["ijms26062473"],"URL":"https:\/\/doi.org\/10.3390\/ijms26062473","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]}}}