{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:02:15Z","timestamp":1760058135305,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health (Bethesda, MD, USA)","award":["P30 EY010572"],"award-info":[{"award-number":["P30 EY010572"]}]},{"name":"Research to Prevent Blindness (New York, NY, USA)","award":["P30 EY010572"],"award-info":[{"award-number":["P30 EY010572"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Autoantibodies have been implicated in the pathogenesis of autoimmune diseases, including autoimmune retinopathies. Our study aimed to identify retinal autoantigens recognized by serum autoantibodies (AAbs) in patients with visual disturbance. We evaluated 2453 serum samples for anti-retinal AAbs from patients with or without cancer and complaints of visual loss. Anti-TULP1 AAbs were more prevalent in the subset of women with breast cancer and vision loss. Epitope mapping was determined by ELISA using peptides covering the conservative carboxy terminal of TULP1, revealing major lineal epitopes within the sequences 334\u2013341 and 480\u2013488. We found no significant difference in the main epitope recognition between sera from patients with or without breast cancer. Although we show a correlation of anti-TULP1 AAbs with breast cancer, we found no TULP1 protein expression in breast cells, making this association unclear. In the retina, anti-TULP1 AAbs can disrupt the transport of proteins to outer segments and be involved in the degeneration of photoreceptors in a similar fashion to the degeneration induced by TULP1 gene mutation. Nevertheless, the strong association of detectable anti-TULP1 AAbs in breast cancer patients with vision problems indicates its potential as a biomarker for cancer-associated autoimmune retinopathy.<\/jats:p>","DOI":"10.3390\/ijms26062569","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:18:32Z","timestamp":1741839512000},"page":"2569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation of Anti-TULP1 Autoantibodies with Breast Cancer and Autoimmune Retinopathy"],"prefix":"10.3390","volume":"26","author":[{"given":"Collin","family":"Kaster","sequence":"first","affiliation":[{"name":"Ocular Immunology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sufang","family":"Yang","sequence":"additional","affiliation":[{"name":"Ocular Immunology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazyna","family":"Adamus","sequence":"additional","affiliation":[{"name":"Ocular Immunology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108317","DOI":"10.1016\/j.clim.2019.108317","article-title":"Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy","volume":"210","author":"Adamus","year":"2020","journal-title":"Clin. 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