{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:00:03Z","timestamp":1773882003465,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fujian Provincial Natural Science Foundation of China","award":["2024J01795"],"award-info":[{"award-number":["2024J01795"]}]},{"name":"Fujian Provincial Natural Science Foundation of China","award":["2022C013R"],"award-info":[{"award-number":["2022C013R"]}]},{"name":"Qingyuan Scholar Award Program","award":["2024J01795"],"award-info":[{"award-number":["2024J01795"]}]},{"name":"Qingyuan Scholar Award Program","award":["2022C013R"],"award-info":[{"award-number":["2022C013R"]}]},{"name":"Quanzhou High-level Talent Innovation and Entrepreneurship Project","award":["2024J01795"],"award-info":[{"award-number":["2024J01795"]}]},{"name":"Quanzhou High-level Talent Innovation and Entrepreneurship Project","award":["2022C013R"],"award-info":[{"award-number":["2022C013R"]}]},{"name":"Quanzhou Tongjiang Scholar Award Plan","award":["2024J01795"],"award-info":[{"award-number":["2024J01795"]}]},{"name":"Quanzhou Tongjiang Scholar Award Plan","award":["2022C013R"],"award-info":[{"award-number":["2022C013R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Perfluorooctane sulfonic acid (PFOS) is a persistent organic pollutant that has attracted much attention due to its wide environmental distribution and potential toxicity. Intestinal microbiota is an important regulator of host health, and its composition and metabolic function are easily interfered with by environmental pollutants. In this study, the effects of PFOS exposure on gut microbiota, lipid metabolism, and host health were investigated in mice. The results showed that PFOS exposure did not significantly change \u03b1 diversity, but significantly affected the \u03b2 diversity and community structure of intestinal microflora in mice. At the taxonomic level, the ratio of Firmicutes to Bacteroidetes decreased, and the changes in the abundance of specific bacteria were closely related to liver diseases and lipid metabolism disorders. PFOS exposure also interfered with the gut\u2013liver axis mechanism, increased blood lipids and liver function related indicators in mice, and induced intestinal and liver histological lesions. This study revealed the toxic mechanism of PFOS mediated by intestinal microbiota, providing a new research perspective for health problems caused by environmental pollutants and theoretical support for the formulation of relevant public health policies.<\/jats:p>","DOI":"10.3390\/ijms26062648","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T13:07:51Z","timestamp":1741957671000},"page":"2648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Perfluorooctane Sulfonic Acid Exposure on Intestinal Microbial Community, Lipid Metabolism, and Liver Lesions in Mice"],"prefix":"10.3390","volume":"26","author":[{"given":"Qianfeng","family":"Chen","sequence":"first","affiliation":[{"name":"College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-5189","authenticated-orcid":false,"given":"Yulang","family":"Chi","sequence":"additional","affiliation":[{"name":"College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Life Science, Hebei University, Baoding 071002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Min","sequence":"additional","affiliation":[{"name":"College of Resources and Environmental Science, Quanzhou Normal University, Quanzhou 362000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouping","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/acs.estlett.6b00260","article-title":"Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants","volume":"3","author":"Hu","year":"2016","journal-title":"Environ. 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