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This approach allows for localized action, increasing its therapeutic effectiveness. In this study, MCF-7 breast cancer cell radiosensitization, induced by the magnetic hyperthermia of PEGylated nickel ferrite magnetic nanoparticles (PEG-NiF MNPs), was evaluated by exposing the cells in the presence of MNPs to an alternating magnetic field followed by 60Co gamma irradiation. Superparamagnetic PEG-NiF MNPs (25.6 \u00b1 0.5 nm) synthesized via the hydrothermal method exhibited a hydrodynamic size below 150 nm, a saturation magnetization of 53 emu\u00b7g\u22121, biocompatibility of up to 100 \u00b5g\u00b7mL\u22121, selectivity for breast cancer cells, and an up-to-fivefold increase in therapeutic efficacy of radiation. When combined with magnetic hyperthermia, this increase reached up-to-sevenfold. These results indicate that PEG-NiF MNPs are suitable thermal radiosensitization agents for breast cancer cells.<\/jats:p>","DOI":"10.3390\/ijms26062706","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T15:24:56Z","timestamp":1742225096000},"page":"2706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiosensitization Induced by Magnetic Hyperthermia of PEGylated Nickel Ferrite Nanoparticles on Breast Cancer Cells"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2853-7638","authenticated-orcid":false,"given":"Daniele A.","family":"Fagundes","sequence":"first","affiliation":[{"name":"Centro de Desenvolvimento da Tecnologia Nuclear, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte 31270-901, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliam V.","family":"Leonel","sequence":"additional","affiliation":[{"name":"Centro de Desenvolvimento da Tecnologia Nuclear, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte 31270-901, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3264-337X","authenticated-orcid":false,"given":"Luis E.","family":"Fernandez-Outon","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte 31270-901, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 D.","family":"Ardisson","sequence":"additional","affiliation":[{"name":"Centro de Desenvolvimento da Tecnologia Nuclear, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte 31270-901, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel G. dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Desenvolvimento da Tecnologia Nuclear, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte 31270-901, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12272-020-01206-5","article-title":"Principles and applications of nanomaterial-based hyperthermia in cancer therapy","volume":"43","author":"Kang","year":"2020","journal-title":"Arch. 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