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infections such as malaria are on the rise worldwide, driven by both climate change and increasing drug resistance. It is therefore paramount that we better understand how the host responds to severe infection. Hematopoiesis is particularly of interest in this context because hematopoietic stem and progenitor cells (HSPCs) maintain the turnover of all blood cells, including all immune cells. Severe infections have been widely acknowledged to affect HSPCs; however, this disruption has been mainly studied during the acute phase, and the process and level of HSPC recovery remain understudied. Using a self-resolving model of natural rodent malaria, infection by Plasmodium chabaudi, here we systematically assess phenotypically defined HSPCs\u2019 acute response and recovery upon pathogen clearance. We demonstrate that during the acute phase of infection the most quiescent and functional stem cells are depleted, multipotent progenitor compartments are drastically enlarged, and oligopotent progenitors virtually disappear, underpinned by dramatic, population-specific and sometimes unexpected changes in proliferation rates. HSPC populations return to homeostatic size and proliferation rate again through specific patterns of recovery. Overall, our data demonstrate that HSPC populations adopt different responses to cope with severe infection and suggest that the ability to adjust proliferative capacity becomes more restricted as differentiation progresses.<\/jats:p>","DOI":"10.3390\/ijms26062816","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T12:23:11Z","timestamp":1742473391000},"page":"2816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differential Response and Recovery Dynamics of HSPC Populations Following Plasmodium chabaudi Infection"],"prefix":"10.3390","volume":"26","author":[{"given":"Federica","family":"Bruno","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"},{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"},{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-3745","authenticated-orcid":false,"given":"Deirdre","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Bett","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine A.","family":"Secchi","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"},{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"},{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gonz\u00e1lez Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"},{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Birch","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"},{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Langhorne","sequence":"additional","affiliation":[{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lo Celso","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW10 9NH, UK"},{"name":"Sir Francis Crick Institute, London NW1 1AT, UK"},{"name":"Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e20201541","DOI":"10.1084\/jem.20201541","article-title":"Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection","volume":"218","author":"Caiado","year":"2021","journal-title":"J. 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