{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T05:14:48Z","timestamp":1768108488409,"version":"3.49.0"},"reference-count":115,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Touro Student Research Fellowship"},{"name":"New York State Empire Clinical Research Investigator Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Thyroid Cancer (TC) is the most common endocrine cancer, of which papillary thyroid cancer (PTC), a well-differentiated type of TC, accounts for 80\u201390%. Long non-coding RNAs (lncRNAs), which comprise non-protein-coding segments of the genome, have been found to play a crucial role in various biological processes, including cancer development. The activity of lncRNAs is modified through epigenetic modifications, with N6-Methyladenosine (m6A) modifications implicated in the progression of several malignancies. The activity of m6A is further regulated by modifying enzymes classified as \u201creaders\u201d, writers\u201d, and \u201cerasers\u201d, of which specific enzymes have been found to play a role in various aspects of PTC. Recent research has highlighted the significance of m6A modification in regulating the expression and function of lncRNAs associated with PTC pathogenesis. Dysregulation of this process implicates tumor proliferation, invasion, and metastasis, with subsequent impact on prognosis. Therefore, understanding the interplay between m6A modification and lncRNAs provides valuable insights into the molecular mechanisms underlying PTC progression. This narrative review aims to explore the established role of several prominent m6A modifying enzymes and lncRNAs on cancer pathogenesis and seeks to clarify the function of these enzymes in PTC pathogenesis.<\/jats:p>","DOI":"10.3390\/ijms26072833","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T04:58:38Z","timestamp":1742533118000},"page":"2833","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of M6A LncRNA Modification in Papillary Thyroid Cancer"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6088-7455","authenticated-orcid":false,"given":"Michelle S.","family":"Klausner","sequence":"first","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-3200","authenticated-orcid":false,"given":"Caylee A.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaleb A.","family":"Noruzi","sequence":"additional","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj K.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, and Department of Otolaryngology, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-7960","authenticated-orcid":false,"given":"Jan","family":"Geliebter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, and Department of Otolaryngology, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/1097-0142(19950101)75:1+<338::AID-CNCR2820751316>3.0.CO;2-F","article-title":"Endocrine gland cancer","volume":"75","author":"Correa","year":"1995","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S2213-8587(21)00049-8","article-title":"A worldwide journey of thyroid cancer incidence centred on tumour histology","volume":"9","author":"Rossi","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/thy.2021.0662","article-title":"Thyroid Cancer Incidence and Mortality Trends in the United States: 2000-2018","volume":"32","author":"Megwalu","year":"2022","journal-title":"Thyroid"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/archsurg.135.3.272","article-title":"Papillary Thyroid Carcinoma: Prognostic Index for Survival Including the Histological Variety","volume":"135","author":"Sebastian","year":"2000","journal-title":"Arch. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/MD.0000000000001063","article-title":"Long-Term Follow-Up of the Therapeutic Outcomes for Papillary Thyroid Carcinoma With Distant Metastasis","volume":"94","author":"Lin","year":"2015","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7150\/jca.2.193","article-title":"Thyroid cancer: Burden of illness and management of disease","volume":"2","author":"Brown","year":"2011","journal-title":"J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"542358","DOI":"10.1155\/2011\/542358","article-title":"Anaplastic thyroid cancer: A review of epidemiology, pathogenesis, and treatment","volume":"2011","author":"Nagaiah","year":"2011","journal-title":"J. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Lyu, Y.S., Hong, R., and Oh, J. (2024). Anaplastic Transformation in Papillary Thyroid Carcinoma: A Case Report. Ear Nose Throat J., 1455613231225872.","DOI":"10.1177\/01455613231225872"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/cncr.21073","article-title":"Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations","volume":"103","author":"Quiros","year":"2005","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lu, L., Wang, J.R., Henderson, Y.C., Bai, S., Yang, J., Hu, M., Shiau, C.-K., Pan, T., Yan, Y., and Tran, T.M. (2023). Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomics. J. Clin. Investig., 11.","DOI":"10.1172\/JCI169653"},{"key":"ref_11","unstructured":"Limaiem, F., Rehman, A., Anastasopoulou, C., and Mazzoni, T. (2025). Papillary Thyroid Carcinoma, StatPearls Publishing."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1038\/s41388-022-02499-0","article-title":"Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability","volume":"41","author":"Hong","year":"2022","journal-title":"Oncogene"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/ERC-17-0188","article-title":"Long noncoding RNAs: Emerging players in thyroid cancer pathogenesis","volume":"25","author":"Murugan","year":"2018","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Feng, J.L., Zheng, W.J., Xu, L., Zhou, Q.Y., and Chen, J. (2023). Identification of potential LncRNAs as papillary thyroid carcinoma biomarkers based on integrated bioinformatics analysis using TCGA and RNA sequencing data. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-30086-0"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3892\/ol.2016.4653","article-title":"Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma","volume":"12","author":"Yang","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-3-030-83282-7_7","article-title":"Noncoding RNAs in Papillary Thyroid Cancer: Interaction with Cancer-Associated Fibroblasts (CAFs) in the Tumor Microenvironment (TME) and Regulators of Differentiation and Lymph Node Metastasis","volume":"1350","author":"Dadafarin","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1086\/675979","article-title":"Epigenetic modifications: Basic mechanisms and role in cardiovascular disease (2013 Grover Conference series)","volume":"4","author":"Loscalzo","year":"2014","journal-title":"Pulm. Circ."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nbt.1678","article-title":"Epigenetic modifications as therapeutic targets","volume":"28","author":"Kelly","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA Methylation and Its Basic Function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-380866-0.60002-2","article-title":"DNA Methylation and Cancer","volume":"Volume 70","author":"Herceg","year":"2010","journal-title":"Advances in Genetics"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Audia, J.E., and Campbell, R.M. (2016). Histone Modifications and Cancer. Cold Spring Harb. Perspect. Biol., 8.","DOI":"10.1101\/cshperspect.a019521"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13148-024-01656-4","article-title":"Nucleosome reorganisation in breast cancer tissues","volume":"16","author":"Jacob","year":"2024","journal-title":"Clin. Epigenetics"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Rodriguez-Casanova, A., Costa-Fraga, N., Bao-Caamano, A., L\u00f3pez-L\u00f3pez, R., Muinelo-Romay, L., and Diaz-Lagares, A. (2021). Epigenetic Landscape of Liquid Biopsy in Colorectal Cancer. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.622459"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Cusenza, V.Y., Tameni, A., Neri, A., and Frazzi, R. (2023). The lncRNA epigenetics: The significance of m6A and m5C lncRNA modifications in cancer. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1063636"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13045-021-01129-8","article-title":"N6-methyladenosine methyltransferases: Functions, regulation, and clinical potential","volume":"14","author":"Huang","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gpb.2012.12.002","article-title":"N6-methyl-adenosine (m6A) in RNA: An old modification with a novel epigenetic function","volume":"11","author":"Niu","year":"2013","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","author":"Desrosiers","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-cellbio-100616-060758","article-title":"Rethinking m6A readers, writers, and erasers","volume":"33","author":"Meyer","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pan, J., Huang, T., Deng, Z., and Zou, C. (2023). Roles and therapeutic implications of m6A modification in cancer immunotherapy. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1132601"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2032 UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1016\/j.ygeno.2021.06.013","article-title":"m6A modification of RNA and its role in cancer, with a special focus on lung cancer","volume":"113","author":"Khan","year":"2021","journal-title":"Genomics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2147\/IJGM.S449827","article-title":"Correlations of m6A Methylation-Related lncRNAs with the Prognosis of Papillary Thyroid Carcinoma","volume":"17","author":"Li","year":"2024","journal-title":"Int. J. Gen. Med."},{"key":"ref_35","first-page":"752","article-title":"Epitranscriptomic m6A modification in the stem cell field and its effects on cell death and survival","volume":"9","author":"Chen","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-020-01263-w","article-title":"The role of m6A, m5C and \u03a8 RNA modifications in cancer: Novel therapeutic opportunities","volume":"20","author":"Nombela","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.molcel.2018.08.004","article-title":"Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development","volume":"71","author":"Mendel","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Li, P., Wang, Y., Sun, Y., Jiang, S., and Li, J. (2022). N6-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1055808"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/EBC20200032","article-title":"Non-coding RNA in cancer","volume":"65","author":"Yan","year":"2021","journal-title":"Essays Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mitra, S.A., Mitra, A.P., and Triche, T.J. (2012). A central role for long non-coding RNA in cancer. Front. Genet., 3.","DOI":"10.3389\/fgene.2012.00017"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1515\/bmc-2013-0014","article-title":"Long antisense non-coding RNAs and the epigenetic regulation of gene expression","volume":"4","author":"Vadaie","year":"2013","journal-title":"Biomol. Concepts"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"924","DOI":"10.4161\/rna.24604","article-title":"On the classification of long non-coding RNAs","volume":"10","author":"Ma","year":"2013","journal-title":"RNA Biol."},{"key":"ref_44","first-page":"1","article-title":"Long noncoding RNA HOTAIR promotes breast cancer development by targeting ZEB1 via sponging miR-601","volume":"20","author":"Wang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_45","first-page":"229","article-title":"Novel lncRNA PSMG3-AS1 functions as a miR-143-3p sponge to increase the proliferation and migration of breast cancer cells","volume":"43","author":"Cui","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1002\/jcb.29621","article-title":"Long noncoding RNA BHLHE40-AS1 promotes early breast cancer progression through modulating IL-6\/STAT3 signaling","volume":"121","author":"DeVaux","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ccell.2018.03.006","article-title":"lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer","volume":"33","author":"Wang","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Dinescu, S., Ignat, S., Lazar, A.D., Constantin, C., Neagu, M., and Costache, M. (2019). Epitranscriptomic signatures in lncRNAs and their possible roles in cancer. Genes, 10.","DOI":"10.3390\/genes10010052"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.canlet.2018.05.013","article-title":"Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma","volume":"430","author":"Li","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1038\/s41388-020-01475-w","article-title":"Aberrant NSUN2-mediated m5C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma","volume":"39","author":"Sun","year":"2020","journal-title":"Oncogene"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00018-022-04402-2","article-title":"ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform","volume":"79","author":"Klec","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10823","DOI":"10.7150\/thno.47830","article-title":"LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12943-020-01293-4","article-title":"Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine","volume":"19","author":"Wen","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.omtn.2020.08.004","article-title":"Crosstalk between RNA m6A modification and non-coding RNA contributes to cancer growth and progression","volume":"22","author":"Dai","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1159\/000491915","article-title":"ALKBH5 inhibits pancreatic cancer motility by decreasing long non-coding RNA KCNK15-AS1 methylation","volume":"48","author":"He","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12935-020-1105-6","article-title":"ALKBH5-mediated m 6 A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma","volume":"20","author":"Chen","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/clinchem\/hvz004","article-title":"Level of N 6-methyladenosine in peripheral blood RNA: A novel predictive biomarker for gastric cancer","volume":"66","author":"Ge","year":"2020","journal-title":"Clin. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Du, J., Hou, K., Mi, S., Ji, H., Ma, S., Ba, Y., Hu, S., Xie, R., and Chen, L. (2020). Malignant evaluation and clinical prognostic values of m6A RNA methylation regulators in glioblastoma. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00208"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41419-023-06244-7","article-title":"FTO-mediated LINC01134 stabilization to promote chemoresistance through miR-140-3p\/WNT5A\/WNT pathway in PDAC","volume":"14","author":"Lu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1038\/s41418-019-0461-z","article-title":"IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader","volume":"27","author":"Hu","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12943-019-1079-y","article-title":"Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m 6 A reader YTHDF3","volume":"18","author":"Ni","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wang, W., Sun, B., Xia, Y., Sun, S., and He, C. (2020). RNA N6-methyladenosine-related gene contribute to clinical prognostic impact on patients with liver cancer. Front. Genet., 11.","DOI":"10.3389\/fgene.2020.00306"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Chen, D.H., Zhang, J.G., Wu, C.X., and Li, Q. (2021). Non-Coding RNA m6A Modification in Cancer: Mechanisms and Therapeutic Targets. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.778582"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s12931-022-02227-y","article-title":"HNRNPC, a predictor of prognosis and immunotherapy response based on bioinformatics analysis, is related to proliferation and invasion of NSCLC cells","volume":"23","author":"Gu","year":"2022","journal-title":"Respir. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7263","DOI":"10.2147\/CMAR.S330713","article-title":"HNRNPC Promotes Proliferation, Metastasis and Predicts Prognosis in Prostate Cancer","volume":"13","author":"Wang","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Mo, L., Meng, L., Huang, Z., Yi, L., Yang, N., and Li, G. (2022). An analysis of the role of HnRNP C dysregulation in cancers. Biomark. Res., 10.","DOI":"10.1186\/s40364-022-00366-4"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"102547","DOI":"10.1016\/j.amjoto.2020.102547","article-title":"m6A RNA methylation regulators have prognostic value in papillary thyroid carcinoma","volume":"41","author":"Hou","year":"2020","journal-title":"Am. J. Otolaryngol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12935-020-01283-y","article-title":"Identification and validation of m 6 A RNA methylation regulators with clinical prognostic value in Papillary thyroid cancer","volume":"20","author":"Wang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.7150\/jca.41193","article-title":"Prognostic values of m6A RNA methylation regulators in differentiated Thyroid Carcinoma","volume":"11","author":"Xu","year":"2020","journal-title":"J. Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wang, W., Shen, C., Zhao, Y., Sun, B., Qiu, X., Yin, S., Chen, J., and Li, X. (2021). The Role of m6A RNA Methylation-Related lncRNAs in the Prognosis and Tumor Immune Microenvironment of Papillary Thyroid Carcinoma. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.719820"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3892\/or.2020.7892","article-title":"IGFBP2 in cancer: Pathological role and clinical significance","volume":"45","author":"Wei","year":"2021","journal-title":"Oncol. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ghir.2015.01.003","article-title":"IGFBP-2\/PTEN: A critical interaction for tumours and for general physiology?","volume":"25","author":"Zeng","year":"2015","journal-title":"Growth Horm. IGF Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1002\/cam4.4680","article-title":"Prognostic value of IGFBP2 in various cancers: A systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2022","journal-title":"Cancer Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13046-022-02254-z","article-title":"FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner","volume":"41","author":"Huang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Sa, R., Liang, R., Qiu, X., He, Z., Liu, Z., and Chen, L. (2022). Targeting IGF2BP2 promotes differentiation of radioiodine refractory papillary thyroid cancer via destabilizing RUNX2 mRNA. Cancers, 14.","DOI":"10.3390\/cancers14051268"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41417-023-00702-2","article-title":"m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma","volume":"31","author":"Wang","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.canlet.2021.12.005","article-title":"IGF2BP2-dependent activation of ERBB2 signaling contributes to acquired resistance to tyrosine kinase inhibitor in differentiation therapy of radioiodine-refractory papillary thyroid cancer","volume":"527","author":"Sa","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12967-024-05293-6","article-title":"The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases","volume":"22","author":"Wu","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1111\/1759-7714.13667","article-title":"Downregulation of m(6) A reader YTHDC2 promotes tumor progression and predicts poor prognosis in non-small cell lung cancer","volume":"11","author":"Sun","year":"2020","journal-title":"Thorac. Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"9188920","DOI":"10.1155\/2022\/9188920","article-title":"YTHDC2 Promotes Malignant Phenotypes of Breast Cancer Cells","volume":"2022","author":"Tanabe","year":"2022","journal-title":"J. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101308","DOI":"10.1016\/j.tranon.2021.101308","article-title":"The N6-methyladenosine reader protein YTHDC2 promotes gastric cancer progression via enhancing YAP mRNA translation","volume":"16","author":"Yuan","year":"2022","journal-title":"Transl. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s12010-023-04540-8","article-title":"YTHDC2 retards cell proliferation and triggers apoptosis in papillary thyroid Cancer by regulating CYLD-Mediated inactivation of akt signaling","volume":"196","author":"Zhou","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13045-020-00951-w","article-title":"Roles of METTL3 in cancer: Mechanisms and therapeutic targeting","volume":"13","author":"Zeng","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41419-022-04817-6","article-title":"METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition","volume":"13","author":"Zhu","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_86","first-page":"5402","article-title":"Genome-wide identification of m6A-associated functional SNPs as potential functional variants for thyroid cancer","volume":"11","author":"Ruan","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Ma, C., Luo, H., Cao, J., Zheng, X., Zhang, J., Zhang, Y., and Fu, Z. (2020). Identification of a novel tumor microenvironment\u2013associated eight-gene signature for prognosis prediction in lung adenocarcinoma. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.571641"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.ymthe.2021.01.019","article-title":"METTL3 restrains papillary thyroid cancer progression via m6A\/c-Rel\/IL-8-mediated neutrophil infiltration","volume":"29","author":"He","year":"2021","journal-title":"Mol. Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1038\/s41418-023-01217-x","article-title":"METTL3 inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via M6A-CD70-mediated immune suppression in thyroid cancer","volume":"30","author":"Ning","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12935-024-03240-5","article-title":"The m6A methyltransferase METTL3 drives thyroid cancer progression and lymph node metastasis by targeting LINC00894","volume":"24","author":"Zhou","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"He, T., Xia, H., Chen, B., Duan, Z., and Huang, C. (2023). m6A writer METTL3-mediated lncRNA LINC01125 prevents the malignancy of papillary thyroid cancer. Crit. Rev.\u2122 Immunol., 43.","DOI":"10.1615\/CritRevImmunol.2023050267"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Dai, Y.-z., Liu, Y.-d., Li, J., Chen, M.-t., Huang, M., Wang, F., Yang, Q.-s., Yuan, J.-h., and Sun, S.-h. (2022). METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner. Cell. Mol. Biol. Lett., 27.","DOI":"10.1186\/s11658-022-00342-8"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2022.10.065","article-title":"METTL16 epigenetically enhances GPX4 expression via m6A modification to promote breast cancer progression by inhibiting ferroptosis","volume":"638","author":"Ye","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1111\/jcmm.16664","article-title":"METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00018-024-05146-x","article-title":"METTL16 inhibits papillary thyroid cancer tumorigenicity through m6A\/YTHDC2\/SCD1-regulated lipid metabolism","volume":"81","author":"Li","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Liu, Y., Wu, G., Tao, X., Dong, J., Shi, T., and Shi, C. (2024). Investigating the mechanism of METTL16-dependent m6A modification regulating the SAMD11 protein signaling pathway to inhibit thyroid cancer phenotypes. Int. J. Biol. Macromol., 280.","DOI":"10.1016\/j.ijbiomac.2024.136176"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Gong, P.-J., Shao, Y.-C., Yang, Y., Song, W.-J., He, X., Zeng, Y.-F., Huang, S.-R., Wei, L., and Zhang, J.-W. (2020). Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.578963"},{"key":"ref_98","first-page":"19","article-title":"N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance","volume":"9","author":"Lin","year":"2022","journal-title":"Mil. Med. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1328444","DOI":"10.1155\/2021\/1328444","article-title":"ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m(6)A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity","volume":"2021","author":"Wang","year":"2021","journal-title":"J. Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jfma.2022.12.019","article-title":"Overexpressed ZC3H13 suppresses papillary thyroid carcinoma growth through m6A modification-mediated IQGAP1 degradation","volume":"122","author":"Xie","year":"2023","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.trecan.2022.02.010","article-title":"FTO in cancer: Functions, molecular mechanisms, and therapeutic implications","volume":"8","author":"Li","year":"2022","journal-title":"Trends Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.2147\/OTT.S329232","article-title":"Roles of N6-Methyladenosine Demethylase FTO in Malignant Tumors Progression","volume":"14","author":"Zheng","year":"2021","journal-title":"OncoTargets Ther."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Zeng, X., Lu, Y., Zeng, T., Liu, W., Huang, W., Yu, T., Tang, X., Huang, P., Li, B., and Wei, H. (2024). RNA demethylase FTO participates in malignant progression of gastric cancer by regulating SP1-AURKB-ATM pathway. Commun. Biol., 7.","DOI":"10.1038\/s42003-024-06477-y"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-019-1004-4","article-title":"RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3","volume":"18","author":"Niu","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Wu, L., Wu, D., Ning, J., Liu, W., and Zhang, D. (2019). Changes of N6-methyladenosine modulators promote breast cancer progression. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5538-z"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s12253-019-00737-7","article-title":"ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer","volume":"26","author":"Yang","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"305","DOI":"10.14701\/ahbps.2018.22.4.305","article-title":"ALKBH5 gene is a novel biomarker that predicts the prognosis of pancreatic cancer: A retrospective multicohort study","volume":"22","author":"Cho","year":"2018","journal-title":"Ahbps"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13045-022-01224-4","article-title":"RNA demethylase ALKBH5 in cancer: From mechanisms to therapeutic potential","volume":"15","author":"Qu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/cas.15772","article-title":"ALKBH5-induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2","volume":"114","author":"Ji","year":"2023","journal-title":"Cancer Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"108286","DOI":"10.1016\/j.intimp.2021.108286","article-title":"Analysis of the prognostic significance and potential mechanisms of lncRNAs associated with m6A methylation in papillary thyroid carcinoma","volume":"101 Pt B","author":"Huang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1080\/07853890.2023.2192049","article-title":"Identification of m6A-associated LncRNAs as predict factors for the immune infiltration and prognosis of thyroid cancer","volume":"55","author":"Su","year":"2023","journal-title":"Ann. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12033-007-9010-y","article-title":"An overview of epigenetic assays","volume":"38","author":"DeAngelis","year":"2008","journal-title":"Mol. Biotechnol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Tumino, D., Frasca, F., and Newbold, K. (2017). Updates on the Management of Advanced, Metastatic, and Radioiodine Refractory Differentiated Thyroid Cancer. Front. Endocrinol., 8.","DOI":"10.3389\/fendo.2017.00312"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2833\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:38Z","timestamp":1760029058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":115,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26072833"],"URL":"https:\/\/doi.org\/10.3390\/ijms26072833","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}