{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:26:53Z","timestamp":1790728013948,"version":"4.1.0"},"reference-count":141,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>There is a significant, rather than just anecdotal, connection between the liver and the eyes. This connection is evident in noticeable cases such as jaundice, where the sclera has a yellow tint. But this can be seen through even more subtle indicators, such as molecules known as hepatokines. This relationship is not merely anecdotal; in some studies, it is referred to as the \u201cliver\u2013eye axis\u201d. Ubiquitous environmental contaminants, such as microplastics (MPs), can enter the bloodstream and human body through the conjunctival sac, nasolacrimal duct, and upper respiratory tract mucosa. Once absorbed, these substances can accumulate in various organs and cause harm. Toxic substances from the surface of the eye can lead to local oxidative damage by inducing apoptosis in corneal and conjunctival cells, and irregularly shaped microparticles can exacerbate this effect. Even other toxicants from the ocular surface may be absorbed into the bloodstream and distributed throughout the body. Environmental toxicology presents a challenge because many pollutants can enter the body through the same ocular route as that used by certain medications. Previous research has indicated that the accumulation of MPs may play a major role in the development of chronic liver disease in humans. It is crucial to investigate whether the buildup of MPs in the liver is a potential cause of fibrosis, or simply a consequence of conditions such as cirrhosis and portal hypertension.<\/jats:p>","DOI":"10.3390\/ijms26072837","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T04:58:38Z","timestamp":1742533118000},"page":"2837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver\u2013Eye Axis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-3734","authenticated-orcid":false,"given":"Ivan","family":"\u0160o\u0161a","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Labinac","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology, General Hospital Pula, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Perkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology, General Hospital Pula, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","unstructured":"European Commission (2025, March 03). Proposal for a Regulation of the European Parliament and of the Council. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/HTML\/?uri=CELEX:52022PC0677."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3748\/wjg.v30.i9.1011","article-title":"Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions","volume":"30","author":"Chiang","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3345\/cep.2022.00661","article-title":"Bisphenol A leaching from polycarbonate baby bottles into baby food causes potential health issues","volume":"65","author":"Jeon","year":"2022","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.32381\/JPM.2022.39.1-2.2","article-title":"Types and Sources of Microplastics; The Ubiquitous Environment Contaminant: A Review","volume":"39","author":"Rani","year":"2022","journal-title":"J. Polym. Mater."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108470","DOI":"10.1016\/j.bioelechem.2023.108470","article-title":"Antibody-assisted MIL-53(Fe)\/Pt-based electrochemical biosensor for the detection of the nicotine metabolite cotinine","volume":"153","author":"Yin","year":"2023","journal-title":"Bioelectrochemistry"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Diab, H., and Thompson, J. (2023). Microplastic Pollution: Chemical Characterization and Impact on Wildlife. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20031745"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.12688\/f1000research.142212.1","article-title":"Micro(nano)plastics: Invisible compounds with a visible impact","volume":"13","author":"Sharma","year":"2024","journal-title":"F1000Research"},{"key":"ref_8","first-page":"100215","article-title":"Microplastics Pollution: A Brief Review of Its Source and Abundance in Different Aquatic Ecosystems","volume":"9","author":"Ashrafy","year":"2023","journal-title":"J. Hazard. Mater. Adv."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lai, H., Liu, X., and Qu, M. (2022). Nanoplastics and Human Health: Hazard Identification and Biointerface. Nanomaterials, 12.","DOI":"10.3390\/nano12081298"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115676","DOI":"10.1016\/j.ecoenv.2023.115676","article-title":"Micro (nano) plastics uptake, toxicity and detoxification in plants: Challenges and prospects","volume":"268","author":"Dehghanian","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11886","DOI":"10.1021\/acs.chemrev.1c00178","article-title":"Chemical Analysis of Microplastics and Nanoplastics: Challenges, Advanced Methods, and Perspectives","volume":"121","author":"Ivleva","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Moore, S., Paalanen, L., Melymuk, L., Katsonouri, A., Kolossa-Gehring, M., and Tolonen, H. (2022). The Association between ADHD and Environmental Chemicals-A Scoping Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19052849"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Botelho, R.M., Silva, A.L.M., and Borbely, A.U. (2024). The Autism Spectrum Disorder and Its Possible Origins in Pregnancy. Int. J. Environ. Res. Public Health, 21.","DOI":"10.3390\/ijerph21030244"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107121","DOI":"10.1016\/j.envint.2022.107121","article-title":"Pre\/post-natal exposure to microplastic as a potential risk factor for autism spectrum disorder","volume":"161","author":"Zaheer","year":"2022","journal-title":"Environ. Int."},{"key":"ref_15","unstructured":"Thi, L.A.P., Nguyen, V.-H., Do, X.D., Dang, T.H.L., Do, H.T., and Nguyen, T.L. (2025). Microplastics occurrence, contamination, and effects on human health\u2014A critical review. Microplastics, Elsevier."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s12035-023-03625-z","article-title":"Exposure to Polystyrene Microplastics Promotes the Progression of Cognitive Impairment in Alzheimer\u2019s Disease: Association with Induction of Microglial Pyroptosis","volume":"61","author":"Wang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"173770","DOI":"10.1016\/j.scitotenv.2024.173770","article-title":"Micro\/nano-plastics impacts in cardiovascular systems across species","volume":"942","author":"Liang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1186\/s12967-024-05731-5","article-title":"Microplastics: An often-overlooked issue in the transition from chronic inflammation to cancer","volume":"22","author":"Cheng","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1002\/tox.24125","article-title":"Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2\/NF-kappaB pathway","volume":"39","author":"Zhu","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"170518","DOI":"10.1016\/j.scitotenv.2024.170518","article-title":"Polyethylene microplastics induced gut microbiota dysbiosis leading to liver injury via the TLR2\/NF-kappaB\/NLRP3 pathway in mice","volume":"917","author":"Xu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Li, Q., Zhu, K., Huang, L., Niu, X., Li, L., Gao, L., and Xia, Z. (2025). Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by the RNA-seq. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-86810-5"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"174215","DOI":"10.1016\/j.scitotenv.2024.174215","article-title":"Microplastics in the human body: A comprehensive review of exposure, distribution, migration mechanisms, and toxicity","volume":"946","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s42452-025-06470-y","article-title":"The histopathological and functional consequences of microplastic exposure","volume":"7","author":"Lee","year":"2025","journal-title":"Discov. Appl. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yee, M.S., Hii, L.W., Looi, C.K., Lim, W.M., Wong, S.F., Kok, Y.Y., Tan, B.K., Wong, C.Y., and Leong, C.O. (2021). Impact of Microplastics and Nanoplastics on Human Health. Nanomater, 11.","DOI":"10.3390\/nano11020496"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Alp\u00edzar Salazar, M., Olgu\u00edn Reyes, S.E., Medina Est\u00e9vez, A., Saturno Lobos, J.A., De Aldecoa Castillo, J.M., Carrera Aguas, J.C., Alaniz Monreal, S., Navarro Rodr\u00edguez, J.A., and Alp\u00edzar S\u00e1nchez, D.M. (2025). Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma. Medicina, 61.","DOI":"10.3390\/medicina61010088"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e30387","DOI":"10.1016\/j.heliyon.2024.e30387","article-title":"From NAFLD to NASH: Understanding the spectrum of non-alcoholic liver diseases and their consequences","volume":"10","author":"Samy","year":"2024","journal-title":"Heliyon"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Stoess, C., Choi, Y.K., Onyuru, J., Friess, H., Hoffman, H.M., Hartmann, D., and Feldstein, A.E. (2024). Cell Death in Liver Disease and Liver Surgery. Biomedicines, 12.","DOI":"10.3390\/biomedicines12030559"},{"key":"ref_28","first-page":"955","article-title":"Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024)","volume":"12","author":"Fan","year":"2024","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1136\/gutjnl-2024-332917","article-title":"Prevalence of steatotic liver disease, advanced fibrosis and cirrhosis among community-dwelling overweight and obese individuals in the USA","volume":"73","author":"Yang","year":"2024","journal-title":"Gut"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Panganiban, J., Kehar, M., Ibrahim, S.H., Hartmann, P., Sood, S., Hassan, S., Ramirez, C.M., Kohli, R., Censani, M., and Mauney, E. (2025). Metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity: An Obesity Medicine Association (OMA) and expert joint perspective 2025. Obes. Pillars, 100164.","DOI":"10.1016\/j.obpill.2025.100164"},{"key":"ref_31","first-page":"1","article-title":"Metabolic and alcohol-associated liver disease (MetALD): A representation of duality","volume":"2","author":"Cubero","year":"2025","journal-title":"NPJ Gut Liver"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e2149641","DOI":"10.1002\/eji.202149641","article-title":"The \u201cDomino effect\u201d in MASLD: The inflammatory cascade of steatohepatitis","volume":"54","author":"Mladenic","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sandireddy, R., Sakthivel, S., Gupta, P., Behari, J., Tripathi, M., and Singh, B.K. (2024). Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1433857"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.3390\/cimb45110570","article-title":"The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease\u2014The Transition from an Adipocentric to Liver-Centric Approach","volume":"45","author":"Macut","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bhol, N.K., Bhanjadeo, M.M., Singh, A.K., Dash, U.C., Ojha, R.R., Majhi, S., Duttaroy, A.K., and Jena, A.B. (2024). The interplay between cytokines, inflammation, and antioxidants: Mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds. Biomed. Pharmacother., 178.","DOI":"10.1016\/j.biopha.2024.117177"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Scarlata, G.G.M., Colaci, C., Scarcella, M., Dallio, M., Federico, A., Boccuto, L., and Abenavoli, L. (2024). The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver Disease. Diseases, 12.","DOI":"10.20944\/preprints202403.0030.v1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"137795","DOI":"10.1016\/j.jhazmat.2025.137795","article-title":"Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models","volume":"490","author":"Bridgeman","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"116102","DOI":"10.1016\/j.ecoenv.2024.116102","article-title":"PS-MPs promotes the progression of inflammation and fibrosis in diabetic nephropathy through NLRP3\/Caspase-1 and TGF-\u03b21\/Smad2\/3 signaling pathways","volume":"273","author":"Feng","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Liu, Y., Xu, K., Xiang, Y., Ma, B., Li, H., Li, Y., Shi, Y., Li, S., and Bai, Y. (2023). Role of MCP-1 as an inflammatory biomarker in nephropathy. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1303076"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Takenoshita, Y., Tokito, A., and Jougasaki, M. (2024). Inhibitory Effects of Eicosapentaenoic Acid on Vascular Endothelial Growth Factor-Induced Monocyte Chemoattractant Protein-1, Interleukin-6, and Interleukin-8 in Human Vascular Endothelial Cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052749"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kany, S., Vollrath, J.T., and Relja, B. (2019). Cytokines in Inflammatory Disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236008"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.adj7050","article-title":"Cellular senescence in normal physiology","volume":"384","year":"2024","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: Molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Mahmud, F., Sarker, D.B., Jocelyn, J.A., and Sang, Q.A. (2024). Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence. Cells, 13.","DOI":"10.3390\/cells13211788"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Dhakal, B., Shiwakoti, S., Park, E.Y., Kang, K.W., Schini-Kerth, V.B., Park, S.H., Ji, H.Y., Park, J.S., Ko, J.Y., and Oak, M.H. (2023). SGLT2 inhibition ameliorates nano plastics-induced premature endothelial senescence and dysfunction. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-33086-2"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Kumari, R., and Jat, P. (2021). Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.645593"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s13075-022-02949-w","article-title":"Epigenetic modification of miR-217 promotes intervertebral disc degeneration by targeting the FBXO21-ERK signalling pathway","volume":"24","author":"Chen","year":"2022","journal-title":"Arthritis. Res. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"118190","DOI":"10.1016\/j.envpol.2021.118190","article-title":"Environmental microplastic and nanoplastic: Exposure routes and effects on coagulation and the cardiovascular system","volume":"291","author":"Lett","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/apt.17762","article-title":"Liver biopsy for assessment of suspected drug-induced liver injury in metabolic dysfunction-associated steatohepatitis clinical trials: Expert consensus from the Liver Forum","volume":"59","author":"Palmer","year":"2024","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"eadi0759","DOI":"10.1126\/scitranslmed.adi0759","article-title":"Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH)","volume":"15","author":"Wang","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2445780","DOI":"10.1080\/07853890.2024.2445780","article-title":"Research advances in the diagnosis and treatment of MASLD\/MASH","volume":"57","author":"Wang","year":"2025","journal-title":"Ann. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00535-024-02098-8","article-title":"The biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis","volume":"59","author":"Ampuero","year":"2024","journal-title":"J. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sergi, C.M. (2024). NAFLD (MASLD)\/NASH (MASH): Does It Bother to Label at All? A Comprehensive Narrative Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25158462"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tseng, M., Syed, T., and Siddiqui, M. (2025). Non-invasive diagnosis of metabolic dysfunction associated steatotic liver disease (MASLD). Hepatology, Elsevier.","DOI":"10.1016\/B978-0-443-26710-9.00004-3"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1038\/s41591-023-02539-6","article-title":"Diagnostic performance of circulating biomarkers for non-alcoholic steatohepatitis","volume":"29","author":"Sanyal","year":"2023","journal-title":"Nat. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"156082","DOI":"10.1016\/j.metabol.2024.156082","article-title":"Accurate non-invasive detection of MASH with fibrosis F2-F3 using a lightweight machine learning model with minimal clinical and metabolomic variables","volume":"163","author":"Stefanakis","year":"2025","journal-title":"Metabolism"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/hep.24127","article-title":"Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: Distinct clinicopathologic meanings","volume":"53","author":"Brunt","year":"2011","journal-title":"Hepatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1365-2036.2011.04695.x","article-title":"Validation of the non-alcoholic fatty liver disease activity score","volume":"34","author":"Hjelkrem","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10311-022-01525-7","article-title":"Analytical methods for microplastics in the environment: A review","volume":"21","author":"Huang","year":"2023","journal-title":"Environ. Chem. Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"107199","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of Various Microplastics in Human Stool: A Prospective Case Series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1007\/s11356-019-07274-5","article-title":"Comparison between manta trawl and in situ pump filtration methods, and guidance for visual identification of microplastics in surface waters","volume":"27","author":"Karlsson","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.marenvres.2016.06.009","article-title":"Factors influencing the detection of beach plastic debris","volume":"119","author":"Lavers","year":"2016","journal-title":"Mar. Environ. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jcis.2020.12.039","article-title":"Measuring particle size distribution and mass concentration of nanoplastics and microplastics: Addressing some analytical challenges in the sub-micron size range","volume":"588","author":"Caputo","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11327","DOI":"10.1021\/es302332w","article-title":"Uptake and effects of microplastics on cells and tissue of the blue mussel Mytilus edulis L. after an experimental exposure","volume":"46","author":"Kohler","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"128208","DOI":"10.1016\/j.cej.2020.128208","article-title":"Analysis of environmental nanoplastics: Progress and challenges","volume":"410","author":"Cai","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trac.2018.12.014","article-title":"Methods for the analysis of submicrometer- and nanoplastic particles in the environment","volume":"112","author":"Schwaferts","year":"2019","journal-title":"Trac-Trends Anal. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12989-023-00556-4","article-title":"Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK\/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo","volume":"20","author":"Huang","year":"2023","journal-title":"Part. Fibre Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa2309822","article-title":"Microplastics and Nanoplastics in Atheromas and Cardiovascular Events","volume":"390","author":"Marfella","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41569-024-01015-z","article-title":"Presence of microplastics in carotid plaques linked to cardiovascular events","volume":"21","author":"Huynh","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Wang, T., Yi, Z., Liu, X., Cai, Y., Huang, X., Fang, J., Shen, R., Lu, W., Xiao, Y., and Zhuang, W. (2024). Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites. EBioMedicine, 103.","DOI":"10.1016\/j.ebiom.2024.105118"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"133855","DOI":"10.1016\/j.jhazmat.2024.133855","article-title":"Microplastics in three types of human arteries detected by pyrolysis-gas chromatography\/mass spectrometry (Py-GC\/MS)","volume":"469","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12989-024-00596-4","article-title":"Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients","volume":"21","author":"Yang","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Anuar, S.T., Altarawnah, R.S., Mohd Ali, A.A., Lee, B.Q., Khalik, W., Yusof, K., and Ibrahim, Y.S. (2022). Utilizing Pyrolysis-Gas Chromatography\/Mass Spectrometry for Monitoring and Analytical Characterization of Microplastics in Polychaete Worms. Polymers, 14.","DOI":"10.3390\/polym14153054"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s43591-024-00090-w","article-title":"Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography\u2013mass spectrometry","volume":"4","author":"Brits","year":"2024","journal-title":"Microplastics Nanoplastics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"118111","DOI":"10.1016\/j.trac.2024.118111","article-title":"Advances in microplastic characterization: Spectroscopic techniques and heavy metal adsorption insights","volume":"183","author":"Vasudeva","year":"2025","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Campanale, C., Savino, I., Massarelli, C., and Uricchio, V.F. (2023). Fourier Transform Infrared Spectroscopy to Assess the Degree of Alteration of Artificially Aged and Environmentally Weathered Microplastics. Polymers, 15.","DOI":"10.3390\/polym15040911"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"143558","DOI":"10.1016\/j.scitotenv.2020.143558","article-title":"Polystyrene microplastics alter the intestinal microbiota function and the hepatic metabolism status in marine medaka (Oryzias melastigma)","volume":"759","author":"Feng","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"116537","DOI":"10.1016\/j.ecoenv.2024.116537","article-title":"Mechanism insights into the histopathological changes of polypropylene microplastics induced gut and liver in zebrafish","volume":"280","author":"Tian","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"115637","DOI":"10.1016\/j.ecoenv.2023.115637","article-title":"Combined exposure to polyvinyl chloride and polystyrene microplastics induces liver injury and perturbs gut microbial and serum metabolic homeostasis in mice","volume":"267","author":"Zhuang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"104152","DOI":"10.1016\/j.psj.2024.104152","article-title":"Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation","volume":"103","author":"Chen","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"143032","DOI":"10.1016\/j.chemosphere.2024.143032","article-title":"Microplastic-induced hepatic adverse effects evaluated in advanced quadruple cell human primary models following three weeks of repeated exposure","volume":"364","author":"Guraka","year":"2024","journal-title":"Chemosphere"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Horvatits, T., Tamminga, M., Liu, B., Sebode, M., Carambia, A., Fischer, L., Puschel, K., Huber, S., and Fischer, E.K. (2022). Microplastics detected in cirrhotic liver tissue. EBioMedicine, 82.","DOI":"10.1016\/j.ebiom.2022.104147"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Patton, G.N., and Lee, H.J. (2024). Chemical Insights into Topical Agents in Intraocular Pressure Management: From Glaucoma Etiopathology to Therapeutic Approaches. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16020274"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11626-020-00533-7","article-title":"In vitro reconstructed 3D corneal tissue models for ocular toxicology and ophthalmic drug development","volume":"57","author":"Kaluzhny","year":"2021","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Rauchman, S.H., Locke, B., Albert, J., De Leon, J., Peltier, M.R., and Reiss, A.B. (2023). Toxic External Exposure Leading to Ocular Surface Injury. Vision, 7.","DOI":"10.3390\/vision7020032"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wu, D., Lim, B.X.H., Seah, I., Xie, S., Jaeger, J.E., Symons, R.K., Heffernan, A.L., Curren, E.E.M., Leong, S.C.Y., and Riau, A.K. (2023). Impact of Microplastics on the Ocular Surface. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043928"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Kitazawa, K., Numa, K., Patel, S.K., King, C.D., Matsumoto, A., Sotozono, C., Desprez, P.Y., Schilling, B., and Campisi, J. (2023). Cellular senescence exacerbates features of aging in the eyes. Aging Biol., 1.","DOI":"10.59368\/agingbio.20230014"},{"key":"ref_89","unstructured":"Hub, E.S. (2025, January 17). Eye Irritation: In Vivo Rabbit Eye Test Template for Pre-Existing Data. Available online: https:\/\/joint-research-centre.ec.europa.eu\/reference-measurement\/european-union-reference-laboratories\/eu-reference-laboratory-alternatives-animal-testing-eurl-ecvam\/alternative-methods-toxicity-testing\/validated-test-methods-health-effects\/eye-irritationserious-eye-damage\/eye-irritation-vivo_en."},{"key":"ref_90","unstructured":"(2013). OECD. Environment Directorate Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology, OECD."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Yamamoto, N., Hiramatsu, N., Kato, Y., Sato, A., and Kojima, H. (2024). Development of an Eye Irritation Test Method Using an In-House Fabrication of a Reconstructed Human Cornea-like Epithelium Model for Eye Hazard Identification. Bioengineering, 11.","DOI":"10.3390\/bioengineering11040302"},{"key":"ref_92","unstructured":"OECD (2025, January 17). Test No. 491: Short Time Exposure In Vitro Test Method for Identifying (i) Chemicals Inducing Serious Eye Damage and (ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage., Available online: https:\/\/www.oecd.org\/en\/publications\/test-no-491-short-time-exposure-in-vitro-test-method-for-identifying-i-chemicals-inducing-serious-eye-damage-and-ii-chemicals-not-requiring-classification-for-eye-irritation-or-serious-eye-damage_9789264242432-en.html."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"230259","DOI":"10.1183\/16000617.0259-2023","article-title":"Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract","volume":"33","author":"Ma","year":"2024","journal-title":"Eur. Respir. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09286586.2023.2183513","article-title":"Air Pollution and Chronic Eye Disease in Adults: A Scoping Review","volume":"31","author":"Millen","year":"2024","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/02713683.2023.2167213","article-title":"Correlation Between Air Quality Index and Tear Film Lipid Layer Thickness: Comparison Between Patients with Sjogren\u2019s Syndrome and with Meibomian Gland Dysfunction","volume":"48","author":"Wang","year":"2023","journal-title":"Curr. Eye Res."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Vitar, R.M.L., Arana, A.G.H., Marchini, T.O., Evelson, P.A., and Ferreira, S.M. (2024). The Ocular Surface as a Target of Air Pollution. Environmental Stressors and OxInflammatory Tissues Responses, CRC Press.","DOI":"10.1201\/9781003328100-10"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Lin, C.C., Chiu, C.C., Lee, P.Y., Chen, K.J., He, C.X., Hsu, S.K., and Cheng, K.C. (2022). The Adverse Effects of Air Pollution on the Eye: A Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031186"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"106","DOI":"10.12997\/jla.2023.12.2.106","article-title":"Roles of Vascular Smooth Muscle Cells in Atherosclerotic Calcification","volume":"12","author":"Woo","year":"2023","journal-title":"J. Lipid Atheroscler."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"108415","DOI":"10.1016\/j.envint.2024.108415","article-title":"Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages","volume":"184","author":"Hu","year":"2024","journal-title":"Environ. Int."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Anwar, K.N., Soleimani, M., Ashraf, M.J., Moghtader, A., Koganti, R., Ghalibafan, S., Baharnoori, M., Arabpour, Z., Cheraqpour, K., and Sebhat, A.M. (2024). Senescence and Stress Signaling Pathways in Corneal Cells After Nitrogen Mustard Injury. Cells, 13.","DOI":"10.3390\/cells13232021"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Dammak, A., Pastrana, C., Martin-Gil, A., Carpena-Torres, C., Peral Cerda, A., Simovart, M., Alarma, P., Huete-Toral, F., and Carracedo, G. (2023). Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020292"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jtos.2024.12.003","article-title":"Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence","volume":"35","author":"Iqbal","year":"2025","journal-title":"Ocul. Surf."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"108736","DOI":"10.1016\/j.envint.2024.108736","article-title":"The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective","volume":"188","author":"Alijagic","year":"2024","journal-title":"Environ. Int."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12403-022-00470-8","article-title":"To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity","volume":"15","author":"Gruber","year":"2023","journal-title":"Expo. Health"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijheh.2019.10.008","article-title":"Biomonitoring of emerging contaminants, perfluoroalkyl and polyfluoroalkyl substances (PFAS), in New Jersey adults in 2016\u20132018","volume":"223","author":"Yu","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e2440018","DOI":"10.1001\/jamanetworkopen.2024.40018","article-title":"Microplastics in the Olfactory Bulb of the Human Brain","volume":"7","author":"Dantas","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Qin, L., Wu, J., Sun, X., Huang, X., Huang, W., Weng, C., and Cai, J. (2023). The regulatory role of metabolic organ-secreted factors in the nonalcoholic fatty liver disease and cardiovascular disease. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1119005"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.7150\/thno.55795","article-title":"Organ-organ communication: The liver\u2019s perspective","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Fritsche, K., Zikova-Kloas, A., Marx-Stoelting, P., and Braeuning, A. (2023). Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032686"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Milani, I., Codini, M., Guarisco, G., Chinucci, M., Gaita, C., Leonetti, F., and Capoccia, D. (2024). Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910795"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kim, T.H., Hong, D.G., and Yang, Y.M. (2021). Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121903"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Orfanidou, M., and Polyzos, S.A. (2025). Retinopathy in Metabolic Dysfunction-Associated Steatotic Liver Disease. Medicina, 61.","DOI":"10.3390\/medicina61010038"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1186\/s12967-023-04543-3","article-title":"Insights into the liver-eyes connections, from epidemiological, mechanical studies to clinical translation","volume":"21","author":"Wu","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Mouliou, D.S. (2023). C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians. Diseases, 11.","DOI":"10.3390\/diseases11040132"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3892\/ijmm.2024.5414","article-title":"Unveiling the multifaceted role of adropin in various diseases (Review)","volume":"54","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/ATVBAHA.123.319789","article-title":"ANGPTLownregulation Increases Intracellular Lipids by Reducing Energy Utilization","volume":"44","author":"Pennisi","year":"2024","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"102250","DOI":"10.1016\/j.tranon.2024.102250","article-title":"ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer","volume":"52","author":"Lin","year":"2025","journal-title":"Transl. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12935-024-03246-z","article-title":"ANGPTL4 regulates ovarian cancer progression by activating the ERK1\/2 pathway","volume":"24","author":"Xu","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Baron-Menguy, C., Freneau, M., Mrad, M.-A., Lebot, C., Rio, M., L\u2019allinec, V., Quillard, T., Desal, H., Redon, R., and Bourcier, R. (2025). ANGPTL6 variant induces cerebral vascular dysfunction and predisposes to intracranial aneurysm in mice. bioRxiv.","DOI":"10.1101\/2025.01.10.632391"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.2147\/DMSO.S330700","article-title":"ANGPTL8\/Betatrophin Improves Glucose Tolerance in Older Mice and Metabolomic Analysis Reveals Its Role in Insulin Resistance in HepG2 Cells","volume":"14","author":"Xu","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Xiao, Z., Yeung, C.L.S., Yam, J.W.P., and Mao, X. (2022). An update on the role of complement in hepatocellular carcinoma. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1007382"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"101138","DOI":"10.1016\/j.molmet.2020.101138","article-title":"Hepatokines and metabolism: Deciphering communication from the liver","volume":"44","author":"Potthoff","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Lee-Odegard, S., Ueland, T., Thorsby, P.M., Aukrust, P., Michelsen, A.E., Halvorsen, B., Drevon, C.A., and Birkeland, K.I. (2022). Fetuin-A mediates the difference in adipose tissue insulin resistance between young adult pakistani and norwegian patients with type 2 diabetes. BMC Endocr. Disord., 22.","DOI":"10.1186\/s12902-022-01127-y"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Dogru, T., Kirik, A., Gurel, H., Rizvi, A.A., Rizzo, M., and Sonmez, A. (2021). The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126627"},{"key":"ref_125","first-page":"1291","article-title":"Hepatokines fetuin A and fetuin B status in women with\/without gestational diabetes mellitus","volume":"15","author":"Yakout","year":"2023","journal-title":"Am. J. Transl. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/oby.23961","article-title":"Fetuin B in white adipose tissue induces inflammation and is associated with peripheral insulin resistance in mice and humans","volume":"32","author":"Pasmans","year":"2024","journal-title":"Obesity"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"De Sousa-Coelho, A., Rodriguez-Rodriguez, R., Softic, S., Jonker, J., and Relat, J. (2023). FGF21 as a therapeutic target for obesity and insulin resistance: From rodent models to humans. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1253675"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"106785","DOI":"10.1016\/j.prostaglandins.2023.106785","article-title":"Follistatin and follistatin-like 3 in metabolic disorders","volume":"169","author":"Bielka","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Crisan, D., Avram, L., Morariu-Barb, A., Grapa, C., Hiriscau, I., Craciun, R., Donca, V., and Nemes, A. (2025). Sarcopenia in MASLD-Eat to Beat Steatosis, Move to Prove Strength. Nutrients, 17.","DOI":"10.3390\/nu17010178"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Elbasiony, E., Cho, W., Mittal, S.K., and Chauhan, S.K. (2022). Suppression of lipopolysaccharide-induced corneal opacity by hepatocyte growth factor. Sci. Rep., 12.","DOI":"10.1038\/s41598-021-04418-x"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Yuan, T.H., Yue, Z.S., Zhang, G.H., Wang, L., and Dou, G.R. (2021). Beyond the Liver: Liver-Eye Communication in Clinical and Experimental Aspects. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.823277"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Takata, N., Ishii, K.A., Takayama, H., Nagashimada, M., Kamoshita, K., Tanaka, T., Kikuchi, A., Takeshita, Y., Matsumoto, Y., and Ota, T. (2021). LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-80689-0"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"111312","DOI":"10.1016\/j.mce.2021.111312","article-title":"Retinol-binding protein 4 in obesity and metabolic dysfunctions","volume":"531","author":"Bluher","year":"2021","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"eaaz8048","DOI":"10.1126\/scitranslmed.aaz8048","article-title":"SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control","volume":"12","author":"Montgomery","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e33393","DOI":"10.1097\/MD.0000000000033393","article-title":"Exploring the relationship between intestinal flora and the pathological mechanism of myopia in adolescents from the perspective of Chinese and Western medicine: A review","volume":"102","author":"Xi","year":"2023","journal-title":"Medicine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.12677\/ACM.2023.134592","article-title":"A bibliographic study of \u201cliver-eye\u201d related research: A correlation function analytic research between age-related macular degeneration (AMD) and traditional chinese medicine (TCM) liver wind internal movement syndrome","volume":"13","author":"Wang","year":"2023","journal-title":"Adv. Clin. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000466694","article-title":"Liver in the Chinese and Western Medicine","volume":"4","author":"Liu","year":"2017","journal-title":"Integr. Med. Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"117409","DOI":"10.1016\/j.carbpol.2020.117409","article-title":"Chitosan-sodium alginate-fatty acid nanocarrier system: Lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H(2)O(2) induced oxidative stress in vitro","volume":"254","author":"Toragall","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Kang, K.H., Shin, D., Ryu, I.H., Kim, J.K., Lee, I.S., Koh, K., and Yoo, T.K. (2024). Association between cataract and fatty liver diseases from a nationwide cross-sectional study in South Korea. Sci. Rep., 14.","DOI":"10.1038\/s41598-023-50582-7"},{"key":"ref_140","first-page":"2544","article-title":"Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea","volume":"34","author":"Wilson","year":"1993","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"P\u0105czek, S., Zajkowska, M., and Mroczko, B. (2024). Pigment Epithelial-Derived Factor in Pancreatic and Liver Cancers\u2014From Inflammation to Cancer. Biomedicines, 12.","DOI":"10.3390\/biomedicines12102260"}],"updated-by":[{"DOI":"10.3390\/ijms27177645","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000}}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2837\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:29:07Z","timestamp":1787761747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":141,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26072837"],"URL":"https:\/\/doi.org\/10.3390\/ijms26072837","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}