{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:16:12Z","timestamp":1791494172519,"version":"4.3.4"},"reference-count":177,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese National Natural Science Foundation","award":["32402845"],"award-info":[{"award-number":["32402845"]}]},{"name":"Chinese National Natural Science Foundation","award":["32172801"],"award-info":[{"award-number":["32172801"]}]},{"name":"Chinese National Natural Science Foundation","award":["32372954"],"award-info":[{"award-number":["32372954"]}]},{"name":"Chinese National Natural Science Foundation","award":["5244041"],"award-info":[{"award-number":["5244041"]}]},{"name":"Chinese National Natural Science Foundation","award":["6222019"],"award-info":[{"award-number":["6222019"]}]},{"name":"Beijing Natural Science Foundation","award":["32402845"],"award-info":[{"award-number":["32402845"]}]},{"name":"Beijing Natural Science Foundation","award":["32172801"],"award-info":[{"award-number":["32172801"]}]},{"name":"Beijing Natural Science Foundation","award":["32372954"],"award-info":[{"award-number":["32372954"]}]},{"name":"Beijing Natural Science Foundation","award":["5244041"],"award-info":[{"award-number":["5244041"]}]},{"name":"Beijing Natural Science Foundation","award":["6222019"],"award-info":[{"award-number":["6222019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The gut plays a crucial role in digestion and immunity, so its balance is essential to overall health. This balance relies on dynamic interactions between intestinal epithelial cells, immune cells, and crypt stem cells. Inflammatory bowel disease (IBD), which consists of ulcerative colitis and Crohn\u2019s disease, is a chronic relapsing inflammatory disease of the gastrointestinal tract closely related to immune dysfunction. Stem cells, known for their ability to self-renew and differentiate, play an important role in repairing damaged intestinal epithelium and maintaining homeostasis in vivo. Macrophages are key gatekeepers of intestinal immune homeostasis and have a significant impact on IBD. Current research has focused on the link between epithelial cells and stem cells, but interactions with macrophages, which have been recognized as attractive targets for the development of new therapeutic approaches to disease, have been less explored. Recently, the developing field of immunometabolism has reinforced that metabolic reprogramming is a key determinant of macrophage function and subsequent disease progression. The aim of this review is to explore the role of the macrophage\u2013stem cell axis in the maintenance of intestinal homeostasis and to summarize potential approaches to treating IBD by manipulating the cellular metabolism of macrophages, as well as the main opportunities and challenges faced. In summary, our overview provides a framework for understanding the critical role of macrophage immunometabolism in maintaining gut health and potential therapeutic targets.<\/jats:p>","DOI":"10.3390\/ijms26072855","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T10:10:08Z","timestamp":1742551808000},"page":"2855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Intestinal Macrophage\u2013Intestinal Stem Cell Axis in Inflammatory Bowel Diseases: From Pathogenesis to Therapy"],"prefix":"10.3390","volume":"26","author":[{"given":"Tao","family":"Quan","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jcmgh.2021.07.005","article-title":"The production and function of endogenous interleukin-10 in intestinal epithelial cells and gut homeostasis","volume":"12","author":"Nguyen","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aninu.2021.09.012","article-title":"The interaction among gut microbes, the intestinal barrier and short chain fatty acids","volume":"9","author":"Ma","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: A potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.immuni.2022.08.005","article-title":"Macrophages in the gut: Masters in multitasking","volume":"55","author":"Delfini","year":"2022","journal-title":"Immunity"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"tkad004","DOI":"10.1093\/burnst\/tkad004","article-title":"Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease","volume":"11","author":"Wang","year":"2023","journal-title":"Burn. Trauma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.3748\/wjg.v29.i16.2380","article-title":"Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis","volume":"29","author":"Zheng","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Eri, R., and Chieppa, M. (2013). Messages from the Inside. The dynamic environment that favors intestinal homeostasis. Front. Immunol., 4.","DOI":"10.3389\/fimmu.2013.00323"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-065X.2008.00713.x","article-title":"Welcome to the neighborhood: Epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites","volume":"226","author":"Saenz","year":"2008","journal-title":"Immunol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/apt.14280","article-title":"Review article: The human intestinal virome in health and disease","volume":"46","author":"Carding","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: Regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cell.2010.01.023","article-title":"Homeostasis and inflammation in the intestine","volume":"140","author":"Garrett","year":"2010","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11882-015-0562-9","article-title":"Immune responses to intestinal microbes in inflammatory bowel diseases","volume":"15","author":"Hansen","year":"2015","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1053\/j.gastro.2014.02.009","article-title":"The Microbiome in inflammatory bowel disease: Current status and the future ahead","volume":"146","author":"Kostic","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/jgh.12859","article-title":"Emerging leadership lecture: Inflammatory bowel disease in Asia: Emergence of a \u201cWestern\u201d disease","volume":"30","author":"Ng","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/mi.2013.73","article-title":"New targets for mucosal healing and therapy in inflammatory bowel diseases","volume":"7","author":"Neurath","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.20.100301.064816","article-title":"The immunology of mucosal models of inflammation","volume":"20","author":"Strober","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1136\/gutjnl-2012-302830","article-title":"Mucosal healing in inflammatory bowel diseases: A systematic review","volume":"61","author":"Neurath","year":"2012","journal-title":"Gut"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1053\/j.gastro.2011.06.054","article-title":"Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis","volume":"141","author":"Colombel","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrgastro.2009.203","article-title":"Clinical implications of mucosal healing for the management of IBD","volume":"7","author":"Lemann","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"532","DOI":"10.5966\/sctm.2014-0199","article-title":"Long-term results of adipose-derived stem cell therapy for the treatment of Crohn\u2019s fistula","volume":"4","author":"Cho","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.mayocp.2015.03.023","article-title":"Long-term follow-up of Crohn disease fistulas after local injections of bone marrow-derived mesenchymal stem cells","volume":"90","author":"Ciccocioppo","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/ecco-jcc\/jjz116","article-title":"Long-term evaluation of allogeneic bone marrow-derived mesenchymal stromal cell therapy for Crohn\u2019s disease perianal fistulas","volume":"14","author":"Barnhoorn","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature09637","article-title":"Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts","volume":"469","author":"Sato","year":"2011","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nm.2695","article-title":"Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell","volume":"18","author":"Yui","year":"2012","journal-title":"Nat. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1101\/gad.245233.114","article-title":"Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon","volume":"28","author":"Fukuda","year":"2014","journal-title":"Genes Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.stem.2017.11.012","article-title":"Reconstruction of the human colon epithelium In Vivo","volume":"22","author":"Sugimoto","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41422-022-00645-7","article-title":"Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons","volume":"32","author":"Zhu","year":"2022","journal-title":"Cell Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"F1000 Faculty Rev-72","DOI":"10.12688\/f1000research.16793.1","article-title":"Recent advances in understanding intestinal stem cell regulation","volume":"8","author":"Hu","year":"2019","journal-title":"F1000Research"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-cellbio-100814-125218","article-title":"Mini-gut organoids: Reconstitution of the stem cell niche","volume":"31","author":"Date","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1007\/s00018-016-2289-8","article-title":"Cytokine responses and epithelial function in the intestinal mucosa","volume":"73","author":"Onyiah","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Andrews, C., McLean, M.H., and Durum, S.K. (2018). Cytokine tuning of intestinal epithelial function. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01270"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.cell.2018.10.008","article-title":"T Helper cell cytokines modulate intestinal stem cell renewal and differentiation","volume":"175","author":"Biton","year":"2018","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"13096","DOI":"10.1038\/ncomms13096","article-title":"Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury","volume":"7","author":"Saha","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.immuni.2019.06.003","article-title":"T cell recruitment to the intestinal stem cell compartment drives immune-mediated intestinal damage after allogeneic transplantation","volume":"51","author":"Fu","year":"2019","journal-title":"Immunity"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"aay8556","DOI":"10.1126\/sciimmunol.aay8556","article-title":"T cell-derived interferon-gamma programs stem cell death in immune-mediated intestinal damage","volume":"4","author":"Takashima","year":"2019","journal-title":"Sci. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.stem.2013.09.015","article-title":"Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury","volume":"13","author":"Fordham","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.immuni.2018.12.010","article-title":"Human fetal TNF-alpha-cytokine-producing CD4+ effector memory T cells promote intestinal development and mediate inflammation early in life","volume":"50","author":"Schreurs","year":"2019","journal-title":"Immunity"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1038\/s41467-018-05450-8","article-title":"Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids","volume":"9","author":"Jung","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.immuni.2020.02.016","article-title":"Innate lymphoid cell-epithelial cell modules sustain intestinal homeostasis","volume":"52","author":"Diefenbach","year":"2020","journal-title":"Immunity"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Panda, S.K., and Colonna, M. (2019). Innate lymphoid cells in mucosal immunity. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00861"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jcmgh.2018.09.006","article-title":"Interleukin 22 expands transit-amplifying cells while depleting Lgr5+ stem cells via inhibition of Wnt and Notch signaling","volume":"7","author":"Zha","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/s41418-018-0070-2","article-title":"Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22","volume":"25","author":"Hou","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature11535","article-title":"IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine","volume":"491","author":"Huber","year":"2012","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.immuni.2008.11.001","article-title":"Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense","volume":"29","author":"Vosshenrich","year":"2008","journal-title":"Immunity"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","article-title":"Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease","volume":"29","author":"Zenewicz","year":"2008","journal-title":"Immunity"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.immuni.2012.05.028","article-title":"Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease","volume":"37","author":"Hanash","year":"2012","journal-title":"Immunity"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature16460","article-title":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration","volume":"528","author":"Lindemans","year":"2015","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/gutjnl-2019-318483","article-title":"Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells","volume":"69","author":"Powell","year":"2020","journal-title":"Gut"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature19768","article-title":"Tissuespecific mutation accumulation in human adult stem cells during life","volume":"538","author":"Blokzijl","year":"2016","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature16166","article-title":"Substantial contribution of extrinsic risk factors to cancer development","volume":"529","author":"Wu","year":"2016","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.stem.2010.12.012","article-title":"DNA-damage response in tissue-specific and cancer stem cells","volume":"8","author":"Blanpain","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-019-0899-7","article-title":"Interleukin-22 protects intestinal stem cells against genotoxic stress","volume":"566","author":"Gronke","year":"2019","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4049\/jimmunol.1800292","article-title":"IL-33 induces murine intestinal goblet cell differentiation indirectly via innate lymphoid cell IL-13 secretion","volume":"202","author":"Waddell","year":"2019","journal-title":"J. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature16527","article-title":"Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites","volume":"529","author":"Gerbe","year":"2016","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1126\/science.aaf1648","article-title":"Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut","volume":"351","author":"Howitt","year":"2016","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature16161","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit","volume":"529","author":"Ji","year":"2016","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2018.05.014","article-title":"A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling","volume":"174","author":"Schneider","year":"2018","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/gutjnl-2020-322129","article-title":"Emerging treatment options for extraintestinal manifestations in IBD","volume":"70","author":"Greuter","year":"2021","journal-title":"Gut"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00424-017-1958-2","article-title":"Macrophages in gastrointestinal homeostasis and infammation","volume":"469","author":"Grainger","year":"2017","journal-title":"Pfl\u00fcgers Arch.-Eur. J. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni.2967","article-title":"Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice","volume":"15","author":"Bain","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/mi.2012.89","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors","volume":"6","author":"Bain","year":"2013","journal-title":"Mucosal Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: Nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Mohammadian","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Han, X., Ding, S., Jiang, H., and Liu, G. (2021). Roles of Macrophages in the Development and Treatment of Gut Inflammation. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.625423"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: Time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"122452","DOI":"10.1016\/j.lfs.2024.122452","article-title":"The intestinal epithelial-macrophage-crypt stem cell axis plays a crucial role in regulating and maintaining intestinal homeostasis","volume":"344","author":"Hu","year":"2024","journal-title":"Life Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"G59","DOI":"10.1152\/ajpgi.00123.2016","article-title":"Colonic macrophage polarization in homeostasis, inflammation, and cancer","volume":"311","author":"Isidro","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1172\/JCI59150","article-title":"CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice","volume":"121","author":"Geem","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.1791","article-title":"Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis","volume":"10","author":"Murai","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12192","article-title":"Macrophages in intestinal homeostasis and inflammation","volume":"260","author":"Bain","year":"2014","journal-title":"Immunol. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Bain, C.C., and Schridde, A. (2018). Origin, Differentiation, and Function of Intestinal Macrophages. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02733"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-immunol-081619-104850","article-title":"Krebs Cycle Reborn in Macrophage Immunometabolism","volume":"38","author":"Ryan","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41577-021-00529-8","article-title":"A guide to interrogating immunometabolism","volume":"21","author":"Voss","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"Kishton","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrrheum.2017.37","article-title":"Metabolic regulation of inflammation","volume":"13","author":"Gaber","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.immuni.2019.11.009","article-title":"Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase","volume":"51","author":"Lauterbach","year":"2019","journal-title":"Immunity"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"107521","DOI":"10.1016\/j.pharmthera.2020.107521","article-title":"Pharmacological targets of metabolism in disease: Opportunities from macrophages","volume":"210","author":"Castegna","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage Immunometabolism: Where Are We (Going)?","volume":"38","author":"Menon","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.tcb.2020.09.006","article-title":"Lipid metabolism in regulation of macrophage functions","volume":"30","author":"Yan","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/advances\/nmy084","article-title":"Glutamine Metabolism in Macrophages: A Novel Target for Obesity\/Type 2 Diabetes","volume":"10","author":"Ren","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3796","article-title":"\u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Rath, M., M\u00fcller, I., Kropf, P., Closs, E.I., and Munder, M. (2014). Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00532"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/s41467-019-10015-4","article-title":"Competition for nutrients and its role in controlling immune responses","volume":"10","author":"Finlay","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Noel, G., Baetz, N.W., Staab, J.F., Donowitz, M., Kovbasnjuk, O., Pasetti, M.F., and Zachos, N.C. (2017). A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions. Sci. Rep., 7.","DOI":"10.1038\/srep46790"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s41467-018-03638-6","article-title":"The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche","volume":"9","author":"Sehgal","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/stem.1452","article-title":"Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?","volume":"31","author":"Griffin","year":"2013","journal-title":"Stem Cells"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/gutjnl-2018-316226","article-title":"Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells","volume":"68","author":"Riehl","year":"2019","journal-title":"Gut"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/mi.2015.123","article-title":"The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD","volume":"9","author":"Calatayud","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.jcmgh.2021.08.021","article-title":"The role of intestinal macrophages in gastrointestinal homeostasis: Heterogeneity and implications in disease","volume":"12","author":"Yip","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","article-title":"Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease","volume":"50","author":"Friedrich","year":"2019","journal-title":"Immunity"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.4049\/jimmunol.175.10.6900","article-title":"Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria","volume":"175","author":"Kamada","year":"2005","journal-title":"J. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/ecco-jcc\/jjab031","article-title":"Restored macrophage function ameliorates disease pathophysiology in a mouse model for IL10 receptor-deficient very early onset inflammatory bowel disease","volume":"15","author":"Ackermann","year":"2021","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1053\/j.gastro.2009.12.041","article-title":"In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice","volume":"138","author":"Hunter","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"G781","DOI":"10.1152\/ajpgi.00055.2013","article-title":"Bone marrow-derived alternatively activated macrophages reduce colitis without promoting fibrosis: Participation of IL-10","volume":"304","author":"Leung","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: Master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0952-7915(01)00307-7","article-title":"Scavenger receptors in innate immunity","volume":"14","author":"Peiser","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.immuni.2016.02.026","article-title":"Phagocytosis: An immunobiologic process","volume":"44","author":"Gordon","year":"2016","journal-title":"Immunity"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1172\/JCI60363","article-title":"CSF-1 signaling mediates recovery from acute kidney injury","volume":"122","author":"Zhang","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.3041594","article-title":"Wound macrophages express TGF-\u03b1 and other growth factors in vivo: Analysis by mRNA phenotyping","volume":"241","author":"Rappolee","year":"1988","journal-title":"Science"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1091\/mbc.3.2.211","article-title":"Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors","volume":"3","author":"Berse","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0092-8674(85)90033-9","article-title":"A significant part of macrophage-derived growth factor consists of at least two forms of PDGF","volume":"43","author":"Shimokado","year":"1985","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jcp.21750","article-title":"Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis","volume":"220","author":"Chujo","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1182\/blood-2012-01-403386","article-title":"CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair","volume":"120","author":"Willenborg","year":"2012","journal-title":"Blood"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3810","article-title":"Targeting the TGF\u03b2 signalling pathway in disease","volume":"11","author":"Akhurst","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1126\/science.1172687","article-title":"The role of stromal stem cells in tissue regeneration and wound repair","volume":"324","author":"Stappenbeck","year":"2009","journal-title":"Science"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0035-1550057","article-title":"Resolution of liver fibrosis: Basic mechanisms and clinical relevance","volume":"35","author":"Ramachandran","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.immuni.2014.03.012","article-title":"Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis","volume":"40","author":"Zigmond","year":"2014","journal-title":"Immunity"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.immuni.2014.03.011","article-title":"Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function","volume":"40","author":"Shouval","year":"2014","journal-title":"Immunity"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.170.3.727","article-title":"Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation","volume":"170","author":"Khalil","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm.2106","article-title":"Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection","volume":"16","author":"Said","year":"2010","journal-title":"Nat. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: Therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"219ra7","DOI":"10.1126\/scitranslmed.3007563","article-title":"Therapeutic inflammatory monocyte modulation using immune-modifying microparticles","volume":"6","author":"Getts","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"250ra113","DOI":"10.1126\/scitranslmed.3009750","article-title":"Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis","volume":"6","author":"Happle","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nrgastro.2017.101","article-title":"Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD","volume":"14","author":"Selfridge","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.celrep.2017.05.065","article-title":"SIRT5 desuccinylates and activates pyruvate kinase M2 to block macrophage IL-1\u03b2 production and to prevent DSS-induced colitis in mice","volume":"19","author":"Wang","year":"2017","journal-title":"Cell Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"9029327","DOI":"10.1155\/2017\/9029327","article-title":"HIF1\u03b1-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages","volume":"2017","author":"Wang","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"dmm033241","DOI":"10.1242\/dmm.033241","article-title":"HIF-1\u03b1 activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice","volume":"11","author":"Kim","year":"2018","journal-title":"Dis. Models Mech."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"B\u00e4cker, V., Cheung, F.Y., Siveke, J.T., Fandrey, J., and Winning, S. (2017). Knockdown of myeloid cell hypoxia-inducible factor-1\u03b1 ameliorates the acute pathology in DSS-induced colitis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0190074"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Curtis","year":"2015","journal-title":"Cell Metab."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.it.2020.11.004","article-title":"Succinate receptor 1: An emerging regulator of myeloid cell function in inflammation","volume":"42","author":"Krzak","year":"2021","journal-title":"Trends Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"109521","DOI":"10.1016\/j.celrep.2021.109521","article-title":"A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state","volume":"36","author":"Fremder","year":"2021","journal-title":"Cell Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41385-018-0087-3","article-title":"Succinate receptor mediates intestinal inflammation and fibrosis","volume":"12","author":"Salvador","year":"2019","journal-title":"Mucosal Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Bauset, C., Lis-Lopez, L., Coll, S., Gisbert-Ferr\u00e1ndiz, L., Macias-Ceja, D.C., Seco-Cervera, M., Navarro, F., Esplugues, J.V., Calatayud, S., and Ortiz-Masia, D. (2022). SUCNR1 mediates the priming step of the inflammasome in intestinal epithelial cells: Relevance in ulcerative colitis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10030532"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.tem.2021.06.003","article-title":"Rethinking succinate: An unexpected hormone-like metabolite in energy homeostasis","volume":"32","author":"Vendrell","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Williams, N.C., and O\u2019Neill, L.A.J. (2018). A Role for the Krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00141"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BJ20111275","article-title":"The mitochondrial citrate carrier: A new player in inflammation","volume":"438","author":"Infantino","year":"2011","journal-title":"Biochem. J."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/pr300139q","article-title":"Quantitative metabolomic profiling of serum, plasma, and urine by 1H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals","volume":"11","author":"Schicho","year":"2012","journal-title":"J. Proteome Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acs.jproteome.9b00440","article-title":"UPLC-QTOF-MS-based plasma lipidomic profiling reveals biomarkers for inflammatory bowel disease diagnosis","volume":"19","author":"Guan","year":"2020","journal-title":"J. Proteome Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11306-017-1311-y","article-title":"Alterations in lipid, amino acid, and energy metabolism distinguish crohn\u2019s disease from ulcerative colitis and control subjects by serum metabolomic profiling","volume":"14","author":"Scoville","year":"2018","journal-title":"Metabolomics"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/83336","article-title":"PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation","volume":"7","author":"Chawla","year":"2001","journal-title":"Nat. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2012.05.001","article-title":"PPARs at the crossroads of lipid signaling and inflammation","volume":"23","author":"Wahli","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"G657","DOI":"10.1152\/ajpgi.00381.2006","article-title":"Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis","volume":"292","author":"Shah","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/mi.2010.75","article-title":"Immunoregulatory mechanisms of macrophage PPAR-\u03b3 in mice with experimental inflammatory bowel disease","volume":"4","author":"Hontecillas","year":"2011","journal-title":"Mucosal Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41590-018-0108-0","article-title":"Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization","volume":"19","author":"Kang","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Bassaganya-Riera, J., Viladomiu, M., Pedragosa, M., De Simone, C., Carbo, A., Shaykhutdinov, R., Jobin, C., Arthur, J.C., Corl, B.A., and Vogel, H. (2012). Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR \u03b3 to suppress colitis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031238"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/MPG.0000000000001812","article-title":"Fecal amino acid analysis can discriminate de novo treatment-na\u00efve pediatric inflammatory bowel disease from controls","volume":"66","author":"Bosch","year":"2018","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_152","first-page":"321","article-title":"Faecal and serum metabolomics in paediatric inflammatory bowel disease","volume":"11","author":"Kolho","year":"2017","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00011-011-0340-7","article-title":"GC\/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis","volume":"60","author":"Ooi","year":"2011","journal-title":"Inflamm. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s10620-006-9473-x","article-title":"Low intestinal glutamine level and low glutaminase activity in Crohn\u2019s disease: A rational for glutamine supplementation?","volume":"51","author":"Sido","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1053\/j.gastro.2018.11.033","article-title":"ATF4 deficiency promotes intestinal inflammation in mice by reducing uptake of glutamine and expression of antimicrobial peptides","volume":"156","author":"Hu","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jnutbio.2011.06.002","article-title":"Pretreatment with alanyl-glutamine suppresses T-helper-cell-associated cytokine expression and reduces inflammatory responses in mice with acute DSS-induced colitis","volume":"23","author":"Chu","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2013.05.004","article-title":"Alanyl-glutamine administration suppresses Th17 and reduces inflammatory reaction in dextran sulfate sodium-induced acute colitis","volume":"17","author":"Hou","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5543003","DOI":"10.1155\/2021\/5543003","article-title":"Dietary bioactive peptide alanyl-glutamine attenuates dextran sodium sulfate-induced colitis by modulating gut microbiota","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00726-013-1551-8","article-title":"Dietary L-glutamine supplementation increases Pasteurella multocida burden and the expression of its major virulence factors in mice","volume":"45","author":"Ren","year":"2013","journal-title":"Amino Acids"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41575-019-0228-5","article-title":"Interrogating host immunity to predict treatment response in inflammatory bowel disease","volume":"17","author":"Atreya","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1606910","article-title":"Tofacitinib as induction and maintenance therapy for ulcerative colitis","volume":"376","author":"Sandborn","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/ibd\/izz213","article-title":"Tofacitinib reprograms human monocytes of IBD patients and healthy controls toward a more regulatory phenotype","volume":"26","author":"Cordes","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/ibd\/izy364","article-title":"A JAK1 selective kinase inhibitor and tofacitinib affect macrophage activation and function","volume":"25","author":"Duarte","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.cgh.2020.06.050","article-title":"Safety of tofacitinib in a real-world cohort of patients with ulcerative colitis","volume":"19","author":"Deepak","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.cgh.2018.11.035","article-title":"Safety of tofacitinib for treatment of ulcerative colitis, based on 4.4 years of data from global clinical trials","volume":"17","author":"Sandborn","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/S0140-6736(21)00666-8","article-title":"Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): A phase 2b\/3 double-blind, randomised, placebo-controlled trial","volume":"397","author":"Feagan","year":"2021","journal-title":"Lancet"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0140-6736(16)32537-5","article-title":"Clinical remission in patients with moderate-to-severe Crohn\u2019s disease treated with filgotinib (the FITZROY study): Results from a phase 2, double-blind, randomised, placebo-controlled trial","volume":"389","author":"Vermeire","year":"2017","journal-title":"Lancet"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1053\/j.gastro.2020.01.047","article-title":"Efficacy and safety of upadacitinib in a randomized trial of patients with crohn\u2019s disease","volume":"158","author":"Sandborn","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1053\/j.gastro.2020.02.030","article-title":"Efficacy of upadacitinib in a randomized trial of patients with active ulcerative colitis","volume":"158","author":"Sandborn","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/S0140-6736(21)00891-6","article-title":"Expanding targeted immune modulators in ulcerative colitis","volume":"397","author":"Holmer","year":"2021","journal-title":"Lancet"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1038\/s41467-020-20164-6","article-title":"D-mannose suppresses macrophage IL-1\u03b2 production","volume":"11","author":"Torretta","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.freeradbiomed.2020.10.029","article-title":"Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1\u03b1 upregulation and autophagy","volume":"161","author":"Liu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Zhuang, H., Lv, Q., Zhong, C., Cui, Y., He, L., Zhang, C., and Yu, J. (2021). Tiliroside ameliorates ulcerative colitis by restoring the M1\/M2 macrophage balance via the HIF-1\u03b1\/glycolysis pathway. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.649463"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"105796","DOI":"10.1016\/j.phrs.2021.105796","article-title":"Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization","volume":"172","author":"Wu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"105613","DOI":"10.1016\/j.phrs.2021.105613","article-title":"Didymin switches M1-like toward M2-like macrophage to ameliorate ulcerative colitis via fatty acid oxidation","volume":"169","author":"Lv","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41419-021-04235-0","article-title":"Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt","volume":"12","author":"Xiong","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Katsandegwaza, B., Horsnell, W., and Smith, K. (2022). Inflammatory bowel disease: A Review of pre-clinical murine models of human disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169344"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2855\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:59Z","timestamp":1760029079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":177,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26072855"],"URL":"https:\/\/doi.org\/10.3390\/ijms26072855","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}