{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:41:01Z","timestamp":1760031661081,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Honey is a complex mixture of various compounds that possesses strong biological properties, among which is its antioxidant activity. It is worth mentioning that the botanical origin and the phytochemical composition are crucial parameters that determine the bioactive profile of honey. Oxidative stress is a biological phenomenon implicated into the pathogenesis of various diseases. Hence, the multifaceted evaluation of the redox-related effects of natural products, rich in bioactive compounds, may lead to the growth of putative strategies for the attenuation of oxidative stress and the prevention of such pathophysiological conditions. Within this context, the aim of the present study was to assess the biological activities of six Greek raw honey samples from Pindos Mountain in vitro, by examining their ability to cause redox alterations in RAW264.7 macrophages. For that purpose, we evaluated a panel of markers associated with antioxidant defense and oxidative damage. According to our findings, most honey samples had positive impacts on cellular redox homeostasis, as indicated by the enhancement of antioxidant defense mechanisms and the protection against oxidative damage to lipids and proteins. Conclusively, this study highlights the Greek raw honey samples potent antioxidant capacity, confirming their promising role in improving redox homeostasis.<\/jats:p>","DOI":"10.3390\/ijms26072868","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T11:06:48Z","timestamp":1742555208000},"page":"2868","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Greek Raw Honey from Pindos Mountain Improves Redox Homeostasis of RAW264.7 Macrophages"],"prefix":"10.3390","volume":"26","author":[{"given":"Anastasia","family":"Patouna","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-0367","authenticated-orcid":false,"given":"Fotis","family":"Tekos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrto","family":"Charouli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Periklis","family":"Vardakas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-6640","authenticated-orcid":false,"given":"Demetrios","family":"Kouretas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3390\/encyclopedia1040099","article-title":"Greek Honey Authentication: Botanical Approach","volume":"1","author":"Xagoraris","year":"2021","journal-title":"Encyclopedia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2174\/092986713804999358","article-title":"Honey as a Source of Dietary Antioxidants: Structures, Bioavailability and Evidence of Protective Effects Against Human Chronic Diseases","volume":"20","author":"Giampieri","year":"2013","journal-title":"Curr. 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