{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:32:12Z","timestamp":1789590732277,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cla Caixa\u201d Foundation","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"Cerebra Foundation for the Brain Injured Child","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["1531"],"award-info":[{"award-number":["1531"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["495318549"],"award-info":[{"award-number":["495318549"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["70114736"],"award-info":[{"award-number":["70114736"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Barcelona","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"University of Barcelona","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"University of Barcelona","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"University of Barcelona","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"University of Barcelona","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"University of Barcelona","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"University of Barcelona","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"University of Barcelona","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"University of Barcelona","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"University of Barcelona","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"University of Barcelona","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"University of Barcelona","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"University of Barcelona","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"University of Barcelona","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"University of Barcelona","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"Centro de Investigaciones Biom\u00e9dicas en Red sobre Enfermedades Raras (CIBERER)","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["1531"],"award-info":[{"award-number":["1531"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["495318549"],"award-info":[{"award-number":["495318549"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["70114736"],"award-info":[{"award-number":["70114736"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"European Union \u201cNextGenerationEU\u201d\/PRTR","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"Deutsche Jos\u00e9-Carreras Leuk\u00e4mie-Stiftung","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["1531"],"award-info":[{"award-number":["1531"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["495318549"],"award-info":[{"award-number":["495318549"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["70114736"],"award-info":[{"award-number":["70114736"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","doi-asserted-by":"publisher","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["1531"],"award-info":[{"award-number":["1531"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["495318549"],"award-info":[{"award-number":["495318549"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["70114736"],"award-info":[{"award-number":["70114736"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe (DKH, German Cancer Aid) within the \u201cCancer Prevention\u2014Graduate School\u201d (CPGS)","doi-asserted-by":"publisher","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"Deutsche Kinderkrebsstiftung (DKKS)","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["1531"],"award-info":[{"award-number":["1531"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["495318549"],"award-info":[{"award-number":["495318549"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["70114736"],"award-info":[{"award-number":["70114736"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF, the German Ministry for Education and Research)","doi-asserted-by":"publisher","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"Bundesamt f\u00fcr Strahlenschutz (BfS)\u2014grant","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN18\/10310003"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["1531"],"award-info":[{"award-number":["1531"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["CM21\/00058"],"award-info":[{"award-number":["CM21\/00058"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["RD21\/0012\/0003"],"award-info":[{"award-number":["RD21\/0012\/0003"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["FJC2021-048123-I"],"award-info":[{"award-number":["FJC2021-048123-I"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["DJCLS 18R\/2021"],"award-info":[{"award-number":["DJCLS 18R\/2021"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["495318549"],"award-info":[{"award-number":["495318549"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["70114736"],"award-info":[{"award-number":["70114736"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["A2023\/31"],"award-info":[{"award-number":["A2023\/31"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["01KD2410A"],"award-info":[{"award-number":["01KD2410A"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["3622S32231"],"award-info":[{"award-number":["3622S32231"]}]},{"name":"MICIN\/AEI\/FEDER, UE","award":["CEX2021-001234-M"],"award-info":[{"award-number":["CEX2021-001234-M"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>ETV6::RUNX1-positive pediatric acute lymphoblastic leukemia frequently has a prenatal origin and follows a two-hit model: a first somatic alteration leads to the formation of the oncogenic fusion gene ETV6::RUNX1 and the generation of a preleukemic clone in utero. Secondary hits after birth are necessary to convert the preleukemic clone into clinically overt leukemia. However, prenatal factors triggering the first hit have not yet been determined. Here, we explore the influence of maternal factors during pregnancy on the prevalence of the ETV6::RUNX1 fusion. To this end, we employed a nested interventional cohort study (IMPACT-BCN trial), including 1221 pregnancies (randomized into usual care, a Mediterranean diet, or mindfulness-based stress reduction) and determined the prevalence of the fusion gene in the DNA of cord blood samples at delivery (n = 741) using the state-of-the-art GIPFEL (genomic inverse PCR for exploration of ligated breakpoints) technique. A total of 6.5% (n = 48 of 741) of healthy newborns tested positive for ETV6::RUNX1. Our multiple regression analyses showed a trend toward lower ETV6::RUNX1 prevalence in offspring of the high-adherence intervention groups. Strikingly, corticosteroid use for lung maturation during pregnancy was significantly associated with ETV6::RUNX1 (adjusted OR 3.9, 95% CI 1.6\u20139.8) in 39 neonates, particularly if applied before 26 weeks of gestation (OR 7.7, 95% CI 1.08\u201350) or if betamethasone (OR 4.0, 95% CI 1.4\u201311.3) was used. Prenatal exposure to corticosteroids within a critical time window may therefore increase the risk of developing ETV6::RUNX1+ preleukemic clones and potentially leukemia after birth. Taken together, this study indicates that ETV6::RUNX1 preleukemia prevalence may be modulated and potentially prevented.<\/jats:p>","DOI":"10.3390\/ijms26072971","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T06:25:15Z","timestamp":1742883915000},"page":"2971","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modulation of the ETV6::RUNX1 Gene Fusion Prevalence in Newborns by Corticosteroid Use During Pregnancy"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-036X","authenticated-orcid":false,"given":"Leticia","family":"Ben\u00edtez","sequence":"first","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children\u2019s Hospital, Medical Faculty, Heinrich Heine University, 40225 D\u00fcsseldorf, Germany"},{"name":"German Cancer Consortium, Partner Site Essen-D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"},{"name":"Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-5240","authenticated-orcid":false,"given":"F\u00e0tima","family":"Crispi","sequence":"additional","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-5443","authenticated-orcid":false,"given":"Sara","family":"Castro-Barquero","sequence":"additional","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"},{"name":"Red Espa\u00f1ola de Terapias Avanzadas\u2014Instituto de Salud Carlos III (ISCII), 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer(CIBER-ONC), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-7411","authenticated-orcid":false,"given":"Francesca","family":"Crovetto","sequence":"additional","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Larroya","sequence":"additional","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-5507","authenticated-orcid":false,"given":"Lina","family":"Youssef","sequence":"additional","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, 08036 Barcelona, Spain"},{"name":"Josep Carreras Leukemia Research Institute, 08916 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersen","family":"Kameri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children\u2019s Hospital, Medical Faculty, Heinrich Heine University, 40225 D\u00fcsseldorf, Germany"},{"name":"Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Castillo","sequence":"additional","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Bueno","sequence":"additional","affiliation":[{"name":"Josep Carreras Leukemia Research Institute, 08916 Barcelona, Spain"},{"name":"Department of Biomedicine, School of Medicine, University of Barcelona, 08014 Barcelona, Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, 08010 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-9166","authenticated-orcid":false,"given":"Rosa","family":"Casas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, 28029 Madrid, Spain"},{"name":"Institut de Recerca en Nutrici\u00f3 i Seguretat Alimentaria, University of Barcelona, 08014 Barcelona, Spain"},{"name":"Department of Internal Medicine, Hospital Clinic, University of Barcelona, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Borras","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Clinic, University of Barcelona, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-0053","authenticated-orcid":false,"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red y Salud Mental, CIBERSAM, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Psychiatry and Psychology, Hospital Clinic, Neuroscience Institute, IDIBAPS, University of Barcelona, CIBERSAM, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-4445","authenticated-orcid":false,"given":"Ramon","family":"Estruch","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, University of Barcelona, 08014 Barcelona, Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, 08010 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Men\u00e9ndez","sequence":"additional","affiliation":[{"name":"Josep Carreras Leukemia Research Institute, 08916 Barcelona, Spain"},{"name":"Department of Biomedicine, School of Medicine, University of Barcelona, 08014 Barcelona, Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, 08010 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children\u2019s Hospital, Medical Faculty, Heinrich Heine University, 40225 D\u00fcsseldorf, Germany"},{"name":"German Cancer Consortium, Partner Site Essen-D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Gratac\u00f3s","sequence":"additional","affiliation":[{"name":"BCNatal|Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, 08036 Barcelona, Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1056\/NEJMra1400972","article-title":"Acute Lymphoblastic Leukemia in Children","volume":"373","author":"Hunger","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International Incidence of Childhood Cancer, 2001\u201310: A Population-Based Registry Study","volume":"18","author":"Colombet","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","first-page":"317","article-title":"Childhood Leukemia and Primary Prevention","volume":"46","author":"Whitehead","year":"2016","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/s41375-021-01211-7","article-title":"Can we prevent childhood Leukaemia?","volume":"35","author":"Greaves","year":"2021","journal-title":"Leukemia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1182\/blood.2020009895","article-title":"Towards prevention of childhood ALL by early-life immune training","volume":"138","author":"Hauer","year":"2021","journal-title":"Blood"},{"key":"ref_7","first-page":"135","article-title":"The genetics of childhood cancer","volume":"75","author":"Knudson","year":"1988","journal-title":"Bull. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41568-018-0015-6","article-title":"A causal mechanism for childhood acute lymphoblastic leukaemia","volume":"18","author":"Greaves","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1182\/blood.2019000893","article-title":"Natural history and cell of origin of TC F3-ZN F384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL","volume":"134","author":"Bueno","year":"2019","journal-title":"Blood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0140-6736(99)09403-9","article-title":"Prenatal origin of acute lymphoblastic leukaemia in children","volume":"354","author":"Wiemels","year":"1999","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1182\/blood.V99.8.2992","article-title":"High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia","volume":"99","author":"Taub","year":"2002","journal-title":"Blood"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood.V97.3.737","article-title":"Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals","volume":"97","author":"Eguchi","year":"2001","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8242","DOI":"10.1073\/pnas.112218799","article-title":"Chromosome translocations and covert leukemic clones are generated during normal fetal development","volume":"99","author":"Mori","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10555-019-09841-1","article-title":"Insights into the prenatal origin of childhood acute lymphoblastic leukemia","volume":"39","author":"Hein","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1182\/blood.V94.3.1057.415k10_1057_1062","article-title":"Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero","volume":"94","author":"Wiemels","year":"1999","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ng.2874","article-title":"RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia","volume":"46","author":"Papaemmanuil","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000539141","article-title":"Maternal Lifestyle and Prenatal Risk Factors for Childhood Leukemia: A Review of the Existing Evidence","volume":"51","author":"Benitez","year":"2024","journal-title":"Fetal Diagn. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Marcotte, E.L., Spector, L.G., Mendes-de-Almeida, D.P., and Nelson, H.H. (2021). The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.639479"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Fueller, E., Schaefer, D., Fischer, U., Krell, P.F., Stanulla, M., Borkhardt, A., and Slany, R.K. (2014). Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104419"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1182\/blood-2017-09-808402","article-title":"Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening","volume":"131","author":"Schafer","year":"2018","journal-title":"Blood"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1182\/blood.2019002215","article-title":"The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in approximately 0.6% of healthy newborns","volume":"134","author":"Hein","year":"2019","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1001\/jama.2021.20178","article-title":"Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial","volume":"326","author":"Crovetto","year":"2021","journal-title":"JAMA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1023\/B:CACO.0000036161.98734.17","article-title":"Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)","volume":"15","author":"Jensen","year":"2004","journal-title":"Cancer Causes Control"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/S0140-6736(01)06959-8","article-title":"Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: A case-control study","volume":"358","author":"Thompson","year":"2001","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10552-015-0593-5","article-title":"Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: The ESTELLE study","volume":"26","author":"Orsi","year":"2015","journal-title":"Cancer Causes Control"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10552-007-9091-8","article-title":"Risk of childhood leukemia associated with parental smoking and alcohol consumption prior to conception and during pregnancy: The cross-Canada childhood leukemia study","volume":"19","author":"MacArthur","year":"2008","journal-title":"Cancer Causes Control"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/EDE.0000000000000141","article-title":"Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring: A Childhood Leukemia International Consortium study","volume":"25","author":"Metayer","year":"2014","journal-title":"Epidemiology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/CEJ.0000000000000350","article-title":"Parental alcohol consumption and risk of leukemia in the offspring: A systematic review and meta-analysis","volume":"26","author":"Karalexi","year":"2017","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/ije\/dyu265","article-title":"Infant birthweight and risk of childhood cancer: International population-based case control studies of 40,000 cases","volume":"44","author":"Murphy","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/pbc.23347","article-title":"Maternal smoking during pregnancy and risk for childhood leukemia: A nationwide case-control study in Greece and meta-analysis","volume":"58","author":"Klimentopoulou","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10552-010-9688-1","article-title":"Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: Results from an Australian case-control study","volume":"22","author":"Milne","year":"2011","journal-title":"Cancer Causes Control"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1365-3016.2007.00824.x","article-title":"Maternal alcohol and coffee drinking, parental smoking and childhood leukaemia: A French population-based case-control study","volume":"21","author":"Menegaux","year":"2007","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/bjc.1997.541","article-title":"The risk profile of childhood leukaemia in Greece: A nationwide case-control study","volume":"76","author":"Petridou","year":"1997","journal-title":"Br. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/sj.bjc.6690609","article-title":"Pre- and perinatal risk factors for childhood leukaemia and other malignancies: A Scottish case control study","volume":"80","author":"McKinney","year":"1999","journal-title":"Br. J. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-3016.2011.01226.x","article-title":"Self-report versus medical record\u2014Perinatal factors in a study of infant leukaemia: A study from the Children\u2019s Oncology Group","volume":"25","author":"Jurek","year":"2011","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/pbc.22628","article-title":"Frequencies of ETV6-RUNX1 Fusion and Hyperdiploidy in Pediatric Acute Lymphoblastic Leukemia Are Lower in Far East than West","volume":"55","author":"Liang","year":"2010","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1158\/1055-9965.EPI-15-0528","article-title":"Pathway Analysis of Genome-Wide Association Study in Childhood Leukemia among Hispanics","volume":"25","author":"Hsu","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00043426-199502000-00001","article-title":"The use of glucocorticoids in acute lymphoblastic leukemia of childhood. Molecular, cellular, and clinical considerations","volume":"17","author":"Gaynon","year":"1995","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1182\/blood-2010-03-275347","article-title":"ETV6\/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling","volume":"117","author":"Kuster","year":"2011","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/gtc.12993","article-title":"Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks","volume":"28","author":"Akter","year":"2023","journal-title":"Genes Cells"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000077514","article-title":"Analysis of ETV6\/RUNX1 fusions for evaluating the late effects of cancer therapy in ALL (acute lymphoblastic leukemia) cured patients","volume":"104","author":"Brassesco","year":"2004","journal-title":"Cytogenet. Genome Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0140-6736(96)09412-3","article-title":"Aetiology of acute leukaemia","volume":"349","author":"Greaves","year":"1997","journal-title":"Lancet"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41398-022-01902-4","article-title":"DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment","volume":"12","author":"Kim","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1002\/ijc.32203","article-title":"Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia","volume":"145","author":"Timms","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13148-014-0039-z","article-title":"DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia","volume":"7","author":"Nordlund","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09744","article-title":"The genomic complexity of primary human prostate cancer","volume":"470","author":"Berger","year":"2011","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1593\/neo.122146","article-title":"Epigenomic alterations in localized and advanced prostate cancer","volume":"15","author":"Lin","year":"2013","journal-title":"Neoplasia"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"(2004). Seckl Prenatal Glucocorticoids and Long-Term Programming. Eur. J. Endocrinol., 151, U49\u2013U62.","DOI":"10.1530\/eje.0.151u049"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1038\/leu.2008.212","article-title":"Etiology of common childhood acute lymphoblastic leukemia: The adrenal hypothesis","volume":"22","author":"Schmiegelow","year":"2008","journal-title":"Leukemia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF00051700","article-title":"Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children\u2019s Cancer Group","volume":"7","author":"Ross","year":"1996","journal-title":"Cancer Causes Control"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1158\/1055-9965.EPI-04-0602","article-title":"Maternal diet and infant leukemia: The DNA topoisomerase II inhibitor hypothesis: A report from the children\u2019s oncology group","volume":"14","author":"Spector","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1080\/01635581.2012.707278","article-title":"Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and the risk of childhood acute lymphoblastic leukemia","volume":"64","author":"Bailey","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1158\/1055-9965.EPI-12-1438","article-title":"Blood levels of folate at birth and risk of childhood leukemia","volume":"22","author":"Chokkalingam","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/ije\/dyi248","article-title":"Socioeconomic status and childhood leukaemia: A review","volume":"35","author":"Poole","year":"2006","journal-title":"Int. J. Epidemiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/rpd\/ncn261","article-title":"Childhood Leukaemia and Socioeconomic Status: What Is the Evidence?","volume":"132","author":"Adam","year":"2008","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s13063-021-05309-2","article-title":"Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): A study protocol for a randomized controlled trial","volume":"22","author":"Crovetto","year":"2021","journal-title":"Trials"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1002\/ijgo.15334","article-title":"Investigation and Care of a Small-for-Gestational-Age Fetus and a Growth Restricted Fetus (Green-top Guideline No. 31)","volume":"131","author":"Morris","year":"2024","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/jamainternmed.2015.4838","article-title":"Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial","volume":"175","author":"Toledo","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/jama.300.11.1350","article-title":"Mindfulness in medicine","volume":"300","author":"Ludwig","year":"2008","journal-title":"JAMA"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Juton, C., Castro-Barquero, S., Casas, R., Freitas, T., Ruiz-Leon, A.M., Crovetto, F., Domenech, M., Crispi, F., Vieta, E., and Gratacos, E. (2021). Reliability and Concurrent and Construct Validity of a Food Frequency Questionnaire for Pregnant Women at High Risk to Develop Fetal Growth Restriction. Nutrients, 13.","DOI":"10.3390\/nu13051629"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2971\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:59:43Z","timestamp":1760029183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/2971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":60,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26072971"],"URL":"https:\/\/doi.org\/10.3390\/ijms26072971","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]}}}