{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:21:03Z","timestamp":1785111663284,"version":"3.55.0"},"reference-count":113,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Culture, and Science of the Government of The Netherlands","award":["024.003.001"],"award-info":[{"award-number":["024.003.001"]}]},{"name":"Ministry of Education, Culture, and Science of the Government of The Netherlands","award":["016.171.047"],"award-info":[{"award-number":["016.171.047"]}]},{"name":"University of Groningen and an NWO VIDI","award":["024.003.001"],"award-info":[{"award-number":["024.003.001"]}]},{"name":"University of Groningen and an NWO VIDI","award":["016.171.047"],"award-info":[{"award-number":["016.171.047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The contribution of genetics to the development of gut-related autoimmune diseases such as celiac disease (CeD) and inflammatory bowel diseases (IBDs) is well-established, especially in immune cells, but pinpointing the significance of genetic variants to other cell types is more elusive. Increasing evidence indicates that intestinal epithelial cells are active players in modulating the immune response, suggesting that genetic variants affecting these cells could change cell behavior during disease. Moreover, fine-mapping genetic variants and causal genes to relevant cell types can help to identify drug targets and develop personalized targeted therapies. In this context, we reviewed the functions of genes in disease-associated loci shared by CeD and IBD that are expressed in epithelial cells and explored their potential impacts.<\/jats:p>","DOI":"10.3390\/ijms26072982","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T08:42:35Z","timestamp":1742892155000},"page":"2982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shared Genetics in Celiac Disease and Inflammatory Bowel Disease Specify a Greater Role for Intestinal Epithelial Cells"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-2766","authenticated-orcid":false,"given":"Nathan Vin\u00edcius","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1059-1009","authenticated-orcid":false,"given":"Sajid","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-3437","authenticated-orcid":false,"given":"Sebo","family":"Withoff","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris H.","family":"Jonkers","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11894-019-0705-6","article-title":"Evolving Epidemiology of IBD","volume":"21","author":"Windsor","year":"2019","journal-title":"Curr. 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