{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:26:05Z","timestamp":1782390365373,"version":"3.54.5"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minister of Education and Science","award":["SKN\/SP\/534956\/2022"],"award-info":[{"award-number":["SKN\/SP\/534956\/2022"]}]},{"name":"Minister of Education and Science","award":["B.SUB.24.128"],"award-info":[{"award-number":["B.SUB.24.128"]}]},{"name":"Minister of Education and Science","award":["B.SUB.24.401"],"award-info":[{"award-number":["B.SUB.24.401"]}]},{"name":"Medical University of Bialystok","award":["SKN\/SP\/534956\/2022"],"award-info":[{"award-number":["SKN\/SP\/534956\/2022"]}]},{"name":"Medical University of Bialystok","award":["B.SUB.24.128"],"award-info":[{"award-number":["B.SUB.24.128"]}]},{"name":"Medical University of Bialystok","award":["B.SUB.24.401"],"award-info":[{"award-number":["B.SUB.24.401"]}]},{"name":"Foundation for Polish Science (FNP)","award":["SKN\/SP\/534956\/2022"],"award-info":[{"award-number":["SKN\/SP\/534956\/2022"]}]},{"name":"Foundation for Polish Science (FNP)","award":["B.SUB.24.128"],"award-info":[{"award-number":["B.SUB.24.128"]}]},{"name":"Foundation for Polish Science (FNP)","award":["B.SUB.24.401"],"award-info":[{"award-number":["B.SUB.24.401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The inflammatory state is a significant factor associated with diabetic kidney disease (DKD), making it one of the significant causes of chronic kidney disease. Despite the availability of data, there is a lack of targeted treatment strategies for diabetes-related kidney disorders. The aim of our study was to determine the impact of cannabigerol (CBG) on lipid precursors for inflammatory mediators during DKD development. A six-week experiment was conducted on male Wistar rats fed standard (Control) or high-fat high-sucrose (HFHS) diets. For the last 14 days of the experiment (5th and 6th weeks), half of the rats from the Control and HFHS groups intragastrically received CBG solution. Gas\u2013liquid chromatography (GLC) was used to measure the activities of n-6 and n-3 polyunsaturated fatty acid (PUFA) metabolic pathways and the concentrations of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) in selected lipid fractions. Immunoblotting was performed to assess the expression of proteins involved in the regulation of the inflammatory state. A multiplex immunoassay kit was used to determine kidney toxicity biomarker levels. Our results revealed that CBG administration to rats fed an HFHS diet decreased n-6 PUFA biosynthetic pathway activity in phospholipid (PL) and triacylglycerol (TAG) and increased n-3 PUFA biosynthetic pathway activity in TAG and free fatty acid (FFA). We also observed a reduction in the AA concentration in PL, FFA, and diacylglycerol (DAG). CBG supplementation reduced the level of kidney damage biomarkers, such as osteopontin (OPN). Our observations confirm that CBG has potential anti-inflammatory properties and may be successfully used for further research to seek targeted therapies of inflammatory disorders, including diabetic kidney disease progression.<\/jats:p>","DOI":"10.3390\/ijms26073114","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T04:11:40Z","timestamp":1743135100000},"page":"3114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Identification of Novel Anti-Inflammatory Effects of Cannabigerol in the Kidney Tissue of Rats Subjected to a High-Fat High-Sucrose Diet"],"prefix":"10.3390","volume":"26","author":[{"given":"Anna","family":"Stepaniuk","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-7585","authenticated-orcid":false,"given":"Klaudia","family":"Sztolsztener","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Konstantynowicz-Nowicka","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Harasim-Symbor","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-987X","authenticated-orcid":false,"given":"Patrycja","family":"Bielawiec","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-8156","authenticated-orcid":false,"given":"Adrian","family":"Chabowski","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","unstructured":"Becker, T.K., Majmundar, M., Harris, K.M., National Academies of Sciences, Engineering, and Medicine, Division of Behavioral and Social Sciences and Education, Committee on National Statistics, Committee on Population, and Committee on Rising Midlife Mortality Rates and Socioeconomic Disparities (2021). High and Rising Mortality Rates Among Working-Age Adults, The National Academies Press."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/er.2008-0024","article-title":"The Metabolic Syndrome","volume":"29","author":"Cornier","year":"2008","journal-title":"Endocr. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chait, A., and den Hartigh, L.J. (2020). Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease. Front. Cardiovasc. Med., 7.","DOI":"10.3389\/fcvm.2020.00022"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jiang, S., Liu, H., and Li, C. (2021). Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases. Foods, 10.","DOI":"10.3390\/foods10081854"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rapa, S.F., Di Iorio, B.R., Campiglia, P., Heidland, A., and Marzocco, S. (2019). Inflammation and Oxidative Stress in Chronic Kidney Disease\u2014Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010263"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/path.1711560204","article-title":"Eicosanoids and Inflammation","volume":"156","author":"Williams","year":"1988","journal-title":"J. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wang, T., Fu, X., Chen, Q., Patra, J.K., Wang, D., Wang, Z., and Gai, Z. (2019). Arachidonic Acid Metabolism and Kidney Inflammation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153683"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u039aB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zatterale, F., Longo, M., Naderi, J., Raciti, G.A., Desiderio, A., Miele, C., and Beguinot, F. (2020). Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01607"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"sfaf001","DOI":"10.1093\/ckj\/sfaf001","article-title":"Effects of Anti-Inflammatory Agents on Clinical Outcomes in People with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomised Control Trials","volume":"18","author":"Webster","year":"2025","journal-title":"Clin. Kidney J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.18103\/mra.v11i2.3614","article-title":"Inflammation in Diabetic Kidney Disease: Focus on New Therapeutic Considerations","volume":"11","author":"Leehey","year":"2023","journal-title":"Med. Res. Arch."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1111\/dom.15109","article-title":"Effects of Albuminuria-Lowering Treatments on Inflammation Markers: A Post Hoc Analysis from the ROTATE Trials","volume":"25","author":"Sen","year":"2023","journal-title":"Diabetes Obes. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/FJC.0000000000001482","article-title":"Targeting Pharmacotherapies for Inflammatory and Cardiorenal Endpoints in Kidney Disease","volume":"83","author":"Huck","year":"2024","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/MNH.0b013e32833aa4ac","article-title":"Renal Lipid Metabolism and Lipotoxicity","volume":"19","author":"Bobulescu","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000101797","article-title":"Cellular and Molecular Mechanisms of Proteinuria in Diabetic Nephropathy","volume":"106","author":"Wolf","year":"2007","journal-title":"Nephron. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"F198","DOI":"10.1152\/ajprenal.00293.2012","article-title":"Isolation of Interstitial Fluid and Demonstration of Local Proinflammatory Cytokine Production and Increased Absorptive Gradient in Chronic Peritoneal Dialysis","volume":"304","author":"Rosengren","year":"2013","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1007\/s00213-016-4397-4","article-title":"Cannabigerol Is a Novel, Well-Tolerated Appetite Stimulant in Pre-Satiated Rats","volume":"233","author":"Brierley","year":"2016","journal-title":"Psychopharmacology"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jastrz\u0105b, A., Jarocka-Karpowicz, I., and Skrzydlewska, E. (2022). The Origin and Biomedical Relevance of Cannabigerol. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147929"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"106822","DOI":"10.1016\/j.prostaglandins.2024.106822","article-title":"High-Fat and Carbohydrate Diet Caused Chronic Kidney Damage by Disrupting Kidney Function, Caspase-3, Oxidative Stress and Inflammation","volume":"172","author":"Erdemli","year":"2024","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Haliem Saleh, N.E., Ibrahim, M.Y., Saad, A.H., Habeeb, W.N., Saleh, R.K., and Abdel-Hakeem, E.A. (2024). High Caloric Carbohydrate Diets Promote Disturbed Metabolic Milieu and Induce Renal Injury in Albino Rats. Minia J. Med. Res.","DOI":"10.21608\/mjmr.2024.271550.1673"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.2174\/1381612829666221020162955","article-title":"Hypercaloric Diet Promotes Metabolic Disorders and Impaired Kidney Function","volume":"28","year":"2022","journal-title":"Curr. Pharm. Des."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gonzalez-Becerra, K., Barron-Cabrera, E., Mu\u00f1oz-Valle, J.F., Torres-Castillo, N., Rivera-Valdes, J.J., Rodriguez-Echevarria, R., and Martinez-Lopez, E. (2023). A Balanced Dietary Ratio of N-6:N-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity. Healthcare, 11.","DOI":"10.3390\/healthcare11162333"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100283","DOI":"10.1016\/j.jlr.2022.100283","article-title":"Elevated N-3\/n-6 PUFA Ratio in Early Life Diet Reverses Adverse Intrauterine Kidney Programming in Female Rats","volume":"63","author":"Voggel","year":"2022","journal-title":"J. Lipid Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Vernail, V.L., Bingaman, S.S., Silberman, Y., Raup-Konsavage, W.M., Vrana, K.E., and Arnold, A.C. (2022). Acute Cannabigerol Administration Lowers Blood Pressure in Mice. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.871962"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3336516","DOI":"10.1155\/2022\/3336516","article-title":"Pharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives","volume":"2022","author":"Calapai","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Poli, A., Agostoni, C., and Visioli, F. (2023). Dietary Fatty Acids and Inflammation: Focus on the n-6 Series. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054567"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Su, H., Lei, C.-T., and Zhang, C. (2017). Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00405"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Bielawiec, P., Harasim-Symbor, E., Sztolsztener, K., Konstantynowicz-Nowicka, K., and Chabowski, A. (2021). Attenuation of Oxidative Stress and Inflammatory Response by Chronic Cannabidiol Administration Is Associated with Improved N-6\/n-3 PUFA Ratio in the White and Red Skeletal Muscle in a Rat Model of High-Fat Diet-Induced Obesity. Nutrients, 13.","DOI":"10.3390\/nu13051603"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3181\/00379727-213-44031","article-title":"Polyunsaturated Fatty Acids and Renal Disease","volume":"213","author":"Lefkowith","year":"1996","journal-title":"Exp. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00418-019-01838-9","article-title":"PUFAs Supplementation Affects the Renal Expression of Pannexin 1 and Connexins in Diabetic Kidney of Rats","volume":"153","author":"Benzon","year":"2020","journal-title":"Histochem. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12974-019-1615-0","article-title":"The Effects of N-6 Polyunsaturated Fatty Acid Deprivation on the Inflammatory Gene Response to Lipopolysaccharide in the Mouse Hippocampus","volume":"16","author":"Alashmali","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Jannas-Vela, S., Espinosa, A., Candia, A.A., Flores-Opazo, M., Pe\u00f1ailillo, L., and Valenzuela, R. (2023). The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15040871"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Pizzini, A., Lunger, L., Sonnweber, T., Weiss, G., and Tancevski, I. (2018). The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review. Nutrients, 10.","DOI":"10.3390\/nu10121864"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Han, E., Yun, Y., Kim, G., Lee, Y.-H., Wang, H.J., Lee, B.-W., Cha, B.S., Kim, B.S., and Kang, E.S. (2016). Effects of Omega-3 Fatty Acid Supplementation on Diabetic Nephropathy Progression in Patients with Diabetes and Hypertriglyceridemia. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154683"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s11745-015-4061-5","article-title":"High-Fat Diet Alters Serum Fatty Acid Profiles in Obesity Prone Rats: Implications for In Vitro Studies","volume":"50","author":"Liu","year":"2015","journal-title":"Lipids"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sonnweber, T., Pizzini, A., Nairz, M., Weiss, G., and Tancevski, I. (2018). Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113285"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1620\/tjem.197.159","article-title":"Upregulated Expression of Transforming Growth Factor-Beta, Type IV Collagen, and Plasminogen Activator Inhibitor-1 MRNA Are Decreased after Release of Unilateral Ureteral Obstruction","volume":"197","author":"Ogata","year":"2002","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Turolo, S., Edefonti, A., Mazzocchi, A., Syren, M.L., Morello, W., Agostoni, C., and Montini, G. (2021). Role of Arachidonic Acid and Its Metabolites in the Biological and Clinical Manifestations of Idiopathic Nephrotic Syndrome. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115452"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1002\/mco2.363","article-title":"Arachidonic Acid Metabolism in Health and Disease","volume":"4","author":"Zhang","year":"2023","journal-title":"MedComm"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.23876\/j.krcp.21.222","article-title":"Prostaglandin E2 Receptors as Therapeutic Targets in Renal Fibrosis","volume":"41","author":"Mutsaers","year":"2022","journal-title":"Kidney Res. Clin."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"37S","DOI":"10.1016\/S0002-9343(99)00115-1","article-title":"Role and Regulation of Cyclooxygenase-2 during Inflammation","volume":"106","author":"Simon","year":"1999","journal-title":"Am. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-020-00443-w","article-title":"Metabolism Pathways of Arachidonic Acids: Mechanisms and Potential Therapeutic Targets","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/sj.bjp.0704528","article-title":"Cyclooxygenase-1 Derived Prostaglandins Are Involved in the Maintenance of Renal Function in Rats with Cirrhosis and Ascites","volume":"135","author":"Titos","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2715718","DOI":"10.1155\/2016\/2715718","article-title":"Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice","volume":"2016","author":"Wu","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1038\/sj.bjp.0707489","article-title":"Endogenous Pro-Resolving and Anti-Inflammatory Lipid Mediators: A New Pharmacologic Genus","volume":"153","author":"Serhan","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1096\/fj.11-185017","article-title":"Lipoxin A4 and Benzo-Lipoxin A4 Attenuate Experimental Renal Fibrosis","volume":"25","author":"Docherty","year":"2011","journal-title":"FASEB J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cmet.2015.05.003","article-title":"Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease","volume":"22","author":"Johnson","year":"2015","journal-title":"Cell Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting Molecular Cross-Talk between Nrf2 and NF-\u039aB Response Pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Jeong, G.H., Kim, K.C., and Lee, J.H. (2025). Anti-Inflammatory Effects of Cannabigerol In Vitro and In Vivo Are Mediated Through the JAK\/STAT\/NF\u03baB Signaling Pathway. Cells, 14.","DOI":"10.3390\/cells14020083"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wang, X., Chen, J., Xu, J., Xie, J., Harris, D.C.H., and Zheng, G. (2021). The Role of Macrophages in Kidney Fibrosis. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.705838"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"825","DOI":"10.33549\/physiolres.934930","article-title":"Hypoxia-Induced Upregulation of Matrix Metalloproteinase 9 Increases Basement Membrane Degradation by Downregulating Collagen Type IV Alpha 1 Chain","volume":"71","author":"Zhu","year":"2022","journal-title":"Physiol. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"jcs225268","DOI":"10.1242\/jcs.225268","article-title":"Evidence for a Regulated Ca2+ Entry in Proximal Tubular Cells and Its Implication in Calcium Stone Formation","volume":"132","author":"Ibeh","year":"2019","journal-title":"J. Cell Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1681\/ASN.2010080878","article-title":"Calcium Mediates Glomerular Filtration through Calcineurin and MTORC2\/Akt Signaling","volume":"22","author":"Vassiliadis","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1681\/ASN.2020101525","article-title":"Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis","volume":"32","author":"Djenoune","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Milinkeviciute, G., and Green, K.N. (2023). Clusterin\/Apolipoprotein J, Its Isoforms and Alzheimer\u2019s Disease. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1167886"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Guo, J., Guan, Q., Liu, X., Wang, H., Gleave, M.E., Nguan, C.Y.C., and Du, C. (2016). Relationship of Clusterin with Renal Inflammation and Fibrosis after the Recovery Phase of Ischemia-Reperfusion Injury. BMC Nephrol., 17.","DOI":"10.1186\/s12882-016-0348-x"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00011-018-1200-5","article-title":"The Role of Osteopontin in Kidney Diseases","volume":"68","author":"Kaleta","year":"2019","journal-title":"Inflamm. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Torino, C., Carbone, F., Pizzini, P., Mezzatesta, S., D\u2019Arrigo, G., Gori, M., Liberale, L., Moriero, M., Michelauz, C., and Fr\u00e8, F. (2024). Osteopontin and Clinical Outcomes in Hemodialysis Patients. Biomedicines, 12.","DOI":"10.3390\/biomedicines12112605"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.2147\/IJGM.S354220","article-title":"Determinant of Osteopontin Levels in Microvascular Complications in Patients with Diabetes","volume":"15","author":"Nawaz","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/ndt\/17.12.2043","article-title":"Monocyte Chemoattractant Protein-1 (MCP-1) in the Kidney: Does It More than Simply Attract Monocytes?","volume":"17","author":"Viedt","year":"2002","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"64","DOI":"10.17691\/stm2021.13.3.08","article-title":"Kidney Injury Molecule 1 (KIM-1): A Multifunctional Glycoprotein and Biological Marker (Review)","volume":"13","author":"Karmakova","year":"2021","journal-title":"Sovrem. Tekhnologii. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sinha, S.K., Mellody, M., Carpio, M.B., Damoiseaux, R., and Nicholas, S.B. (2023). Osteopontin as a Biomarker in Chronic Kidney Disease. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051356"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Layton, G.R., Antoun, I., Copperwheat, A., Khan, Z.L., Bhandari, S.S., Somani, R., Ng, A., and Zakkar, M. (2025). Osteopontin as a Biomarker for Coronary Artery Disease. Cells, 14.","DOI":"10.3390\/cells14020106"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/FBP.0b013e328356c3c9","article-title":"The Role of the Endocannabinoid System in Eating Disorders: Pharmacological Implications","volume":"23","author":"Marco","year":"2012","journal-title":"Behav. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1038\/nutd.2013.9","article-title":"The Cannabinoid \u0394(9)-Tetrahydrocannabivarin (THCV) Ameliorates Insulin Sensitivity in Two Mouse Models of Obesity","volume":"3","author":"Wargent","year":"2013","journal-title":"Nutr. Diabetes"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0378-4347(00)85091-4","article-title":"Gas-Liquid Chromatographic Determination of Fatty Acid Composition of Cholesteryl Esters in Human Serum Using Silica Sep-Pak Cartridges","volume":"276","author":"Wang","year":"1983","journal-title":"J. Chromatogr. B Biomed. Sci. 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