{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:05:20Z","timestamp":1791021920083,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"The Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["BLX202218"],"award-info":[{"award-number":["BLX202218"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Circadian rhythm disruption is a modifiable risk factor for Alzheimer\u2019s disease (AD) progression, marked by neuroinflammation, oxidative stress, and amyloid-\u03b2 (A\u03b2) accumulation. Hypoxia-inducible factor 3\u03b1 (Hif3\u03b1) has emerged as a key regulator of inflammatory and oxidative pathways. To evaluate the impacts of circadian disruption on AD progression and investigate the therapeutic potential of bamboo leaf flavonoids (BLFs), C57BL\/6N mice (normal mice) and APP\/PS1 transgenic mice (AD mice) were exposed to circadian disruption via randomized light exposure and stress, as the in vivo model. Then, BLFs were administered to assess effects on neuroinflammation, oxidative stress, and organ damage. Next, Nissl body staining and A\u03b2 protein immunohistochemistry were performed to evaluate the effects of BLFs on brain pathology. Through transcriptome sequencing, key factors and the related pathway were screened out. In vitro, molecular mechanisms were explored in PC12 cells treated with A\u03b242 and Hif3\u03b1 siRNA fragments. Results demonstrated that circadian disruption increased oxidative stress and early liver and kidney damage degrees, with greater severity in AD mice. BLFs partially reversed oxidative damage and reduced A\u03b2 deposition. Transcriptome analysis revealed upregulation of Hif3\u03b1 in circadian-disrupted mice, linked to inflammation and oxidative stress. In vitro, the knockdown of Hif3\u03b1 reduced inflammation and normalized protein expression, which could be regulated by BLFs and suppressed AD progression. In conclusion, circadian disruption exacerbated AD progression via regulating Hif3\u03b1\/Rab7\/TNF\u03b1\/IL1\u03b2 pathway. BLFs offered neuroprotection roles by mitigating inflammation and oxidative damage, highlighting Hif3\u03b1 as a promising target for AD therapy and biomarker development.<\/jats:p>","DOI":"10.3390\/ijms26073169","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T03:25:02Z","timestamp":1743391502000},"page":"3169","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bamboo Leaf Flavonoids from Phyllostachys glauca McClure Suppress the Progression of Alzheimer\u2019s Disease Induced by Circadian Rhythm Disruption Through Regulating Hif3\u03b1\/Rab7\/TNF\u03b1\/IL1\u03b2 Pathway"],"prefix":"10.3390","volume":"26","author":[{"given":"Junru","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Food Processing and Safety in Forestry, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0386-2930","authenticated-orcid":false,"given":"Victor I. K.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Food Processing and Safety in Forestry, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Food Processing and Safety in Forestry, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Du","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Food Processing and Safety in Forestry, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Food Processing and Safety in Forestry, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-8457","authenticated-orcid":false,"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Food Processing and Safety in Forestry, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Devranis, P., Vassilopoulou, \u0395., Tsironis, V., Sotiriadis, P.M., Chourdakis, M., Aivaliotis, M., and Tsolaki, M. 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