{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:21:07Z","timestamp":1791429667866,"version":"4.3.3"},"reference-count":159,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DMU"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The \u03b17 nicotinic acetylcholine receptor (\u03b17-nAChR) is a pivotal regulator of neurotransmission, neuroprotection, and immune modulation in the central nervous system. This review explores its structural and functional attributes, highlighting its therapeutic potential in neurodegenerative disorders, particularly Parkinson\u2019s disease (PD). \u03b17-nAChRs mediate synaptic plasticity, modulate inflammatory responses, and influence dopamine release, positioning them as a promising pharmacological target. Positive allosteric modulators (PAMs) enhance \u03b17-nAChR activity mainly by reducing desensitization, offering a superior therapeutic approach compared with direct agonists. Emerging preclinical studies suggest that \u03b17-nAChR activation mitigates dopaminergic neurodegeneration, improves L-dopa-induced dyskinesia, and reduces neuroinflammation. Despite promising findings, clinical trials have yielded mixed results, necessitating further research into optimizing \u03b17-targeted therapies. This review underscores the significance of \u03b17-nAChRs in PD pathophysiology and highlights future directions for their translational potential in neuroprotection and symptomatic relief.<\/jats:p>","DOI":"10.3390\/ijms26073210","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T03:25:02Z","timestamp":1743391502000},"page":"3210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Role of \u03b17-Nicotinic Acetylcholine Receptors in the Pathophysiology and Treatment of Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-1749","authenticated-orcid":false,"given":"Eslam","family":"ElNebrisi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Dubai Medical College for Girls, Dubai Medical University, Dubai 20170, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-1053","authenticated-orcid":false,"given":"Yosra","family":"Lozon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Dubai Pharmacy College for Girls, Dubai Medical University, Dubai 20170, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-0085","authenticated-orcid":false,"given":"Murat","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Pharmacy, Kuwait University, Safat 13110, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/0115672050306008240321034006","article-title":"Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer\u2019s Disease","volume":"21","author":"Nagori","year":"2024","journal-title":"Curr. 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