{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:35:51Z","timestamp":1770287751222,"version":"3.49.0"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israeli Science Foundation","doi-asserted-by":"publisher","award":["(ISF# 1639\/14)"],"award-info":[{"award-number":["(ISF# 1639\/14)"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"internal Hadassah-Hebrew University Research Funds","award":["(ISF# 1639\/14)"],"award-info":[{"award-number":["(ISF# 1639\/14)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory Bowel Disease (IBD) is a multifactorial gastrointestinal condition encompassing two major forms of intestinal inflammation: Crohn\u2019s disease (CD) and ulcerative colitis (UC). Both conditions are linked to auto-inflammatory reactions and genetic predispositions. Various drug therapies and biological treatments proposed to reduce IBD-associated inflammation. We induced IBD in a mouse model by stimulating bowel inflammation with an oral dextran sodium sulfate (DSS) beverage. Our novel cell therapy approach for IBD involves intramuscular (IM) and intraperitoneal (IP) delivery of non-matched, expanded, potent xenogeneic fetal human mesenchymal stromal cells (f-hPSCs) in 2 \u00d7 106 cell injections. This cell therapy has already been shown previously to induce pro-regenerative and anti-inflammatory effects in different systemic and local disorders, where the injected f-hPSCs were shown to respond to the stress of the host and secrete the adequate secretome in response to this stress. In the current study, the IP-injected f-hPSCs treatment of the DSS-induced IBD enhanced the regenerative processes of the damaged bowel and reduced the inflammatory process. This was associated with rapid regain of the mice\u2019s weight and a decrease in inflammation-associated parameters, such as colon edema, bowel shortening, and a threefold increase in bowel mass, as estimated by increased colon weight and reduced length. This ratio best emphasized the induced inflammatory response associated with the decrease in the inflamed colon length with an increase in its mass. Although IM f-hPSCs delivery was somehow effective by a few parameters, the IP delivery produced a superior response. The IP f-hPSCs treated mice lost only ~15% of their weight at the peak of the IBD effect, compared to ~25% in untreated mice. A reduction in the inflammatory response of the gut was also indicated by a decrease in neutrophil infiltration, as assayed by a myeloperoxidase (MPO) assay. Additionally, a significant improvement in the histological score of the gut and faster recovery to 90% of its original size was observed. These findings suggest that f-hPSC treatments could serve as an effective and safe anti-inflammatory and pro-regenerative treatment for IBD.<\/jats:p>","DOI":"10.3390\/ijms26073222","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T03:25:02Z","timestamp":1743391502000},"page":"3222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Potent Populations of Expanded Fetal Human Placental Stromal Cells for the Treatment of Dextran Sodium Sulfate-Induced Colitis in a Mouse Model"],"prefix":"10.3390","volume":"26","author":[{"given":"Raphael","family":"Gorodetsky","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astar","family":"Lazmi Hailu","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Volinsky","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boaz","family":"Adani","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Pappo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-4363","authenticated-orcid":false,"given":"Eran","family":"Israeli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3748\/wjg.v20.i5.1192","article-title":"Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?","volume":"20","author":"Hold","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.it.2013.07.001","article-title":"Impact of the gut microbiome on mucosal inflammation","volume":"34","author":"Strober","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cellimm.2013.11.003","article-title":"Crohn\u2019s disease: A review of treatment options and current research","volume":"286","author":"Bandzar","year":"2013","journal-title":"Cell. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/apt.14466","article-title":"Comparison of infliximab with adalimumab in 827 biologic-naive patients with Crohn\u2019s disease: A population-based Danish cohort study","volume":"47","author":"Singh","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1215734","article-title":"Vedolizumab as induction and maintenance therapy for ulcerative colitis","volume":"369","author":"Feagan","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa2314076","article-title":"Phase 2 trial of anti-TL1A monoclonal antibody Tulisokibart for ulcerative colitis","volume":"391","author":"Sands","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.4252\/wjsc.v12.i10.1050","article-title":"Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy","volume":"12","author":"Mishra","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/MIB.0b013e31827f27df","article-title":"Safety and tolerability of human placenta-derived cells (PDA001) in treatment-resistant crohn\u2019s disease: A phase 1 study","volume":"19","author":"Mayer","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pak, S., Hwang, S.W., Shim, I.K., Bae, S.M., Ryu, Y.M., Kim, H.B., Do, E.J., Son, H.N., Choi, E.J., and Park, S.H. (2018). Endoscopic transplantation of mesenchymal stem cell sheets in experimental colitis in rats. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-29617-x"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/mt.2016.140","article-title":"Mesenchymal stromal cells mitigate experimental colitis via insulin-like growth factor binding protein 7-mediated Immunosuppression","volume":"24","author":"Liao","year":"2016","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4252\/wjsc.v14.i1.117","article-title":"Stem cell therapy applied for digestive anastomosis: Current state and future perspectives","volume":"14","author":"Trebol","year":"2022","journal-title":"World J. Stem Cells"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2174\/1574888X16666210910112403","article-title":"Stem cell therapy for the treatment of Crohn\u2019s disease; Current obstacles and future hopes","volume":"17","year":"2022","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1097\/MIB.0000000000000441","article-title":"Human placenta-derived cells (PDA-001) for the treatment of moderate-to-severe Crohn\u2019s Disease: A Phase 1b\/2a Study, Inflamm","volume":"21","author":"Melmed","year":"2015","journal-title":"Bowel Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/sctm.17-0051","article-title":"Mesenchymal Stem Cells: Time to change the name!","volume":"6","author":"Caplan","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6","volume":"5","author":"Lee","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e66549","DOI":"10.1371\/journal.pone.0066549","article-title":"Mitigation of Lethal Radiation Syndrome in Mice by Intramuscular Injection of 3D Cultured Adherent Human Placental Stromal Cells","volume":"8","author":"Gaberman","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/s13287-020-01850-0","article-title":"Alleviation of acute radiation-induced bone marrow failure in mice with human fetal placental stromal cell therapy","volume":"11","author":"Volinsky","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cryobiol.2019.05.010","article-title":"Alleviation of severe skin insults following high-dose irradiation with isolated human fetal placental stromal cells","volume":"89","author":"Adani","year":"2022","journal-title":"Cryobiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/jcsm.12342","article-title":"Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells","volume":"9","author":"Pinzur","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Amend, B., Buttgereit, L., Abruzzese, T., Harland, N., Abele, H., Jakubowski, P., Stenzl, A., Gorodetsky, R., and Aicher, W.K. (2023). Regulation of immune checkpoint antigen CD276 (B7-H3) on human placenta-derived mesenchymal stromal cells in GMP-compliant cell culture media. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216422"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.5966\/sctm.2015-0363","article-title":"Placental stromal cell therapy for experimental autoimmune encephalomyelitis: The role of route of cell delivery","volume":"6","author":"Shapira","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s12015-020-10104-8","article-title":"Human amnion-derived mesenchymal stromal cells in cirrhotic patients with refractory ascites: A possible anti-inflammatory therapy for preventing spontaneous bacterial Peritonitis","volume":"17","author":"Pampalone","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12015-012-9385-4","article-title":"Phenotypic and functional characterization of mesenchymal stem cells from chorionic villi of human term placenta","volume":"9","author":"Abumaree","year":"2013","journal-title":"Stem Cell Rev."},{"key":"ref_24","first-page":"1551","article-title":"Extracellular vesicles derived from human placental mesenchymal stem cells alleviate experimental colitis in mice by inhibiting inflammation and oxidative stress","volume":"46","author":"Duan","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Eiro, N., Fraile, M., Gonzalez-Jubete, A., Gonzalez, L.O., and Vizoso, F.J. (2022). Mesenchymal (Stem) stromal Cells based as new therapeutic alternative in inflammatory bowel disease: Basic mechanisms. experimental and clinical evidence and challenges. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23168905"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"122189","DOI":"10.1016\/j.lfs.2023.122189","article-title":"Human umbilical cord mesenchymal stem cells alleviated TNBS-induced colitis in mice by restoring the balance of intestinal microbes and immunoregulation","volume":"334","author":"Fu","year":"2023","journal-title":"Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2174\/1574888X10666150528143138","article-title":"Mesenchymal stem cell therapy for inflammatory bowel diseases: Promise and challenge","volume":"10","author":"Ke","year":"2015","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s40259-024-00661-6","article-title":"Stem cells and stem cell-derived factors for the treatment of inflammatory bowel disease with a particular focus on perianal fistulizing disease: A Minireview on future perspectives","volume":"38","author":"Lightner","year":"2024","journal-title":"BioDrugs"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.7150\/thno.45434","article-title":"IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE(2)-mediated M2 macrophage polarization","volume":"10","author":"Cao","year":"2020","journal-title":"Theranostics"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bai, K., Li, X., Zhong, J., Ng, E.H.Y., Yeung, W.S.B., Lee, C.L., and Chiu, P.C.N. (2021). Placenta-derived exosomes as a modulator in maternal immune tolerance during pregnancy. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.671093"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sendon-Lago, J., Rio, L.G., Eiro, N., Diaz-Rodriguez, P., Avila, L., Gonzalez, L.O., Vizoso, F.J., Perez-Fernandez, R., and Landin, M. (2021). Tailored hydrogels as delivery platforms for conditioned medium from mesenchymal stem cells in a model of acute colitis in mice. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081127"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Perse, M., and Cerar, A. (2012). Dextran sodium sulphate colitis mouse model: Traps and tricks. J. Biomed. Biotechnol., 2012.","DOI":"10.1155\/2012\/718617"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"928461","DOI":"10.1155\/2014\/928461","article-title":"Role of Th17 cells in the pathogenesis of human IBD","volume":"2014","author":"Galvez","year":"2014","journal-title":"ISRN Inflamm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5184601","DOI":"10.1155\/2016\/5184601","article-title":"Phenotypic and functional characterization of mesenchymal stem\/multipotent stromal cells from Decidua Basalis of human term placenta","volume":"2016","author":"Abomaray","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bbrc.2019.01.123","article-title":"Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease","volume":"510","author":"Yi","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.placenta.2011.12.012","article-title":"The characterization of fibrocyte-like cells: A novel fibroblastic cell of the placenta","volume":"33","author":"Riddell","year":"2012","journal-title":"Placenta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.jtcvs.2013.09.041","article-title":"Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model","volume":"147","author":"Zhao","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bbamcr.2014.11.009","article-title":"Human placental eXpanded (PLX) mesenchymal-like adherent stromal cells confer neuroprotection to nerve growth factor (NGF)-differentiated PC12 cells exposed to ischemia by secretion of IL-6 and VEGF","volume":"1853","author":"Lahiani","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jamaneurol.2015.4321","article-title":"Safety and clinical effects of mesenchymal stem cells secreting neurotrophic factor transplantation in patients with amyotrophic lateral Sclerosis: Results of Phase 1\/2 and 2a Clinical Trials","volume":"73","author":"Petrou","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.placenta.2006.07.003","article-title":"The changing maternal \u201cself\u201d hypothesis: A mechanism for maternal tolerance of the fetus","volume":"28","author":"Adams","year":"2007","journal-title":"Placenta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1634\/stemcells.2006-0071","article-title":"Placenta-derived multipotent cells exhibit immunosuppressive properties that are enhanced in the presence of interferon-gamma","volume":"24","author":"Chang","year":"2006","journal-title":"Stem Cells"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gorodetsky, R., and Aicher, W.K. (2021). Allogenic use of human placenta-derived stromal cells as a highly active subtype of mesenchymal stromal cells for cell-based therapies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105302"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/ATVBAHA.110.217117","article-title":"Human placental pericytes poorly stimulate and actively regulate allogeneic CD4 T cell responses","volume":"31","author":"Maier","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_45","first-page":"154","article-title":"Latest findings on the placenta from the point of view of immunology. tolerance and mesenchymal stem cells, Ceska gynekologie\/Ceska lekarska spolecnost","volume":"84","author":"Macholdova","year":"2019","journal-title":"J. Ev. Purkyne"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000449091","article-title":"Mesenchymal Stromal Cell Therapy in Crohn\u2019s Disease","volume":"35","author":"Forbes","year":"2017","journal-title":"Dig Dis"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1634\/stemcells.2007-0491","article-title":"Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities","volume":"26","author":"Magatti","year":"2008","journal-title":"Stem Cells"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhao, X., Li, Z., Wang, W., Jiang, Y., Zhang, H., Liu, X., Ren, Y., Xu, X., and Hu, X. (2024). Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection. Commun Biol, 7.","DOI":"10.1038\/s42003-024-06365-5"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.placenta.2012.10.005","article-title":"Immunomodulatory molecules are released from the first trimester and term placenta via exosomes","volume":"33","author":"Kshirsagar","year":"2012","journal-title":"Placenta"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Chen, X., Zhao, X., Wang, H., Yang, Z., Li, J., and Suo, H. (2017). Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice. Nutrients, 9.","DOI":"10.3390\/nu9060545"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s003840050095","article-title":"Small bowel length in inflammatory bowel disease","volume":"12","author":"Nordgren","year":"1997","journal-title":"J. Colorect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10620-011-1878-5","article-title":"Intravenous injection of endogenous microbial components abrogates DSS-induced colitis","volume":"57","author":"Sydora","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00441-007-0504-5","article-title":"Human-placenta-derived mesenchymal stem cells inhibit proliferation and function of allogeneic immune cells","volume":"330","author":"Li","year":"2007","journal-title":"Cell Tissue Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1038\/cti.2014.5","article-title":"Human placenta-derived adherent cells induce tolerogenic immune responses","volume":"3","author":"Liu","year":"2014","journal-title":"Clin. Transl. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.placenta.2013.11.002","article-title":"Review: Placenta-specific microRNAs in exosomes\u2014Good things come in nano-packages","volume":"35","author":"Ouyang","year":"2014","journal-title":"Placenta"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41409-023-02068-3","article-title":"Placental expanded mesenchymal-like cells (PLX-R18) for poor graft function after hematopoietic cell transplantation: A phase I study","volume":"58","author":"McGuirk","year":"2023","journal-title":"Bone Marrow Transpl."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/3222\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:06:09Z","timestamp":1760029569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/3222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,30]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26073222"],"URL":"https:\/\/doi.org\/10.3390\/ijms26073222","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,30]]}}}