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Carboxymethylcellulose (CMC) and chitosan (CHS) membranes were fabricated with 7% glycerol and 1% doxycycline (DOX). Their mechanical and physical properties, biocompatibility, and antimicrobial effects were thoroughly evaluated. The results demonstrated effective antibacterial activity against S. aureus and S. mutans. Based on the mechanical, physical, and hemolytic data, DOX-loaded CMC\/CHS\/G membranes show promise as a topical wound delivery system.<\/jats:p>","DOI":"10.3390\/ijms26073274","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T08:21:41Z","timestamp":1743495701000},"page":"3274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antibacterial Properties of Polymeric Membranes Containing Doxycycline for Potential Applications in Foot Ulcer Treatment"],"prefix":"10.3390","volume":"26","author":[{"given":"Stevaly","family":"P\u00e9rez-Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Meritorious Autonomous University of Puebla (BUAP), Puebla 72410, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas \u00c1ngel","family":"Ram\u00edrez-Enciso","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Meritorious Autonomous University of Puebla (BUAP), Puebla 72410, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-4012","authenticated-orcid":false,"given":"Laura Abisai","family":"Pazos-Rojas","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology, Meritorious Autonomous University of Puebla (BUAP), Puebla 72410, Mexico"},{"name":"Tecnol\u00f3gico de Monterrey, Escuela de Ingenier\u00eda y Ciencias, Puebla 72453, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-4820","authenticated-orcid":false,"given":"Abigailt","family":"Flores-Ledesma","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology, Meritorious Autonomous University of Puebla (BUAP), Puebla 72410, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Reyes-Cervantes","sequence":"additional","affiliation":[{"name":"Direccion de Innovaci\u00f3n y Transferencia de Conocimiento, Meritorious Autonomous University of Puebla, Puebla 72592, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana del C.","family":"Pazos-Guarneros","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology, Meritorious Autonomous University of Puebla (BUAP), Puebla 72410, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael","family":"Ju\u00e1rez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology, Meritorious Autonomous University of Puebla (BUAP), Puebla 72410, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4600-5574","authenticated-orcid":false,"given":"Paola G.","family":"Gordillo-Guerra","sequence":"additional","affiliation":[{"name":"Departamento de Sistemas Biol\u00f3gicos, Unidad Xochimilco, Universidad Aut\u00f3noma Metropolitana, Coyoacan, Calzada del Hueso 1100, Col. 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