{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:37:56Z","timestamp":1788975476082,"version":"build-2803163510"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the key scientific research project of Henan Province","award":["25A180021"],"award-info":[{"award-number":["25A180021"]}]},{"name":"the key scientific research project of Henan Province","award":["30500424"],"award-info":[{"award-number":["30500424"]}]},{"name":"the key scientific research project of Henan Province","award":["30501299"],"award-info":[{"award-number":["30501299"]}]},{"name":"the special support fund for high-level talents of Henan Agricultural University","award":["25A180021"],"award-info":[{"award-number":["25A180021"]}]},{"name":"the special support fund for high-level talents of Henan Agricultural University","award":["30500424"],"award-info":[{"award-number":["30500424"]}]},{"name":"the special support fund for high-level talents of Henan Agricultural University","award":["30501299"],"award-info":[{"award-number":["30501299"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epithelial ovarian cancer (EOC) is a gynecological tumor with high mortality. Despite aggressive treatment, survival rates for patients with advanced EOC are low, and more effective methods of diagnosis and treatment are urgently needed. Inflammation and cancer are strongly associated; however, the mechanisms that mediate this relationship are not fully understood. In this study, we found that the expression of interleukin-1\u03b2 (IL-1\u03b2), a proinflammatory cytokine, increased in an ovarian cancer tissue microarray (TMA) and inhibited A2780 and SKOV3 cell viability and metastasis. Recombinant IL-1\u03b2 protein and the overexpression of IL-1\u03b2 decreased the proliferation and metastasis of ovarian cancer cells. IL-1\u03b2 deficiency promoted proliferation and metastasis. Moreover, transcriptome sequencing revealed that IL-1\u03b2 downregulates the expression of matrix metalloproteinase 12 (MMP12). The signaling pathway involving MAPK\/AP-1\/MMP12 is involved in IL-1\u03b2-regulated ovarian cancer progression. Overall, we found that the proinflammatory cytokine IL-1\u03b2 inhibits ovarian cancer cell viability and metastasis. These findings provided deeper insights into inflammation and cancer progression.<\/jats:p>","DOI":"10.3390\/ijms26073287","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T04:06:05Z","timestamp":1743566765000},"page":"3287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin-1\u03b2 Inhibits Ovarian Cancer Cell Proliferation and Metastasis Through the MAPK\/MMP12 Pathway"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4791-928X","authenticated-orcid":false,"given":"Zhenling","family":"Ma","sequence":"first","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulu","family":"Han","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanxiang","family":"Lei","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, X.M., Yang, K., and Tong, W.H. 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