{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:40:43Z","timestamp":1780774843898,"version":"3.54.1"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["82301907"],"award-info":[{"award-number":["82301907"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2024A1515030279"],"award-info":[{"award-number":["2024A1515030279"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["JCYJ20220818101218040"],"award-info":[{"award-number":["JCYJ20220818101218040"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["JCYJ20220818102811025"],"award-info":[{"award-number":["JCYJ20220818102811025"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["0099\/2022\/AFJ"],"award-info":[{"award-number":["0099\/2022\/AFJ"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["0061\/2022\/A"],"award-info":[{"award-number":["0061\/2022\/A"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Medical Research Fund","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}]},{"name":"Shenzhen Medical Research Fund","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}]},{"name":"Shenzhen Medical Research Fund","award":["82301907"],"award-info":[{"award-number":["82301907"]}]},{"name":"Shenzhen Medical Research Fund","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}]},{"name":"Shenzhen Medical Research Fund","award":["2024A1515030279"],"award-info":[{"award-number":["2024A1515030279"]}]},{"name":"Shenzhen Medical Research Fund","award":["JCYJ20220818101218040"],"award-info":[{"award-number":["JCYJ20220818101218040"]}]},{"name":"Shenzhen Medical Research Fund","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}]},{"name":"Shenzhen Medical Research Fund","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}]},{"name":"Shenzhen Medical Research Fund","award":["JCYJ20220818102811025"],"award-info":[{"award-number":["JCYJ20220818102811025"]}]},{"name":"Shenzhen Medical Research Fund","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}]},{"name":"Shenzhen Medical Research Fund","award":["0099\/2022\/AFJ"],"award-info":[{"award-number":["0099\/2022\/AFJ"]}]},{"name":"Shenzhen Medical Research Fund","award":["0061\/2022\/A"],"award-info":[{"award-number":["0061\/2022\/A"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301907"],"award-info":[{"award-number":["82301907"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024A1515030279"],"award-info":[{"award-number":["2024A1515030279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ20220818101218040"],"award-info":[{"award-number":["JCYJ20220818101218040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ20220818102811025"],"award-info":[{"award-number":["JCYJ20220818102811025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["0099\/2022\/AFJ"],"award-info":[{"award-number":["0099\/2022\/AFJ"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["0061\/2022\/A"],"award-info":[{"award-number":["0061\/2022\/A"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["82301907"],"award-info":[{"award-number":["82301907"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2024A1515030279"],"award-info":[{"award-number":["2024A1515030279"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["JCYJ20220818101218040"],"award-info":[{"award-number":["JCYJ20220818101218040"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["JCYJ20220818102811025"],"award-info":[{"award-number":["JCYJ20220818102811025"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["0099\/2022\/AFJ"],"award-info":[{"award-number":["0099\/2022\/AFJ"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["0061\/2022\/A"],"award-info":[{"award-number":["0061\/2022\/A"]}]},{"name":"Shenzhen Science and Technology Program","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}]},{"name":"Shenzhen Science and Technology Program","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}]},{"name":"Shenzhen Science and Technology Program","award":["82301907"],"award-info":[{"award-number":["82301907"]}]},{"name":"Shenzhen Science and Technology Program","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}]},{"name":"Shenzhen Science and Technology Program","award":["2024A1515030279"],"award-info":[{"award-number":["2024A1515030279"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220818101218040"],"award-info":[{"award-number":["JCYJ20220818101218040"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220818102811025"],"award-info":[{"award-number":["JCYJ20220818102811025"]}]},{"name":"Shenzhen Science and Technology Program","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}]},{"name":"Shenzhen Science and Technology Program","award":["0099\/2022\/AFJ"],"award-info":[{"award-number":["0099\/2022\/AFJ"]}]},{"name":"Shenzhen Science and Technology Program","award":["0061\/2022\/A"],"award-info":[{"award-number":["0061\/2022\/A"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["82301907"],"award-info":[{"award-number":["82301907"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["2024A1515030279"],"award-info":[{"award-number":["2024A1515030279"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["JCYJ20220818101218040"],"award-info":[{"award-number":["JCYJ20220818101218040"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["JCYJ20220818102811025"],"award-info":[{"award-number":["JCYJ20220818102811025"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["0099\/2022\/AFJ"],"award-info":[{"award-number":["0099\/2022\/AFJ"]}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["0061\/2022\/A"],"award-info":[{"award-number":["0061\/2022\/A"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["82301907"],"award-info":[{"award-number":["82301907"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["2024A1515030279"],"award-info":[{"award-number":["2024A1515030279"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["JCYJ20220818101218040"],"award-info":[{"award-number":["JCYJ20220818101218040"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["JCYJ20220818102811025"],"award-info":[{"award-number":["JCYJ20220818102811025"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["0099\/2022\/AFJ"],"award-info":[{"award-number":["0099\/2022\/AFJ"]}]},{"name":"The Science and Technology Development Fund, Macau SAR","award":["0061\/2022\/A"],"award-info":[{"award-number":["0061\/2022\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ovarian endometriosis (OEM) is a chronic inflammatory condition that impairs ovarian function. While its effects on ovarian reserve are well established, the long-term consequences of OEM on ovarian dysfunction, premature ovarian failure (POF), and systemic health, particularly in the context of accelerated aging, remain insufficiently studied. In this study, we employed an OEM mouse model and bulk RNA sequencing to investigate the underlying mechanisms. Our results show that OEM accelerates primordial follicle depletion and upregulates mTOR signaling pathway gene expression, along with mechanical stress and paracrine signaling via the Hippo and Myc pathways. OEM also induces irregular estrus and ovarian fibrosis in aging mice, decreases serum AMH levels, and increases FSH levels. Systemically, elevated serum IgG levels contribute to osteoporosis and cognitive decline, both linked to ovarian dysfunction and POF in OEM. These findings elucidate the mechanisms driving premature ovarian reserve depletion in OEM and highlight its broader systemic effects. This study emphasizes the importance of monitoring ovarian health and ectopic tissue to safeguard ovarian reserves and mitigate long-term risks such as osteoporosis and cognitive decline.<\/jats:p>","DOI":"10.3390\/ijms26073313","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T16:19:16Z","timestamp":1743610756000},"page":"3313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ovarian Endometriosis Accelerates Premature Ovarian Failure and Contributes to Osteoporosis and Cognitive Decline in Aging Mice"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3152-6440","authenticated-orcid":false,"given":"Lei","family":"Ge","sequence":"first","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxia","family":"Xiao","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen 518000, China"},{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-2033","authenticated-orcid":false,"given":"Wakam","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Du","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-8327","authenticated-orcid":false,"given":"Ming","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1427-8957","authenticated-orcid":false,"given":"Jian V.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen 518000, China"},{"name":"Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen 518028, China"},{"name":"Sino-European Center of Biomedicine and Health, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: Pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.fertnstert.2007.11.020","article-title":"Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis","volume":"91","author":"Greene","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.5935\/1518-0557.20220051","article-title":"Stages of endometriosis: Does it affect oocyte quality, embryo development and fertilization rate?","volume":"26","author":"Esmaeilzadeh","year":"2022","journal-title":"JBRA Assist. Reprod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1210\/jc.2019-00281","article-title":"Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway","volume":"104","author":"Takeuchi","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.fertnstert.2013.12.049","article-title":"Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas","volume":"101","author":"Kitajima","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ge, L., Yang, Y., Gao, Y., Xiao, T., Chang, W., Wang, H., Xiao, Z., Chen, J., Li, M., and Yu, M. (2025). Ovarian Endometrioma Disrupts Oocyte-Cumulus Communication and Mitochondrial Function. Cell Prolif., e13800.","DOI":"10.1111\/cpr.13800"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sreerangaraja Urs, D.B., Wu, W.H., Komrskova, K., Postlerova, P., Lin, Y.F., Tzeng, C.R., and Kao, S.H. (2020). Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103592"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.fertnstert.2018.03.015","article-title":"Endometrioma-related reduction in ovarian reserve (ERROR): A prospective longitudinal study","volume":"110","author":"Kasapoglu","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/humupd\/dmac045","article-title":"Anti-Mullerian hormone for the diagnosis and prediction of menopause: A systematic review","volume":"29","author":"Nelson","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.fertnstert.2018.06.025","article-title":"Antimullerian hormone is reduced in the presence of ovarian endometriomas: A systematic review and meta-analysis","volume":"110","author":"Muzii","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jad.2024.04.019","article-title":"Osteoporosis and depression in perimenopausal women: From clinical association to genetic causality","volume":"356","author":"Guo","year":"2024","journal-title":"J. Affect. Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e072612","DOI":"10.1136\/bmj-2022-072612","article-title":"Management of perimenopausal and menopausal symptoms","volume":"382","author":"Duralde","year":"2023","journal-title":"BMJ"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/jamacardio.2016.2415","article-title":"Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality: A Systematic Review and Meta-analysis","volume":"1","author":"Muka","year":"2016","journal-title":"JAMA Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1007\/s11357-023-00768-8","article-title":"Ovarian aging in humans: Potential strategies for extending reproductive lifespan","volume":"45","author":"Cavalcante","year":"2023","journal-title":"Geroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/EBC20240028","article-title":"Steroid metabolism and hormonal dynamics in normal and malignant ovaries","volume":"68","author":"Beevors","year":"2024","journal-title":"Essays Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1016\/j.cell.2024.10.019","article-title":"Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging","volume":"187","author":"Ma","year":"2024","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1210\/jc.2005-1836","article-title":"Hormone predictors of bone mineral density changes during the menopausal transition","volume":"91","author":"Sowers","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neurobiolaging.2018.04.004","article-title":"Sexual dimorphism in predisposition to Alzheimer\u2019s disease","volume":"70","author":"Fisher","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41586-022-04463-0","article-title":"FSH blockade improves cognition in mice with Alzheimer\u2019s disease","volume":"603","author":"Xiong","year":"2022","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"R145","DOI":"10.1530\/REP-20-0265","article-title":"Hyperactivation of dormant primordial follicles in ovarian endometrioma patients","volume":"160","author":"Matsuzaki","year":"2020","journal-title":"Reproduction"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1152\/physrev.00032.2022","article-title":"Making a good egg: Human oocyte health, aging, and in vitro development","volume":"103","author":"Telfer","year":"2023","journal-title":"Physiol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tan, Z., Gong, X., Wang, C.C., Zhang, T., and Huang, J. (2023). Diminished Ovarian Reserve in Endometriosis: Insights from In Vitro, In Vivo, and Human Studies-A Systematic Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115967"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/er.2018-00242","article-title":"Endometriosis","volume":"40","author":"Bulun","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41574-022-00725-z","article-title":"Strategies for modelling endometrial diseases","volume":"18","author":"Murphy","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41574-020-0335-y","article-title":"The role of cellular senescence in ageing and endocrine disease","volume":"16","author":"Khosla","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/humupd\/dmv012","article-title":"Risks of conservative management in women with ovarian endometriomas undergoing IVF","volume":"21","author":"Somigliana","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102496","DOI":"10.1016\/j.bpobgyn.2024.102496","article-title":"Impact of surgery for endometriosis on the outcomes of in vitro fertilization","volume":"95","author":"Ferrero","year":"2024","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s43032-022-00932-z","article-title":"Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen in the Ovary","volume":"30","author":"Xiao","year":"2023","journal-title":"Reprod. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humupd\/dmac031","article-title":"Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: Implications for fertility","volume":"29","author":"Fiorentino","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"eabn4564","DOI":"10.1126\/sciadv.abn4564","article-title":"Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary","volume":"8","author":"Umehara","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hayashi, S., Nakamura, T., Motooka, Y., Ito, F., Jiang, L., Akatsuka, S., Iwase, A., Kajiyama, H., Kikkawa, F., and Toyokuni, S. (2020). Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice. Redox Biol., 37.","DOI":"10.1016\/j.redox.2020.101726"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1530\/REP-16-0129","article-title":"Reproductive age-associated fibrosis in the stroma of the mammalian ovary","volume":"152","author":"Briley","year":"2016","journal-title":"Reproduction"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/endrev\/bnab012","article-title":"Anti-Mullerian Hormone in Female Reproduction","volume":"42","author":"Racine","year":"2021","journal-title":"Endocr. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1210\/clinem\/dgac039","article-title":"Evaluation of Female Fertility-AMH and Ovarian Reserve Testing","volume":"107","author":"Cedars","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1111\/jog.12830","article-title":"Surgical excision of ovarian endometriomas: Does it truly impair ovarian reserve? Long term anti-Mullerian hormone (AMH) changes after surgery","volume":"41","author":"Vignali","year":"2015","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ajog.2021.06.102","article-title":"Endometrioma surgery\u2014A systematic review and meta-analysis of the effect on antral follicle count and anti-Mullerian hormone","volume":"226","author":"Younis","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijgo.2011.07.026","article-title":"Follicle loss after laparoscopic treatment of ovarian endometriotic cysts","volume":"115","author":"Shi","year":"2011","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/humrep\/deu199","article-title":"The effect of surgery for endometrioma on ovarian reserve evaluated by antral follicle count: A systematic review and meta-analysis","volume":"29","author":"Muzii","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.fertnstert.2015.01.032","article-title":"Second surgery for recurrent unilateral endometriomas and impact on ovarian reserve: A case-control study","volume":"103","author":"Ferrero","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: Clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ajog.2019.02.033","article-title":"Assessing research gaps and unmet needs in endometriosis","volume":"221","author":"Black","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cmet.2024.01.015","article-title":"IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline","volume":"36","author":"Yu","year":"2024","journal-title":"Cell Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/uog.24892","article-title":"Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research","volume":"60","author":"Pascoal","year":"2022","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e13174","DOI":"10.1111\/cpr.13174","article-title":"LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation","volume":"55","author":"Peng","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Al-Daghestani, H., Qaisar, R., Al Kawas, S., Ghani, N., Rani, K.G.A., Azeem, M., Hasnan, H.K., Kassim, N.K., and Samsudin, A.R. (2024). Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-54944-7"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Yoshizaki, K., Furuse, T., Kimura, R., Tucci, V., Kaneda, H., Wakana, S., and Osumi, N. (2016). Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene\/Environment Interaction in Understanding Neurodevelopmental Disorders. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166665"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1523\/JNEUROSCI.2718-07.2007","article-title":"Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice","volume":"27","author":"Carroll","year":"2007","journal-title":"J. Neurosci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/3313\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:08:46Z","timestamp":1760029726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/3313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26073313"],"URL":"https:\/\/doi.org\/10.3390\/ijms26073313","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]}}}