{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:37:41Z","timestamp":1760441861213,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o da UFPA (PROPESP)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multiple myeloma ranks as the second most common hematopoietic malignancy in terms of both incidence and mortality. Prognostic stratification is critical for optimizing therapeutic strategies, as certain genetic alterations can significantly influence disease progression and treatment response. The meta-analysis analyzed data from 3421 multiple myeloma patients and 14,720 controls. PubMed, Web of Science, and Scopus were used as databases. Associations between the SNPs and multiple myeloma were calculated as a measure of pooled odds ratios (ORs) and 95% confidence intervals. Statistical analysis was performed using Review Manager (RevMan). DNAH11 rs4487645 A\/C genotype (OR = 1.35; 95% CI: 1.24\u20131.46; p &lt; 0.00001; I2 = 0%), ULK4 rs1052501 G\/G genotype (OR = 1.21; 95% CI: 0.98\u20131.50; p = 0.08; I2 = 64%), ULK4 rs1052501 A\/G genotype (OR = 1.23; 95% CI: 1.13\u20131.34; p &lt; 0.00001; I2 = 0%), DTNB rs6746082 A\/A genotype (OR = 1.10; 95% CI: 1.01\u20131.20; p = 0.03; I2 = 45%), and VDR rs1544410 A\/G genotype (OR = 1.87; 95% CI: 1.04\u20133.36; p = 0.04; I2 = 0%) increased multiple myeloma risk. Our study concludes that DNAH11, ULK4, DTNB, and VDR may serve as predictive biomarkers for MM risk.<\/jats:p>","DOI":"10.3390\/ijms26073369","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:52:56Z","timestamp":1743749576000},"page":"3369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Single-Nucleotide Polymorphisms Related to Multiple Myeloma Risk: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"26","author":[{"given":"Giovanna","family":"Gilioli da Costa Nunes","sequence":"first","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"},{"name":"Faculty of Medicine, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Cezar Aquino de Moraes","sequence":"additional","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"},{"name":"Faculty of Medicine, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6714-6165","authenticated-orcid":false,"given":"Aline Beatriz","family":"Carvalho de Almeida","sequence":"additional","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"},{"name":"Faculty of Medicine, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Goes Costa","sequence":"additional","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"},{"name":"Faculty of Medicine, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Fernando","family":"Duarte de Andrade Junior","sequence":"additional","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"},{"name":"Faculty of Medicine, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vit\u00f3ria","family":"Sabino Hupp","sequence":"additional","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"},{"name":"Faculty of Medicine, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruan","family":"Rotondano Assun\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-3442","authenticated-orcid":false,"given":"Marianne","family":"Rodrigues Fernandes","sequence":"additional","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8622-9417","authenticated-orcid":false,"given":"Sidney","family":"Emanuel Batista dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Human and Medical Genetics, Institute of Biological Science, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66077-830, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ney","family":"Pereira Carneiro dos Santos","sequence":"additional","affiliation":[{"name":"Research Center of Oncology, Federal University of Par\u00e1 Bel\u00e9m, Bel\u00e9m 66073-000, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2478\/ahp-2020-0035","article-title":"Monoclonal gammopathies of undetermined significance and smoldering myeloma","volume":"51","author":"Jurczyszyn","year":"2020","journal-title":"Acta Haematol. 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