{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:04:02Z","timestamp":1788912242924,"version":"build-2803163510"},"reference-count":78,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360952"],"award-info":[{"award-number":["82360952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["gzwkj2021-543"],"award-info":[{"award-number":["gzwkj2021-543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guizhou Provincial Health Commission Science and Technology Fund Project","award":["82360952"],"award-info":[{"award-number":["82360952"]}]},{"name":"Guizhou Provincial Health Commission Science and Technology Fund Project","award":["gzwkj2021-543"],"award-info":[{"award-number":["gzwkj2021-543"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The global rise in aging populations has made healthy longevity a critical priority in medical research. 2,3,5,4\u2032-Tetrahydroxystilbene-2-O-\u03b2-D-glucoside (TSG), the primary bioactive component of Polygonum multiflorum Thunb. (commonly known as Fallopia multiflora Thunb., He shou wu, Fo-ti, or Polygoni multiflori radix), has emerged as a promising agent for combating aging and age-related diseases. This systematic review evaluates the anti-aging properties of TSG and its protective effects against age-related pathologies. The current evidence demonstrates that TSG exhibits comprehensive anti-aging effects, including lifespan extension, neuroprotection (e.g., ameliorating Alzheimer\u2019s and Parkinson\u2019s diseases), cardiovascular protection (e.g., reducing atherosclerosis and hypertension), delay of gonadal aging, reduction in bone loss (e.g., mitigating osteoporosis), and promotion of hair regrowth. Mechanistically, TSG alleviates oxidative stress, inflammation, and apoptosis while enhancing mitophagy, mitochondrial function telomerase activity, and epigenetic regulation. These multi-target actions align with the holistic principles of traditional Chinese medicine, highlighting TSG\u2019s potential as a multifaceted anti-aging agent. However, further research is required to establish standardized quantitative systems for evaluating TSG\u2019s efficacy, paving the way for its broader clinical application in promoting healthy aging.<\/jats:p>","DOI":"10.3390\/ijms26073381","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:52:56Z","timestamp":1743749576000},"page":"3381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["2,3,5,4\u2032-Tetrahydroxystilbene-2-O-\u03b2-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-2788","authenticated-orcid":false,"given":"Can","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhong","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfu","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jacc.2019.12.033","article-title":"The Alzheimer\u2019s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar","volume":"75","author":"Stakos","year":"2020","journal-title":"J. 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