{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:23:44Z","timestamp":1790889824564,"version":"4.1.0"},"reference-count":155,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Fund for Regenerative Medicine","award":["23C0125L1"],"award-info":[{"award-number":["23C0125L1"]}]},{"name":"Korean Fund for Regenerative Medicine","award":["24D0102L1"],"award-info":[{"award-number":["24D0102L1"]}]},{"name":"Ministry of Science and ICT","award":["23C0125L1"],"award-info":[{"award-number":["23C0125L1"]}]},{"name":"Ministry of Science and ICT","award":["24D0102L1"],"award-info":[{"award-number":["24D0102L1"]}]},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["23C0125L1"],"award-info":[{"award-number":["23C0125L1"]}]},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["24D0102L1"],"award-info":[{"award-number":["24D0102L1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hair loss disorders pose a substantial global health burden, affecting millions of individuals and significantly impacting quality of life. Despite the widespread use of approved therapeutics like minoxidil and finasteride, their clinical efficacy remains limited. These challenges underscore the pressing need for more targeted and effective therapeutic solutions. This review examines the latest innovations in hair loss drug discovery, with a focus on small-molecule inhibitors, biologics, and stem cell-based therapies. By integrating insights from molecular mechanisms and leveraging advancements in research methods, the development of next-generation therapeutics holds the potential to transform the clinical management of hair loss disorders. Future drug development for hair loss disorders should prioritize antibody therapy and cell-based treatments, as these approaches offer unprecedented opportunities to address the limitations of existing options. Antibody therapies enable precise targeting of key molecular pathways involved in hair follicle regulation, providing highly specific and effective interventions. Similarly, cell-based therapies, including stem cell transplantation and dermal papilla cell regeneration, directly address the regenerative capacity of hair follicles, offering transformative potential for hair restoration.<\/jats:p>","DOI":"10.3390\/ijms26083461","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T09:47:55Z","timestamp":1744105675000},"page":"3461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Recent Advances in Drug Development for Hair Loss"],"prefix":"10.3390","volume":"26","author":[{"given":"Jino","family":"Kim","sequence":"first","affiliation":[{"name":"New Hair Institute, Seoul 06034, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3145-7463","authenticated-orcid":false,"given":"Seung-Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul 06134, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hyuk","family":"Sung","sequence":"additional","affiliation":[{"name":"Epi Biotech Co., Ltd., Incheon 21983, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1080\/17460441.2024.2409660","article-title":"Innovative strategies for the discovery of new drugs against alopecia areata: Taking aim at the immune system","volume":"19","author":"Guo","year":"2024","journal-title":"Expert. 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