{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:09:26Z","timestamp":1760058566137,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009543","name":"Pontificia Universidad Javeriana","doi-asserted-by":"publisher","award":["20644","94314"],"award-info":[{"award-number":["20644","94314"]}],"id":[{"id":"10.13039\/501100009543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Minciencias Bogot\u00e1","award":["20644","94314"],"award-info":[{"award-number":["20644","94314"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Extracellular vesicles (EVs) are small capsular bodies released by cells, mediating responses in intercellular communication. The role of EVs in A\u03b2 pathology spreading in the Alzheimer\u2019s disease (AD) brain has been evidenced, although whether this occurs due to the co-transportation of A\u03b2 peptides or contribution of other factors, such as EV-associated transcripts, remains uncertain. In vitro studies of miRNA cargo in neuron-derived extracellular vesicles (NDEVs) show that A\u03b2 hyperexpression alters the transcriptomic profile; however, it is not clear to what extent this causes changes at the organ level. By utilizing datasets from published studies, we generated competing endogenous RNA (ceRNA) networks for miRNAs co-expressed in NDEVs and the brain in different stages of pathology, using both an APP overexpressing neuronal model (in vitro) and brain cortices from 6- and 9-month-old APP\/PSEN1 mice (in vivo). Networks integrating information from mRNAs, lncRNAs, and circRNAs showed two candidate lncRNAs (Kcnq1ot1 and Gm42969) and a circRNA (Pum1), while enrichment analyses detected that NDEVs miRNAs signal to other CNS cells and that this signal can be disrupted by A\u03b2 pathology, contributing to the loss of long-term potentiation seen in early AD.<\/jats:p>","DOI":"10.3390\/ijms26083544","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:05:56Z","timestamp":1744200356000},"page":"3544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular Competing Endogenous RNA Networks Reveal Key Regulators of Early Amyloid Pathology Propagation in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2676-2292","authenticated-orcid":false,"given":"Misael Leonardo","family":"L\u00f3pez-Cepeda","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Angarita-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"},{"name":"Laboratorio de Bioinform\u00e1tica y Biolog\u00eda de Sistemas, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-0914","authenticated-orcid":false,"given":"Alexis Felipe","family":"Rojas-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8164-0330","authenticated-orcid":false,"given":"Juli\u00e1n","family":"P\u00e9rez Mejia","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Khatri","sequence":"additional","affiliation":[{"name":"Institute of Medical Systems Bioinformatics, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brehler","sequence":"additional","affiliation":[{"name":"Institute of Medical Systems Bioinformatics, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-559X","authenticated-orcid":false,"given":"Eduardo","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Communication & Extracellular Vesicles, Instituto Nacional de Medicina Gen\u00f3mica, Mexico City 14610, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Pinz\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioinform\u00e1tica y Biolog\u00eda de Sistemas, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-4867","authenticated-orcid":false,"given":"Andr\u00e9s Felipe","family":"Aristizabal-Pachon","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2009-3374","authenticated-orcid":false,"given":"Janneth","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 Pathway in Alzheimer\u2019s Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. 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