{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:30:26Z","timestamp":1789079426381,"version":"build-2803163510"},"reference-count":212,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Hubei Province","award":["2024AFB537"],"award-info":[{"award-number":["2024AFB537"]}]},{"name":"Natural Science Foundation of Hubei Province","award":["32400623"],"award-info":[{"award-number":["32400623"]}]},{"name":"Natural Science Foundation of Hubei Province","award":["2023107002001038"],"award-info":[{"award-number":["2023107002001038"]}]},{"name":"National Natural Science Foundation of China","award":["2024AFB537"],"award-info":[{"award-number":["2024AFB537"]}]},{"name":"National Natural Science Foundation of China","award":["32400623"],"award-info":[{"award-number":["32400623"]}]},{"name":"National Natural Science Foundation of China","award":["2023107002001038"],"award-info":[{"award-number":["2023107002001038"]}]},{"name":"Horizontal Project of Hubei Provincial Hospital of Traditional Chinese Medicine","award":["2024AFB537"],"award-info":[{"award-number":["2024AFB537"]}]},{"name":"Horizontal Project of Hubei Provincial Hospital of Traditional Chinese Medicine","award":["32400623"],"award-info":[{"award-number":["32400623"]}]},{"name":"Horizontal Project of Hubei Provincial Hospital of Traditional Chinese Medicine","award":["2023107002001038"],"award-info":[{"award-number":["2023107002001038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Skeletal muscle development is a complex biological process regulated by many factors, such as transcription factors, signaling pathways, and epigenetic modifications. Histone modifications are important epigenetic regulatory factors involved in various biological processes, including skeletal muscle development, and play a crucial role in the pathogenesis of skeletal muscle diseases. Histone modification regulators affect the expression of many genes involved in skeletal muscle development and disease by adding or removing certain chemical modifications. In this review, we comprehensively summarize the functions and regulatory activities of the histone modification regulators involved in skeletal muscle development, regeneration, and disease.<\/jats:p>","DOI":"10.3390\/ijms26083644","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T06:18:36Z","timestamp":1744611516000},"page":"3644","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Functions and Regulatory Mechanisms of Histone Modifications in Skeletal Muscle Development and Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Zining","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, School of Life Sciences, Hubei University, Wuhan 430062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqing","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, School of Life Sciences, Hubei University, Wuhan 430062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, School of Life Sciences, Hubei University, Wuhan 430062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105807","DOI":"10.1016\/j.phrs.2021.105807","article-title":"Skeletal muscle atrophy: From mechanisms to treatments","volume":"172","author":"Yin","year":"2021","journal-title":"Pharmacol. 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