{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:35:46Z","timestamp":1789745746600,"version":"4.0.1"},"reference-count":102,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Croatian Ministry of Science and Education","award":["IP7-FDMZ-2023"],"award-info":[{"award-number":["IP7-FDMZ-2023"]}]},{"name":"Croatian Ministry of Science and Education","award":["IP-FDMZ-2024.2025-09"],"award-info":[{"award-number":["IP-FDMZ-2024.2025-09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hashimoto\u2019s thyroiditis (HT) is an autoimmune disorder of the thyroid gland characterized by chronic inflammation, which in most cases results in hypothyroidism. The melatonin receptor MTNR1B is sporadically expressed in the thyroid gland. It modulates immune responses, and alterations in the melatonin\u2013MTNR1B receptor signaling pathway may play a role in developing autoimmune diseases. Obesity worsens the severity and progression of some autoimmune diseases and reduces treatment efficacy. This study aimed to investigate the association of MTNR1B gene polymorphisms (rs10830963, rs1387153, and rs4753426) with HT with regards to the body mass index (BMI). Patients with HT were categorized into normal weight BMI \u2264 25 kg\/m2 and overweight\/obese BMI &gt; 25 kg\/m2 groups. This study included 115 patients with a clinical-, ultrasound-, and laboratory-confirmed diagnosis of HT (64 normal-weight patients and 51 overweight\/obese patients) with a mean age of 43 \u00b1 12 years. The results showed that specific MTNR1B polymorphisms are associated with obesity in HT patients. BMI was found to be associated with the rs10830963 polymorphism, and the G allele and GG genotype of the rs10830963 polymorphism were more common in overweight\/obese HT patients. Furthermore, the results suggest that genetic factors associated with BMI play a role in developing HT and open new possibilities for personalized treatment approaches.<\/jats:p>","DOI":"10.3390\/ijms26083667","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T06:18:36Z","timestamp":1744611516000},"page":"3667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of MTNR1B Gene Polymorphisms with Body Mass Index in Hashimoto\u2019s Thyroiditis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-930X","authenticated-orcid":false,"given":"Ivana","family":"\u0160krlec","sequence":"first","affiliation":[{"name":"Faculty of Dental Medicine and Health, University J. J. Strossmayer Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3245-001X","authenticated-orcid":false,"given":"Zrinka","family":"Biloglav","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Epidemiology and Medical Informatics, School of Public Health Andrija \u0160tampar, 10000 Zagreb, Croatia"},{"name":"School of Medicine, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Le\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Fizio Educa, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-0807","authenticated-orcid":false,"given":"Jasminka","family":"Talapko","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Health, University J. J. Strossmayer Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6380-1460","authenticated-orcid":false,"given":"Igor","family":"\u017dabi\u0107","sequence":"additional","affiliation":[{"name":"County Hospital Koprivnica, 48000 Koprivnica, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-338X","authenticated-orcid":false,"given":"Darko","family":"Katalini\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Health, University J. J. Strossmayer Osijek, 31000 Osijek, Croatia"},{"name":"Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mikulska, A.A., Kara\u017aniewicz-\u0142ada, M., Filipowicz, D., Rucha\u0142a, M., and G\u0142\u00f3wka, F.K. (2022). Metabolic Characteristics of Hashimoto\u2019s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management\u2014An Overview. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126580"},{"key":"ref_2","first-page":"710","article-title":"Spectrum of Hashimoto\u2019s Thyroiditis: Clinical, Biochemical & Cytomorphologic Profile","volume":"140","author":"Sanyal","year":"2014","journal-title":"Indian J. Med. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wang, S.H., and Baker, J.R. (2008). 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