{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:40:25Z","timestamp":1781617225418,"version":"3.54.5"},"reference-count":111,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Arising from the anterior lobe of the hypophysis, pituitary neuroendocrine tumors (PitNETs), previously known as pituitary adenomas, constitute an intricate and heterogeneous entity. Although they are defined as benign pathology, these tumors can often invade neighboring structures and demonstrate aggressive behavior. The continuous advancement of molecular biology has begun to shed light on the genetic mutations behind the development and evolution of this pathology, providing a better understanding. Notwithstanding, the rising occurrence in recent decades can mainly be attributed to advanced diagnostic techniques; however, these tumors continue to increase in prevalence and incidence, creating a heavy burden on healthcare systems. Consequently, the need for further studies is dire, primarily due to a lack of tailored therapeutic approaches. Thus, this article aims to offer a brief overview of the molecular biology behind these complex tumors to contribute, even on a small scale, to more comprehensive care.<\/jats:p>","DOI":"10.3390\/ijms26083717","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T03:59:06Z","timestamp":1744689546000},"page":"3717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Brief Overview of Molecular Biology in Pituitary Adenomas with a Focus on Aggressive Lesions"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-5833","authenticated-orcid":false,"given":"Ligia Gabriela","family":"Tataranu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Neurosurgery, Bagdasar-Arseni Emergency Clinical Hospital, 041915 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1056\/NEJMra1810772","article-title":"Pituitary-Tumor Endocrinopathies","volume":"382","author":"Melmed","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013\u20132017","volume":"22","author":"Ostrom","year":"2020","journal-title":"Neuro Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/17446651.2022.2082942","article-title":"Recent advancements in the molecular biology of pituitary adenomas","volume":"17","author":"Zheng","year":"2022","journal-title":"Expert Rev. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ecl.2020.04.002","article-title":"The Epidemiology of Pituitary Adenomas","volume":"49","author":"Daly","year":"2020","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","article-title":"Overview of the 2022 WHO Classification of Pituitary Tumors","volume":"33","author":"Asa","year":"2022","journal-title":"Endocr. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"C5","DOI":"10.1530\/ERC-17-0004","article-title":"From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): An International Pituitary Pathology Club proposal","volume":"24","author":"Asa","year":"2017","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.4103\/0028-3886.287667","article-title":"Newer Concepts in the Classification of Pituitary Adenomas","volume":"68","author":"Sathyakumar","year":"2020","journal-title":"Neurol. India"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s11102-019-00988-2","article-title":"A tale of pituitary adenomas: To NET or not to NET: Pituitary Society position statement","volume":"22","author":"Ho","year":"2019","journal-title":"Pituitary"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.21037\/tcr-20-3446","article-title":"Pituitary adenoma or pituitary neuroendocrine tumor: A narrative review of controversy and perspective","volume":"10","author":"Liu","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S2213-8587(23)00382-0","article-title":"A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis","volume":"12","author":"Ho","year":"2024","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_11","first-page":"319","article-title":"Pituitary adenomas: An overview","volume":"88","author":"Lake","year":"2013","journal-title":"Am. Fam. Physician"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhan, X., and Desiderio, D.M. (2020). Editorial: Molecular Network Study of Pituitary Adenomas. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00026"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s13167-018-0128-8","article-title":"The crucial role of multiomic approach in cancer research and clinically relevant outcomes","volume":"9","author":"Lu","year":"2018","journal-title":"EPMA J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1878-5085-4-2","article-title":"Multi-parameter systematic strategies for predictive, preventive and personalised medicine in cancer","volume":"4","author":"Hu","year":"2013","journal-title":"EPMA J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13167-017-0083-9","article-title":"Pattern recognition for predictive, preventive, and personalized medicine in cancer","volume":"8","author":"Cheng","year":"2017","journal-title":"EPMA J."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chang, M., Yang, C., Bao, X., and Wang, R. (2020). Genetic and Epigenetic Causes of Pituitary Adenomas. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.596554"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dai, C., Kang, J., Liu, X., Yao, Y., Wang, H., and Wang, R. (2021). How to Classify and Define Pituitary Tumors: Recent Advances and Current Controversies. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.604644"},{"key":"ref_18","first-page":"610","article-title":"Pituitary adenomas with invasion of the cavernous sinus space: A magnetic resonance imaging classification compared with surgical findings","volume":"33","author":"Knosp","year":"1993","journal-title":"Neurosurgery"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11154-019-09531-x","article-title":"Definition and diagnosis of aggressive pituitary tumors","volume":"21","author":"Kasuki","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10014-021-00410-5","article-title":"Molecular, functional, and histopathological classification of the pituitary neuroendocrine neoplasms","volume":"38","author":"Inomoto","year":"2021","journal-title":"Brain Tumor Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-17-0796","article-title":"European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas","volume":"178","author":"Raverot","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.21037\/gs-20-873","article-title":"Diagnosis and treatment of refractory pituitary adenomas: A narrative review","volume":"10","author":"Liu","year":"2021","journal-title":"Gland Surgery"},{"key":"ref_23","first-page":"8","article-title":"Hereditary pituitary tumor syndromes: Genetic and clinical aspects","volume":"72","author":"Mercado","year":"2020","journal-title":"Rev. Investig. Clin."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/a-1143-5930","article-title":"Clinical and Molecular Update on Genetic Causes of Pituitary Adenomas","volume":"52","author":"Vasilev","year":"2020","journal-title":"Horm. Metab. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ecl.2020.05.005","article-title":"Update on the Genetics of Pituitary Tumors","volume":"49","author":"Barry","year":"2020","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1517\/14728220903170675","article-title":"Targeting MAPK (Ras\/ERK) and PI3K\/Akt pathways in pituitary tumorigenesis","volume":"13","author":"Cakir","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1677\/ERC-09-0101","article-title":"Activation of RAF\/MEK\/ERK and PI3K\/AKT\/mTOR pathways in pituitary adenomas and their effects on downstream effectors","volume":"16","author":"Dworakowska","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0065-230X(08)60765-4","article-title":"Signal transduction through MAP kinase cascades","volume":"74","author":"Lewis","year":"1998","journal-title":"Adv. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101392","DOI":"10.1016\/j.tranon.2022.101392","article-title":"Aminoacyl-tRNA synthetases of the multi-tRNA synthetase complex and their role in tumorigenesis","volume":"19","author":"Khan","year":"2022","journal-title":"Transl. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lamb, L.S., Sim, H.W., and McCormack, A.I. (2020). Exploring the Role of Novel Medical Therapies for Aggressive Pituitary Tumors: A Review of the Literature-\u201cAre We There Yet?\u201d. Cancers, 12.","DOI":"10.3390\/cancers12020308"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"A160","DOI":"10.1289\/ehp.114-a160","article-title":"Epigenetics: The science of change","volume":"114","author":"Weinhold","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.12659\/MSM.910608","article-title":"Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas","volume":"24","author":"Ma","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1507\/endocrj.K08E-082","article-title":"Epigenetic control in pituitary tumors","volume":"55","author":"Ezzat","year":"2008","journal-title":"Endocr. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02789395","article-title":"cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas","volume":"9","author":"Usui","year":"1997","journal-title":"J. Mol. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1677\/ERC-09-0008","article-title":"Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma","volume":"16","author":"Revill","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/sj.onc.1205195","article-title":"Preferential loss of Death Associated Protein kinase expression in invasive pituitary tumours is associated with either CpG island methylation or homozygous deletion","volume":"21","author":"Simpson","year":"2002","journal-title":"Oncogene"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/neuonc\/noac050","article-title":"Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors","volume":"24","author":"Herrgott","year":"2022","journal-title":"Neuro Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12020-014-0383-y","article-title":"Growth hormone tumor histological subtypes predict response to surgical and medical therapy","volume":"49","author":"Carlson","year":"2015","journal-title":"Endocrine"},{"key":"ref_39","first-page":"e28722","article-title":"A Comprehensive Review of Four Clinical Practice Guidelines of Acromegaly","volume":"14","author":"Ogedegbe","year":"2022","journal-title":"Cureus"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Syro, L.V., Rotondo, F., Ramirez, A., Di Ieva, A., Sav, M.A., Restrepo, L.M., Serna, C.A., and Kovacs, K. (2015). Progress in the Diagnosis and Classification of Pituitary Adenomas. Front. Endocrinol., 6.","DOI":"10.3389\/fendo.2015.00097"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5603\/EP.a2020.0090","article-title":"Pituitary transcription factors in the immunohistochemical and molecular diagnosis of pituitary tumours\u2014A systematic review","volume":"72","author":"Burcea","year":"2021","journal-title":"Endokrynol. Pol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.nec.2019.05.001","article-title":"Molecular Biology of Pituitary Adenomas","volume":"30","author":"Faltermeier","year":"2019","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1210\/jc.2017-02287","article-title":"Genomic Alterations and Complex Subclonal Architecture in Sporadic GH-Secreting Pituitary Adenomas","volume":"103","author":"Hage","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/cr.2016.114","article-title":"The genome-wide mutational landscape of pituitary adenomas","volume":"26","author":"Song","year":"2016","journal-title":"Cell Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1210\/jc.2015-3129","article-title":"Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas","volume":"100","author":"Demir","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/EJE-15-1064","article-title":"Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas","volume":"174","author":"Ronchi","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrendo.2014.181","article-title":"Genetic mutations in sporadic pituitary adenomas\u2014What to screen for?","volume":"11","author":"Lecoq","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/onc.2014.50","article-title":"AIP inactivation leads to pituitary tumorigenesis through defective G\u03b1i-cAMP signaling","volume":"34","author":"Tuominen","year":"2015","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bogus\u0142awska, A., and Korbonits, M. (2021). Genetics of Acromegaly and Gigantism. J. Clin. Med., 10.","DOI":"10.3390\/jcm10071377"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1017\/cjn.2021.170","article-title":"Somatotroph Adenoma with Dual Transcription Factor Expression","volume":"48","author":"Pejhan","year":"2021","journal-title":"Can. J. Neurol. Sci.\/J. Can. Sci. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/eje.0.1480203","article-title":"The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas","volume":"148","author":"Hunter","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"E3331","DOI":"10.1073\/pnas.1310589110","article-title":"Growth hormone is a cellular senescence target in pituitary and nonpituitary cells","volume":"110","author":"Chesnokova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12022-017-9498-z","article-title":"Overview of the 2017 WHO Classification of Pituitary Tumors","volume":"28","author":"Mete","year":"2017","journal-title":"Endocr. Pathol."},{"key":"ref_54","first-page":"4","article-title":"Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician","volume":"31","author":"Ezzat","year":"2015","journal-title":"Turk Patoloji Derg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000499382","article-title":"Clinical, Pathological, and Molecular Factors of Aggressiveness in Lactotroph Tumours","volume":"109","author":"Trouillas","year":"2019","journal-title":"Neuroendocrinology"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wierinckx, A., Delgrange, E., Bertolino, P., Fran\u00e7ois, P., Chanson, P., Jouanneau, E., Lachuer, J., Trouillas, J., and Raverot, G. (2018). Sex-Related Differences in Lactotroph Tumor Aggressiveness Are Associated With a Specific Gene-Expression Signature and Genome Instability. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00706"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12020-010-9341-5","article-title":"A case of fugitive acromegaly, initially presented as invasive prolactinoma","volume":"38","author":"Lim","year":"2010","journal-title":"Endocrine"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000495184","article-title":"Giant Prolactinomas","volume":"109","author":"Shimon","year":"2018","journal-title":"Neuroendocrinology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/jama.2016.19699","article-title":"Diagnosis and Treatment of Pituitary Adenomas: A Review","volume":"317","author":"Molitch","year":"2017","journal-title":"JAMA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13046-014-0056-y","article-title":"The expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: A study of 197 cases and indications for the medical therapy","volume":"33","author":"Wang","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s40618-017-0725-8","article-title":"Frequency of familial pituitary adenoma syndromes among patients with functioning pituitary adenomas in a reference outpatient clinic","volume":"40","author":"Marques","year":"2017","journal-title":"J. Endocrinol. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"104080","DOI":"10.1016\/j.lpm.2021.104080","article-title":"Prolactinomas","volume":"50","author":"Wildemberg","year":"2021","journal-title":"La Presse M\u00e9dicale"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e16594","DOI":"10.1097\/MD.0000000000016594","article-title":"Pheochromocytoma, paragangliomas, and pituitary adenoma: An unusual association in a patient with an SDHD mutation. Case report","volume":"98","author":"Lemelin","year":"2019","journal-title":"Medicine"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Cotton, E., and Ray, D. (2018). DICER1 mutation and pituitary prolactinoma. Endocrinol. Diabetes Metab. Case Rep., 2018.","DOI":"10.1530\/EDM-18-0087"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/humu.21292","article-title":"Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families","volume":"31","author":"Igreja","year":"2010","journal-title":"Hum. Mutat."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1530\/EC-17-0237","article-title":"AIP mutations in Brazilian patients with sporadic pituitary adenomas: A single-center evaluation","volume":"6","author":"Araujo","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1210\/jc.2009-1191","article-title":"Prognostic Factors in Prolactin Pituitary Tumors: Clinical, Histological, and Molecular Data from a Series of 94 Patients with a Long Postoperative Follow-Up","volume":"95","author":"Raverot","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Roche, M., Wierinckx, A., Croze, S., Rey, C., Legras-Lachuer, C., Morel, A.P., Fusco, A., Raverot, G., Trouillas, J., and Lachuer, J. (2015). Deregulation of miR-183 and KIAA0101 in Aggressive and Malignant Pituitary Tumors. Front. Med., 2.","DOI":"10.3389\/fmed.2015.00054"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1750-3639.2011.00476.x","article-title":"Integrated genomic profiling identifies loss of chromosome 11p impacting transcriptomic activity in aggressive pituitary PRL tumors","volume":"21","author":"Wierinckx","year":"2011","journal-title":"Brain Pathol."},{"key":"ref_70","first-page":"2398","article-title":"The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas","volume":"62","author":"Finelli","year":"2002","journal-title":"Cancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.lpm.2008.10.008","article-title":"Ad\u00e9nome corticotrope","volume":"38","author":"Guignat","year":"2009","journal-title":"La Presse M\u00e9dicale"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1097\/00000478-200310000-00005","article-title":"Crooke\u2019s cell adenoma of the pituitary: An aggressive variant of corticotroph adenoma","volume":"27","author":"George","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1227\/01.neu.0000429858.96652.1e","article-title":"A comprehensive long-term retrospective analysis of silent corticotrophic adenomas vs hormone-negative adenomas","volume":"73","author":"Jahangiri","year":"2013","journal-title":"Neurosurgery"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s40618-018-0901-5","article-title":"Advances and controversies in the classification and grading of pituitary tumors","volume":"42","author":"Laws","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Yamamoto, M., Nakao, T., Ogawa, W., and Fukuoka, H. (2021). Aggressive Cushing\u2019s Disease: Molecular Pathology and Its Therapeutic Approach. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.650791"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Liu, X., Feng, M., Dai, C., Bao, X., Deng, K., Yao, Y., and Wang, R. (2019). Expression of EGFR in Pituitary Corticotroph Adenomas and Its Relationship With Tumor Behavior. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00785"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"bqab167","DOI":"10.1210\/endocr\/bqab167","article-title":"Effect of 3 NR3C1 Mutations in the Pathogenesis of Pituitary ACTH Adenoma","volume":"162","author":"Miao","year":"2021","journal-title":"Endocrinology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12020-021-02903-x","article-title":"USP8, USP48, and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing\u2019s disease","volume":"75","author":"Abraham","year":"2022","journal-title":"Endocrine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1210\/clinem\/dgaa160","article-title":"Germline CDKN1B Loss-of-Function Variants Cause Pediatric Cushing\u2019s Disease With or Without an MEN4 Phenotype","volume":"105","author":"Chasseloup","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1073\/pnas.1306182110","article-title":"Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease","volume":"110","author":"Du","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nm.3776","article-title":"A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease","volume":"21","author":"Riebold","year":"2015","journal-title":"Nat. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s11102-017-0805-y","article-title":"Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke\u2019s cell morphology","volume":"20","author":"Garbicz","year":"2017","journal-title":"Pituitary"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/neuonc\/noz109","article-title":"Driver mutations in USP8 wild-type Cushing\u2019s disease","volume":"21","author":"Sbiera","year":"2019","journal-title":"Neuro Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1210\/clinem\/dgaa749","article-title":"Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations","volume":"106","author":"Boldt","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_85","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Thyrotropin-Secreting Pituitary Adenomas. Endotext, MDText.com, Inc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12022-015-9395-2","article-title":"Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism","volume":"27","author":"Pereira","year":"2016","journal-title":"Endocr. Pathol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1023\/A:1012917701756","article-title":"Thyrotropin-secreting pituitary adenomas. Clinical and biological heterogeneity and current treatment","volume":"54","author":"Sanno","year":"2001","journal-title":"J. Neurooncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/BF03343929","article-title":"Loss of heterozygosity of the MEN1 gene in a large series of TSH-secreting pituitary adenomas","volume":"24","author":"Asteria","year":"2001","journal-title":"J. Endocrinol. Investig."},{"key":"ref_89","first-page":"1134","article-title":"Screening of candidate oncogenes in human thyrotroph tumors: Absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes","volume":"81","author":"Dong","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"E373","DOI":"10.1210\/jc.2009-2556","article-title":"Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: An international collaborative study","volume":"95","author":"Daly","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/jc.2006-2702","article-title":"Mutations in the aryl hydrocarbon receptor interacting protein gene are not highly prevalent among subjects with sporadic pituitary adenomas","volume":"92","author":"Barlier","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccell.2019.11.002","article-title":"Pangenomic Classification of Pituitary Neuroendocrine Tumors","volume":"37","author":"Neou","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1210\/mend.15.9.0687","article-title":"Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance","volume":"15","author":"Ando","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/CM9.0000000000000184","article-title":"Functioning gonadotroph adenoma","volume":"132","author":"Zhao","year":"2019","journal-title":"Chin. Med. J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1227\/NEU.0000000000001188","article-title":"Functional Gonadotroph Adenomas: Case Series and Report of Literature","volume":"79","author":"Cote","year":"2016","journal-title":"Neurosurgery"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"24731","DOI":"10.1074\/jbc.M702029200","article-title":"Activation of p53 by MEG3 non-coding RNA","volume":"282","author":"Zhou","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1210\/jc.2014-2362","article-title":"Clinical review: Functioning gonadotroph adenomas","volume":"99","author":"Ntali","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_98","first-page":"EP867","article-title":"Null cell adenoma: Case report","volume":"90","author":"Lachkhem","year":"2023","journal-title":"Endocrine Abstracts"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12105-018-0972-9","article-title":"Null Cell Adenoma of the Pituitary: Pseudo-rosettes Say It Best When Immunohistochemistry Says Nothing At All!","volume":"13","author":"Singh","year":"2019","journal-title":"Head Neck Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"E796","DOI":"10.1210\/jc.2012-4028","article-title":"Whole-Exome Sequencing Studies of Nonfunctioning Pituitary Adenomas","volume":"98","author":"Newey","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/sj.onc.1207193","article-title":"Loss of expression of the growth inhibitory gene GADD45\u03b3, in human pituitary adenomas, is associated with CpG island methylation","volume":"23","author":"Bahar","year":"2004","journal-title":"Oncogene"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/(SICI)1098-2264(199904)24:4<328::AID-GCC6>3.0.CO;2-P","article-title":"Hypermethylation of the p16\/CDKN2A\/MTS1 gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas","volume":"24","author":"Simpson","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11102-010-0268-x","article-title":"MicroRNA profile indicates downregulation of the TGF\u03b2 pathway in sporadic non-functioning pituitary adenomas","volume":"14","author":"Butz","year":"2011","journal-title":"Pituitary"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Biagetti, B., and Sim\u00f2, R. (2022). Pituitary Apoplexy: Risk Factors and Underlying Molecular Mechanisms. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158721"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Gupta, P., and Dutta, P. (2018). Landscape of Molecular Events in Pituitary Apoplexy. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00107"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.3390\/ijms12064165","article-title":"TNF-\u03b1-induced VEGF and MMP-9 expression promotes hemorrhagic transformation in pituitary adenomas","volume":"12","author":"Xiao","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_107","first-page":"1457","article-title":"Hypoxia induces hemorrhagic transformation in pituitary adenomas via the HIF-1\u03b1 signaling pathway","volume":"26","author":"Xiao","year":"2011","journal-title":"Oncol. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/ERC-11-0211","article-title":"RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells","volume":"19","author":"Shan","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jocn.2008.02.012","article-title":"Clinical features and immunohistochemical changes of pituitary apoplexy","volume":"16","author":"Mou","year":"2009","journal-title":"J. Clin. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jocn.2015.02.021","article-title":"Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-2: Prognostic biological markers in invasive prolactinomas","volume":"22","author":"Vural","year":"2015","journal-title":"J. Clin. Neurosci."},{"key":"ref_111","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Non-Functioning Pituitary Adenomas. Endotext, MDText.com, Inc."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/8\/3717\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:14:36Z","timestamp":1760030076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/8\/3717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":111,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26083717"],"URL":"https:\/\/doi.org\/10.3390\/ijms26083717","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]}}}